New Towns - Promises Towards Sustainable Urban Form : From "Shushtar-No" to "Shahre Javan Community"

Zugleich gedruckt erschienen im Universitätsverlag der Technischen Universität Berlin, 2013. - ISBN 978-3-7983-2512-8, ISSN 2193-6099This book presents a comparative study between Shahre Javan Community Pilot Project and Shushtar-No, the latter a residential complex designed and partly realized 35 years ago in the southern part of Iran, the former a residential quarter in Hashtgerd New Town in the west of Tehran as the Pilot Project of the "Young Cities Research Project", which has been conducted by a multidisciplinary research group at Technische Universität Berlin in cooperation with the Building and Housing Research Center (BHRC) of Iran. This comparative study shows how these two projects have planned to meet the place-specific and time-related prerequisites expected from an optimal residential community

Evaluation of Sediment Removal Efficiency of Flushing Devices Regarding Sewer System Characteristics

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

The Necessity of Redefining and Presenting a New Perception on the Comprehensive Interpretation of the Holy Quran

The Holy Quran is an infinite ocean which benefits everyone to the extent of their scientific ability and scope of existence. This divine book would not be only a text; rather, its interpretation and explanation open various chapters of science, wisdom, and knowledge to human beings. Therefore, the only way to enter this gate of science, wisdom, and knowledge is its interpretation. Up to now, various approaches and interpretive books have been emerged to decipher and decode this divine blessing, but non of them has been perfect, and each is considered as a defect. Therefore, the best and the safest way would be to refer to a new definition of the “comprehensive” interpretation. In the following research paper, we will try to express the need and necessity of applying a comprehensive approach to the interpretation of the Holy Quran, providing a new definition of it in the description of the divine words

Factors affecting simulators of the hospital emergency department during emergencies and disasters in Iran: a qualitative study

Objective: The simulation strategy is so important for appropriate responses and preparedness of hospital emergency department staff in emergencies to strengthen team building and care focused on the interdisciplinary community. Therefore, this study aimed to identify the factors affecting the hospital emergency department's simulators during emergencies and disasters. Methods: This conventional content analysis study was conducted in 2021. Participants were selected from Iranian experts using purposeful and snowball sampling methods. Data were collected using semi-structured interviews and were analyzed by the content analysis. Results: Analysis of the data results through semi-structured interviews showed 4 main categories and 11 subcategories including management and leadership (the structure, casualty management, command, interactions and coordination, communications and information, as well as human resources), and increasing the capacity (resources (physical resources, and financial resources)), modern technology approaches (information technology), laws and policies (policies, guidelines, and rules). Conclusion: The simulation technology use can be effective in preparing the hospital emergency department in the event of disasters, strengthening management and leadership, proper planning, appropriate organizational culture, organizational learning, interactions and coordination, casualty management, as well as providing resources, equipment, items, processes, and instructions. So, the use of these new technological training is recommended to improve responses in times of emergencies and disasters

Isolation and characterization of novel phage displayed scFv antibody for human tumor necrosis factor alpha and molecular docking analysis of their interactions

Introduction: Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunogenicity, but also proved several benefits including better tumor penetration and more rapid blood clearance.This study highlights the use of phage display for identification of human single chain fragment antibody against disulfide-bonded TNF-α using phage display technology. Methods and Results: Using affinity selection procedures in this study, a scFv antibody clone was isolated from naïve Tomlinson I phage display library that specifically recognizes and binds to TNF-α. The TNF-α recombinant protein was expressed in genetically engineered Escherichia coli SHuffle® T7 Express, for the first time, which is able to express disulfide-bonded recombinant proteins into their correctly folded states. Conclusions: ELISA-based affinity characterization results indicated that the isolated novel 29.2 kDa scFv binds TNF-α with suitable affinity. In silico homology modeling study using ‘ModWeb’ as well as molecular docking study using Hex program confirmed the scFv and TNF-α interactions with a scFv-TNF- α binding energy of around -593 kj/mol which is well in agreement with our ELSIA results. The cloned scFv antibody may potentially be useful for research and therapeutic applications in the future

Assessment of an Unshielded Electron Field Diode Dosimeter for Beam Scanning in Small-to Medium-Sized 6 MV Photon Fields

Abstract Introduction Radiotherapy planning systems require many percentage depth dose (PDD) and profile measurements and there are various dosimeters that can be used to obtain these scans. As dose perturbation is particularly troublesome in smaller photon fields, using a low-perturbation, unshielded electron field diode (EFD) in these fields is of interest. The aim of this work was to investigate the suitability of an unshielded diode for beam scanning in 3×3 cm 2 , 5×5 cm 2 , and 10×10 cm 2 , 6 MV fields. Materials and Methods An EFD was used for all the scans. For comparison, in profile measurements, a tungsten-shielded photon field diode (PFD) was also used. PDDs were measured using the PFD and an RK ionization chamber. Results Very good agreement (0.4%) was found between the PDDs measured with EFD and PFD for the two larger fields. However, the difference between them exceeded 1.0% slightly for the smallest field, which may be attributed to the effect of the larger PFD perturbation. The RK chamber PDDs around 10 cm depth were 1-2% lower than those measured with the diodes. There was good agreement (<1 mm) between EFD-and PFD-measured penumbra widths. Conclusion The EFD generally agrees well with the PFD and may even perform better in smaller fields