A Study on the Thin Plate with Carbon Fiber Reinforced Hybrid Composite

In this paper we describe an experimental study, this article is to report fundamental data of constructions attained by carbon fiber reinforced hybrid composite of O.9mm in thickness whose resin base was reinforced. As a result of this series of test and experiments, it was found that; it is possible to attain reinforced resin base of hybrid composite of C.F.R.P. 16 times as much in rigidity against bending load as compared with that of single construction was observed with composite of O.9mm lamina. It was found that sandwich construction of C.F.R.P. is superior, while, in the case of canape construction, it was found necessary to have C.F.R.P. on the tension side. G.F.R.P. has possibility to be reinforced composite material, although it is considerably less superior to C.F.R.P

The effect of magnesium oxide supplementation to aluminum oxide slip on the jointing of aluminum oxide bars

The purpose of this study was to investigate the effect of modifying aluminum oxide slips with magnesium oxide (MgO) tocreate a jointing material for In-CeramR Alumina. Jointed In-CeramR Alumina bars with In-CeramR Alumina slips containing0－1.0 mass％ MgO were examined by a three-point bending test. Joint-free bars were also tested as controls.Fracture surfaces were evaluated by scanning electron microscopy. In addition, linear shrinkage and fracture toughnesswere assessed.　　The 0.3 mass％ MgO group showed the highest flexural strength among the jointed groups, and there were no statisticaldifferences between the joint-free control groups. The fracture surface of 0.3 mass％ MgO group showed increasedsintering densification with reduced micropore size. No linear shrinkage was observed with the addition of MgO to thealumina slip. Added MgO was also effective in boosting fracture toughness. The present findings indicate that the MgOsupplementedbinding material is useful for clinical applications

Physical Function and Health-Related Quality of Life after Surgery for Nontuberculous Mycobacterial Pulmonary Disease: A Prospective Cohort Study

Purpose: To investigate the exercise capacity and health-related quality of life (HRQOL) of surgical patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) preoperatively versus 6 months postoperatively.Methods: This prospective observational study included patients with NTM-PD and was conducted at a single center. The intervention was surgical resection plus perioperative and post-discharge physical therapy. The physical function was assessed preoperatively and 6 months postoperatively using the 6-minute walk test (6MWT). HRQOL was assessed preoperatively and 6 months postoperatively using the Short-Form 36 (SF-36) health survey questionnaire and St. George’s Respiratory Questionnaire. The postoperative HRQOL was compared between patients with and without preoperative clinical symptoms.Results: In total, 35 patients were analyzed. The preoperatively symptomatic group had significantly lower preoperative HRQOL than the preoperatively asymptomatic group (p <0.05). Compared with preoperatively, there were significant improvements at 6 months postoperatively in the 6MWT (p <0.01) and HRQOL, mainly in the SF-36 mental component summary (p <0.01). The SF-36 mental component summary in the preoperatively symptomatic group was very significantly improved from preoperatively to 6 months postoperatively (p <0.05).Conclusion: The combination of surgical treatment and physical therapy for NTM-PD contributes to improvements in physical function and HRQOL

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.

横紋筋肉腫におけるゲノム・エピゲノム異常の全体図を解明 -横紋筋肉腫を4群に分類-. 京都大学プレスリリース. 2015-07-03.Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and clinical behaviours. A1 and A2 subtypes, especially A1, largely correspond to alveolar histology with frequent PAX3/7 fusions and alterations in cell cycle regulators. In contrast, mostly showing embryonal histology, both E1 and E2 subtypes are characterized by high frequency of CN alterations and/or allelic imbalances, FGFR4/RAS/AKT pathway mutations and PTEN mutations/methylation and in E2, also by p53 inactivation. Despite the better prognosis of embryonal RMS, patients in the E2 are likely to have a poor prognosis. Our results highlight the close relationships of the methylation status and gene mutations with the biological behaviour in RMS

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries