2,118 research outputs found
Random matrix models with log-singular level confinement: method of fictitious fermions
Joint distribution function of N eigenvalues of U(N) invariant random-matrix
ensemble can be interpreted as a probability density to find N fictitious
non-interacting fermions to be confined in a one-dimensional space. Within this
picture a general formalism is developed to study the eigenvalue correlations
in non-Gaussian ensembles of large random matrices possessing non-monotonic,
log-singular level confinement. An effective one-particle Schroedinger equation
for wave-functions of fictitious fermions is derived. It is shown that
eigenvalue correlations are completely determined by the Dyson's density of
states and by the parameter of the logarithmic singularity. Closed analytical
expressions for the two-point kernel in the origin, bulk, and soft-edge scaling
limits are deduced in a unified way, and novel universal correlations are
predicted near the end point of the single spectrum support.Comment: 13 pages (latex), Presented at the MINERVA Workshop on Mesoscopics,
Fractals and Neural Networks, Eilat, Israel, March 199
Zeros of linear combinations of Laguerre polynomials from different sequences
We study interlacing properties of the zeros of two types of linear
combinations of Laguerre polynomials with different parameters, namely
and .
Proofs and numerical counterexamples are given in situations where the zeros of
, and , respectively, interlace (or do not in general) with the zeros
of , , or . The results we prove hold
for continuous, as well as integral, shifts of the parameter
Cefazolin Prophylaxis for Total Joint Arthroplasty: Obese Patients Are Frequently Underdosed and at Increased Risk of Periprosthetic Joint Infection
Background
One of the most effective prophylactic strategies against periprosthetic joint infection (PJI) is administration of perioperative antibiotics. Many orthopedic surgeons are unaware of the weight-based dosing protocol for cefazolin. This study aimed at elucidating what proportion of patients receiving cefazolin prophylaxis are underdosed and whether this increases the risk of PJI.
Methods
A retrospective study of 17,393 primary total joint arthroplasties receiving cefazolin as perioperative prophylaxis from 2005 to 2017 was performed. Patients were stratified into 2 groups (underdosed and adequately dosed) based on patient weight and antibiotic dosage. Patients who developed PJI within 1 year following index procedure were identified. A bivariate and multiple logistic regression analyses were performed to control for potential confounders and identify risk factors for PJI.
Results
The majority of patients weighing greater than 120 kg (95.9%, 944/984) were underdosed. Underdosed patients had a higher rate of PJI at 1 year compared with adequately dosed patients (1.51% vs 0.86%, P = .002). Patients weighing greater than 120 kg had higher 1-year PJI rate than patients weighing less than 120 kg (3.25% vs 0.83%, P < .001). Patients who were underdosed (odds ratio, 1.665; P = .006) with greater comorbidities (odds ratio, 1.259; P < .001) were more likely to develop PJI at 1 year.
Conclusion
Cefazolin underdosing is common, especially for patients weighing more than 120 kg. Our study reports that underdosed patients were more likely to develop PJI. Orthopedic surgeons should pay attention to the weight-based dosing of antibiotics in the perioperative period to avoid increasing risk of PJI
Solving moment problems by dimensional extension
The first part of this paper is devoted to an analysis of moment problems in
R^n with supports contained in a closed set defined by finitely many polynomial
inequalities. The second part of the paper uses the representation results of
positive functionals on certain spaces of rational functions developed in the
first part, for decomposing a polynomial which is positive on such a
semi-algebraic set into a canonical sum of squares of rational functions times
explicit multipliers.Comment: 21 pages, published version, abstract added in migratio
Aging on the edge of stability in disordered systems
Many complex and disordered systems fail to reach equilibrium after they have
been quenched or perturbed. Instead, they sluggishly relax toward equilibrium
at an ever-slowing, history-dependent rate, a process termed physical aging.
The microscopic processes underlying the dynamic slow-down during aging and the
reason for its similar occurrence in different systems remain poorly
understood. Here, through experiments in crumpled sheets and simulations of a
minimal mechanical model - a disordered network of bi-stable elastic elements -
we reveal the structural mechanism underlying logarithmic aging in this system.
We show that under load, the system self-organizes to a metastable state poised
on the verge of an instability, where it can remain for long, but finite times.
The system's relaxation is intermittent, advancing via rapid sequences of
instabilities, grouped into self-similar, aging avalanches. Crucially, the
quiescent dwell times between avalanches grow in proportion to the system's
age, due to a slow increase of the lowest effective energy barrier. This
slow-down leads to an overall logarithmic aging process.Comment: 7 pages, 3 figure
Tension-controlled switch between collective actuations in active solids
The recent finding of collective actuation in active solids, namely solids
embedded with active units, opens the path towards multifunctional materials
with genuine autonomy. In such systems, collective dynamics emerge
spontaneously and little is known about the way to control or drive them. Here,
we combine the experimental study of centimetric model active solids, the
numerical study of an agent based model and theoretical arguments to reveal how
mechanical tension can serve as a general mechanism for switching between
different collective actuation regimes in active solids. We further show the
existence of a hysteresis when varying back and forth mechanical tension,
highlighting the non-trivial selectivity of collective actuations.Comment: 5 pages, 4 figure
Nonrelativistic Particle in Free Random Gauge Background
The problem of a nonrelativistic particle with an internal color degree of
freedom, with and without spin, moving in a free random gauge background is
discussed. Freeness is a concept developed recently in the mathematical
literature connected with noncommuting random variables. In the context of
large-N hermitian matrices, it means that the the multi-matrix model considered
contains no bias with respect to the relative orientations of the matrices. In
such a gauge background, the spectrum of a colored particle can be solved for
analytically. In three dimensions, near zero momentum, the energy distribution
for the spinless particle displays a gap, while the energy distribution for the
particle with spin does not.Comment: 20 pages, 6 figure
Entanglement and nonclassicality for multi-mode radiation field states
Nonclassicality in the sense of quantum optics is a prerequisite for
entanglement in multi-mode radiation states. In this work we bring out the
possibilities of passing from the former to the latter, via action of
classicality preserving systems like beamsplitters, in a transparent manner.
For single mode states, a complete description of nonclassicality is available
via the classical theory of moments, as a set of necessary and sufficient
conditions on the photon number distribution. We show that when the mode is
coupled to an ancilla in any coherent state, and the system is then acted upon
by a beamsplitter, these conditions turn exactly into signatures of NPT
entanglement of the output state. Since the classical moment problem does not
generalize to two or more modes, we turn in these cases to other familiar
sufficient but not necessary conditions for nonclassicality, namely the Mandel
parameter criterion and its extensions. We generalize the Mandel matrix from
one-mode states to the two-mode situation, leading to a natural classification
of states with varying levels of nonclassicality. For two--mode states we
present a single test that can, if successful, simultaneously show
nonclassicality as well as NPT entanglement. We also develop a test for NPT
entanglement after beamsplitter action on a nonclassical state, tracing
carefully the way in which it goes beyond the Mandel nonclassicality test. The
result of three--mode beamsplitter action after coupling to an ancilla in the
ground state is treated in the same spirit. The concept of genuine tripartite
entanglement, and scalar measures of nonclassicality at the Mandel level for
two-mode systems, are discussed. Numerous examples illustrating all these
concepts are presented.Comment: Latex, 46 page
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