11 research outputs found
A influência do padrão de aleitamento no desenvolvimento de hábitos de sucção não nutritivos na primeira infância
- Author
- Aarts C
- Adair SM
- Alessandro Leite Cavalcanti
- Aravena P
- Aznar T
- Bayardo RE
- Caglar E
- Carrascoza KC
- Ganesh M
- Hanna JC
- Infante PF
- Johnson ED
- Lande B
- Larson E
- Legovic M
- López Del Valle LM
- Meyers A
- Monguilhott LMJ
- Paunio P
- Poyac J
- Ricardo Cavalcanti Duarte
- Sabrina Sales Lins de Albuquerque
- Senarath U
- Serra-Negra JMC
- Shoaf HK
- Silva Filho OG
- Solis CEM
- Turgeon-O'Brien H
- Viggiano D
- Warren JJ
- Zardetto CG
- Érika de Morais Beltrão
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Portable chlorophyll meter for the quantification of photosynthetic pigments, nitrogen and the possible use for assessment of the photochemical process in Carica papaya L.
- Author
- Alena Torres Netto
- Allen JF
- Arnon DI
- Balasubramanian V
- Bilger W
- Björkman O
- Bolhàr-Nordenkampf HR
- Brown SB
- Bruinsma J
- Buckland SM
- Eliemar Campostrini
- Govindjee
- Havaux M
- Hendry GAF
- Hiscox JD
- Inskeep WP
- Jackson ML
- Jurandi Gonçalves de Oliveira
- Krause GH
- Krause GH
- Lichtenthaler HK
- Maquard RD
- Marini RP
- Mckinney G
- Miranda V
- Mohammed GH
- Moran R
- Moran R
- Osvaldo Kiyoshi Yamanishi
- Peng S
- Rohacek K
- Schaper H
- Schreiber U
- Schreiber U
- Schreiber U
- Shimizu T
- Shoaf TW
- Smeal D
- Smille RM
- Strant M
- Van Kooten O
- Wellburn AR
- Wolf FT
- Ögren E
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Criteria for Hyponatremic Overcorrection: Systematic Review and Cohort Study of Emergently Ill Patients
- Author
- A Jahangiri
- A Romanovsky
- A Soupart
- A Upadhyay
- Abdulla K. Salahudeen
- B Winzeler
- C Rafat
- Carl van Walraven
- Frank L. Ward
- G Kim
- G Spasovski
- HK Mohmand
- Jason C. George
- Jason D. Woodfine
- JC Ayus
- JCQ Velez
- JG Verbalis
- JG Verbalis
- JH Morris
- JK Ghali
- JR Chiong
- JW Lohr
- K Cheung
- L Sood
- LM Castello
- M Peters
- MA Crook
- MA Katz
- RW Schrier
- SE Shoaf
- T Byrt
- TE MacMillan
- V Burst
- V Burst
- WT Abraham
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evaluation and Comparison between Formocresol and Sodium Hypochlorite as Pulpotomy Medicament: A Randomized Study
- Author
- Clegg MS Vertucci FJ, Walker C, Belanger M, Britto LR.
- Doyle WA McDonald RE, Mitchell DF.
- Gopikrishna V.
- Hafez AA Kopel HM, Cox CF.
- Ingle JI Bakland LK, Baumgartner JC.
- Kuo HY Lin JR, Huang WH, Chiang ML.
- Myers DR Shoaf HK, Dirksen TR, Pashley DH, Whitford GM, Reynolds KE.
- Pashley EL Myers DR, Pashley DH, Whitford GM.
- Ranly DM.
- Ranly DM.
- Redig DF.
- Rosenfeld EF James GA, Burch BS.
- Sweet CA.
- Vargas KG Packham B, Lowman D.
