326 research outputs found
Endocrine cells distribution in human proximal small intestine: an immunohistochemical and morphometrical study
Atrophy of the pancreatic remnant after pancreaticoduodenectomy might be consequent to deregulation
of pancreatic endocrine stimuli after duodenal removal. Relative technical surgical solution
could be the anastomosis of the 1st jejunal loop to the stomach and the 2nd to the pancreatic
stump. Data on the distribution of endocrine cells within the proximal intestine might represent
the lacking tile of the problem. Our aims were to investigate the distribution pattern of serotonin,
cholecystokinin and secretin cells in the duodenum, the 1st and 2nd jejunal loops of humans.
Bowel specimens of ten patients submitted to pancreaticoduodenectomy were collected; immunohistochemical
reactions and morphometric analyses were performed. A general ab-oral decrease
of enteroendocrine cells was found. The rate of serotonin cells showed a significant 30.67±8.13%
reduction starting from the 1st jejunal loop versus duodenum. The rate of both cholecystokinin
and secretin cells in the duodenum was superimposable to that in the 1st jejunal loop, with a significant
62.88±4.80% loss of cholecystokinin and 39.5±9.31% of secretin cells in the 2nd loop. After
removal of duodenum, preservation of the 1st jejunal loop could impact the function of pancreatic
remnant maintaining the physiological enteroendocrine stimulus for pancreatic secretion that can
compensate, at least in part for the abolished duodenal hormonal release
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