Tidal Distortions in NGC1052-DF2 and NGC1052-DF4: Independent Evidence for a Lack of Dark Matter

Two ultra diffuse galaxies in the same group, NGC1052-DF2 and NGC1052-DF4, have been found to have little or no dark matter and to host unusually luminous globular cluster populations. Such low mass diffuse objects in a group environment are easily disrupted and are expected to show evidence of tidal distortions. In this work we present deep new imaging of the NGC1052 group obtained with the Dragonfly Telephoto Array to test this hypothesis. We find that both galaxies show strong position angle twists and are significantly more elongated in their outskirts than in their interiors. The group's central massive elliptical NGC1052 is the most likely source of these tidal disturbances. The observed distortions imply that the galaxies have a low total mass or are very close to NGC1052. Considering constraints on the galaxies' relative distances, we infer that the dark matter halo masses of these galaxies cannot be much greater than their stellar masses. Calculating pericenters from the distortions, we find that the galaxies are on highly elliptical orbits, with a ratio of pericenter to present-day radius Rperi/R0~0.1 if the galaxies are dark matter-free and Rperi/R0~0.01 if they have a normal dark halo. Our findings provide strong evidence, independent of kinematic constraints, that both galaxies are dark matter deficient. Furthermore, the similarity of the tidal features in NGC1052-DF2 and NGC1052-DF4 strongly suggests that they arose at comparable distances from NGC1052. In Appendix A, we describe sbcontrast, a robust method to determine the surface brightness limits of images.Comment: Resubmitted to ApJ after incorporating the referee's comments. The revised version includes a new Appendix A which describes sbcontrast, a method for determining the surface brightness depth of image

Haptoglobin Genotype Is a Consistent Marker of Coronary Heart Disease Risk Among Individuals With Elevated Glycosylated Hemoglobin

ObjectivesThis study sought to investigate into the biologically plausible interaction between the common haptoglobin (Hp) polymorphism rs#72294371 and glycosylated hemoglobin (HbA1c) on risk of coronary heart disease (CHD).BackgroundStudies of the association between the Hp polymorphism and CHD report inconsistent results. Individuals with the Hp2-2 genotype produce Hp proteins with an impaired ability to prevent oxidative injury caused by elevated HbA1c.MethodsHbA1c concentration and Hp genotype were determined for 407 CHD cases matched 1:1 to controls (from the NHS [Nurses' Health Study]) and in a replication cohort of 2,070 individuals who served as the nontreatment group in the ICARE (Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment) study, with 29 CHD events during follow-up. Multivariate models were adjusted for lifestyle and CHD risk factors as appropriate. A pooled analysis was conducted of NHS, ICARE, and the 1 previously published analysis (a cardiovascular disease case-control sample from the Strong Heart Study).ResultsIn the NHS, Hp2-2 genotype (39% frequency) was strongly related to CHD risk only among individuals with elevated HbA1c (≥6.5%), an association that was similar in the ICARE trial and the Strong Heart Study. In a pooled analysis, participants with both the Hp2-2 genotype and elevated HbA1c had a relative risk of 7.90 (95% confidence interval: 4.43 to 14.10) for CHD compared with participants with both an Hp1 allele and HbA1c <6.5% (p for interaction = 0.004), whereas the Hp2-2 genotype with HbA1c <6.5% was not associated with risk (relative risk: 1.34 [95% confidence interval: 0.73 to 2.46]).ConclusionsHp genotype was a significant predictor of CHD among individuals with elevated HbA1c

Galaxies lacking dark matter produced by close encounters in a cosmological simulation

The standard cold dark matter plus cosmological constant model predicts that galaxies form within dark-matter haloes, and that low-mass galaxies are more dark-matter dominated than massive ones. The unexpected discovery of two low-mass galaxies lacking dark matter immediately provoked concerns about the standard cosmology and ignited explorations of alternatives, including self-interacting dark matter and modified gravity. Apprehension grew after several cosmological simulations using the conventional model failed to form adequate numerical analogues with comparable internal characteristics (stellar masses, sizes, velocity dispersions and morphologies). Here we show that the standard paradigm naturally produces galaxies lacking dark matter with internal characteristics in agreement with observations. Using a state-of-the-art cosmological simulation and a meticulous galaxy-identification technique, we find that extreme close encounters with massive neighbours can be responsible for this. We predict that ~30% of massive central galaxies (with at least 1011 solar masses in stars) harbour at least one dark-matter-deficient satellite (with 108–109 solar masses in stars). This distinctive class of galaxies provides an additional layer in our understanding of the role of interactions in shaping galactic properties. Future observations surveying galaxies in the aforementioned regime will provide a crucial test of this scenario

Social Cognition in Alzheimer's Disease: A Separate Construct Contributing to Dependence

The extent to which social cognitive changes reflect a discrete constellation of symptoms dissociable from general cognitive changes in Alzheimer's disease (AD) is unclear. Moreover, whether social cognitive symptoms contribute to disease severity and progression is unknown. The current multicenter study investigated cross-sectional and longitudinal associations between social cognition measured with six items from the Blessed Dementia Rating Scale, general cognition, and dependence in 517 participants with probable AD. Participants were monitored every 6 months for 5.5 years. Results from multivariate latent growth curve models adjusted for sex, age, education, depression, and recruitment site revealed that social cognition and general cognition were unrelated cross-sectionally and throughout time. However, baseline levels of each were related independently to dependence, and change values of each were related independently to change in dependence. These findings highlight the separability of social and general cognition in AD. Results underscore the relevance of considering social cognition when modeling disease and estimating clinical outcomes related to patient disability

Predicting Friendship Quality in Autism Spectrum Disorders and Typical Development

The role played by social relationship variables (attachment security; mother–child relationship qualities) and social-cognitive capacities (theory of mind) was examined in both observed friendship behaviors and in children’s descriptions of friendships (age 8–12) with high functioning children with autism spectrum disorders (HFASD) (n = 44) and with typical development (TYP) (n = 38). Overall, half of the HFASD sample (54.45%) reported maternal attachment security, corroborating data from younger children with ASD. The hypothesized predictors and their interrelations had both direct and indirect effects on friendship for both groups of children, highlighting the importance of these factors in children’s friendship development and suggesting both compensatory and amplification mechanisms for friendship qualities. Practical and clinical implications are discussed for friendship support in both ASD and TYP

Abstract Reasoning and Friendship in High Functioning Preadolescents with Autism Spectrum Disorders

To investigate the relationship between cognitive and social functioning, 20 Israeli individuals with HFASD aged 8–12 and 22 age, maternal education, and receptive vocabulary–matched preadolescents with typical development (TYP) came to the lab with a close friend. Measures of abstract reasoning, friendship quality, and dyadic interaction during a play session were obtained. As hypothesized, individuals with HFASD were significantly impaired in abstract reasoning, and there were significant group differences in friend and observer reports of friendship quality. There also was consistency in reports between friends. Two factors—“relationship appearance” and “relationship quality” described positive aspects of the relationships. Disability status and age related to relationship appearance. Proband abstract reasoning was related to relationship quality