ALTERNATIF PENGELOLA WISATA PANTAI HALASSY NEGERI MORELLA KABUPATEN MALUKU TENGAH PADA FASE PRA DAN PASCA-KRISIS COVID-19

The involvement of related parties is needed in determining the right alternative to manage Halassy Beach Tourism, Morella Village, Central Maluku Regency. The purpose of this study was to determine the role of the government, private sector, and community in managing and determining the appropriate alternative managers in the pre and post crisis phases of covid-19. Through the purposive sampling method, 20 respondents were obtained from experts or stakeholders in the field of tourism and the economics of fisheries and marine resources. Primary data collection was conducted by interview using a google form questionnaire. Descriptive method is used to describe the general condition of the study area, the characteristics of the respondents, as well as the role of the government, private sector and community. Data analysis used analytical hierarchy process (AHP).The results show that in the pre covid-19 crisis phase, the government can build tourist areas that are environmentally and culturally aware; the community as managers are able to improve the information access for tourists; and the private sector contributes economic and social benefits to management capacity. In the post covid-19 crisis, the government needs to pay attention to tourism potential that can be developed; the community can apply the 4A concept; and the private sector can create more interesting ideas to bring in tourists. The right alternative for Halassy Beach Tourism management in the pre and post-covid-19 crisis phases is collaboration between the community, government and private sector, in the triple helix concept

Reduced FOXO1 Expression Accelerates Skin Wound Healing and Attenuates Scarring

The forkhead box O (FOXO) family has been extensively investigated in aging and metabolism, but its role in tissue-repair processes remains largely unknown. Herein, we clarify the molecular aspect of the FOXO family in skin wound healing. We demonstrated that Foxo1 and Foxo3a were both up-regulated during murine skin wound healing. Partial knockout of Foxo1 in Foxo1 +/- mice throughout the body led to accelerated skin wound healing with enhanced keratinocyte migration, reduced granulation tissue formation, and decreased collagen density, accompanied by an attenuated inflammatory response, but we observed no wound phenotype in Foxo3a-/- mice. Fibroblast growth factor 2, adiponectin, and notch1 genes were significantly increased at wound sites in Foxo1+/- mice, along with markedly altered extracellular signal-regulated kinase 1/2 and AKT phosphorylation. Similarly, transient knockdown of Foxo1 at the wound site by local delivery of antisense oligodeoxynucleotides enhanced skin wound healing. The link between FOXO1 and scarring extends to patients, in particular keloid scars, where we see FOXO1 expression markedly increased in fibroblasts and inflammatory cells within the otherwise normal dermis. This occurs in the immediate vicinity of the keloid by comparison to the center of the mature keloid, indicating that FOXO1 is associated with the overgrowth of this fibrotic response into adjacent normal skin. Overall, our data indicate that molecular targeting of FOXO1 may improve the quality of healing and reduce pathological scarring

Teaching reading in small groups : differentiated instruction for building strategic, independent readers/ Serravallo

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