Pengaruh Model Continuity of Care dalam Asuhan Kehamilan dan Persalinan terhadap Luaran Bayi Baru Lahir

The aim of this research is to analyze the influence of the continuity of care model in pregnancy and childbirth care on the outcomes of newborn babies. The research method used is quasi-experimental with the Posttest-Only Control Design method. The research was carried out in the working area of the Weru and Danowudu Bitung Community Health Centers, North Sulawesi, from 16 March to 16 June 2023. The population was 173 respondents and the sampling technique, namely consecutive sampling, obtained 70 pregnant women divided into 2 groups, 35 each for the intervention group and 35 for the intervention group. for the control group. The results of the research show that the probability value in the chi-square test is 0.007 in the intervention and control groups, where this value is smaller than the standard significant value of 0.05, which means there is a significant influence from the results of the Continuity of Care model in pregnancy and delivery care on the outcomes of new babies. born. The conclusion obtained is that the influence of continuity of care in pregnancy and childbirth care can influence the outcomes of newborn babies. So to improve and maintain the quality of services for pregnant women, giving birth, BBL, it is necessary to provide continuous midwifery care.   Keywords: ANC, Continuity of Care, Pregnant Women, Baby Outcome

Case Report : Cervical Cellular Angiofibroma

Background: Cellular angiofibroma is a rare benign tumor in the distal genitalia introduced by Nucci et al in 1997 that can occur in both women and men with an age range of 46 – 54 years. In women it usually occurs in the vulva and vagina. These tumors are often diagnosed as Bartholin cysts, vulvar cysts, myomas, and unspecified complex tumors. Objective: Report a case of cellular angiofibroma previously diagnosed with cervical myoma Case: A 51-year-old female patient para 5 abortion 0 with complaints of lumps that have been felt to come in and out since 4 months but since 1 week it feels enlarged and cannot be inserted again, and diagnosed as cervical tumor. History of menopause since 1 year ago. The general condition of the patient is good with vital signs within normal limits. On physical examination of the abdomen, there was no tumor mass, tenderness or flux. On inspection, there was a reddish mass coming out of the vaginal introitus with some blackish necrotic appearance. On vaginal examination, a mass with a solid consistency was found with the impression of the cervix with a border of the tumor stalk that was not palpable. In this patient, Total Abdominal Hysterectomy and Bilateral Salpingoophorectomy were performed and the tissue was examined for anatomical pathology with cervical angiofibroma results with non-specific chronic inflammation and atypical complex endometrial gland hyperplasia.  Conclusion : Cellular angiofibroma is a rare tumor that usually occur in the vulva and vagina, which is often diagnosed as Bartholin's cyst, vulvar cyst, myoma and unspecified complex tumor. Action in the form of total excision of tumor tissue gives a low recurrence. Keywords : Cervical angiofibroma, cervical tumo

Ekspresi Phosphatase Regenerating Liver-3 dan E-Cadherin pada Kanker Serviks Stadium Awal dan Lanjut Lokoregional

Tujuan: untuk menyelidiki hubungan antara ekspresi PRL-3 dan E-Cadherin dengan stadium, jenis histopatologi, dan derajat diferensiasi kanker serviks. Metode: penelitian ini merupakan studi analitik dengan pendekatan potong lintang di beberapa rumah sakit pendidikan Bagian Obstetri dan Ginekologi, Makassar, mulai Januari hingga Juni 2011. Ekspresi PRL-3 dan E-Cadherin diperiksa dengan pengecatan imunohistokimia pada 16 kanker serviks stadium awal dan 15 stadium lanjut lokoregional. Hasil: ekspresi PRL-3 tidak berbeda bermakna antara kanker serviks stadium awal dengan stadium lanjut lokoregional, antara berbagai jenis histopatologik dan derajat diferensiasi (p>0,05). Ekspresi E-Cadherin juga menunjukkan tidak ada perbedaan bermakna antara berbagai stadium, jenis histopatologi, dan derajat diferensiasi (p>0,05). Tidak didapatkan korelasi bermakna antara ekspresi PRL-3 dengan E-Cadherin pada penelitian ini. Kesimpulan: tidak ada hubungan antara ekspresi PRL-3 dan E-Cadherin dengan stadium, jenis histopatologi, dan derajat diferensiasi kanker serviks

