A Genetic Study of Heterochromatin Formation Mediated by a GAA310 Triplet Repeat in Drosophila melanogaster

From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Elena Gracheva and Sarah C. R. Elgi

Design And Development Of Boost A Converter Using Planar Inductor For Dual Supply Automotive System

Today, innovation in electronic automobile components has resulted in the need for higher voltage power supplies. In future automotive vehicles will have 36V operating system. In order to convert to 36V operating system, a 14V/42V dual power supply design is currently being tested and implemented in electric and hybrid vehicles. In future all electrical and diesel vehicle components will be using 42V electronic components ( bulbs, alarms, radio, ICU etc). Boost converter 14V step up to 42V will be an essential component in all vehicles. This work comprises of designing an efficient boost converter which can be easily manufactured and will work for dual supply electrical vehicle as well as diesel vehicle. Current available electric vehicle converters are either buck or bidirectional type. Various topologies have been used in electric vehicle converters. In the early days, auto-transformer topology was common, followed by toroidal inductor which became popular. Currently E-I planar core with spiral PCB inductor are being gradually applied in industry. Jumpstart post embedded in the converter is another key area of electric vehicle converters with dual power supply being studied. The scopes of this research are to evaluate and experiment ideas before building and testing a design with auxiliary start (cracking) aid boost converter that would be compatible the 14V/42V power net. In this research dual supply vehicle boost converter prototype designs were experimented. The work consists of design study of CCM DC-DC Boost Converter with E-I Planar core spiral PCB inductor using a SMT UCC38C43D PWM chip controller. The experimental results are obtained using the Planar spiral inductor DC-DC boost converter, designed to operate in CCM for 120W with an efficient of 85% and output voltage ripple of 5%

Diode Laser - A Novel Therapeutic Approach in the Treatment of Chronic Periodontitis in Type 2 Diabetes Mellitus Patients: A Prospective Randomized Controlled Clinical Trial

Introduction: Maturity-onset diabetes mellitus affecting the elderly population is marked by insulin resistance and decreased insulin production. The relationship between periodontitis and diabetes is bidirectional. Type 2 diabetic patients are more prone to chronic periodontitis (CP) and severe periodontitis affects the glycemic control in such patients. Recently, dental diode laser has become an effective tool in controlling CP. To date, very few studies have been conducted to check the efficacy of diode laser in control of periodontal destruction in type 2 diabetes mellitus (DM2) patients. Hence, the need of the study was to evaluate whether diode laser helps improvement of periodontal outcome and reduction in anaerobic bacteria in elderly diabetic patients with CP.Methods: Forty DM2 patients with CP were randomized into group A (control): scaling and root planing (SRP) only and group B (test): SRP followed by soft tissue dental diode laser (808 nm) application. Four patients (2 in each group) were lost during follow up. Clinical parameters, plaque samples and glycated hemoglobin levels were evaluated at both baseline and 90 days post-treatment.Results: Improvement in clinical, microbiological and glycemic parameters were noted in the group that received SRP as well as SRP + LANAP (laser-assisted new attachment procedure). The reductions in clinical parameters were statistically significant after 3 months (P < 0.001). The microbial analysis of plaque samples for Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) decreased significantly after 3 months in group B than in group A. Glycated hemoglobin level (HbA1c) decreased significantly after 90 days in both the groups (P < 0.001) with more reduction in the SRP+LANAP group (6.49%) in comparison to SRP alone (16.25% vs. 9.76%). However, on the intergroup comparison, the difference in HbA1c reduction was nonsignificant.Conclusion: Laser as an adjunct to SRP is an effective procedure for improving clinical and microbiological parameters in maturity onset diabetes mellitus patients with CP. Also, there was a better improvement in glycemic control in the test group compared to control group after 3 months. Hence, medically compromised patients like DM2 with CP with delayed wound healing can effectively be treated by laser as an adjunct to nonsurgical periodontal therapy for better results

PAOD: a predictive approach for optimization of design in FinFET/SRAM

The evolutions in the modern memory units are comeup with FinFET/SRAM which can be utilized over high scaled computing units and in other devices. Some of the recent systems were surveyed through which it is known that existing systems lags with improving the performance and optimization of FinFET/SRAM design. Thus, the paper introduces an optimized model based on Search Optimization mechanism that uses Predictive Approach to optimize the design structure of FinFET/SRAM (PAOD). Using this can achieve significant fault tolerance under dynamic cumpting devices and applications. The model uses mathematical methodology which helps to attain less computational time and significant output even at more simulation iteration. This POAD is cost effective as it provides better convergence of FinFET/SRAM design than recursive design

SOLID DISPERSION TECHNIQUE TO ENHANCE THE SOLUBILITY AND DISSOLUTION RATE OF ARIPIPRAZOLE BY FUSION METHOD

Objective: The objective of the present study was to enhance the solubility and dissolution rate of Aripiprazole (APZ), a water insoluble drug, by a solid dispersion technique.Methods: Solid dispersions (SD) of APZ were prepared by fusion method using water-soluble carriers like, polyethylene glycol 4000 (PEG 4000), Croscarmellose sodium (CCS) and Crospovidone (CP) and were characterized by in-vitro dissolution, Fourier transform infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC) studies.Results: PEG 4000 physical mixtures containing APZ, showed enhanced dissolution rate as compared with pure drug. Binary solid dispersions showed an improvement in the dissolution rate when compared to the physical mixtures (PM) and pure drug. From ternary solid dispersions with CCS, formulation code SD9 showed 88.2% and with CP, formulation code SD15 showed 70.9%, whereas pure drug showed 18.8 % drug release at the end of 60 min. Based on the in-vitro dissolution studies of solid dispersions, the SD9 was selected to prepare tablets. From the dissolution studies of tablets, the formulation 4F3 showed rapid dissolution than other formulations and pure drug. FTIR, DSC studies suggesting that there was no physical and chemical interaction in between APZ and carriers.Conclusion: Hence, it can be concluded that ternary solid dispersions in association with super disintegrants were more effective to increase the dissolution rate of low soluble drug than solid binary dispersions, physical mixtures, and pure drug.Â

Recent Developments in Selected Sesquiterpenes: Molecular Rearrangements, Biosynthesis, and Structural Relationship among Congeners

Recent developments in selected sesquiterpenoids are reviewed for the past one decade (2005–2017) with special reference to Mechanisms of multistep molecular rearrangements of some sesquiterpenes or derivatives based on isotopic labeling studies and extensive spectroscopic analysis such as molecular rearrangement of acetyl cedrene to cedrene follower, acid catalyzed rearrangement of moreliane-based triketone, synthesis of (−)-isocomene and (−)-triquinane by acid-catalyzed rearrangement of (−)-modhephene, Total synthesis of (+)-cymbodiacetal, BF3 catalyzed molecular rearrangements of mono epoxides of α- and β-himachalenes, santonic acid: Zn-HCl-ether reduction. Insights into biosynthesis of albaflavenone, caryol-1(11)-ene-10-ol, (+)-koraiol, pogostol, patchouli alcohol and valerenadiene are discussed. Congeners for probing structure-biosynthetic relationship. This approach is discussed with the availability of very interesting results on the isolation of highly oxygenated secondary metabolites from endophytic fungi, Xylaria sp