Android Based Employee Absence and Leaving Application Information System

Attendance in general is the recording of employee attendance and is one aspect of assessment in a company. The purposes of this study are finding out how employees can apply for leave and how to design and build an Android-based attendance system application. Data collection methods that used in this research include observation, interviews and literature study. The system development method that will be used is the System Development Life Cycle (SDLC) model of the Waterfall. With this system, employees and companies will be helped in the problem of absence and leave. The company will get accurate, fast and precise data in decision making. &nbsp

UPAYA GURU PENDIDIKAN AKHLAK DALAM MENINGKATKAN PRESTASI BELAJAR ANAK YATIM (Studi Kasus di Pondok Pesantren Darul Marhamah Lil Aitam Desa Sukamantri Kecamatan Tamansari Kabupaten Bogor)

Anak yatim sama halnya dengan anak lain pada umumnya, yaitu membutuhkan perhatian orangtuanya termasuk membutuhkan pendidikan. Berdasarkan rasionalitas tersebut, tujuan penelitian adalah untuk mendiskripsikan dan menjelaskan kurikulum yang diterapkan guru  pendidikan akhlak, mendiskripsikan dan menjelaskan upaya-upaya guru pendidikan akhlak, serta untuk mendiskripsikan dan menjelaskan faktor pendukung dan penghambat terhadap peningkatan prestasi belajar  anak yatim. Penelitian ini merupakan penelitian kualitatif studi kasus. Teknik pengumpulan data penelitian ini adalah wawancara, observasi, dan studi dokumen. Sedangkan tempat penelitian di Pesantren Darul Marhamah Lil Aitam Desa Sukamantri Kecamatan Tamansari Kabupaten Bogor. Adapun hasil penelitiannya sebagai berikut: Pertama, kurikulum pembelajaran di Pesantren Darul Marhamah Lil Aitam menggunakan kurikulum mandiri. Kedua, upaya guru Pendidikan Akhlak dalam meningkatkan prestasi belajar anak yatim antara lain menggunakan metode-metode yang dapat disesuaikan dengan materi pembelajaran, memotivasi dengan memberikan kisah-kisah teladan para nabi dan sahabat, membuat halaqah (kelompok belajar), memberikan pertanyaan-pertanyaan yang dapat merangsang keaktifan siswa, dan menetapkan Kriteria Ketuntasan Minimal (KKM) minimal tujuh koma lima (7,5). Ketiga, faktor pendukung yang mempengaruhi prestasi belajar anak yatim antara lain prasarana yang memadai, dan adanya tambahan jam belajar. Keempat, faktor penghambat yang mempengaruhi prestasi belajar anak yatim antara lain terbatasnya tenaga pengajar, sarana yang belum memadai, dan masalah psikologis anak.      Kata kunci: upaya guru, pendidikan akhlak

JSPS-9 Microbiologial Quality of Chicken Carcasses in Bogor Indonesia Based on Campylobater sp. and Salmonella sp. Counts

Unhygienic handling chicken carcasses during slaughtering until selling to costumers can lead to contamination by pathogenic bacteria such as Campylobacter sp., and Salmonella sp. entering human’s body can cause foodborne diseaseThe aims of this study were to detect contamination and enumuration of Campylobacter sp, and Salmonella sp. in chicken carcasses from poultry slauhterhouses and markets in Bogor Indonesia

PENGARUH MOTIVASI DAN TINGKAT KECEMASAN TERHADAP PEMECAHAN SOAL MATEMATIKA

Penelitian ini bertujuan untuk mengetahui pengaruh motivasi dan tingkat kecemasan siswa terhadap pemecahan soal matematika.Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif dengan tujuan untuk menguji hipotesis yang telah ditetapkan dan desain penelitian yang digunakan yaitu penelitian korelasional. Teknik pengambilan sampel yang digunakan adalah cluster random sampling yang menghasilkan kelas V SD N 2 Bendan Pete menjadi subjek penelitian dengan sampel berjumlah 17 siswa. Instrumen yang digunakan dalam penelitian ini adalah angket motivasi belajar,angket tingkat kecemasan dan tes soal pemecahan matematika.Metode pengumpulan data dilakukan melalui tes dan angket.Berdasarkan analisis regresi linear sederhana diperoleh Y= 74,145+ (-0,025X1)+ 0,028 X2 disederhanakan menjadi Y= 74,145-0,025X1+0,028X2.yang artinya nilai α = 74,145. Nilai β1 = -0,025 . Artinya dengan asumsi tingkat kecemasan siswa (tidak berubah), maka setiap peningkatan tingkat kecemasan sebesar 1 satuan maka akan mengurangi kemampuan pemecahan soal matematika pada siswa sebesar (-0,025) Hasil ini tidak signifikan pada alpha 5% Nilai β2 = 0.028 Artinya dengan asumsi motivasi bernilai tetap (tidak berubah), maka setiap peningkatan motivasi sebesar 1 Satuan akan meningkatkan kemampuan matematis siswa sebesar 0,028 . Hasil ini tidak signifikan pada Alpha 5%. Kata Kunci: Motivasi; Tingkat Kecemasan Pemecahan Soal Matematika

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

SARS-CoV-2オミクロンBA.2.75株（通称ケンタウロス）のウイルス学的性状の解明. 京都大学プレスリリース. 2022-10-12.The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5

Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions

PELAKSANAAN PEMBERIAN HAK ATAS TANAH BAGI PERUSAHAAN DI KAWASAN INDUSTRI TERBOYO KOTA SEMARANG

Pembangunan yang dilaksanakan di Kota Semarang, khususnya yang bersifat fisik diharapkan membawa dampak positif yang menunjang tercapainya pembangunan di sektor lainnya, seperti sektor ekonomi, sosial, budaya dan sebagainya. Diantara kedua sektor pembangunan tersebut, yaitu sektor fisik dan non fisik terdapat keterkaitan yang sating menunjang satu sama lain. Seiring dengan bertambahnya jumlah penduduk, luas tanah yang tersedia semakin terbatas, sedangkan kebutuhan akan tanah semakin meningkat. Maka Pemerintah mengusahakan agar setiap daerah mempunyai Rencan Tata Ruang Wilayah (RTRW), sehingga dalam pemanfaatan tanah untuk setiap kepentingan dapat dilaksanakan secara terpadu, berdaya guna dan berhasil guna, serasi, selaras dan secara optimal, sebagaimana yang disyaratkan oleh Undang-undang No.24 Tahun 1992 tentang Penataan Ruang. RTRW Kota Semarang sebagaimana telah diuraikan tersebut di atas menjadi pedoman untuk penetapan lokasi investasi oleh pihak Pemerintah, swasta mauptm masyarakat, terutama para investor yang akan melakukan kegiatan industri di Kota Semarang. RTRW tersebut juga menjadi pedoman untuk penerbitan izin lokasi bagi perusahaan yang akan menjalankan kegiatan perindustrian di Kota Semarang. Izin lokasi diberikan kepada investor, yang berisi rencana penggunaan lahan dalam suatu wilayah tertentu dengan maksud untuk pembebasan hak atas tanah yang pelaksanaannya sesuai dengan Rericana Tata Ruang Wilayah setempat. Dalam pelaksanaan kegiatan perolehan tanah, pemerintah dapat ikut berpartisipasi apabila diminta oleh para pihak yaitu Pimpinan Proyek dan pemilik tanah. Setelalt kegiatan perolehan tanah selesai dilaksanakan, maka perusahaan wajib mengajukan permohonan untuk mendapatkan hak atas tanah. Pemohon hams bersedia untuk mematuhi syarat-syarat yang ditetapkan dalam Surat Keputusan Pemberian Hak (SKPH). Adapun It atas tanah yang diberikan untuk perusahaan yang menjalankan kegiatan perindustrian terbatas pada Hak Guna Bangunan (HGB), seperti ketentuan dalam Pasal 3 Peraturan Menteri Agraria (Permenagria) No.2 Tahun 1997 tentang Perolehan Izin Lokasi dan Hak Guna Bangunan Bagi Perusahaan Kawasan Industri dan Perusahaan Industri. The development conducted in Semarang, especially physical development is hoped causing positives impact to support the achievement of the development of the other sectors, e.g. economics, social and cultural sector. Between the two sectors of development, i.e. physical and non-physical sector, there are connections that support one another. As the population grows, the width of land available becomes limited, while the necessity of land becomes larger. Thus, the Government had done some efforts in order every region has its own RTRW (Rencana Tata Ruang Wilayah), so that the use of land for every purpose can be conducted integratedly, efficiently, harmoniously and optimally as required in UU No. 24 Tahun 1992 about Penataan Ruang. RTRW in Semarang becomes the orientation to decide the location of the infestation that will be done by the Government, private or society who wants to have business in Semarang. RTRW also becomes orientation to publish permission for any company that will have industrial business in Semarang. The permission of location given to the investors contains the use of land planning in a certain region, with the purpose to give them liberation of rights on the land, which the operation should be consistent with the local RTRW. In the process to get the land, the Government can participate if the head of project or the owner the land asks. After the process to get the land finish, the company should registries for the permission to get rights on land. The registrant should obey the prerequirements ruled in Surat Keputusan Pemberton Hak (SKPH). However, the rights on land given to the company conducting industry is limited on flak Guna 13angunan (11GB), as ruled on Pasal 3 Peraturan Menteri Agraria (Permenagria) No. 2 Tahun 1997 about Perolehan Ijin Lokasi dun Hak Guna Bangunan Bagi Perusahaan Kawasan Industri clan Perusahaan Industri

Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation.

Because pigs are intermediate or amplifying hosts for several zoonotic viruses, the pig-derived PK-15 cell line is an indispensable tool for studying viral pathogenicity and developing treatments, vaccines, and preventive measures to mitigate the risk of disease outbreaks. However, we must consider the possibility of contamination by type I interferons (IFNs), such as IFNα and IFNβ, or IFN-inducing substances, such as virus-derived double-stranded RNA or bacterial lipopolysaccharides, in clinical samples, leading to lower rates of viral isolation. In this study, we aimed to generate a PK-15 cell line that can be used to isolate viruses from clinical samples carrying a risk of contamination by IFN-inducing substances. To this end, we depleted the IFN alpha and beta receptor subunit 1 (Ifnar1) gene or signal transducer and activator of transcription 2 (Stat2) gene in PK-15 cells using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 method. Treatment of PK-15 cells lacking Ifnar1 or Stat2 with IFNβ or poly (I:C) resulted in no inhibitory effects on viral infection by a lentiviral vector, influenza virus, and Akabane virus. These results demonstrate that PK-15 cells lacking Ifnar1 or Stat2 could represent a valuable and promising tool for viral isolation, vaccine production, and virological investigations