Lung Injuries on Computerized Tomography Due to Pellet Gun

Pellet gun used by law enforcement agencies have the potential to cause grevious or life threatening injuries as metallic projectiles fired at high speeds from pellet gun have potential to damage air containing organs like lungs which occupy a large portion of chest cavity and lie in close approximation to chest wall. Thoracic injury overall is the third most common cause of trauma following injury to the head and extremities. Objective. The objective of this study was to evaluate lung pellet gun injuries in patients of a conflict zone by a so called non-lethal weapon. Methods. The study was conducted in post graduate department of Radiodiagnosis and Imaging, Government Medical College, Srinagar Jammu and Kashmir. Our study was performed between the 6th January 2019 to the 22th May 2019. A total of 40 patients with pellet injuries were taken up for study. Inclusion criteria were patients with pellet gun injuries without any immediate life threatening injury like head injury; patients willing to be part of study. Radiographs of all the patients were studied.  Whenever there was suspicion of severe injury, CT scan was done. We obtained thin-section axial CT scans (0.625– 1.25 mm) with multiplanar reformation with an interval of 3-5 mm. Results. All of the patients were males with most of patients in age group of 20 to 30 years. About 14 patients out of 40 had lung injuries. The most common pattern of lung injury was pneumothorax followed by pulmonary hemorrhage. In conclusion, a so called non-lethal pellet gun used by law enforcement agencies has the potential to cause lung injuries which can sometimes be lethal to life especially when  fired from short distance

Concept, Design and Implementation of Automatic Waste Management System

One of the main concerns with our environment has been solid waste management which in addition to disturbing the balance of the environment also has adverse effects on the health of the society. The detection, monitoring and management of wastes is one of the primary problems of the present era. The traditional way of manually monitoring the wastes in waste bins is a complex, cumbersome process and utilizes more human effort, time and cost which is not compatible with the present day technologies in any wa y. This paper proposes an advanced method in which waste management is automated. Radio frequency identification (RFID) is one of the most promising and anticipated technologies in recent years. The system makes use of radio frequency (RF) tags and web sup port. This work presented here certainly provides a novel approach in handling and disposing off the day to day solid wastes in an efficient and easy way. The system consists of four main subsystems namely Smart Trash System (STS), Local Base Station (LBS) , Smart Vehicle System (SVS) and Smart Monitoring and Controlling Hut (SMCH). The proposed system would be able to automate the solid waste monitoring process and management of the overall collection process. The technologies that would be used in the prop osed system are good enough to ensure the practical and perfect for solid waste collection process monitoring and management for green environment

In vivo evaluation of ziram induced acute toxicity on pathomorphology of broiler chicken

Fungicides are usually used in agriculture and often find their way in poultry feed. Therefore, a study was undertaken to study the in vivo effect of one such fungicide (ziram) induced intoxication on pathomorphology of broiler chicken. After 2 weeks of age the birds were given fungicide (Ziram) in feed as a single oral dose of 100 mg/kg body weight. Out of 10 birds, 3 died due to ziram intoxication (30% mortality rate). Birds that died rapidly showed pronounced neurological signs like convulsions. The carcasses of ziram intoxicated birds appeared dehydrated and their mucous membrane was pale in colour. Marked vascular congestion was observed in brain on gross examination. The livers showed congestion and haemorrhages with necrotic foci. Kidneys and lungs had ecchymotic haemorrhages and heart revealed gelatinization of pericardium, distention and pericarditis. Atrophy of bursa of Fabricius and thymus; hypertrophy of thyroid was found. Histopathological examination revealed neuronal degeneration and necrosis associated with mild gliosis in brain. Lungs, pericardium and epicardium had severe congestion and there was degeneration with separation of myofibers. Glomeruli were congested and frequently revealed hypercellularity. There were sinusoidal congestion and varying degrees of hepatocellular degeneration. Bursa revealed mild depletion of lymphoid cells in few lobules while as thymus showed hypoplasia with depletion of lymphocytes. Thyroid had mild mononuclear cell infiltration and caecum showed marked necrosis and denudation of the mucosa. In conclusion, the depletion of lymphoid tissue from lymphoid organs was suggestive of immunosuppressive and immunomodulatory effects of ziram toxicity in broiler chicken

