Data de naixement i èxit en el basquetbol professional

Objectiu: Determinar si la data de naixement (mes de naixement) és un factor que intervé en la selecció de futurs talents en l'esport del basquetbol. L'efecte de l'edat relativa (RAE) mostrarà si hi ha una variació en el percentatge del nombre de naixements durant l'any natural. Mètode: Es determinen els mesos de naixement dels jugadors de l'Asociació de Clubs de Bàsquet (ACB), Liga Española de Baloncesto (LEB I), LEB2, National Basquetball Association (NBA) i del basquetbol base de diversos clubs. Les dades es disposen en trimestres. Resultat: Hi ha una forta tendència a la selecció dels nois nascuts els primers trimestres de l'any respecte dels nascuts els últims trimestres. Aquesta tendència es manté, però perd força a mesura que es va pujant de categoria, fins a arribar al bàsquet professional. Aquest fet s'explica perquè en les primeres etapes d'aquest esport els nois se seleccionen només per la seva maduració avançada o per un dels seus indicadors, la talla. D'aquesta manera, una gran quantitat de possibles futurs talents tendeixen a perdre's i altres nois amb menys aptituds, només per haver nascut a principi d'any, podran arribar a un nivell professional. Conclusió: A Espanya, hi ha un predomini de la selecció de jugadors de basquetbol en funció del mes de naixement. S'haurien d'establir les eines i el sistema adequat de selecció, a fi d'optimitzar la selecció i el desenvolupament dels jugadors, en el futur

Fecha de nacimiento y éxito en el baloncesto profesional

Objetivo: Determinar si la fecha de nacimiento (mes de nacimiento) es un factor que interviene en la selección de futuros talentos en el deporte del baloncesto. El efecto de la edad relativa (RAE) mostrará si existe una variación en el porcentaje de número de nacimientos a lo largo del año natural. Método: Se determinan los meses de nacimiento de los jugadores de la Asociación de Clubes de Baloncesto (ACB), la Liga Española de Baloncesto (LEB1y la LEB2), la National Basketball Association (NBA) y del baloncesto base de diversos clubes. Los datos se disponen en trimestres. Resultado: Hay una fuerte tendencia a la selección de los chicos nacidos en los primeros trimestres del año frente a los nacidos en los últimos. Esta tendencia se mantiene pero pierde fuerza a medida que se sube de categorías, hasta llegar al baloncesto profesional. Este hecho se explica por qué en las primeras etapas de este deporte los chicos se seleccionan sólo por su maduración avanzada o por uno de sus indicadores: la talla. De esta forma, una gran cantidad de posibles futuros talentos tiende a perderse y otros chicos con menos aptitudes, sólo por haber nacido a principios de año, podrán llegar a un nivel profesional. Conclusión: En España hay un predominio de la selección de jugadores de baloncesto en función del mes de nacimiento. Debería establecerse las herramientas y el sistema adecuado de selección, con el objeto de optimizar la selección y el desarrollo de los jugadores en el futuro

Development of a database for the study of food additives in food chemistry subjects

Las TIC o tecnologías de la información y comunicación son una herramienta que permite un mayor desarrollo personal para el alumno, siendo él el protagonista en lugar del profesor. Con estas herramientas se adquieren diferentes competencias básicas necesarias para los alumnos universitarios, como son la capacidad de trabajo en equipo, la creatividad, el aprendizaje autónomo, entre otras. Además, los alumnos fueron partícipes en la evaluación de las actividades fomentando así también las competencias básicas relacionadas con la evaluación, como la reflexión. El objetivo de este trabajo era desarrollar una base de datos sobre aditivos, incluyendo información sobre clasificación, fórmula química, grupo al que pertenece, masa molecular, toxicidad, ingesta diaria admitida. La base de datos se crea mediante la participación de alumnos en diferentes actividades de búsqueda de información. Esta base de datos estaría disponible para los alumnos y serviría a su vez al profesor para la realización de nuevas actividades a través de la plataforma Moodle de la Universidad de Córdoba.ICT or information and communication technologies are a tool that allows a greater personal development for the student, being the protagonist instead of the teacher. With these tools, different basic competencies necessary for university students are acquired, such as teamwork, creativity, autonomous learning, among others. In addition, students were involved in the evaluation of activities, thus also promoting the basic competencies related to evaluation, such as reflection. The objective of this job was to develop a database on additives, including information on classification, chemical formula, group to which it belongs, molecular mass, toxicity, acceptable daily intake. The database is created through the participation of students in different information search activities. This database would be available to students and would in turn serve the professor for the realization of new activities through the Moodle platform of the University of Córdoba

Striatum-projecting prefrontal cortex neurons support working memory maintenance

Neurons in the medial prefrontal cortex (mPFC) are functionally linked to working memory (WM) but how distinct projection pathways contribute to WM remains unclear. Based on optical recordings, optogenetic perturbations, and pharmacological interventions in male mice, we report here that dorsomedial striatum (dmStr)-projecting mPFC neurons are essential for WM maintenance, but not encoding or retrieval, in a T-maze spatial memory task. Fiber photometry of GCaMP6m-labeled mPFC→dmStr neurons revealed strongest activity during the maintenance period, and optogenetic inhibition of these neurons impaired performance only when applied during this period. Conversely, enhancing mPFC→dmStr pathway activity—via pharmacological suppression of HCN1 or by optogenetic activation during the maintenance period—alleviated WM impairment induced by NMDA receptor blockade. Moreover, cellular-resolution miniscope imaging revealed that >50% of mPFC→dmStr neurons are active during WM maintenance and that this subpopulation is distinct from neurons active during encoding and retrieval. In all task periods, neuronal sequences were evident. Striatum-projecting mPFC neurons thus critically contribute to spatial WM maintenance