- Vostatek SF Kanellis MJ, Weber-Gasparoni K, Gregorsok RL.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Effects of a synbiotic on fecal quality, short-chain fatty acid concentrations, and the microbiome of healthy sled dogs
- Author
- AH Sparkes
- BL Pool-Zobel
- D O’Mahony
- Dawn A Brown
- E McKenzie
- EA Flickinger
- F Shanahan
- G Moxham
- George C Fahey
- GH Cantor
- GR Gibson
- HE Banse
- HK Herstad
- IS Middelbos
- Jason W Gagné
- JF Garcia-Mazcorro
- Joseph J Wakshlag
- JS Weese
- JS Weese
- K Shoaf
- KA Barry
- Kelly S Swanson
- Kenneth W Simpson
- Kit Brown
- KS Swanson
- KS Swanson
- KS Swanson
- KS Swanson
- M Chrzastowska
- MLA Baillon
- N Berghoff
- P Gourbeyre
- R Barker
- RA Rastall
- RD Long
- RL Kelley
- Scot E Dowd
- Shalini Latchman
- SM Collins
- SN Sauter
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The impact of behavior on the risk of injury and death during an earthquake: a simulation-based study
- Author
- A Salamon
- A Salamon
- AE Sanders
- ATC-13
- B Gulati
- CA Kircher
- CA Kircher
- FH Norris
- G Chock
- G Prati
- G Shenhar
- H Chaulagain
- HH Wei
- HK Armenian
- J Badal
- JW Remo
- K Jaiswal
- KA Korkmaz
- KI Shoaf
- KW Campbell
- Limor Aharonson-Daniel
- M Bruneau
- M Nastev
- M Wyss
- M Zohar
- MC Roces
- MK Lindell
- RI Glass
- RN Nof
- RT Eguchi
- S Cutter
- S Doocy
- S Doocy
- S Marco
- S Shapira
- SE Chang
- SK Huang
- SK Ploeger
- SL Cutter
- Stav Shapira
- T Levi
- Tsafrir Levi
- U Hancilar
- UNISDR (United Nations International Strategy for Disaster Reduction)
- V Pinsky
- W Donner
- Y Hamiel
- Y Osaki
- Y Wang
- Yaron Bar-Dayan
- YJ Chou
- Z Garfunkel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Drugs’ development in acute heart failure: what went wrong?
- Author
- A Lala
- A Louis
- A Mallick
- A Mebazaa
- A Mebazaa
- A Mebazaa
- A Nohria
- A Singh
- A Wada
- Alex Matter
- America HFSO
- AP Coletta
- AP Davie
- AS Maisel
- B Schmidt
- B Ziaeian
- BA Borlaug
- BA Davison
- BM Massie
- C Miller-Davis
- CJ Allen
- CM O'Connor
- CM O'Connor
- CP Harkin
- D Bani
- D Elsner
- D Farmakis
- DC Kuo
- Deborah Chen
- DG Soergel
- DN Cruz
- DO Debrah
- E Bradley
- E Brass
- E Masini
- E Monnet
- F Follath
- F Zannad
- FA Zouein
- FDA
- FI Malik
- G Boerrigter
- G Cotter
- G Torre-Amione
- GC Fonarow
- GC Fonarow
- GM Felker
- GM Felker
- GM Felker
- GM Felker
- GM Felker
- GT Tucker
- H Yokoshiki
- HA Tran
- HC Dittrich
- HH Chen
- HK Gaggin
- HN Sabbah
- HS Park
- I Ferreira-Gonzalez
- J Butler
- J Dingemanse
- J Fang
- J Krupicka
- J Ritchie
- J Searle
- J Walczewska
- JA Bennett
- JD Neaton
- JD Violin
- JE Blair
