Prevalence of hypospadias patients with undescended testis

Hypospadias is an anomaly of meatus urethra externus on ventral penis. It caused by incomplete fusion of urethral folds. The purpose of this study was to investigate the prevalence of hypospadias with undescended testis in the Department of Surgery Mohammad Hoesin Hospital in Palembang Indonesia. A prevalence study was done in the Medical Records Department of Mohammad Hoesin Hospital from July 2018 to February of 2019. 103 patients met study inclusion criteria. Univariate analysis of the patients’ data was conducted using IBM SPSS Statistics 25. The study found that hypospadias was most common in the age group of 1 to 5 years old (49.5%) and the most common type of hypospadias was severe hypospadias (68.9%). Furthermore, 7 out of 103 patients (6.8%) were hypospadias patients with undescended testis and the most common types of undescended testis among them were bilateral undescended testis and left undescended testis with 3 patients each (42,85%). Prevalence of hypospadias with undescended testis were 7 people (6,8%)

Hubungan Antara Kontrol Diri dengan Kesejahteraan Subjektif Pada Remaja

This study aims to determine the relationship between self-control with subjective well-being in adolescents. The method used in this research is a quantitative method. The variables studied were self-control independent variables (X) and the dependent variable was subjective welfare (Y). The technique used in this study is a non-probability technique, namely purposive sampling, which means that the sampling technique uses certain criteria. The population of this study was the students of SMKN 2 Jepara. The sample of this study amounted to 60 students at SMKN 2 Jepara taken from class X and XI vocational textil. Collecting data by using a questionnaire using a Likert model scale, namely the scale used in the form of a survey. Test the instrument with validity and reliability. Data analysis technique with normality test, linearity test, hypothesis testing with product moment technique. With the conclusion that there is a significant relationship between self-control variables with subjective well-being variables in adolescents. The value of the positive correlation coefficient which means that there is a positive relationship between self-control and subjective well-being and the hypothesis in the study was accepted. Which means that self-control has a positive impact on improving subjective well-being in adolescents. The results of the study prove that the category for the self-control variable is in the high category and also for the subjective welfare variable in the very high category

Major Families of Multiresistant Plasmids from Geographically and Epidemiologically Diverse Staphylococci

Staphylococci are increasingly aggressive human pathogens suggesting that active evolution is spreading novel virulence and resistance phenotypes. Large staphylococcal plasmids commonly carry antibiotic resistances and virulence loci, but relatively few have been completely sequenced. We determined the plasmid content of 280 staphylococci isolated in diverse geographical regions from the 1940s to the 2000s and found that 79% of strains carried at least one large plasmid >20 kb and that 75% of these large plasmids were 20–30 kb. Using restriction fragment length polymorphism (RFLP) analysis, we grouped 43% of all large plasmids into three major families, showing remarkably conserved intercontinental spread of multiresistant staphylococcal plasmids over seven decades. In total, we sequenced 93 complete and 57 partial staphylococcal plasmids ranging in size from 1.3 kb to 64.9 kb, tripling the number of complete sequences for staphylococcal plasmids >20 kb in the NCBI RefSeq database. These plasmids typically carried multiple antimicrobial and metal resistances and virulence genes, transposases and recombinases. Remarkably, plasmids within each of the three main families were >98% identical, apart from insertions and deletions, despite being isolated from strains decades apart and on different continents. This suggests enormous selective pressure has optimized the content of certain plasmids despite their large size and complex organization

Pengaruh derajat desentralisasi, retribusi daerah,pertumbuhan ekonomi dan pajak daerah terhadap belanja modal (studi empiris seluruh kabupaten/kota di seluruh indonesia tahun 2019-2020)

This study aims to test whether the degree of decentralization, regional levies, economic growth and local taxes have an effect on capital expenditure. The independent variables in this study are the degree of decentralization, regional levies, economic growth and local taxes. In addition, this study also uses secondary data collection methods. The hypothesis testing of this research was conducted using multiple linear regression analysis. This study provides statistical results showing that the degree of decentralization, regional levies, economic growth has a significant positive effect on capital expenditures, while regional taxes have a significant negative effect on capital expenditures

Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy

The content of human sweat is studied by high-resolution NMR, and the majority of organic components most often found in sweat of conditionally healthy people are identified. Original and simple tools are designed for sweat sampling from different areas of human body. The minimal surface area needed for sampling is in the range of 50–100 cm2. On all the surface parts of the human body examined in this work, the main constituents forming a sweat metabolic profile are lactate, glycerol, pyruvate, and serine. The only exception is the sole of the foot (planta pedis), where trace amounts of glycerol are found. An attempt is made to explain the presence of specified metabolites and their possible origin

Sensory processing patterns, coping strategies, and quality of life among patients with unipolar and bipolar disorders.

OBJECTIVE: To compare sensory processing, coping strategies, and quality of life (QoL) in unipolar and bipolar patients; to examine correlations between sensory processing and QoL; and to investigate the relative contribution of sociodemographic characteristics, sensory processing, and coping strategies to the prediction of QoL. METHODS: Two hundred sixty-seven participants, aged 16-85 years (53.6+/-15.7), of whom 157 had a diagnosis of unipolar major depressive disorder and 110 had bipolar disorder type I and type II, completed the Adolescent/Adult Sensory Profile, Coping Orientations to Problems Experienced, and 12-item Short-Form Health Survey version 2. The two groups were compared with multivariate analyses. RESULTS: The unipolar and bipolar groups did not differ concerning sensory processing, coping strategies, or QoL. Sensory processing patterns correlated with QoL independently of mediation by coping strategies. Correlations between low registration, sensory sensitivity, sensation avoidance, and reduced QoL were found more frequently in unipolar patients than bipolar patients. Higher physical QoL was mainly predicted by lower age and lower sensory sensitivity, whereas higher mental QoL was mainly predicted by coping strategies. CONCLUSION: While age may predict physical QoL, coping strategies predict mental QoL. Future studies should further investigate the impact of sensory processing and coping strategies on patients' QoL in order to enhance adaptive and functional behaviors related to affective disturbances

Why Your Encrypted Database Is Not Secure

Encrypted databases, a popular approach to protecting data from compromised database management systems (DBMS’s), use abstract threat models that capture neither realistic databases, nor realistic attack scenarios. In particular, the “snapshot attacker” model used to support the security claims for many encrypted databases does not reflect the information about past queries available in any snapshot attack on an actual DBMS. We demonstrate how this gap between theory and reality causes encrypted databases to fail to achieve their “provable security” guarantees

Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model

Insulin-like growth factor I (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune response. Here, we wanted to know whether an RNA interference approach targeted to IGF-IR could be used for specific antitumor immunostimulation in a breast cancer model. For that, we evaluated short interfering RNA (siRNAs) for inhibition of in vivo tumor growth and immunological stimulation in immunocompetent mice. We designed 2′-O-methyl-modified siRNAs to inhibit expression of IGF-IR in two murine breast cancer cell lines (EMT6, C4HD). Cell transfection of IGF-IR siRNAs decreased proliferation, diminished phosphorylation of downstream signaling pathway proteins, AKT and ERK, and caused a G0/G1 cell cycle block. The IGF-IR silencing also induced secretion of two proinflammatory cytokines, TNF- α and IFN-γ. When we transfected C4HD cells with siRNAs targeting IGF-IR, mammary tumor growth was strongly delayed in syngenic mice. Histology of developing tumors in mice grafted with IGF-IR siRNA treated C4HD cells revealed a low mitotic index, and infiltration of lymphocytes and polymorphonuclear neutrophils, suggesting activation of an antitumor immune response. When we used C4HD cells treated with siRNA as an immunogen, we observed an increase in delayed-type hypersensitivity and the presence of cytotoxic splenocytes against wild-type C4HD cells, indicative of evolving immune response. Our findings show that silencing IGF-IR using synthetic siRNA bearing 2′-O-methyl nucleotides may offer a new clinical approach for treatment of mammary tumors expressing IGF-IR. Interestingly, our work also suggests that crosstalk between IGF-I axis and antitumor immune response can mobilize proinflammatory cytokines