Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study

Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes. Aims: To delineate the functional patterns of brain network activity and connectivity underlying visual hallucinations in Parkinson’s disease. Methods: In this study, we combined functional magnetic resonance imaging (MRI) with a behavioral task capable of eliciting visual misperceptions, a confirmed surrogate for visual hallucinations, in 35 patients with idiopathic Parkinson’s disease. We then applied an independent component analysis to extract time series information for large-scale neuronal networks that have been previously implicated in the pathophysiology of visual hallucinations. These data were subjected to a task-based functional connectivity analysis, thus providing the first objective description of the neural activity and connectivity during visual hallucinations in patients with Parkinson’s disease. Results: Correct performance of the task was associated with increased activity in primary visual regions; however, during visual misperceptions, this same visual network became actively coupled with the default mode network (DMN). Further, the frequency of misperception errors on the task was positively correlated with the strength of connectivity between these two systems, as well as with decreased activity in the dorsal attention network (DAN), and with impaired connectivity between the DAN and the DMNs, and ventral attention networks. Finally, each of the network abnormalities identified in our analysis were significantly correlated with two independent clinical measures of hallucination severity. Conclusions: Together, these results provide evidence that visual hallucinations are due to increased engagement of the DMN with the primary visual system, and emphasize the role of dysfunctional engagement of attentional networks in the pathophysiology of hallucinations

Mineralogy and Geochemistry of the Asanje Iron Ore Deposit within the Mayamaya-Hombolo Belt, Dodoma Region, Central Tanzania

This paper presents the mineralogy and chemical composition including iron ore impurities to ascertain its suitability for industrial applications. The Asanje iron ore deposit is hosted in Precambrian volcano-sedimentary rocks in the Mayamaya-Hombolo Belt in Dodoma region, within the Lake Nyanza Superterrane. Iron ores are found in two parallel ridges trending NW-SE. Ridge I occurs as vein and banded hematite-type ore and Ridge II as massive-type ore. A total of 24 ore samples were analysed for major and trace elements by XRF and petrographic studies by optical microscopy and XRD. The XRD results revealed that hematite and goethite are the main components and quartz is the gangue mineral in the iron ores. The XRF data shows the Fe2O3t content ranges from 20.8 to 87.3 wt% with an average of 52.7 wt%. The average concentrations in wt% of impurities such as SiO2, Al2O3, P2O5 and S are 37.9, 0.9, 1.2, and 0.2, respectively. By comparison, Ridge II has greater iron content (30.5–87.3 = Avg. 64.66 wt% Fe2O3t) than Ridge I (20.8–78.22 = Avg. 48.68 wt% Fe2O3t). Based on the chemical composition, the quality of iron ore is categorised as low to medium grade, and can be used in metallurgical and cement industries. Keywords:    Mineralogy, Geochemistry, Asanje Iron ore deposit, Mayamaya-Hombolo Belt, Tanzani

Changes in structural network topology correlate with severity of hallucinatory behavior in Parkinson's disease

Inefficient integration between bottom-up visual input and higher order visual processing regions is implicated in visual hallucinations in Parkinson's disease (PD). Here, we investigated white matter contributions to this perceptual imbalance hypothesis. Twenty-nine PD patients were assessed for hallucinatory behavior. Hallucination severity was correlated to connectivity strength of the network using the network-based statistic approach. The results showed that hallucination severity was associated with reduced connectivity within a subnetwork that included the majority of the diverse club. This network showed overall greater between-module scores compared with nodes not associated with hallucination severity. Reduced between-module connectivity in the lateral occipital cortex, insula, and pars orbitalis and decreased within-module connectivity in the prefrontal, somatosensory, and primary visual cortices were associated with hallucination severity. Conversely, hallucination severity was associated with increased between- and within-module connectivity in the orbitofrontal and temporal cortex, as well as regions comprising the dorsal attentional and default mode network. These results suggest that hallucination severity is associated with marked alterations in structural network topology with changes in participation along the perceptual hierarchy. This may result in the inefficient transfer of information that gives rise to hallucinations in PD. Author SummaryInefficient integration of information between external stimuli and internal perceptual predictions may lead to misperceptions or visual hallucinations in Parkinson's disease (PD). In this study, we show that hallucinatory behavior in PD patients is associated with marked alterations in structural network topology. Severity of hallucinatory behavior was associated with decreased connectivity in a large subnetwork that included the majority of the diverse club, nodes with a high number of between-module connections. Furthermore, changes in between-module connectivity were found across brain regions involved in visual processing, top-down prediction centers, and endogenous attention, including the occipital, orbitofrontal, and posterior cingulate cortex. Together, these findings suggest that impaired integration across different sides across different perceptual processing regions may result in inefficient transfer of information

Radiative forcing of climate

An update of the scientific discussions presented in Chapter 2 of the Intergovernmental Panel on Climate Change (IPCC) report is presented. The update discusses the atmospheric radiative and chemical species of significance for climate change. There are two major objectives of the present update. The first is an extension of the discussion on the Global Warming Potentials (GWP's), including a reevaluation in view of the updates in the lifetimes of the radiatively active species. The second important objective is to underscore major developments in the radiative forcing of climate due to the observed stratospheric ozone losses occurring between 1979 and 1990

Global warming potentials and radiative efficiencies of halocarbons and related compounds: a comprehensive review