Eco-Friendly Fluorescent Carbon Nanodots: Characteristics and Potential Applications

Carbon nanodots are zero-dimensional tiny particles of carbon with outstanding characteristics and potential applications. Carbon nanodots are fluorescent materials and possess unique characteristics such as biocompatibility, photostability, low toxicity, sustainable, and eco-friendly. Fluorescent carbon nanodots are emerging nanomaterials that show promising potential in bioimaging, optical sensing, information encryption and storage, photocatalysis, lasers, drug delivery, energy conversion, and photovoltaic applications. Carbon nanodots can be synthesized at very low cost through various sustainable approaches that employ inexpensive renewable resources as starting materials. Carbon nanodots are fascinating carbon-based materials that have received mass attention from past few years for their substantial applications in diverse fields. Carbon nanodots have a huge impact on both health and environmental applications because of their potential to serve as nontoxic replacements to traditional heavy metal-based quantum dots. Herein we highlight the intriguing characteristics and potential applications of fluorescent carbon nanodots in various fields and their perspective in future

Disease modifying activity of methanolic extract of Colchicum luteum against experimental gout in broiler chicken

Colchicum luteum, a Himalayan herb has been found associated with immense pharmaceutical properties. The present study was aimed to study the protective effect of methanolic extract of C. luteum against the haemato-biochemical alterations due to sodium bicarbonate induced gout in broiler chicken. A total of 72 day old broiler chicks of average body weights 178±20.8 g were divided into 6 groups (I to VI, n=12). Group I served as vehicle-treated control and was given drinking water by oral gavage. Group II and III were given sodium bicarbonate @ 2.5 and 5% respectively in drinking water. Group IV and V were provided with 2.5 and 5% sodium bicarbonate along with C. luteum extract @ 50 mg/kg body weight respectively. Group VI served as treatment control and was given C. luteum extract @ 50 mg/kg body weight alone. Haematological and biochemical analysis revealed a significant increase in haematological parameters (Hb, PCV, TEC, TLC, and heterophil) and biochemical parameters (AST, ALT, uric acid, BUN, creatinine, total protein and albumin) in sodium bicarbonate intoxicated groups. All these parameters however, were comparatively reduced in the birds given C. luteum extract. Also, heterophil and monocyte counts were decreased significantly in group VI birds, supplemented with C. luteum extract only with no adverse effect on health of birds. The results from the present study establish the protective role of C. luteum extract against sodium bicarbonate induced haematological and biochemical alterations

Nanoremediation technologies for sustainable remediation of contaminated environments: Recent advances and challenges

A major and growing concern within society is the lack of innovative and effective solutions to mitigate the challenge of environmental pollution. Uncontrolled release of pollutants into the environment as a result of urbanisation and industrialisation is a staggering problem of global concern. Although, the eco-toxicity of nanotechnology is still an issue of debate, however, nanoremediation is a promising emerging technology to tackle environmental contamination, especially dealing with recalcitrant contaminants. Nanoremediation represents an innovative approach for safe and sustainable remediation of persistent organic compounds such as pesticides, chlorinated solvents, brominated or halogenated chemicals, perfluoroalkyl and polyfluoroalkyl substances (PFAS), and heavy metals. This comprehensive review article provides a critical outlook on the recent advances and future perspectives of nanoremediation technologies such as photocatalysis, nano-sensing etc., applied for environmental decontamination. Moreover, sustainability assessment of nanoremediation technologies was taken into consideration for tackling legacy contamination with special focus on health and environmental impacts. The review further outlines the ecological implications of nanotechnology and provides consensus recommendations on the use of nanotechnology for a better present and sustainable futur

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial