INCOLLOCABILI. ANTROPOLOGIA APPLICATA IN CONTESTI DI DROGA E CRONICITÀ

This dissertation offers a contribution to the debate on drug anthropology and anthropology of social services, with a particular focus on their application in the field of drug abusers. Furthermore, it advances propositions on the professionalization of the discipline in these contexts. The question leading this research arises from a prior experience at a rehabilitation center for drug addicts located in the suburbs of Bologna, and from an additional fieldwork research among at-risk-subjects who autonomously assembled in a cultural association. Refusing the hierarchical approaches typical of drug treatments, this study aims at applying relational tools developed during the fieldwork drawing on the studies of the intentional community. For this reason, a second fieldwork was conducted in Arcosanti (USA), in order to learn and optimize the researcher\u2019s toolbox. My work intends to use anthropology as a specialized expertise for the reconstruction of compromised social relationships, using the discipline\u2019s distinctive methodologies in connection with those of other disciplines and professional approaches

Outcomes analysis of new entrant screening for active tuberculosis in Heathrow and Gatwick airports, United Kingdom 2009/2010

BACKGROUND: In 2012, the United Kingdom (UK) Government announced that the new entrant screening for active tuberculosis (TB) in Heathrow and Gatwick airports would end. Our study objective was to estimate screening yield and diagnostic accuracy, and identify those at risk of active TB after entry. METHODS: We designed a retrospective cohort study and linked new entrants screened from June 2009 to September 2010 through probabilistic matching with UK Enhanced TB Surveillance (ETS) data (June 2009 to December 2010). Yield was the proportion of cases reported to ETS within three months of airport screening in the screened population. To estimate screening diagnostic accuracy we assessed sensitivity, specificity, positive and negative predictive values. Through Poisson regression we identified groups at increased risk of TB diagnosis after entry. RESULTS: We identified 200,199 screened entrants, of these 59 had suspected TB at screening and were reported within 3 months to ETS (yield = 0.03 %). Sensitivity was 26 %; specificity was 99.7 %; positive predictive value was 13.2 %; negative predictive value was 99.9 %. Overall, 350 entrants were reported in ETS. Persons from countries with annual TB incidence higher than 150 cases per 100,000 population and refugees and asylum seekers were at increased risk of TB diagnosis after entry (population attributable risk 77 and 3 % respectively). CONCLUSION: Airport screening has very low screening yields, sensitivity and positive predictive value. New entrants coming from countries with annual TB incidence higher than 150 per 100,000 population, refugees and asylum seekers should be prioritised at pre- or post-entry screening

Butyrylcholinesterase distribution in the mouse gastrointestinal tract: An immunohistochemical study

Butyrylcholinesterase (BChE) is a hydrolytic enzyme that together with acetylcholinesterase (AChE) belongs to the cholinesterase family. Whereas AChE has a well-established role in regulating cholinergic neurotransmission in central and peripheral synapses, the physiological role of BChE remains elusive. In this morphological immunohistochemical and double-label confocal microscopy study we investigated the distribution of BChE in the mouse gastrointestinal tract. BChE-positive cells were detected in the liver (both in hepatocytes and cholangiocytes), in the keratinised layers of the squamous epithelium of the oesophagus and forestomach, in the oxyntic mucosa of the stomach, in the mucus-secreting cells of duodenal Brunner glands and the small and large intestinal mucosa. Interestingly, BChE-positive cells were often detected close to gastrointestinal proliferative niches. In the oxyntic mucosa, the close proximity of ghrelin-producing and BChE-positive parietal cells suggests that BChE may be involved in ghrelin hydrolysation through paracrine action. To our knowledge, this is the first comprehensive morphological study performed to gain insight into the physiological role of BChE in the gastrointestinal tract

A smartphone-based chemosensor to evaluate antioxidants in agri-food matrices by in situ AuNP formation

In recent years, there has been a continuously growing interest in antioxidants by both customers and food industry. The beneficial health effects of antioxidants led to their widespread use in fortified functional foods, as dietary supplements and as preservatives. A variety of analytical methods are available to evaluate the total antioxidant capacity (TAC) of food extracts and beverages. However, most of them are expensive, time-consuming, and require laboratory instrumentation. Therefore, simple, cheap, and fast portable sensors for point-of-need measurement of antioxidants in food samples are needed. Here, we describe a smartphone-based chemosensor for on-site assessment of TAC of aqueous matrices, relying on the antioxidant-induced formation of gold nanoparticles. The reaction takes place in ready-to-use analytical cartridges containing an hydrogel reaction medium preloaded with Au(III) and is monitored by using the smartphone’s CMOS camera. An analytical device including an LED-based lighting system was developed to ensure uniform and reproducible illumination of the analytical cartridge. The chemosensor permitted rapid TAC measurements of aqueous samples, including teas, herbal infusions, beverages, and extra virgin olive oil extracts, providing results that correlated with those of the reference methods for TAC assessment, e.g., oxygen radical absorbance capacity (ORAC)

Compositions of Dust and Sea Salts in the Dome C and Dome Fuji Ice Cores From Last Glacial Maximum to Early Holocene Based on Ice-Sublimation and Single-Particle Measurements