- JG Cleland
- JJ McMurray
- JJ McMurray
- JJ You
- JR Teerlink
- JR Teerlink
- JR Teerlink
- JR Teerlink
- JS Borer
- JS Forrester
- K Boland
- K Dickstein
- KE Karlsson
- KF Adams
- L Pani
- L Thabane
- LA Allen
- LA Allen
- LA Danielson
- LR Potter
- M Clozel
- M Dahlke
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Gheorghiade
- M Kawabata
- M Kentsch
- M Metra
- M Packer
- M Packer
- M Sarraf
- M Vaduganathan
- MA Konstam
- MA Secilmis
- MD Samsky
- MM Givertz
- MM Givertz
- MR Cowie
- MR Shah
- MS Nieminen
- MS Nieminen
- MS Nieminen
- MT Rademaker
- NC Wang
- Nithy Sivakumar
- O Gealekman
- P Camacho
- P Jose
- P Kaheinen
- P McCullogh
- P Mulder
- P Pollesello
- P Pollesello
- P Ponikowski
- P Ponikowski
- P Ponikowski
- P Ponikowski
- PB Watkins
- PK Owens
- PS Pagel
- PS Pang
- Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF)
- R Ferrari
- RAD Boer
- RC Bourge
- RK Ghosh
- RM Mills
- S Collins
- S Hanigan
- S Venkatasubramanian
- SD Anker
- SE Shoaf
- SF Mohammed
- SJ Greene
- SJ Holmes
- SP Collins
- SS Rajaram
- SU Rehman
- T Denayer
- T Onogawa
- TA Mcdonagh
- TB Horwich
- TL Stevens
- V Mitrovic
- V Mitrovic
- Vincenzo Teneggi
- VS Moiseyev
- WF Peacock 4th
- WM Yarbrough
- WY Chan
- Y Aki
- Y Gerber
- Y Yamamura
- YT Shen
- ZA Abassi
- ZW Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Microalgal Biomass of Industrial Interest: Methods of Characterization
- Author
- A Albalasmeh
- A Bajguz
- A Barka
- A Chiovitti
- A Concas
- A Ginzberg
- A Guionet
- A Hara
- A Ishimatsu
- A Laurentin
- A Leyva
- A Marcati
- A Mishra
- A Méjean
- A Nakazawa
- A Parmar
- A Ranjan
- A Richmond
- A Richmond
- A Yano
- A Zak
- A Zuorro
- AC Garima
- AC Guedes
- AC Guedes
- AGJ Voragen
- AGP Samaranayaka
- AI Carrapiso
- AK Lee
- AK Patel
- AM Adel
- AM Briones
- AM Hammed
- AM Lawrence
- AM Tarola
- AMM Essa
- Anne Berit Samuelsen
- AP Batista
- AR Domínguez-Bocanegra
- B Bister
- B Casu
- B Delrue
- B Fernandes
- B Frølund
- B Gugi
- B Jaki
- B Klejdus
- B Liu
- B Muynck De
- B Nobre
- B Serive
- B Serive
- B. P. Eddy
- BJ Bellinger
- BV McCleary
- C Bertocchi
- C Besombes
- C Bumke-Vogt
- C Charcosset
- C Dayananda
- C Delattre
- C Moreira
- C Petrier
- C Romay
- C Safi
- C Udenigwe
- C Udenigwe
- C Wang
- C. Dayananda
- CD Kang
- CE Ejike
- Christian Galasso
- CI Sheih
- CJ Hulatt
- CJ Zhu
- CL Hsu
- CR Tomas
- CT Arranja
- CVG Gonzales Lopez
- CZ Obando
- D Cardenas
- D Dvoretsky
- D Fu
- D Leal
- D Mc Gee
- D Pal
- D. Peyronel
- DA Carbone
- DA Mc Cracken
- DFK Rawn
- DG Mann
- Diego A. Esquivel‐Hernández
- DJ Kovač
- DM Greuzburg
- DW Templeton
