Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity

Enhanced Nonperturbative Effects in Z Decays to Hadrons

We use soft collinear effective field theory (SCET) to study nonperturbative strong interaction effects in Z decays to hadronic final states that are enhanced in corners of phase space. These occur, for example, in the jet energy distribution for two jet events near E_J=M_Z/2, the thrust distribution near unity and the jet invariant mass distribution near zero. The extent to which such nonperturbative effects for different observables are related is discussed.Comment: 17 pages. Paper reorganized, and more discussion and results include

CO(1-0) detection of molecular gas in the massive Spiderweb Galaxy (z=2)

The high-redshift radio galaxy MRC 1138−262 (‘Spiderweb Galaxy’; z = 2.16) is one of the most massive systems in the early Universe and surrounded by a dense ‘web’ of proto-cluster galaxies. Using the Australia Telescope Compact Array, we detected CO(1–0) emission from cold molecular gas – the raw ingredient for star formation – across the Spiderweb Galaxy. We infer a molecular gas mass of MH2 = 6 × 1010 M⊙ (for MH2/L′CO = 0.8). While the bulk of the molecular gas coincides with the central radio galaxy, there are indications that a substantial fraction of this gas is associated with satellite galaxies or spread across the intergalactic medium on scales of tens of kpc. In addition, we tentatively detect CO(1–0) in the star-forming proto-cluster galaxy HAE 229, 250 kpc to the West. Our observations are consistent with the fact that the Spiderweb Galaxy is building up its stellar mass through a massive burst of widespread star formation. At maximum star formation efficiency, the molecular gas will be able to sustain the current star formation rate (SFR ≈ 1400 M⊙ yr−1, as traced by Seymour et al.) for about 40 Myr. This is similar to the estimated typical lifetime of a major starburst event in infrared luminous merger systems

Global agricultural productivity is threatened by increasing pollinator dependence without a parallel increase in crop diversification

The global increase in the proportion of land cultivated with pollinator-dependent crops implies increased reliance on pollination services. Yet agricultural practices themselves can profoundly affect pollinator supply and pollination. Extensive monocultures are associated with a limited pollinator supply and reduced pollination, whereas agricultural diversification can enhance both. Therefore, areas where agricultural diversity has increased, or at least been maintained, may better sustain high and more stable productivity of pollinator-dependent crops. Given that >80% of all crops depend, to varying extents, on insect pollination, a global increase in agricultural pollinator dependence over recent decades might have led to a concomitant increase in agricultural diversification. We evaluated whether an increase in the area of pollinator-dependent crops has indeed been associated with an increase in agricultural diversity, measured here as crop diversity, at the global, regional, and country scales for the period 1961-2016. Globally, results show a relatively weak and decelerating rise in agricultural diversity over time that was largely decoupled from the strong and continually increasing trend in agricultural dependency on pollinators. At regional and country levels, there was no consistent relationship between temporal changes in pollinator dependence and crop diversification. Instead, our results show heterogeneous responses in which increasing pollinator dependence for some countries and regions has been associated with either an increase or a decrease in agricultural diversity. Particularly worrisome is a rapid expansion of pollinator-dependent oilseed crops in several countries of the Americas and Asia that has resulted in a decrease in agricultural diversity. In these regions, reliance on pollinators is increasing, yet agricultural practices that undermine pollination services are expanding. Our analysis has thereby identified world regions of particular concern where environmentally damaging practices associated with large-scale, industrial agriculture threaten key ecosystem services that underlie productivity, in addition to other benefits provided by biodiversity.Environmental Biolog

CO(1-0) survey of high-z radio galaxies: alignment of molecular halo gas with distant radio sources

We present a CO(1–0) survey for cold molecular gas in a representative sample of 13 highz radio galaxies (HzRGs) at 1.4 <z< 2.8, using the Australia Telescope Compact Array. We detect CO(1–0) emission associated with five sources: MRC 0114-211, MRC 0152-209, MRC 0156-252, MRC 1138-262 and MRC 2048-272. The CO(1–0) luminosities are in the range L CO ∼ (5–9) × 1010 K km s−1 pc2. For MRC 0152-209 and MRC 1138-262, part of the CO(1–0) emission coincides with the radio galaxy, while part is spread on scales of tens of kpc and likely associated with galaxy mergers. The molecular gas mass derived for these two systems is MH2 ∼ 6 × 1010 M� (MH2/L CO = 0.8). For the remaining three CO-detected sources, the CO(1–0) emission is located in the halo (∼50-kpc) environment. These three HzRGs are among the fainter far-IR emitters in our sample, suggesting that similar reservoirs of cold molecular halo gas may have been missed in earlier studies due to pre-selection of IR-bright sources. In all three cases, the CO(1–0) is aligned along the radio axis and found beyond the brightest radio hotspot, in a region devoid of 4.5 µm emission in Spitzerimaging. The CO(1–0) profiles are broad, with velocity widths of ∼1000–3600 km s−1. We discuss several possible scenarios to explain these halo reservoirs of CO(1–0). Following these results, we complement our CO(1–0) study with detections of extended CO from the literature and find at marginal statistical significance (95 per cent level) that CO in HzRGs is preferentially aligned towards the radio jet axis. For the eight sources in which we do not detect CO(1–0), we set realistic upper limits of L CO ∼ 3–4 × 1010 K km s−1 pc2. Our survey reveals a CO(1–0) detection rate of 38 per cent, allowing us to compare the CO(1–0) content of HzRGs with that of other types of high-z galaxies

