The Rice-Wheat Consortium: an Institutional Innovation in International Agricultural Research on the Rice-Wheat Cropping Systems of the Indo-Gangetic Plains (IGP) : The Review Panel Report

The present review was commissioned by CIMMYT at the request of the Regional Steering Committee (RSC) of the Rice-Wheat Consortium (RWC). The goal of the review was todetermine the changes in research priorities, organization and methods that will be required for the RWC to continue to make a significant impact on the livelihoods of those employed in agriculture, especially the poor, on the sustainable management of natural resources in the IGP, and on regional food security. (RSC) of the RWC. Findings of the review show that the RWC has emerged as an innovative model for regional and international collaboration, which is now beginning to develop a credible record of achievements. It is operating as an inter-institutional and inter-center, multidisciplinary network facilitating systems based farmer participatory research in the rice-wheat ecology of the IGP. The main source of strength of RWC is the commitment of its key stakeholders to the founding principles and ownership of its work program spanning strategic, applied, and adaptive research and knowledge dissemination activities

Role of endogenous hormones in premenopausal females with breast carcinoma - a pilot study in north Indian population

The objective of this study is to evaluate hormone levels in premenopausal females with breast cancer at the time of diagnosis and to predict their role as a risk factor of breast cancer in females. Circulating hormone levels were measured in 345 previously untreated premenopausal breast cancer patients during luteal phase (19th-21st day). Their results were compared with a group of 345 age-matched healthy controls. Serum prolactin, testosterone, estrogen and progesterone levels were higher in patients as compared to controls. Regression analysis showed that changes in hormone levels have significant impact on breast cancer. Female patients with breast cancer have abnormalities in hormone levels. These abnormalities may be considered in the pathogenesis of the disease and should be taken into account for the treatment of patients of breast cancer. Reduction of hormone levels might prove to be helpful in preventing breast cancer but further studies are required to prove the benefit of analyzing hormone levels at an early stage.Keywords: Breast cancer; Prolactin; Testosterone; Estrogen; ProgesteroneInternet Journal of Medical Update 2012 July;7(2):25-3

Cooperative Text and Line Art Extraction from a Topographic Map

The black layer is digitized from a USGS topographic map digitized at 1000 dpi. The connected components of this layer are analyzed and separated into line art, text, and icons in two passes. The paired street casings are converted to polylines by vectorization and associated with street labels from the character recognition phase. The accuracy of character recognition is shown to improve by taking account of the frequently occurring overlap of line art with street labels. The experiments show that complete vectorization of the black line-layer bitmap is the major remaining problem

Transcatheter Aortic Valve Implantation for Severe Bicuspid Aortic Stenosis – 2 Years Follow up Experience From India