- E D’Haese
- E Gómez-Ordóñez
- E Günerken
- E Li
- E Magaletti
- E Molina Grima
- E Nara
- E Ryckebosch
- E Stephens
- E Takahashi
- E. Conde
- EA Ehimen
- EC Odjadjare
- EG Bligh
- EL Schymanski
- Elisabete Barbarino
- EP Feofilova
- ES Egeland
- EW Becker
- F Bouaziz
- F Hempel
- F Ruiz-Ruiz
- F Soxhlet
- F Vidussi
- FB Metting Jr
- FG Naghdi
- Folahan O. Ayorinde
- FR Wolf
- G Breuer
- G Nuzzo
- G Pierre
- G Pierre
- G Pierre
- G Vicente
- GJ Zhang
- GJC Underwood
- GJC Underwood
- GJC Underwood
- GL Baruah
- GL Klein
- GQ Chen
- GR Nireesha
- Graciliana Lopes
- H Li
- H Liu
- H Matsuura
- H Ozaki
- H Takeda
- H Zheng
- HG Gerken
- HGM Edwards
- HK Mæhre
- HS Cho
- HY Yang
- I Dianursanti
- I Lang
- I Poirier
- I Ponnuswamy
- IE Ezeagu
- J Azeredo
- J Benavides
- J Berdy
- J Bleton
- J Brückner
- J Davies
- J Dumay
- J Fabregas
- J Folch
- J Jones
- J Montreuil
- J Nordbäck
- J Nui
- J Serodio
- J Sheng
- J Wang
- J Wei
- JA Berges
- JA Maschek
- JAE Cavanagh
- JB Guckert
- JC Servaites
- JD Everette
- JE Turnbull
- JF Cornet
- JFC Brouwer De
- JG Correa-Reyes
- JG Day
- JH Jhaveri
- JH Lin
- JH Sloneker
- JL Pinckney
- JM Brown
- JP Kamerling
- JP Kamerling
- JP Yuan
- JS Craigie
- JS Walker
- JSP Kumar
- JT Lisle
- JU Grobbelaar
- JY Lee
- JØ Duus
- K Aschermann
- K Bingol
- K Bingol
- K Blin
- K Gademann
- K Ichihara
- K Kawachi
- K Kaya
- K Kitada
- K Kleigrewe
- K Suetsuna
- K Tobe
- K Zhang
- Kai Blin
- Kai Blin
- KE Milligan
- KJ Schäffler
- KK Lum
- KM MacDougall
- KM Manoylov
- KM Phillipis
- KS Dodgson
- KS Lynn
- KW Fan
- L Dufossé
- L Dufossé
- L Gouveia
- L Heukelem Van
- L Marchal
- L Sørensen
- L Yao
- LB Jaques
- LC Mata-Gómez
- LJ Zeman
- LML Laurens
- LML Nollet
- LR Cavonius
- M Baba
- M Castro-Puyana
- M Chioccioli
- M Dubois
- M Gao
- M Giordanoa
- M Graeve
- M Gross
- M Hein
- M Ito
- M Mathlouthi
- M Monsigny
- M Namikoshi
- M Olaizola
- M Orosa
- M Preisitsch
- M Rickman
- M Rico
- M Sato
- M Sánchez
- M Thyrel
- M Tran
- M Zapata
- MA Borowitzka
- Ma Dolores Macías-Sánchez
- MA Hejazi
- MA Strege
- Martin Axelsson
- MB Allen
- ME Barrios-Llerena
- MG Kulkarni
- MH Medema
- MJ Griffiths
- MJ Peña
- ML Gerardo
- MM Bradford
- MPFJ Raposo
- MPFJ Raposo
- MT Guarnieri
- N Blumenkrantz
- N Boussetta
- N Dubrulle
- N Rossi
- N Rossi
- N Yonezawa
- N Ziemert
- NAT Tran
- NH Caicedo
- NJ Kruger
- NW Bigelow
- O Depraetere
- O Pignolet
- O Pulz
- OH Lowry
- P Deschamps
- P Hyka
- P Janczyk
- P Laakso
- P Metzger
- P Pohl
- P Prabakaran
- P Spolaore
- PG Becher
- PK Smith
- PM Allard
- PM Rodrigues
- Q Li
- R Abilasha
- R Azevedo
- R Bermejo
- R Bermejo Román
- R Carle
- R Chaiklahan
- R Gnanasambandam
- R Halim
- R Larsen
- R Mesmay De
- R Oliveira
- R Pangestuti
- R Philippis De
- R Philippis De
- R Radakovits
- R Rippka
- R Rose
- R Sarada
- R Sarada
- R Singh
- R Suzuki
- Ramaraj Sathasivam
- RB Breemen van
- RB Volk
- RB Volk
- RG Barlow
- RH Wijffels
- RK Saini
- RL Mendes
- RRL Guillard
- RRL Guillard
- RT Lorenz
- RW Rickards
- RYN Ma
- S Al-Zuhair
- S Angelis
- S Bleakley
- S Comte
- S Dumitriu
- S Gatrell
- S Hara
- S Jeffrey
- S Jubeau
- S Krichnavaruk
- S Levigne
- S Li
- S Mo
- S Okada
- S Pereira
- S Ratnasingham
- S Rellan
- S Sekar
- S Singh
- S Viswanathan
- S Yu
- SA Barker
- SB Velasquez-Orta
- SJ Iverson
- SJ Lee
- SJ Zhang
- SM Arad
- SM Milenković
- SM Rivera
- SO Lourenço
- SO Lourenço
- Solène Connan
- SP Cuellar-Bermudez
- SP Gunasekera
- SP Slocombe
- Susanne Faltermann
- SW Wright
- SY Lee
- T Dong
- T Driver
- T Herraiz
- T Kind
- T Kobayashi
- T Kruger
- T Lewis
- T Masuko
- T Rausch
- T Tanoi
- T Yi
- T. Verleyen
- Tilmann Weber
- TL Silva Da
- TM Filisetti-Cozzi
- TR Parsons
- TV Ramachandra
- V Dashkova
- V Gloaguen
- V Kiron
- V Pasquet
- V Righi
- V Samburova
- V Shorupskaite
- V Singlton
- VH Work
- W Blanken
- W Chen
- W Chen
- W Peng
- W Reichelt
- W Sattler
- W Widmer
- W Zhang
- WF Wu
- WM Bishop
- WT Shoaf
- WW Christie
- WWC Gieskes
- X Luo
- X Meng
- X Yu
- Y Chisti
- Y Chisti
- Y Ge
- Y Han
- Y Ji
- Y Jia
- Y Jiang
- Y Maréchal
- Y Ye
- Y Zhang
- YS Cheng
- YW Sari
- Z Pilat
- Z Wu
- Z Yaakob
- Z Zhang
- ZA Mohamed
- ZG Kamenarska
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
International audienceMicroalgae represent a new source of biomass for many applications. The advantage of microalgae over higher plants is their high productivities. The photoautotrophic microalgae include all photosynthetic microorganisms, i.e. Cyanobacteria (prokaryotes) or microalgae (eukaryotes). These microorganisms are characterized by a large biodiversity and chimiodiversity. Then, the analysis of microalgal and cyanobacterial biomass often needs specific adaptations of the classical protocols for extraction as well as for quantification of their contents. This chapter reviewed the main analytical methods used for the analysis of microalgae biomass and its main vaporizable compounds: proteins, polysaccharides, lipids, pigments and secondary metabolites
The Role of Serotonin, Vasopressin, and Serotonin/Vasopressin Interactions in Aggressive Behavior
- Author
- A Cologer-Clifford
- A Drincic
- A Franzini
- A Quattrone
- A Roy
- AD Munro
- AH Veenema
- AJ Bond
- AJ Cleare
