LDB1 (LIM domain binding 1)

Review on LDB1 (LIM domain binding 1), with data on DNA, on the protein encoded, and where the gene is implicated

報酬探索における行動成績に対する自己選択の効果

筑波大学 (University of Tsukuba)201

アルツハイマー病モデルマウスにおける障害物回避歩行時の記憶誘導性動作の障害

学位の種別: 課程博士審査委員会委員 : (主査)東京大学准教授 柳原 大, 東京大学教授 中澤 公孝, 東京大学教授 福井 尚志, 東京大学准教授 工藤 和俊, 東京大学准教授 吉岡 伸輔University of Tokyo(東京大学

Effects of Microgravity on Cerebral Hemodynamics

After centuries of wonder, human being finally realized the decisive possibility of going to the moon a little more than 50 years ago, and in 1969 this became a reality, no longer a dream. The human body, however, is designed to live under 1 g as on Earth. Thus, it is important to understand what happens in the human body under microgravity in order to make rapid progress in space development. One of the most serious problems produced by microgravity is a fluid shift from lower to upper body. This cephalad fluid shift may change the hemodynamics in the brain. In this review, effects of actual or simulated microgravity on cerebral blood flow, intracranial pressure, formation of brain edema, and orthostatic intolerance will be discussed. These studies provide us lots of information not only to maintain the health of astronauts but also to treat senile persons who, on rare occasions, sit or stand up

Neurons in the monkey orbitofrontal cortex mediate reward value computation and decision-making

Choice reflects the values of available alternatives; more valuable options are chosen more often than less valuable ones. Here we studied whether neuronal responses in orbitofrontal cortex (OFC) reflect the value difference between options, and whether there is a causal link between OFC neuronal activity and choice. Using a decision-making task where two visual stimuli were presented sequentially, each signifying a value, we showed that when the second stimulus appears many neurons encode the value difference between alternatives. Later when the choice occurs, that difference signal disappears and a signal indicating the chosen value emerges. Pharmacological inactivation of OFC neurons coding for choice-related values increases the monkey’s latency to make a choice and the likelihood that it will choose the less valuable alternative, when the value difference is small. Thus, OFC neurons code for value information that could be used to directly influence choice

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas

GATA4 loss as a result of promoter hypermethylation or somatic mutation promotes growth and chemotherapy resistance of human astrocytomas

HOMOGENIZATION OF COMPOSITE BEAMS WITH PERIODIC MICROSTRUCTURES

The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo, Japan

Asian ethnicity in the West : preference for Chinese, Indian and Korean service staff

The emergence of ethnic markets has been rapid following the growing trend of intra-national diversity in developed nations. These new markets have attracted researchers to investigate the role of ethnicity in consumer behaviour; however, to date, literature has focused on the role of the origin of tangible goods/products. In contrast, ethnic marketing for services has gained little attention. This study fills this gap by investigating the effect of ethnicity of service staff on consumers’ preferences for services. These effects are tested for the four service types identified in Lovelock’s service classification scheme. This study examined consumers’ preferences in services based on the ethnicity/racial category of service staff (Caucasian, Chinese, Indian and Korean) and service type (Medical, Education, Financial and Cleaning). A shopping mall intercept survey included a sample of 471. Multivariate analysis of variance was applied to test for significant variances between the mean preferences. Significant differences in preferences for the ethnicity of service staff were empirically established. Consumers, regardless of their ethnicity, prefer service staff of the same ethnicity. This creates a gap between preferences for one’s own ethnicity and preferences for others. This tendency was especially strong in medical services. Consumers’ preferences for service staff ethnicity are explained by the theories of country of origin, animosity, homophily and language. This study encourages service providers to make use of ethnic marketing, since a better match between service staff and customers’ preferences results in less miscommunication and better cultural understanding. Training on cultural sensitivity is also encouraged. This study establishes the important role of the country of origin in services. We name this the ‘country of origin of service staff (COSS)’ effect.19 page(s

Distribution and body size changes of the moonsnail Laguncula pulchella in tidal flats in Hiroshima, Japan

Abundance of the invasive and predatory moonsnail Laguncula pulchella was investigated at 10 tidal flats along the coast of Hiroshima, western Japan. They were found from two tidal flats where this species has already been known to occur. The size and density of egg collars of L. pulchella became smaller from 2015 to 2017 but thereafter recovered in 2018. This tendency was common between the two sites, indicating that the population and body size of adult L. pulchella are highly variable among years.本研究の一部は笹川科学研究助成を受けて行われた（研究番号 : 28-749）