BackgroundTranscatheter aortic valve implantation (TAVI) is challenging in bicuspid aortic valve (BAV) anatomy. The patients are young, morphological phenotypes are many, calcium burden is high and there are technical challenges for best outcomes. Observational studies and registries are available with favorable data and experiences from around the world sharing methodologies and algorithms for sizing and implantation. We, therefore, analysed our data of procedural and in-hospital outcomes of TAVI in Bicuspid Aortic Valve cases performed at two high volume centres in India and their follow up for two years.Methods and ResultsThe data were collated and analysed from two centres (Fortis Escorts Heart Institute, New Delhi and Apollo Hospitals, Chennai) in India for patients who underwent TAVI in a BAV anatomy. It included a total of 70 cases from 2 centres. All symptomatic severe AS patients more than and equal to 65 years having bicuspid anatomy were included in the study irrespective of their STS score. Patients under 65 years of age were advised TAVI only if they were at high risk for open heart surgery. These patients were followed for a period of 2 years and the data were analysed. Pre TAVI imaging tools utilised were 2D echo, transthoracic echocardiography (TTE), trans oesophageal echocardiography (TEE), and ECG gated multi slice CT (MSCT) scan imaging. MSCT was utilised for confirmation of the anatomy and classifying the morphological type of valve, measuring, and evaluating all anatomic determinants of aortic root complex for planning the procedure and choice of the valve and its size. Sizing in balloon expanding valve (BEV) and self-expanding valve sizing (SEV) were based primarily on annulus area and perimeter, respectively. The SEV used in our study were the Core Valve and Evolut R (Medtronic, United States) and the BEVs included Sapien3 (Edwards Lifesciences, United States) and Myval (Meril Lifesciences, India). The BAV cohort constituted 24.4% of the total 287 TAVI cases, followed up for 2 years. The mean age of these patients was 72 years. The incidence of male patients was 68.57% and female patients was 31.4%. The Sievers type 1 included 78.5%, type 0 were 21.4% of the cases and there was no case of type 2 in the study. The procedural success was to the tune of 98%. Patients with normal left ventricular ejection fraction (LVEF) improved their symptoms class after TAVI and remained so at 2 years follow up. The poor LVEF subset of patients did not have heart failure admissions and also had improvement in their symptom status. The peak-to-peak aortic valve gradient decreased to 0 mmHg at the end of the procedure in most of the cases. The mean pressure gradient (PG) across the new valve ranged between 0 and 15 mmHg and the aortic valve area (AVA) was close to 2 cm2. These numbers were consistent at 2 years follow up. Significant paravalvular leak (PVL) 24.28% was seen immediately after deployment of the valve in heavily calcified anatomy but it reduced to mild or trivial PVL after post-dilation and one patient needed a second valve to treat PVL. No patient had more than mild PVL with either type of valve at the end of the procedure. Permanent pacemaker implantation (PPI) was required in 11.4% of the patients within 24 h to 7 days of the procedure. No one needed a PPI in the 2 year follow up. Coronary occlusion did not happen to any patient. No patient had a disabling stroke. Non-disabling stroke was seen in 10% of cases and mostly in the first week or 30 days of the procedure and the incidence was more with BEV (14%) as compared to SEV (8%). There was one case of valve embolisation after 24 h of the procedure, which needed a surgical valve replacement. There was no case of annular injury or injury to other parts of the aortic root complex. Two cases had access vessel (femoral artery) thrombosis at end of the procedure and a third patient had proglide related residual stenosis. Two cases had acute kidney injury and needed dialysis. There was no major bleeding complication in any patient. Peri procedural mortality occurred in two patients. Valve thrombosis was seen in one patient after 3 months, which was treated with oral anticoagulation. Valve degeneration and failure or infective endocarditis were not seen in any patient.ConclusionThe patients with BAV stenosis who underwent TAVI in this study had good procedural success rates and clinical outcomes. The haemodynamics achieved with both SEV and BEV were good at 2 years. The rates of PVL, PPI, and stroke are similar to that of many other studies and registries. PPI rate and non-disabling stroke incidence appear to be higher similar to many studies done. There was no case of coronary occlusion in the study. Meticulous CT analysis of the aortic root complex, selection of appropriate type and size of the valve, and best implantation practices along with cerebral protection will probably be the key to safer and more successful TAVI in this population

The Chemodynamics of the Stellar Populations in M31 from APOGEE Integrated Light Spectroscopy

We present analysis of nearly 1,000 near-infrared, integrated light spectra from APOGEE in the inner $\sim$7 kpc of M31. We utilize full spectrum fitting with A-LIST simple stellar population spectral templates that represent a population of stars with the same age, [M/H], and [$\alpha$/M]. With this, we determine the mean kinematics, metallicities, $\alpha$ abundances, and ages of the stellar populations of M31's bar, bulge, and inner disk ($\sim$4-7 kpc). We find a non-axisymmetric velocity field in M31 resulting from the presence of a bar. The bulge of M31 is metal-poor relative to the disk ([M/H] = $-0.149^{+0.067}_{-0.081}$ dex), features minima in metallicity on either side of the bar ([M/H] $\sim$ -0.2), and is enhanced in $\alpha$ abundance ([$\alpha$/M] = $0.281^{+0.035}_{-0.038}$). The disk of M31 within $\sim$7 kpc is enhanced in both metallicity ([M/H] = $-0.023^{+0.050}_{-0.052}$) and $\alpha$ abundance ([$\alpha$/M] = $0.274^{+0.020}_{-0.025}$). Both of these structural components are uniformly old at $\simeq$ 12 Gyr. We find the metallicity increases with distance from the center of M31, with the steepest gradient along the disk major axis ($0.043\pm0.021$ dex/kpc). This gradient is the result of changing light contributions from the metal-poor bulge and metal-rich disk. The chemodynamics of stellar populations encodes information about a galaxy's chemical enrichment, star formation history, and merger history, allowing us to discuss new constraints on M31's formation. Our results provide a stepping stone between our understanding of the Milky Way and other external galaxies

