1,049 research outputs found
Professionalism and the Millbank Tendency: The Political Sociology of New Labour's employees
This article analyses party employees, one of the most under-researched subjects in the study of British political parties. We draw on a blend of quantitative and qualitative data in order to shed light on the social and political profiles of Labour Party staff, and on the question of their professionalisation. The latter theme is developed through a model derived from the sociology of professions. While a relatively limited proportion of party employees conform to the pure ideal-type of professionalism, a considerably greater number manifest enough of the core characteristics of specialisation, commitment, mobility, autonomy and self-regulation to be reasonably described as 'professionals in pursuit of political outcomes'
Observable Effects of Scalar Fields and Varying Constants
We show by using the method of matched asymptotic expansions that a
sufficient condition can be derived which determines when a local experiment
will detect the cosmological variation of a scalar field which is driving the
spacetime variation of a supposed constant of Nature. We extend our earlier
analyses of this problem by including the possibility that the local region is
undergoing collapse inside a virialised structure, like a galaxy or galaxy
cluster. We show by direct calculation that the sufficient condition is met to
high precision in our own local region and we can therefore legitimately use
local observations to place constraints upon the variation of "constants" of
Nature on cosmological scales.Comment: Invited Festscrift Articl
The Dynamic Insulin Sensitivity and Secretion Test (DISST) - a novel measure of insulin sensitivity
Objective: To validate the methodology for the Dynamic Insulin Sensitivity and Secretion Test (DISST) and to demonstrate its potential in clinical and research settings.
Methods: 123 men and women had routine clinical and biochemical measurements, an oral glucose tolerance test and a DISST. For the DISST, participants were cannulated for blood sampling and bolus administration. Blood samples were drawn at t=0, 10, 15, 25 and 35 minutes for measurement of glucose, insulin and C-peptide. A 10g bolus of intravenous glucose at t=5 minutes and 1U of intravenous insulin immediately after the t=15 minute sample were given. Fifty participants also had a hyperinsulinaemic euglycaemic clamp. Relationships between DISST insulin sensitivity (SI) and the clamp, and both DISST SI and secretion and other metabolic variables were measured.
Results: A Bland-Altman plot showed little bias in the comparison of DISST with the clamp; with DISST underestimating the glucose clamp by 0.1·10-2·mg·l·kg-1·min-1·pmol-1 (90%CI -0.2 to 0). The correlation between SI as measured by DISST and the clamp was 0.82, the c unit for the ROC analysis for the two tests was 0.96. Metabolic variables showed significant correlations with DISST IS, and the second phase of insulin release. DISST also appears able to distinguish different insulin secretion patterns in individuals with identical SI values.
Conclusions: DISST is a simple, dynamic test that compares favourably with the clamp in assessing SI and allows simultaneous assessment of insulin secretion. DISST has the potential to provide even more information about the pathophysiology of diabetes than more complicated tests
Modeled Insulin Sensitivity and Interstitial Insulin Action from a Pilot Study of Dynamic Insulin Sensitivity Tests
An accurate test for insulin resistance can delay or prevent the development of Type 2 diabetes and its complications. The current gold standard test, CLAMP, is too labor intensive to be used in general practice. A recently developed dynamic insulin sensitivity test,
DIST, uses a glucose-insulin-C-peptide model to calculate model-based insulin sensitivity, SI.