Chlamydia Trachomatis Infection and Ectopic Pregnancy: Infeksi Chlamydia Trachomatis dan Kehamilan Ektopik

  Objective: To determine the relationship of Chlamydia trachomatis infection in patient with ruptured ectopic pregnancy through examination of endocervical swabs, tubal tissue using Polymerase chain reaction (PCR) and Enzyme linked immunoabsorb and assay (ELISA) serum IgG antibodies Specific to Chlamydia trachomatis.Method: This study was an observational analytic study with a cross sectional study design. In this study, there were 50 participants consisting of 25 ruptured ectopic pregnancy patients and 25 non-ruptured ectopic pregnancy patients who underwent treatment at Dr.Wahidin Sudirohusodo Hospital as well as networking hospitals at the Universitas Hasanuddin in Makassar City.Results: The results showed that Chlamydia trachomatis infection in patients with ruptured ectopic pregnancies was found to be 84% positive in tubal tissue, 72% with endocervical swabs and 64% with serum examination. There was a significant relationship between chlamydial tracheal infection obtained through examination of tubal tissue, endocervical swab and specific serum IgG in patients with ruptured ectopic pregnancy (p <0.001).Conclusion: Based on the results of the study, it can be concluded that Chlamydia trachomatis infection can significantly affect the occurrence of ruptured ectopic pregnancy.Keywords: Chlamydia trachomatis, endocervical swab, ruptured ectopic pregnancy, serum IgG, tubal tissue.   Abstrak Tujuan : Untuk mengetahui hubungan infeksi Chlamydia trachomatis pada pasien penderita Kehamilan Ektopik Terganggu (KET) melalui swab endoserviks dan jaringan tuba menggunakan pemeriksaan Polymerase Chain Reaction (PCR) dan Enzyme linked immunoabsorb and assay (ELISA).Metode : Penelitian ini merupakan studi analitik observasional dengan desain studi potong lintang. Pada penelitian ini terdapat 50 orang partisipan yang terdiri atas 25 orang pasien kehamilan ektopik terganggu dan 25 orang pasien non-kehamilan ektopik terganggu yang menjalani pengobatan di RSUP Dr.Wahidin Sudirohusodo serta RS jejaring Universitas Hasanuddin di Kota Makassar.Hasil : Hasil penelitian menunjukkan bahwa infeksi Chlamydia trachomatis pada pasien dengan kehamilan ektopik tergangu didapatkan sebesar 84% positif di jaringan tuba, 72% dengan swab endoserviks dan 64% dengan pemeriksaan serum. Terdapat hubungan yang signifikan antara infeksi klamidia trakomatis yang didapatkan melalui pemeriksaan jaringan tuba, swab endoserviks maupun serum IgG spesifik pasien kehamilan ektopik terganggu (p<0,001).Kesimpulan : Berdasarkan hasil penelitian, dapat disimpulkan bahwa infeksi Chlamydia trachomatis secara signifikan dapat mempengaruhi terjadinya kehamilan ektopik terganggu.Kata kunci : chlamydia trachomatis, jaringan tuba, kehamilan ektopik terganggu, swab endoserviks, serum Ig

Endoglin Expression (CD105) in Ephithelial Ovarian Cancer

Abstract Objective: Endoglin ( CD105 ) is one of the factors that play a role in vascular development , angiogenesis and vascular homeostasis. The aim of this research is to address the endoglin expression (CD105) in primary tumor and metastasis tumor (omentum) and their relation with clinicopathological factor: stadium, differentiation level, and histological epithelial ovarian cancer. Method: The research was performed at Public Service Hall of Dr. Wahidin Sudirohusodo Hospital and educational networking hospital of Obstetrics and Gynecology Departement of Medical Faculty Hasanuddin University Makassar. The research design is cross sectional with 55 samples consisting of 55 samples of primary tumor and 55 matastasis tumor. Imunohistochemistry examination was performed to all samples. Result:The results show a significant relation between endoglin (CD105) at omentum metastasis tumor and stadium and cell differentiation level of epithelial ovarian cancer. There is no significant relation between endoglin (CD105) expression at primary tumor of ovarian cancer and stadium and differentiation and type of histopathological cell. In addition, there is no significant relation between endoglin expression (CD105) at omentum metastasis tumor and type of histophatological cell of ovarian cancer. There is a significant correlation (strong category) between endoglin expression at omentum metastasis tumor and endoglin expression at primary tumor of epithelial ovarian cancer. Conclusion: Endoglin expression in ovarian cancer metastatic tumor to omentum is correlated to clinical stage and differentiation level of ovarian cancer. And endoglin is one of the pro angiogenic and pro metastasis factors. Keywords:epithelial ovarian cancer, endoglin expression, CD105, immunohistochemistr

