Fluorescent probes of the orientation of myosin regulatory light chains in relaxed, rigor, and contracting muscle.

The orientation of the light-chain region of myosin heads in relaxed, rigor, and isometrically contracting fibers from rabbit psoas muscle was studied by fluorescence polarization. Cysteine 108 of chicken gizzard myosin regulatory light chain (cgRLC) was covalently modified with iodoacetamidotetramethylrhodamine (iodo-ATR). Native RLC of single glycerinated muscle fibers was exchanged for labeled cgRLC in a low [Mg2+] rigor solution at 30 degrees C. Troponin and troponin C removed in this procedure were replaced. RLC exchange had little effect on active force production. X-ray diffraction showed normal structure in rigor after RLC exchange, but loss of axial and helical order in relaxation. In isolated myofibrils labeled cgRLC was confined to the regions of the sarcomere containing myosin heads. The ATR dipoles showed a preference for orientations perpendicular to the fiber axis, combined with limited nanosecond rotational motion, in all conditions studied. The perpendicular orientation preference was more marked in rigor than in either relaxation or active contraction. Stretching relaxed fibers to sarcomere length 4 microns to eliminate overlap between actin- and myosin-containing filaments had little effect on the orientation preference. There was no change in orientation preference when fibers were put into rigor at sarcomere length 4.0 microns. Qualitatively similar results were obtained with ATR-labeled rabbit skeletal RLC

Swinburne and the Novel

This study examines Algernon Charles Swinburne’s work as a critic and creator of prose fiction, arguing that it deserves to play a larger role than it has done hitherto in our understanding of him as a writer. It considers a wide range of Swinburne’s prose, situating it in the intellectual movements of his time, and identifying recurrent themes and interests. Finally, it makes a case for a broader view of Swinburne that includes his literary criticism and imaginative prose. The first chapter discusses Swinburne’s prescient criticism of the Brontës and his suggestion that the novel ought to aspire to the status of high art. The second chapter reviews Swinburne’s assessment of Wilkie Collins, which uses the language of the stage to draw comparisons between sensation fiction and drama. Turning to Swinburne’s continental European influences, the third chapter establishes Baudelaire and Hugo as inspirations for Swinburne’s theory of aesthetic practice, though neither directly shaped his serious prose fiction. Gautier’s Mademoiselle de Maupin, which had a much more direct impact through its promotion of sexual and aesthetic autonomy, is discussed in Chapter Four. The fifth chapter studies Boccaccio and The Decameron as a significant source for Swinburne’s proposed Triameron and its surviving short stories. The sixth and seventh chapters focus on Laclos and Balzac, arguably the greatest influences on Swinburne’s novels. Laclos’s epistolary fiction and Balzac’s cycle of interlocking tales are immensely important for Swinburne’s theory of the novel and for his novels themselves. Chapter Eight is an extended study of Swinburne’s novel A Year’s Letters, which displays innovative epistolary form and incisive character studies. Chapter Nine interrogates Lesbia Brandon as a meditation on the youth of a poet and an avant-garde example of Swinburne’s hybrid, poetic prose.This thesis is not currently available on ORA

Sybil Or the Two Nations

Disraeli vividly depicts the appalling conditions of the poor-their pitiful wages, their miserably overcrowded tenements, and their exploitation by the new breed of powerful industrialists-as an indirect plea for social and political reform and for the fulfilment of his dream of a new, more democratic England.Cover -- OXFORD WORLD'S CLASSICS: BENJAMIN DISRAELI: SYBIL OR THE TWO NATIONS -- COPYRIGHT -- CONTENTS -- INTRODUCTION -- NOTE ON THE TEXT -- SELECT BIBLIOGRAPHY -- Life and Letters -- Historical and Political Background -- Critical Studies -- A CHRONOLOGY OF BINJAMIN DISRAELI -- SYBIL -- OR, THE TWO NATIONS. BY B. DISRAELI, M.P. -- ADVERTISEMENT -- VOLUME I -- BOOK I. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- BOOK II. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- Chapter VII. -- Chapter VIII. -- Chapter IX. -- Chapter X. -- Chapter XI. -- Chapter XII. -- Chapter XIII. -- Chapter XIV. -- Chapter XV. -- Chapter XVI. -- VOLUME II -- BOOK III. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- Chapter VII. -- Chapter VIII. -- Chapter IX. -- Chapter X. -- BOOK IV. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- Chapter VII. -- Chapter VIII. -- Chapter IX. -- Chapter X. -- Chapter XI. -- Chapter XII. -- Chapter XIII. -- Chapter XIV. -- Chapter XV. -- VOLUME III -- BOOK V. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- Chapter VII. -- Chapter VIII. -- Chapter IX. -- Chapter X. -- Chapter XI. -- BOOK VI. -- Chapter I. -- Chapter II. -- Chapter III. -- Chapter IV. -- Chapter V. -- Chapter VI. -- Chapter VII. -- Chapter VIII. -- Chapter IX. -- Chapter X. -- Chapter XI. -- Chapter XII. -- Chapter XIII. -- EXPLANATORY NOTES -- TITLE PAGE, DEDICATION, AND ADVERTISEMENT -- BOOK I -- BOOK II -- BOOK III -- BOOK IV -- BOOK V -- BOOK VI -- MORE ABOUT OXFORD WORLD'S CLASSICS -- MORE ABOUT OXFORD WORLD'S CLASSICS -- A SELECTION OF OXFORD WORLD'S CLASSICS -- A SELECTION OF OXFORD WORLD'S CLASSICSDisraeli vividly depicts the appalling conditions of the poor-their pitiful wages, their miserably overcrowded tenements, and their exploitation by the new breed of powerful industrialists-as an indirect plea for social and political reform and for the fulfilment of his dream of a new, more democratic England.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

A visionary among the radicals : William Blake and the circle of Joseph Johnson, 1790-95

Blake’s critics have never attempted to illustrate in a systematic manner how Blake used information he learned from writings published by members of the circle of Joseph Johnson in his own works during the period 1790-95. Although Blake was a peripheral figure in the Johnson circle – known to them through his profession of engraving and marginalized on account of his social position and lack of university education – his works reveal a continuing engagement with topics addressed in the writings of authors associated with Johnson, perhaps signifying Blake’s desire to be recognized as an author participating, like them, in the literary deliberations of the public sphere. Chapter 1, ‘Blake, Priestley and Swedenborg’, examines Blake’s treatment in The Marriage of Heaven and Hell of body and soul, the natures of God and Jesus Christ, and Swedenborgianism in relation to Joseph Priestley’s History of the Corruptions of Christianity (1782) and Letters to the Members of The New Jerusalem Church (1791). Chapter 2, ‘The Voice of a Devil and the Printing House in Hell’, considers The Marriage as an attempt to join the Revolution controversy and compares this work with writings by Richard Price, Mary Wollstonecraft and Thomas Paine. Chapter 2 also assesses the relationship between The Marriage and radical diabolism and Blake’s engagement with ‘energy’ as a distinctively radical concept in the work of Erasmus Darwin, Henry Fuseli, William Godwin, Priestley and Mary Wollstonecraft. Chapter 3, ‘Topical Representations in The French Revolution’, considers Blake’s engagement with Edmund Burke’s Reflections on the Revolution in France (1790) and the Bastille in relation to responses to Reflections by Wollstonecraft, Paine and other authors published by Johnson. Chapter 3 concludes with an analysis of the response The French Revolution might have elicited from the Analytical Review. Chapter 4, ‘The French Revolution and Three Contemporary Discourses’, approaches this poem in terms of the discourses of ancient liberty, nature and the sublime, once again in comparison with responses to Reflections by members of the Johnson circle. My discussion of the sublime considers the possible influence on The French Revolution of Burke’s Philosophical Enquiry into the Origin of our Ideas of the Sublime and Beautiful (1757) and Bishop Robert Lowth’s Lectures on the Sacred Poetry of the Hebrews (1787). Chapter 5, ‘The Continental Prophecies: Prophetic Form and Contemporary Prophecy’, examines America, Europe and The Song of Los in relation to writings concerning prophecy published by Johnson (with special emphasis on Lowth’s Lectures and Priestley’s 1793 and 1794 Fast Day sermons). The second part of Chapter 5 compares aspects of the works of Blake and Richard Brothers with Priestley’s Fast Day sermons, suggesting that Priestley and Blake’s works of 1793 and 1794 are rather less dissimilar than traditionally assumed. Chapter 6, ‘Blake’s “Bible of Hell” and Contemporary Critics of the Bible’, discusses Urizen, The Book of Ahania and The Book of Los in light of biblical criticism from the 1780s and 1790s (with particular reference to the Analytical and the writings of Alexander Geddes, Priestley and Paine). The final section of Chapter 6 reads Ahania in terms of the contemporary debate regarding the doctrine of the Atonement. The Conclusion, ‘ “melting apparent surfaces away”: Continuities in the Thought of Priestley and Blake’, revisits my discussion in Chapter 5 of similarities between Priestley and Blake and proposes that they are not so far apart in ideas and the content of their works as modern scholars usually argue.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The 'Aesthetics of Personalism' in Caryl Phillips's Writing: Complexity as a New Brand of Humanism

This paper attempts to underline the epistemological implications of Phillips's handling of diasporic history through a focus on individual lives in Cambridge (1991) and The Nature of Blood (1997). His confessional first-person narratives highlight the intricacies inherent in human nature, thereby resisting the globalizing discourse of liberal humanism. Even more importantly, his fictions seem to illustrate a new, more understanding approach to this often hackneyed term, for they give voice to individuals whose multiple differences are, paradoxically, part proof of a common humanity, viewed here as an inclusive rather than exclusive concept

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