Preliminary results show good correlation to CLAMP. However both CLAMP and DIST ignore
saturation in insulin-mediated glucose removal. This study uses the data from 17 patients who
underwent multiple DISTs to investigate interstitial insulin action and its influence on modeled
insulin sensitivity. The critical parameters influencing interstitial insulin action are saturation
in insulin receptor binding, αG, and plasma-interstitial difiusion rate, nI . Very low values of αG
and very low values of nI produced the most intra-patient variability in SI. Repeatability in SI
is enhanced with modeled insulin receptor saturation. Future parameter study on subjects with
varying degree of insulin resistance may provide a better understanding of different contributing
factors of insulin resistance
Observation of exclusive DVCS in polarized electron beam asymmetry measurements
We report the first results of the beam spin asymmetry measured in the
reaction e + p -> e + p + gamma at a beam energy of 4.25 GeV. A large asymmetry
with a sin(phi) modulation is observed, as predicted for the interference term
of Deeply Virtual Compton Scattering and the Bethe-Heitler process. The
amplitude of this modulation is alpha = 0.202 +/- 0.028. In leading-order and
leading-twist pQCD, the alpha is directly proportional to the imaginary part of
the DVCS amplitude.Comment: 6 pages, 5 figure
Exploiting the benefits of multi-scale analysis in reliability analysis for composite structures
This paper investigates two critical issues, namely propagation of multi-scale uncertainty, and selection of failure criteria, related to reliability analysis of composites by using multi-scale methods. Due to the multi-scale architecture of composites, uncertainties exist in both microscale and macroscale parameters. It is necessary, therefore, to consider random variables at various length scales to ensure accurate estimates of the reliability of composites. Three types of homogenization methods, namely rule of mixtures, MoriâTanaka and computational homogenization, are adopted to link these two scales, and to propagate uncertainty from micro to macro scales. By integrating these homogenization methods with the stochastic finite element method and structural reliability methods, the reliability of composites can be investigated with a limit state function based on a chosen failure criterion. This multi-scale reliability analysis procedure has been applied to analyse laminated fibre reinforced composites made of AS4/3501 carbon/epoxy. Firstly, a comparative study has been conducted to evaluate the performance of the assumed homogenization methods for the reliability of composites, and to identify advantages compared with a single scale analysis. The results show that multi-scale analysis can provide more accurate reliability estimates. Secondly, several popularly used failure criteria for composites have been compared using multi-scale reliability analysis
Complete measurement of three-body photodisintegration of 3He for photon energies between 0.35 and 1.55 GeV
The three-body photodisintegration of 3He has been measured with the CLAS
detector at Jefferson Lab, using tagged photons of energies between 0.35 GeV
and 1.55 GeV. The large acceptance of the spectrometer allowed us for the first
time to cover a wide momentum and angular range for the two outgoing protons.
Three kinematic regions dominated by either two- or three-body contributions
have been distinguished and analyzed. The measured cross sections have been
compared with results of a theoretical model, which, in certain kinematic
ranges, have been found to be in reasonable agreement with the data.Comment: 22 pages, 25 eps figures, 2 tables, submitted to PRC. Modifications:
removed 2 figures, improvements on others, a few minor modifications to the
tex
A Kinematically Complete Measurement of the Proton Structure Function F2 in the Resonance Region and Evaluation of Its Moments
We measured the inclusive electron-proton cross section in the nucleon
resonance region (W < 2.5 GeV) at momentum transfers Q**2 below 4.5 (GeV/c)**2
with the CLAS detector. The large acceptance of CLAS allowed for the first time
the measurement of the cross section in a large, contiguous two-dimensional
range of Q**2 and x, making it possible to perform an integration of the data
at fixed Q**2 over the whole significant x-interval. From these data we
extracted the structure function F2 and, by including other world data, we
studied the Q**2 evolution of its moments, Mn(Q**2), in order to estimate
higher twist contributions. The small statistical and systematic uncertainties
of the CLAS data allow a precise extraction of the higher twists and demand
significant improvements in theoretical predictions for a meaningful comparison
with new experimental results.Comment: revtex4 18 pp., 12 figure
eta-prime photoproduction on the proton for photon energies from 1.527 to 2.227 GeV
Differential cross sections for the reaction gamma p -> eta-prime p have been
measured with the CLAS spectrometer and a tagged photon beam with energies from
1.527 to 2.227 GeV. The results reported here possess much greater accuracy
than previous measurements. Analyses of these data indicate for the first time
the coupling of the etaprime N channel to both the S_11(1535) and P_11(1710)
resonances, known to couple strongly to the eta N channel in photoproduction on
the proton, and the importance of j=3/2 resonances in the process.Comment: 6 pages, 3 figure
Measurement of the Deuteron Structure Function F2 in the Resonance Region and Evaluation of Its Moments
Inclusive electron scattering off the deuteron has been measured to extract
the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer
(CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement
covers the entire resonance region from the quasi-elastic peak up to the
invariant mass of the final-state hadronic system W~2.7 GeV with four-momentum
transfers Q2 from 0.4 to 6 (GeV/c)^2. These data are complementary to previous
measurements of the proton structure function F2 and cover a similar
two-dimensional region of Q2 and Bjorken variable x. Determination of the
deuteron F2 over a large x interval including the quasi-elastic peak as a
function of Q2, together with the other world data, permit a direct evaluation
of the structure function moments for the first time. By fitting the Q2
evolution of these moments with an OPE-based twist expansion we have obtained a
separation of the leading twist and higher twist terms. The observed Q2
behaviour of the higher twist contribution suggests a partial cancellation of
different higher twists entering into the expansion with opposite signs. This
cancellation, found also in the proton moments, is a manifestation of the
"duality" phenomenon in the F2 structure function
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