Micro- and macro-porosity of dry- and saturatedstate recycled aggregate concrete

Society is becoming aware of the environment and progressively using more recycled aggregates to produce recycled structural aggregate concrete. In addition, many researches have analysed the properties of hardened recycled aggregate concrete, but few of them have focused on the mixing method and the consequences that it has on the properties of concrete. In this research, recycled aggregate concrete using dry, with extra water supply, and saturated recycled aggregate has been prepared. The different mixing conditions induce differences the micro and macroporosity of concrete that have been evaluated by computerized axial tomography, scanning electron microscopy and a new developed methodology, based on digital image analysis, developed to analyse the distribution and size of macroporosity. The software has been implemented in Matlab© and is available to the readers of the journal for downloading and use. The results show that the dry and saturated recycled aggregate lead to very different concrete properties. On the one hand, the use of dry aggregate causes a local reduction of the w/c ratio, increasing heterogeneity and decreasing workability. On the other hand, the saturated aggregate incorporates extra water by adsorption that causes an increase in the water/cement ratio, thus increasing the porosity volume and size of the new mortar of the recycled aggregate concrete

First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial

BACKGROUND: Org 25435 is a new water-soluble alpha-amino acid ester intravenous anaesthetic which proved satisfactory in animal studies. This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data. METHODS: In the Short Infusion study 8 healthy male volunteers received a 1 minute infusion of 0.25, 0.5, 1.0, or 2.0 mg/kg (n = 2 per group); a further 10 received 3.0 mg/kg (n = 5) or 4.0 mg/kg (n = 5). Following preliminary pharmacokinetic modelling 7 subjects received a titrated 30 minute Target Controlled Infusion (TCI), total dose 5.8-20 mg/kg. RESULTS: Within the Short Infusion study, all subjects were successfully anaesthetised at 3 and 4 mg/kg. Within the TCI study 5 subjects were anaesthetised and 2 showed signs of sedation. Org 25435 caused hypotension and tachycardia at doses over 2 mg/kg. Recovery from anaesthesia after a 30 min administration of Org 25435 was slow (13.7 min). Pharmacokinetic modelling suggests that the context sensitive half-time of Org 25435 is slightly shorter than that of propofol in infusions up to 20 minutes but progressively longer thereafter. CONCLUSIONS: Org 25435 is an effective intravenous anaesthetic in man at doses of 3 and 4 mg/kg given over 1 minute. Longer infusions can maintain anaesthesia but recovery is slow. Hypotension and tachycardia during anaesthesia and slow recovery of consciousness after cessation of drug administration suggest this compound has no advantages over currently available intravenous anaesthetics

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Noncoding RNAs play regulatory roles in physiopathology, but their involvement in neurodevelopmental diseases is poorly understood. Rett syndrome is a severe, progressive neurodevelopmental disorder linked to loss-of-function mutations of the MeCP2 gene for which no cure is yet available. Analysis of the noncoding RNA profile corresponding to the brain-abundant circular RNA (circRNA) and transcribed-ultraconserved region (T-UCR) populations in a mouse model of the disease reveals widespread dysregulation and enrichment in glutamatergic excitatory signaling and microtubule cytoskeleton pathways of the corresponding host genes. Proteomic analysis of hippocampal samples from affected individuals confirms abnormal levels of several cytoskeleton-related proteins together with key alterations in neurotransmission. Importantly, the glutamate receptor GRIA3 gene displays altered biogenesis in affected individuals and in vitro human cells and is influenced by expression of two ultraconserved RNAs. We also describe post-transcriptional regulation of SIRT2 by circRNAs, which modulates acetylation and total protein levels of GluR-1. As a consequence, both regulatory mechanisms converge on the biogenesis of AMPA receptors, with an effect on neuronal differentiation. In both cases, the noncoding RNAs antagonize MeCP2-directed regulation. Our findings indicate that noncoding transcripts may contribute to key alterations in Rett syndrome and are not only useful tools for revealing dysregulated processes but also molecules of biomarker value

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene in the endoplasmic reticulum-associated protein degradation pathway, in human tumours. The restoration of in vitro and in vivo DERL3 activity highlights the tumour suppressor features of the gene. Using the stable isotopic labelling of amino acids in cell culture workflow for differential proteome analysis, we identify SLC2A1 (glucose transporter 1, GLUT1) as a downstream target of DERL3. Most importantly, SLC2A1 overexpression mediated by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subset of human tumours with greater vulnerability to drugs targeting glycolysis

Evidence for Novel Hepaciviruses in Rodents

Hepatitis C virus (HCV) is among the most relevant causes of liver cirrhosis and hepatocellular carcinoma. Research is complicated by a lack of accessible small animal models. The systematic investigation of viruses of small mammals could guide efforts to establish such models, while providing insight into viral evolutionary biology. We have assembled the so-far largest collection of small-mammal samples from around the world, qualified to be screened for bloodborne viruses, including sera and organs from 4,770 roden

Boletín del Centro de Estudios Americanistas, Año VII, 1920, Núms. 36 y 37

72 páginasÍNDICE: Relaciones geográficas de Yucatán. Don Diego Sarmiento Figueroa. Censos de la población del Virreinato de Nueva España en el siglo XVI. Autor: Germán Latorre. Vida de Madrid. Autor: F. Martín Caballero. Bibliografía americanista.Real Sociedad Colombina Onubens

Sustainable mangement of construction and demolition waste: generation, recovery and applications

4 pages, 4 figures, 5 tables.-- En: 1st Spanish National Conference on Advances in Materials Recycling and Eco – Energy Madrid, 12-13 November 2009.-- Editors: F. A. López, F. Puertas, F. J. Alguacil and A. Guerrero.The present study aims to establish a classification of different qualities of recycled aggregate (RA) generated from construction and demolition waste (CDW). Likewise, the emphasis is on the recovery of the same suggesting applications, ranging from less demanding benefits, such as fillers, to a highest responsibility, such as recycled structural concrete application. To achieve these objectives, it has been set a waste classification system and a group of tests that will allow characterizing recycled aggregates and the recycled materials obtained with them.Thanks to the Ministry of Environment of Spain the funding and, also the coordination by CEDEX, the Project RECNHOR (Ref. 111/2006/2-3.2). Thanks to SADISA GROUP for provide economically the Investigation Project “Plan Integral para el Control de Residuos en Obras de Construcción” and for the materials used in some of the studies.Peer reviewe