D* Production in Deep Inelastic Scattering at HERA

This paper presents measurements of D^{*\pm} production in deep inelastic scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The data have been taken with the ZEUS detector at HERA. The decay channel $D^{*+}\to (D^0 \to K^- \pi^+) \pi^+$ (+ c.c.) has been used in the study. The $e^+p$ cross section for inclusive D^{*\pm} production with $5<Q^2<100 GeV^2$ and $y<0.7$ is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region {$1.3<p_T(D^{*\pm})<9.0$ GeV and $| \eta(D^{*\pm}) |<1.5$}. Differential cross sections as functions of p_T(D^{*\pm}), $\eta(D^{*\pm}), W$ and $Q^2$ are compared with next-to-leading order QCD calculations based on the photon-gluon fusion production mechanism. After an extrapolation of the cross section to the full kinematic region in p_T(D^{*\pm}) and $\eta$(D^{*\pm}), the charm contribution $F_2^{c\bar{c}}(x,Q^2)$ to the proton structure function is determined for Bjorken $x$ between 2 $\cdot$ 10$^{-4}$ and 5 $\cdot$ 10$^{-3}$.Comment: 17 pages including 4 figure

Aerobic and anaerobic energy expenditure during rest and activity in montane Bufo b. boreas and Rana pipiens

The relations of standard and active aerobic and anaerobic metabolism and heart rate to body temperature ( T b ) were measured in montane groups of Bufo b. boreas and Rana pipiens maintained under field conditions. These amphibians experience daily variation of T b over 30°C and 23°C, respectively (Carey, 1978). Standard and active aerobic and anaerobic metabolism, heart rate, aerobic and anaerobic scope are markedly temperature-dependent with no broad plateaus of thermal independence. Heart rate increments provide little augmentation of oxygen transport during activity; increased extraction of oxygen from the blood probably contributes importantly to oxygen supply during activity. Development of extensive aerobic capacities in Bufo may be related to aggressive behavior of males during breeding. Standard metabolic rates of both species are more thermally dependent than comparable values for lowland relatives. Thermal sensitivity of physiological functions may have distinct advantages over thermally compensated rates in the short growing season and daily thermal fluctuations of the montane environment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47726/1/442_2004_Article_BF00348070.pd

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set

Background Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Methods Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set. Results Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001). Conclusions The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy

Repeated surveying over 6 years reveals that fine-scale habitat variables are key to tropical mountain ant assemblage composition and functional diversity

High-altitude-adapted ectotherms can escape competition from dominant species by tolerating low temperatures at cooler elevations, but climate change is eroding such advantages. Studies evaluating broad-scale impacts of global change for high-altitude organisms often overlook the mitigating role of biotic factors. Yet, at fine spatial-scales, vegetation-associated microclimates provide refuges from climatic extremes. Using one of the largest standardised data sets collected to date, we tested how ant species composition and functional diversity (i.e., the range and value of species traits found within assemblages) respond to large-scale abiotic factors (altitude, aspect), and fine-scale factors (vegetation, soil structure) along an elevational gradient in tropical Africa. Altitude emerged as the principal factor explaining species composition. Analysis of nestedness and turnover components of beta diversity indicated that ant assemblages are specific to each elevation, so species are not filtered out but replaced with new species as elevation increases. Similarity of assemblages over time (assessed using beta decay) did not change significantly at low and mid elevations but declined at the highest elevations. Assemblages also differed between northern and southern mountain aspects, although at highest elevations, composition was restricted to a set of species found on both aspects. Functional diversity was not explained by large scale variables like elevation, but by factors associated with elevation that operate at fine scales (i.e., temperature and habitat structure). Our findings highlight the significance of fine-scale variables in predicting organisms’ responses to changing temperature, offering management possibilities that might dilute climate change impacts, and caution when predicting assemblage responses using climate models, alone