We analyzed the chemical compositions of dust and sea‐salt particles in the EPICA Dome C (EDC) ice core during 26–7 kyr BP using an ice‐sublimation technique and compared the results with existing data of the Dome Fuji (DF) ice core. Combined with ion concentration data, our data suggested similar sea‐salt fluxes in both cores and significantly lower dust flux in the EDC core. The differences in modal size and aspect ratio of dust particles between the two cores support the dominance of Patagonian source suggested by earlier works. The compositions of calcic dust showed major change at ~17 kyr BP, possibly reflecting a relative increase in dust transported via the upper troposphere. The calcium sulfate fraction was higher in the DF core than in the EDC core after ~17 kyr BP, suggesting that higher Patagonian dust contribution to the DF region. Abundant NaCl particles were found in the DF core in comparison with the EDC core from the LGM to early Holocene, possibly because of the high concentration of terrestrial dust in the DF core that reduced acid availability for sea‐salt modification. During the Holocene, the lower NaCl fraction and Cl−/Na+ ratio in the EDC core suggested that most Cl− was lost to the atmosphere from snow at Dome C, while it was preserved at Dome Fuji as NaCl and solid solution.Royal Society E

Selective organic functionalization of polycrystalline silicon-germanium for bioMEMS applications

AbstractWe selectively immobilized organofunctional silanes on top of polycrystalline silicon-germanium (poly-SiGe) layers, as a first step towards the fabrication of poly-SiGe-based bioMEMS (biomedical MicroElectroMechanicalSystems) by means of standard UV photolithography. 3-aminopropyl-dimethyl-ethoxysilane (APDMES) and 3-aminopropyl-triethoxysilane (APTES) molecules were immobilized onto resist-patterned poly-SiGe surfaces. The protocols for surface hydroxylation and silane immobilization were designed to be CMOS-compatible and to avoid damage to photoresist. Silanized surfaces were investigated both by means of fluorescence microscopy, and by FEG-SEM observation after labeling with 30 nm-diameter gold nanoparticles (NPs). We report the silanization protocols, together with the results indicating successful organic functionalization of the samples

A Catastrophe Theory Based Model for Optimal Control of Chemical Reactions by means of Oriented Electric Fields

The e ect of oriented external electric  elds (OEEF) on chemical reactivity has been studied theoretically and computationally in the last decades. A central goal in this research area is to predict the orientation and the smallest amplitude electric  eld that renders a barrierles chemical process with the smallest possible strength. Recently, a model to  nd the optimal electric  eld has been proposed and described (J. M. Bo ll et. al., J. Chem. Theory Comput. 18, 935 (2022)). We here proof that this model is based on Catastrophe and Optimum Control Theories. Based on both theories a technical treatment of the model is given and applied to a two-dimensional generic example that provides insight into its nature and capability. Finally, the model is applied to determine the optimal OEEF for the trans-to-cis isomerization of a [3]cumulene derivative

Compositions of Dust and Sea Salts in the Dome C and Dome Fuji Ice Cores From Last Glacial Maximum to Early Holocene Based on Ice‐Sublimation and Single‐Particle Measurements

We analyzed the chemical compositions of dust and sea‐salt particles in the EPICA Dome C (EDC) ice core during 26–7 kyr BP using an ice‐sublimation technique and compared the results with existing data of the Dome Fuji (DF) ice core. Combined with ion concentration data, our data suggested similar sea‐salt fluxes in both cores and significantly lower dust flux in the EDC core. The differences in modal size and aspect ratio of dust particles between the two cores support the dominance of Patagonian source suggested by earlier works. The compositions of calcic dust showed major change at ~17 kyr BP, possibly reflecting a relative increase in dust transported via the upper troposphere. The calcium sulfate fraction was higher in the DF core than in the EDC core after ~17 kyr BP, suggesting that higher Patagonian dust contribution to the DF region. Abundant NaCl particles were found in the DF core in comparison with the EDC core from the LGM to early Holocene, possibly because of the high concentration of terrestrial dust in the DF core that reduced acid availability for sea‐salt modification. During the Holocene, the lower NaCl fraction and Cl−/Na+ ratio in the EDC core suggested that most Cl− was lost to the atmosphere from snow at Dome C, while it was preserved at Dome Fuji as NaCl and solid solution

Schizophrenia: The new etiological synthesis

Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated with decreased reproductive success. The causal genetic variants underlying schizophrenia are thought to be under weak negative selection. To unravel this paradox, many evolutionary explanations have been suggested for schizophrenia. We critically discuss the constellation of evolutionary hypotheses for schizophrenia, highlighting the lack of empirical support for most existing evolutionary hypotheses—with the exception of the relatively well supported evolutionary mismatch hypothesis. It posits that evolutionarily novel features of contemporary environments, such as chronic stress, low-grade systemic inflammation, and gut dysbiosis, increase susceptibility to schizophrenia. Environmental factors such as microbial infections (e.g., Toxoplasma gondii) can better predict the onset of schizophrenia than polygenic risk scores. However, researchers have not been able to explain why only a small minority of infected people develop schizophrenia. The new etiological synthesis of schizophrenia indicates that an interaction between host genotype, microbe infection, and chronic stress causes schizophrenia, with neuroinflammation and gut dysbiosis mediating this etiological pathway. Instead of just alleviating symptoms with drugs, the parasite x genotype x stress model emphasizes that schizophrenia treatment should focus on detecting and treating possible underlying microbial infection(s), neuroinflammation, gut dysbiosis, and chronic stress.</p

On the classification of OADP varieties

The main purpose of this paper is to show that OADP varieties stand at an important crossroad of various main streets in different disciplines like projective geometry, birational geometry and algebra. This is a good reason for studying and classifying them. Main specific results are: (a) the classification of all OADP surfaces (regardless to their smoothness); (b) the classification of a relevant class of normal OADP varieties of any dimension, which includes interesting examples like lagrangian grassmannians. Following [PR], the equivalence of the classification in (b) with the one of quadro-quadric Cremona transformations and of complex, unitary, cubic Jordan algebras are explained.Comment: 13 pages. Dedicated to Fabrizio Catanese on the occasion of his 60th birthday. To appear in a special issue of Science in China Series A: Mathematic