Composite Bulges -- III. A Study of Nuclear Star Clusters in Nearby Spiral Galaxies

We present photometric and morphological analyses of nuclear star clusters (NSCs) -- very dense, massive star clusters present in the central regions of most galaxies -- in a sample of 33 massive disk galaxies within 20 Mpc, part of the "Composite Bulges Survey." We use data from the Hubble Space Telescope including optical (F475W and F814W) and near-IR (F160W) images from the Wide Field Camera 3. We fit the images in 2D to take into account the full complexity of the inner regions of these galaxies (including the contributions of nuclear disks and bars), isolating the nuclear star cluster and bulge components. We derive NSC radii and magnitudes in all 3 bands, which we then use to estimate NSC masses. Our sample significantly expands the sample of massive late-type galaxies with measured NSC properties. We clearly identify nuclear star clusters in nearly 80% of our galaxies, putting a lower limit on the nucleation fraction in these galaxies that is higher than previous estimates. We find that the NSCs in our massive disk galaxies are consistent with previous NSC mass-NSC radius and Galaxy Mass-NSC Mass relations. However, we also find a large spread in NSC masses, with a handful of galaxies hosting very low-mass, compact clusters. Our NSCs are aligned in PA with their host galaxy disks but are less flattened. They show no correlations with bar or bulge properties. Finally, we find the ratio of NSC to BH mass in our massive disk galaxy sample spans a factor of $\sim$300.Comment: Accepted to The Astrophysical Journa

Obesity Worsens Gulf War Illness Symptom Persistence Pathology by Linking Altered Gut Microbiome Species to Long-Term Gastrointestinal, Hepatic, and Neuronal Inflammation in a Mouse Model

Persistence of Gulf War illness (GWI) pathology among deployed veterans is a clinical challenge even after almost three decades. Recent studies show a higher prevalence of obesity and metabolic disturbances among Gulf War veterans primarily due to the existence of post-traumatic stress disorder (PTSD), chronic fatigue, sedentary lifestyle, and consumption of a high-carbohydrate/high-fat diet. We test the hypothesis that obesity from a Western-style diet alters host gut microbial species and worsens gastrointestinal and neuroinflammatory symptom persistence. We used a 5 month Western diet feeding in mice that received prior Gulf War (GW) chemical exposure to mimic the home phase obese phenotype of the deployed GW veterans. The host microbial profile in the Western diet-fed GWI mice showed a significant decrease in butyrogenic and immune health-restoring bacteria. The altered microbiome was associated with increased levels of IL6 in the serum, Claudin-2, IL6, and IL1β in the distal intestine with concurrent inflammatory lesions in the liver and hyperinsulinemia. Microbial dysbiosis was also associated with frontal cortex levels of increased IL6 and IL1β, activated microglia, decreased levels of brain derived neurotrophic factor (BDNF), and higher accumulation of phosphorylated Tau, an indicator of neuroinflammation-led increased risk of cognitive deficiencies. Mechanistically, serum from Western diet-fed mice with GWI significantly increased microglial activation in transformed microglial cells, increased tyrosyl radicals, and secreted IL6. Collectively, the results suggest that an existing obese phenotype in GWI worsens persistent gastrointestinal and neuronal inflammation, which may contribute to poor outcomes in restoring cognitive function and resolving fatigue, leading to the deterioration of quality of life