Persiapan Persalinan dan Kelahiran Di Masa Pandemi COVID-19

Pandemi COVID-19 berdampak di segala aspek, salah satunya adalah aspek Kesehatan yang megakibatkan kegiatan langsung tatap muka dengan tenaga kesehatan dalam pelayanan Antenatal Care (ANC) di batasi. Hal tersebut menimbulkan kecemasan bagi ibu hamil dalam menghadapi persalinan dan kelahiran mereka. Berdasarkan kondisi tersebut, maka pengabdian masyarakat dilaksanakan dengan cara sosialisasi peningkatan dan pengetahuan ibu hamil tentang persiapan persalinan dan kelahiran di masa pandemi COVID-19. Pelaksanaan sosialisasi dilaksanakan dengan 2 pendekatan yaitu survei daring dengan e-form melalui media whatsapp dan menemui secara lagsung ibu-ibu yang sedang hamil dari rumah ke rumah yang tentu saja dilaksanakan sesuai protokol Kesehatan COVID-19. Hasil survey didapatkan pada kelompok yang memakai google form pengetahuan pretest didapatkan nilai rata-rata 49% meningkat setelah posttest menjadi 89%. Sedangkan pada kelompok yang kunjungan rumah pengetahuan pretest didapatkan hasil 47% meningkat setelah posttest menjadi 87%. Pelaksanaan pengabdian ini berjalan lancar karena didukung oleh pemerintah dan masyarakat sekitar. Kedepannya diharapkan sosialisasi seperti ini dapat diterapkan oleh stakeholder dalam menangani dan mengambil kebijakan kesehatan terkait dengan pelayanan Kesehatan kepada ibu hamil di masa pandemi saat ini

The Risk of Infection Human Papilloma Virus Infection in Acceptors of Depot Medroxyprogesterone Acetate Contraceptions

Objective: Cervical cancer is the second most prevalent cancer in women around the world and the most common cancer in women causing death. This study aims to analyze the connection between infection of human papilloma virus (HPV) 16/18 and cervical changes in the acceptors of Depot Medroxyprogesterone Acetate (DMPA) Contraceptions and nonacceptors of Depot Medroxyprogesterone Acetate (DMPA) Contraceptions. Methods: The research was conducted at the Public Service Institution of Dr. Wahidin Sudirohusodo hospital, and private midwife clinics for seven months from December 2015 to June 2016. The research design is cross-sectional with. The samples were forty acceptors of Depot Medroxyprogesterone Acetate (DMPA) and forty non-acceptors of Depot Medroxyprogesterone Acetate (DMPA) contraception. Prevalence of HPV 16/18 and cervical cytology changes were examine using the polymerase chain reaction and liquid base cervical cytology. Results: The results showed there was no significant relationship between long-term use of DMPA contraceptives with HPV 16 and 18. There was no significant relationship between long-term use of DMPA contraceptives with cervical cytology changes. There was no significant relationship between HPV 16 and 18 infections with the occurrence of cervical cytology changes in long-term use of DMPA contraceptives. Conclusion: The long-term use of DMPA contraceptive does not increase the risk of HPV 16 and 18 infections. Also does not cause cervical cytology changes that lead to cervical malignancy. Keywords: cervical cytology changes, Depot Medroxyprogesterone Acetate (DMPA) contraception, HPV 16/18 infectio

Peran Phosphatase Regenerating Liver-3 dan Vascular Endothelial Growth Factor dalam Progresivitas Kanker Ovarium Epitelial

