Classes of low-frequency earthquakes based on inter-time distribution reveal a precursor event for the 2011 Great Tohoku Earthquake

Recently, slow earthquakes (slow EQ) have received much attention relative to understanding the mechanisms underlying large earthquakes and to detecting their precursors. Low-frequency earthquakes (LFE) are a specific type of slow EQ. In the present paper, we reveal the relevance of LFEs to the 2011 Great Tohoku Earthquake (Tohoku-oki EQ) by means of cluster analysis. We classified LFEs in northern Japan in a data-driven manner, based on inter-time, the time interval between neighboring LFEs occurring within 10 km. We found that there are four classes of LFE that are characterized by median inter-times of 24 seconds, 27 minutes, 2.0 days, and 35 days, respectively. Remarkably, in examining the relevance of these classes to the Tohoku-oki EQ, we found that activity in the shortest inter-time class (median 23 seconds) diminished significantly at least three months before the Tohoku-oki EQ, and became completely quiescent 30 days before the event (p-value = 0.00014). Further statistical analysis implies that this class, together with a similar class of volcanic tremor, may have served as a precursor of the Tohoku-oki EQ. We discuss a generative model for these classes of LFE, in which the shortest inter-time class is characterized by a generalized gamma distribution with the product of shape parameters 1.54 in the domain of inter-time close to zero. We give a possible geodetic interpretation for the relevance of LFE to the Tohoku-oki EQ

Single-Flux-Quantum Bipolar Digital-to-Analog Converter Comprising Polarity-Switchable Double-Flux-Quantum Amplifier

We present a single-flux-quantum (SFQ)-based digital-to-analog converter (DAC) generating bipolar output voltages, in which the key component is a polarity-switchable double-flux-quantum amplifier (PS-DFQA). The DAC comprised a dc/SFQ converter, an 8-bit variable pulse-number-multiplier (PNM), and a 8-fold PS-DFQA integrated on a single chip. SFQ pulse-frequency modulation was employed to realize variable output voltage amplitude, for which the multiplication factor of the variable-PNM was controlled by a commercial data generator situated at room temperature. The variable-PNM realized 8-bit resolution with a multiplication factor between 0 and 255. Bias currents fed to the 8-fold PS-DFQA were polarity-switched in synchronization with the digital code for the variable-PNM. The whole circuits including I/O elements were designed using SFQ cell libraries, and fabricated using a niobium integration process. Sinusoidal bipolar voltage waveform of 0.38 mVpp was demonstrated using a reference signal source of 43.94 MHz

1000-Fold Double-Flux-Quantum Voltage Multiplier Employing Directional Propagation of Flux Quanta Through Asymmetrically Damped Junction Branches

Precise voltage generation is a unique feature of single-flux-quantum (SFQ) circuits, in addition to their high-speed digital signal processing with low power consumption. We investigated SFQ pulse-frequency modulation D/A converters for metrological applications. In our SFQ-based D/A converters, the maximum output voltage is determined by the maximum SFQ pulse-frequency at the pulse number multiplier, and by the voltage multiplication factor at the voltage multiplier. In this study, we present our new design for a double-flux-quantum amplifier (DFQA) that works as a quantum voltage multiplier. In the new parameter set, we tuned the damping parameters of the Josephson junctions to realize proper propagation of SFQ pulses. A 1000-fold DFQA designed with the new parameter set was fabricated using a 25-μ A/μ m 2 Nb/AlOx/Nb integration technology. A 1000-fold voltage multiplication was confirmed for the input voltage up to 43 μV, with a corresponding SFQ repetition frequency of 21 GHz. That is, the output voltage reached 43 mV

4-bit Bipolar Triangle Voltage Waveform Generator Using Single-Flux-Quantum Circuit

AbstractSFQ digital-to-analog converters (DACs) are one of the candidates for AC voltage standards. We have proposed SFQ-DACs based on frequency modulation (FM). Bipolar output is required for applications of AC voltage standards, while our previous SFQ-DACs generated only positive voltages. In this paper, we present our design of a 4-bit bipolar triangle voltage waveform generator comprising an SFQ-DAC. The waveform generator has two output ports. Synthesized half-period waveforms are alternately generated in one of the output ports. The bipolar output is realized by observing the differential voltage between the ports. We confirmed a 72-μVPP bipolar triangle voltage waveform at the frequency of 35.7Hz

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats.

BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall. However, the role of HHcy in the growth and rupture of cerebral aneurysms remains unclear.MethodsThirteen-week-old female Sprague-Dawley rats were subject to bilateral ovariectomy and ligation of the right common carotid artery and fed an 8 % high-salt diet to induce cerebral aneurysms. Two weeks later, they underwent ligation of the bilateral posterior renal arteries. They were divided into two groups and methionine (MET) was or was not added to their drinking water. In another set of experiments, the role of folic acid (FA) against cerebral aneurysms was assessed.ResultsDuring a 12-week observation period, subarachnoid hemorrhage due to aneurysm rupture was observed at the anterior communicating artery (AcomA) or the posterior half of the circle of Willis. HHcy induced by excessive MET intake significantly increased the incidence of ruptured aneurysms at 6-8 weeks. At the AcomA of rats treated with MET, we observed the promotion of aneurysmal growth and infiltration by M1 macrophages. Furthermore, the mRNA level of MMP-9, the ratio of MMP-9 to the tissue inhibitor of metalloproteinase-2, and the level of interleukin-6 were higher in these rats. Treatment with FA abolished the effect of MET, suggesting that the inflammatory response and vascular degradation at the AcomA is attributable to HHcy due to excessive MET intake.ConclusionsWe first demonstrate that in hypertensive ovariectomized rats, HHcy induced by excessive MET intake may be associated with the propensity of the aneurysm wall to rupture

Influence of gas environment and heating on atomic structures of platinum nanoparticle catalysts for proton-exchange membrane fuel cells

Atomic-scale relaxations of platinum nanoparticles (Pt NPs) for fuel-cell catalysts are evaluated by spherical-aberration corrected environmental transmission electron microscopy (ETEM) under reference high-vacuum and N2 atmospheres, and then under reactive H2, CO and O2 atmospheres, combined with ex situ durability test using an electrochemical half-cell. In high-vacuum, increasing roughness due to continuous relaxation of surface-adsorbed Pt atoms is quantified in real-space. Under H2 and N2 atmospheres at a critical partial pressure of 1 × 10-2 Pa the stability of the surface facets is for the first time found to be improved. The adsorption behaviour of CO molecules is investigated using experimentally measured Pt-Pt bond lengths on the topmost surface layer of Pt NPs. The deactivation of Pt NPs in the anode environment of a proton-exchange-membrane fuel-cell is demonstrated at the atomic-scale in the ETEM, and the transformation of NPs into disordered nanoclusters is systematically quantified using the partial size distribution of Pt atomic clusters under controlled heating experiments at 423, 573 and 723 K

Nitridation of Titanate Nanoparticles and their Electrochemical Properties

ナノダイナミクス国際シンポジウム 平成22年1月21日(木) 於長崎大学Nagasaki Symposium on Nano-Dynamics 2010 (NSND2010), January 21, 2010, Nagasaki University, Nagasaki, Japan, Invited Lectur

Renal mitochondrial complex in 5/6 Nx mice

Hyperglycemia induces nonconcordant regulation of renal mitochondrial respiratory complexes, increases oxidative stress, and causes diabetic nephropathy. Hypertension is a complication associated with diabetes and involves glomerular hyperfiltration, the effects of which on mitochondrial respiratory complexes are not well understood. To investigate the effect of glomerular hyperfiltration on renal mitochondrial respiratory complexes, we used the 5/6 nephrectomized BKS.Cg-Dock7m+/+Leprdb/J, Dock7m+/+Leprdb mice (db/m-5/6Nx mice) as a model for glomerular hyperfiltration. The BKS.Cg-Dock7m+/+Leprdb/J, +Leprdb/+Leprdb mice (db/db mice), a model for type 2 diabetes, was used as the positive control. We investigated the activities and protein levels of the mitochondrial complex, and themitochondrial DNA and adenosine triphosphate content in the kidneys of these models. Blood chemistry and renal histopathological examination were performed for characterization of the disease. Both models showed expansion of the mesangial matrix of the glomeruli, which is indicative of glomerular hyperfiltration. The activities of complexes I and IV and the protein levels of complexes I and III were nonconcordant in db/m-5/6Nx mice. In conclusion, we demonstrated that nonconcordant regulation of mitochondrial complexes in db/m-5/6Nx mice involved with glomerular hyperfiltration. The progression and/or severity of nephropathymight be affected through a synergistic effect of mitochondrial dysfunction in hyperglycemia and glomerular hyperfiltration

Dielectrophoretic Assembly of Gold Nanoparticle Arrays Evaluated in Terms of Room-Temperature Resistance

Gold nanoparticles (GNPs) are often used as island electrodes of single-electron (SE) devices. One of technical challenges in fabrication of SE devices with GNPs is the placement of GNPs in a nanogap between two lead electrodes. Utilization of dielectrophoresis (DEP) phenomena is one of possible solutions for this challenge, whereas the fabrication process with DEP includes stochastic aspects. In this brief paper, we present our experimental results on electric resistance of GNP arrays assembled by DEP. More than 300 pairs of electrodes were investigated under various DEP conditions by trial and error approach. We evaluated the relationship between the DEP conditions and the electric resistance of assembled GNP arrays, which would indicate possible DEP conditions for fabrication of SE devices