- AJ Vomachka
- AM Erp Van
- AR Caffé
- AS Horn
- AS New
- AV Kulikov
- AW Deckel
- B Chamberlain
- B Gough
- B Kessel
- B Olivier
- B Olivier
- B Olivier
- BC Nephew
- BD Rood
- BF Kania
- BJ Vegt Van Der
- BL Roth
- BM Patel
- C Barberis
- C Montigny
- C Reist
- C Sánchez
- C Sánchez
- C Vaccari
- C Villalba
- C-M Vacher
- C-M Vacher
- CC Zai
- CF Adams
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CF Ferris
- CH Summers
- CL Holmes
- CP Veiga
- D Ibi
- D Jackson
- D Maciag
- D Popa
- DA Carter
- DA Lewis
- DB Adams
- DC Blanchard
- DE Wright
- DL Maxwell
- DM Dorsa
- DM Wood
- DR Cherek
- DR Cherek
- E Castro de Souza
- E Dremencov
- E Kirilly
- E Mocaer
- E Tribollet
- EB Ribeiro
- EC Azmitia
- EC Azmitia
- ED Clotfelter
- EF Coccaro
- EF Coccaro
- EF Coccaro
- EF Coccaro
- EJ Hermans
- EM Hoorneman
- EM Sammler
- EM Scordalakes
- ET Leonardi
- EW Fish
- F Hernando
- F Muehlenkamp
- F Saudou
- FA Antoni
- G Griebel
- G Griebel
- G Griebel
- G Pinna
- G Pinna
- G Pinna
- GC Wagner
- GJ Vries De
- GJ Vries De
- GJ Vries De
- GJ Vries De
- GK Aghajanian
- GL Brown
- H Gainer
- H Jarrell
- H Perreault
- H Shimizu
- H Sijbesma
- HA Spiller
- HE Albers
- HE Albers
- HK Caldwell
- HK Caldwell
- HP Ho
- I Knyshevski
- I Knyshevski
- IC Fraga
- IF Bielsky
- J Arnt
- J Lappalainen
- J Maj
- J Mos
- J Sprouse
- J Stemmelin
- J-L Vincent
- JA Bouwknecht
- JA Fass
- JA Henry
- JB Thurmond
- JC Blader
- JC Crabbe
- JD Guo
- JD Militante
- JF Navarro
- JJ Schwartzer
- JK Bester-Meredith
- JM Barreto-Medeiros
- JM Bjork
- JM Grimes
- JM Grimes
- JM Grimes
- JM Grimes
- JM Grimes
- JM Koolhaas
- JM Koolhaas
- JM Koolhaas
- JM Stribley
- JM Whitsett
- JO Willoughby
- JP Tupin
- JR Homberg
- JS DeNapoli
- JS Sprouse
- JT Winslow
- K Semsar
- K Taravosh-Lahn
- KA Miczek
- KA Miczek
- KA Miczek
- KE Sabol
- KL Gobrogge
- KP Datla
- KP Datla
- KP Lesch
- KR DeLeon
- KR DeLeon
- KW Perry
- L Share
- L Zhang
- L Zhang
- LA Centenaro
- LA Fairbanks
- LA Ricci
- LA Ricci
- LA Ricci
- LA Ricci
- LJ Pitkow
- LJ Spanos
- LJ Young
- LL Miller
- LN Yatham
- LW Swanson
- M Altemus
- M Birnbaumer
- M Campbell
- M Campbell
- M Carrillo
- M Dolan
- M Dubois-Dauphin
- M Dubois-Dauphin
- M Engelmann
- M Engelmann
- M Iovino
- M Linnoila
- M Mansari El
- M Morales
- M Potegal
- M Rosa
- M Saito
- M Vergnes
- M Vergnes
- M Vergnes
- M Zimmermann
- MA Cooper
- MA Joppa
- MB Malay
- ME Berman
- MF Dorrego
- MG Cunningham
- MH Baumann
- MH Sheard
- MJ Kruesi
- MJ Raleigh
- MN Budisavljevic
- MP Johnson
- MS Ansorge
- MS Ansorge
- MY Banjaw
- N Salomé
- NA Darmani
- NB Keele
- NK Popova
- NL Ostrowski
