52 research outputs found
Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates
Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum
Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations
Aspergillus oryzae CsyB Catalyzes the Condensation of Two Ξ²-Ketoacyl-CoAs to Form 3-Acetyl-4-hydroxy-6-alkyl-Ξ±-pyrone
The Botrytis cinerea type III polyketide synthase shows unprecedented high catalytic efficiency toward long chain acyl-CoAs
Type III polyketide synthase is involved in the biosynthesis of protocatechuic acid in Aspergillus niger
Expression of Alternaria solani PKSF Generates a Set of Complex Reduced-Type Polyketides with Different Carbon-Lengths and Cyclization
Pentaketide Resorcylic Acid Synthesis by Type III Polyketide Synthase from Neurospora crassa
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