In the mid-1970s it was recognized that, as well as being substances that deplete stratospheric ozone, chlorofluorocarbons (CFCs) were strong greenhouse gases that could have substantial impacts on radiative forcing of climate change. Around a decade later, this group of radiatively active compounds was expanded to include a large number of replacements for ozone-depleting substances such as chlorocarbons, hydrochlorocarbons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), bromofluorocarbons, and bromochlorofluorocarbons. This paper systematically reviews the published literature concerning the radiative efficiencies (REs) of CFCs, bromofluorocarbons and bromochlorofluorocarbons (halons), HCFCs, HFCs, PFCs, SF6, NF3, and related halogen containing compounds. In addition we provide a comprehensive and self-consistent set of new calculations of REs and global warming potentials (GWPs) for these compounds, mostly employing atmospheric lifetimes taken from the available literature. We also present Global Temperature change Potentials (GTPs) for selected gases. Infrared absorption spectra used in the RE calculations were taken from databases and individual studies, and from experimental and ab initio computational studies. Evaluations of REs and GWPs are presented for more than 200 compounds. Our calculations yield REs significantly (> 5%) different from those in the Intergovernmental Panel on Climate Change Fourth Assessment Report (AR4) for 49 compounds. We present new RE values for more than 100 gases which were not included in AR4. A widely-used simple method to calculate REs and GWPs from absorption spectra and atmospheric lifetimes is assessed and updated. This is the most comprehensive review of the radiative efficiencies and global warming potentials of halogenated compounds performed to date

Polar ozone

The observation and interpretation of a large, unexpected ozone depletion over Antarctica has changed the international scientific view of stratospheric chemistry. The observations which show the veracity, seasonal nature, and vertical structure of the Antarctic ozone hole are presented. Evidence for Arctic and midlatitude ozone loss is also discussed. The chemical theory for Antarctic ozone depletion centers around the occurrence of polar stratospheric clouds (PSCs) in Antarctic winter and spring; the climatology and radiative properties of these clouds are presented. Lab studies of the physical properties of PSCs and the chemical processes that subsequently influence ozone depletion are discussed. Observations and interpretation of the chemical composition of the Antarctic stratosphere are described. It is shown that the observed, greatly enhanced abundances of chlorine monoxide in the lower stratosphere are sufficient to explain much if not all of the ozone decrease. The dynamic meteorology of both polar regions is given, interannual and interhemispheric variations in dynamical processes are outlined, and their likely roles in ozone loss are discussed

A Tale Of Two Spicules: The Impact of Spicules on the Magnetic Chromosphere

We use high-resolution observations of the Sun in Ca II H 3968 A from the Solar Optical Telescope on Hinode to show that there are at least two types of spicules that dominate the structure of the magnetic solar chromosphere. Both types are tied to the relentless magnetoconvective driving in the photosphere, but have very different dynamic properties. ``Type-I'' spicules are driven by shock waves that form when global oscillations and convective flows leak into the upper atmosphere along magnetic field lines on 3-7 minute timescales. ``Type-II'' spicules are much more dynamic: they form rapidly (in ~10s), are very thin (<200km wide), have lifetimes of 10-150s (at any one height) and seem to be rapidly heated to (at least) transition region temperatures, sending material through the chromosphere at speeds of order 50-150 km/s. The properties of Type II spicules suggest a formation process that is a consequence of magnetic reconnection, typically in the vicinity of magnetic flux concentrations in plage and network. Both types of spicules are observed to carry Alfven waves with significant amplitudes of order 20 km/s.Comment: 8 pages, 5 figures, accepted for Hinode special issue of PAS

Vector spectropolarimetry of dark-cored penumbral filaments with Hinode

We present spectropolarimetric measurements of dark-cored penumbral filaments taken with Hinode at a resolution of 0.3". Our observations demonstrate that dark-cored filaments are more prominent in polarized light than in continuum intensity. Far from disk center, the Stokes profiles emerging from these structures are very asymmetric and show evidence for magnetic fields of different inclinations along the line of sight, together with strong Evershed flows of at least 6-7 km/s. In sunspots closer to disk center, dark-cored penumbral filaments exhibit regular Stokes profiles with little asymmetries due to the vanishing line-of-sight component of the horizontal Evershed flow. An inversion of the observed spectra indicates that the magnetic field is weaker and more inclined in the dark cores as compared with the surrounding bright structures. This is compatible with the idea that dark-cored filaments are the manifestation of flux tubes carrying hot Evershed flows.Comment: Accepted for publication in ApJ Letters. Use the Postscript version for high quality figure

Disintegration of Magnetic Flux in Decaying Sunspots as Observed with the Hinode SOT

Continuous observations of sunspot penumbrae with the Solar Optical Telescope aboard \textit{Hinode} clearly show that the outer boundary of the penumbra fluctuates around its averaged position. The penumbral outer boundary moves inward when granules appear in the outer penumbra. We discover that such granules appear one after another while moving magnetic features (MMFs) are separating from the penumbral ``spines'' (penumbral features that have stronger and more vertical fields than those of their surroundings). These granules that appear in the outer penumbra often merge with bright features inside the penumbra that move with the spines as they elongate toward the moat region. This suggests that convective motions around the penumbral outer boundary are related to the disintegration of magnetic flux in the sunspot. We also find that dark penumbral filaments frequently elongate into the moat region in the vicinity of MMFs that detach from penumbral spines. Such elongating dark penumbral filaments correspond to nearly horizontal fields extending from the penumbra. Pairs of MMFs with positive and negative polarities are sometimes observed along the elongating dark penumbral filaments. This strongly supports the notion that such elongating dark penumbral filaments have magnetic fields with a ``sea serpent''-like structure. Evershed flows, which are associated with the penumbral horizontal fields, may be related to the detachment of the MMFs from the penumbral spines, as well as to the formation of the MMFs along the dark penumbral filaments that elongate into the moat region.Comment: Accepted for publication in Ap