Nonischemic left ventricular scar as a substrate of life-threatening ventricular arrhythmias and sudden cardiac death in competitive athletes

Background\u2014The clinical profile and arrhythmic outcome of competitive athletes with isolated nonischemic left ventricular (LV) scar as evidenced by contrast-enhanced cardiac magnetic resonance remain to be elucidated. Methods and Results\u2014We compared 35 athletes (80% men, age: 14\u201348 years) with ventricular arrhythmias and isolated LV subepicardial/midmyocardial late gadolinium enhancement (LGE) on contrast-enhanced cardiac magnetic resonance (group A) with 38 athletes with ventricular arrhythmias and no LGE (group B) and 40 healthy control athletes (group C). A stria LGE pattern with subepicardial/midmyocardial distribution, mostly involving the lateral LV wall, was found in 27 (77%) of group A versus 0 controls (group C; P<0.001), whereas a spotty pattern of LGE localized at the junction of the right ventricle to the septum was respectively observed in 11 (31%) versus 10 (25%; P=0.52). All athletes with stria pattern showed ventricular arrhythmias with a predominant right bundle branch block morphology, 13 of 27 (48%) showed ECG repolarization abnormalities, and 5 of 27 (19%) showed echocardiographic hypokinesis of the lateral LV wall. The majority of athletes with no or spotty LGE pattern had ventricular arrhythmias with a predominant left bundle branch block morphology and no ECG or echocardiographic abnormalities. During a follow-up of 38\ub125 months, 6 of 27 (22%) athletes with stria pattern experienced malignant arrhythmic events such as appropriate implantable cardiac defibrillator shock (n=4), sustained ventricular tachycardia (n=1), or sudden death (n=1), compared with none of athletes with no or LGE spotty pattern and controls. Conclusions\u2014Isolated nonischemic LV LGE with a stria pattern may be associated with life-threatening arrhythmias and sudden death in the athlete. Because of its subepicardial/midmyocardial location, LV scar is often not detected by echocardiography

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells

MicroRNAs are critical regulators of gene networks in normal and abnormal biological processes. Focusing on invasive ductal breast cancer (IDC), we have found dysregulated expression in tumor samples of several microRNAs, including the miR-200 family, along progression from primary tumors to distant metastases, further reflected in higher blood levels of miR-200b and miR-7 in IDC patients with regional or distant metastases relative to patients with primary node-negative tumors. Forced expression of miR-200s in MCF10CA1h mammary cells induced an enhanced epithelial program, aldehyde dehydrogenase (ALDH) activity, mammosphere growth and ability to form branched tubuloalveolar structures while promoting orthotopic tumor growth and lung colonization in vivo. MiR-200s also induced the constitutive activation of the PI3K-Akt signaling through downregulation of PTEN, and the enhanced mammosphere growth and ALDH activity induced in MCF10CA1h cells by miR-200s required the activation of this signaling pathway. Interestingly, the morphology of tumors formed in vivo by cells expressing miR-200s was reminiscent of metaplastic breast cancer (MBC). Indeed, the epithelial components of MBC samples expressed significantly higher levels of miR-200s than their mesenchymal components and displayed a marker profile compatible with luminal progenitor cells. We propose that microRNAs of the miR-200 family promote traits of highly proliferative breast luminal progenitor cells, thereby exacerbating the growth and metastatic properties of transformed mammary epithelial cells

Tracking data highlight the importance of human-induced mortality for large migratory birds at a flyway scale

Human-induced direct mortality affects huge numbers of birds each year, threatening hundreds of species worldwide. Tracking technologies can be an important tool to investigate temporal and spatial patterns of bird mortality as well as their drivers. We compiled 1704 mortality records from tracking studies across the African-Eurasian flyway for 45 species, including raptors, storks, and cranes, covering the period from 2003 to 2021. Our results show a higher frequency of human-induced causes of mortality than natural causes across taxonomic groups, geographical areas, and age classes. Moreover, we found that the frequency of human-induced mortality remained stable over the study period. From the human-induced mortality events with a known cause (n = 637), three main causes were identified: electrocution (40.5 %), illegal killing (21.7 %), and poisoning (16.3 %). Additionally, combined energy infrastructure-related mortality (i.e., electrocution, power line collision, and wind-farm collision) represented 49 % of all human-induced mortality events. Using a random forest model, the main predictors of human-induced mortality were found to be taxonomic group, geographic location (latitude and longitude), and human footprint index value at the location of mortality. Despite conservation efforts, human drivers of bird mortality in the African-Eurasian flyway do not appear to have declined over the last 15 years for the studied group of species. Results suggest that stronger conservation actions to address these threats across the flyway can reduce their impacts on species. In particular, projected future development of energy infrastructure is a representative example where application of planning, operation, and mitigation measures can enhance bird conservation

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Recomendaciones para la participación deportiva de atletas con miocardiopatías. ESC-AEPC 2019

XIII Curso de Fisiopatología Carciovascular. Madrid, 13-14 diciembre, 2019Centro Nacional de Investigaciones Cardiovasculares; Sociedad Española de Cardiologí

Características morfológicas del corazón del deportista de élite: estudio ecocardiográfico

Tesis doctoral inédita leída el en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 25 de Junio de 1998