Tujuan: Mengetahui peran phosphatase regenerating liver-3 (PRL-3) dan vascular endothelial growth factor (VEGF) dalam progresivitas kanker ovarium.Metode: Penelitian dilakukan pada penderita kanker ovarium di beberapa rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin Makassar. Pengambilan sampel dilaksanakan secara consecutive sampling. Pengambilan cairan ascites dan jaringan tumor pada saat operasi dilakukan untuk pemeriksaan hematoksilin eosin dan immunohistokimia, dan pemeriksaan mRNA dengan RT-PCR. Pemeriksaan hematoksilin eosin untuk mengukur histopatologi. Pemeriksaan imunohistokimia dilakukan untuk mengetahui ekskpresi PRL-3 dan VEGF. RT-PCR digunakan untuk melakukan pemeriksaaan mRNA PRL-3. Data dianalisis dengan uji chi-square dan analisis korelasi Spearman pada taraf signifikansi 5%.Hasil: Hasil diperoleh 38 subyek penelitian yang terdiri dari 26,3% stadium awal dan 73,7% stadium lanjut. Ekspresi PRL-3 tidak berbeda secara bermakna berdasarkan stadium, derajat diferensiasi, dan lokasi tumor dengan p > 0,05. Ekspresi PRL-3 pada kanker ovarium primer yang disertai metastasis lebih tinggi secara bermakna dibandingkan dengan kanker ovarium primer tanpa metastasis (p 0,05. Ada korelasi positif yang bermakna antara ekspresi PRL-3 dengan VEGF pada kanker ovarium epitelial (p 0.05. PRL-3 expression in primary ovarian cancer with metastases was significantly higher than in primary ovarian cancer without metastases (p 0.05. There was a significant positive correlation between PRL-3 expression and VEGF in epithelial ovarian cancer (p<0.05). Conclusion: The high expression of PRL-3 increases the expression of VEGF and the progression of epithelial ovarian cancer. Key words: ovarian cancer, phosphatase regenerating liver-3, vascular endothelial growth facto

Pengabdian Masyarakat tentang Penyuluhan Kanker Payudara Untuk Meningkatkan Derajat Kesehatan Ibu

Wanita memiliki banyak permasalahan kesehatan reproduksi yang perlu mendapat perhatian khusus. Menurut data GLOBOCAN International Agency for Research on Cancer (IARC) tahun 2012 diketahui kanker serviks merupakan salah satu penyebab kematian kaum wanita yang cukup tinggi, baik di negara-negara maju maupun di negara berkembang seperti Indonesia dan terbanyak yang dialami oleh wanita di seluruh dunia dengan persentase sementara untuk kanker serviks 14,0 dan persentase kematian sebesar 6,8 %.Tujuan kegiatan ini agar masyarakat dapat memahami penyebab dan gejala kanker payudara serta pencegahan dan pemeriksaan sendiri pada payudara (SADARI). Kegiatan ini dilakukan di Puskesmas Ballaparang Kecamatan Rappocini. Kegiatan ini merupakan lankah awal untuk meningkatkan kesadaran masyarakat tentang pentingnya pemeriksaan payudara sendiri untuk mendeteksi dini kanker payudara

Differences of heparin binding protein levels in preeclampsian and non preeclampsian women

This study aims to the incidence of preeclampsia and determine differences in heparin-binding protein levels in preeclamptic and non-preeclamptic mothers and determine the relationship between urinary tract infections in pregnancy. The research design was cross-sectional on 65 respondents with an accidental sampling technique. The research data were obtained from a questionnaire containing a list of questions given to respondents, measurement of middle urine samples to measure nitrite, leukocytes urine using dipstick method, and to determine heparin binding protein (HBP) levels using the ELISA method in the Hasanuddin University RSP Research Laboratory. The results of the study found there was a difference in the levels of heparin-binding protein in pregnant women without preeclampsia, namely 1.90±0.22 Ng/ml and HBP levels in pregnant women preeclampsia ie 2.39±0.3 Ng/ml. That there was no significant relationship between urinary tract infections (UTI) and the incidence of preeclampsia with p= 0.074. The conclusion in this study is that the levels of heparin-binding protein differ in preeclamptic and non-preeclamptic mothers, the increase in HBP levels in preeclampsia is due to inflammation, the cause is not through UTI. There is no association between urinary tract infections in pregnant women and the incidence of preeclampsia