- NL Ostrowski
- O Puciłowski
- O Rilke
- P Blier
- P Campbell
- P Nencini
- P Steensland
- PA Phillips
- PB Clarke
- PD Mahoney
- PE Pergola
- PE Sawchenko
- PH Soloff
- PJ Mitchell
- PR Giri
- R Bell
- R Gerona
- R Gerstberger
- R Holden
- R Invernizzi
- R Invernizzi
- R Invernizzi
- R Whale
- RA Fenton
- RE Adamec
- RH Melloni
- RH Melloni
- RJ Blanchard
- RJ Harrison
- RM Almeida de
- RM Almeida de
- RM Bluthé
- RMM Almeida de
- RMM Almeida de
- RP Malone
- RP Vertes
- RW Berlinger
- RW Irvin
- S Bexis
- S Faccidomo
- S Giammanco
- S Nielsen
- S Ramboz
- S Rittig
- SB Auerbach
- SC Dulawa
- SE Lynn
- SE Shoaf
- SF Boer De
- SF Boer De
- SJ Lolait
- SL Klein
- SL Treiser
- SR Wersinger
- SR Wersinger
- SR Wersinger
- T Deller
- T Putten Van
- T Schoenfeld
- TS Sperry
- TS Sperry
- V Matto
- V Micev
- W Kostowski
- WS Young
- WT Mason
- X Duan
- Y Delville
- Y Delville
- Y Kuroda
- Y Qu
- YY Huang
- Z Roliński
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
- Accini M
- Acikel M
- Acikel M
- Adachi C
- Adams K
- Adams K
- Adamus J
- Adler J
- Adler P
- Agarwal D
- Aggarwal R
- Aggarwal R
- Agirov M
- Agraou B
- Ahmad A
- Ahmadpour H
- Ahuad Guerrero R
- Ajioka M
- Akhter F
- Akihisa U
- Akilli H
- Al-Maliky T
- Al-Zoebi A
- Albert L. Waldo
- Albisu J
- Albulescu P
- Alexander J
- Alexandrova L
- Alexopoulos D
- Alexopoulos D
- Alhakim M
- Aliyar P
- Allall O
- Allison J
- Allman J
- Almaraz SP
- Almeida A
- Almeida M
- Almquist A
- Aloni I
- Alsheikh T
- Altonen D
- Alvarez C
- Alvarez M
- Alvarez RF
- Amarenco P
- Amato Vincenzo de Paola A
- Ambrovic I
- Ambrovicova V
- Ameriso P
- Ameriso S
- Amin K
- Amin M
- Amuchastegui M
- Anciu M
- Anderson C
- Anderson J
- Anderson J
- Andersson R
- Andor M
- Andrade Lotufo P
- Andresen T
- Andrews A
- Angel J
- Anscombe R
- Anthony A
- Antle S
- Antman EM
- Antman EM
- Antonino M
- Anzai T
- Apetrei E
- Apostolovic S
- Appelros P
- Aquino M
- Arakawa S
- Araújo E
- Archibald J
- Arcocha Torres M
- Ardelean A
- Arfaoui M
- Arias J
- Armas BH
- Arneja J
- Arnold T
- Arora T
- Arora V
- Arouni A
- Arrieta M
- Arroyave C
- Arstall M
- Arutyunov G
- Asakura H
- Asensio A
- Astier L
- Ata N
- Ata N
- Atar D
- Atar D
- Atar S
- Atie J
- Atkinson C
- Attanti S
- Aude Y
- Augusto Alves da Costa F
- Aull L
- Ault S
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- Avellar K
- Averett P
- Avery D
- Avila H
- Avvaru G
- Awasty V
- Awtry E
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- Ayesu K
- Aylward P
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- Ŝpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)