Convective Heat Transfer and Pumping Power Analysis of MWCNT + Fe3O4/Water Hybrid Nanofluid in a Helical Coiled Heat Exchanger with Orthogonal Rib Turbulators

Utilizing nanofluids in heat exchangers can lead to improved thermal performance. Nanofluids with suspended carbon nanotubes are specifically desirable in thermal systems because of their unique capabilities. In this study, convective heat transfer and required pumping power are studied simultaneously for a helical coiled heat exchanger with laminar water flow while incorporating 0.1 and 0.3 percent volume fraction of the hybrid nanofluid MWCNT + Fe3O4/water. Two different geometries of bare and ribbed tubes are used for the heat exchanger part. The ribs are chosen to be orthogonal, i.e., 90° with respect to the inclined ones. Three different Reynolds numbers are selected for investigation, all in laminar flow regime based on the non-dimensional M number defined in coiled tubes. Computational fluid dynamics is used to study thermal and fluid behavior of the problem. The convective heat transfer coefficient can serve as a criterion to measure the effectiveness of utilizing nanofluids in heat exchangers by taking the pressure drop and pumping power of the system into consideration. Finally, the artificial neural network curve fitting tool of MATLAB is used to make a good fit in the data range of the problem. It is shown that for most cases of the study, the pumping power ratio is less than 1 that can be considered appropriate from energy consumption viewpoint.publishedVersio

CAG repeat polymorphism in androgen receptor and infertility: A case-control study

Background: Androgens play a role in the development of male phenotype and spermatogenesis during puberty, the function of which is regulated by the androgen receptor (AR) gene. There is a polymorphism site in exon 1 of the gene encoding this receptor that can have different frequencies of CAG trinucleotide repeats and leads to the formation of polyglutamine chains of different lengths in the N-terminal domain of the AR protein and reduced sperm production by affecting spermatogenesis. Objective: To investigate whether the cause of a group of unexplained infertilities could be the increased frequency of CAG repeats in the AR gene of patients with oligozoospermia and azoospermia. Materials and Methods: In this case-control study, 84 men including 42 with unexplained infertility As a case group and 42 fertile men as a control group were selected. The frequency of CAG repeats was determined by the polymerase chain reaction method and then the difference in the frequency of these repeats was determined based on the difference in band size on the agarose gel. Results: The mean CAG repeat length in the azoospermia and oligozoospermia group was 17.5 ± 0.63 and in the fertile group it was 16.11 ± 0.75 (p = 0.46). In addition, most men (88.1% in the case group and 71.41% in the control group) had 13-23 repeats. Conclusion: No significant correlation was found between CAG repeat length and the risk of male factor infertility in an ethnically defined population of Iranian men. The role of regulatory factors and epigenetic changes should be taken into account too. Key words: Infertility, Azoospermia, Androgens, X chromosome, Spermatogenesis