Geomatic methods applied to the change study of the la Paúl Rock Glacier, Spanish Pyrenees

Producción CientíficaRock glaciers are one of the most important features of the mountain permafrost in the Pyrenees. La Paúl is an active rock glacier located in the north face of the Posets massif in the La Paúl glacier cirque (Spanish Pyrenees). This study presents the preliminary results of the La Paúl rock glacier monitoring works carried out through two geomatic technologies since 2013: Global Navigation Satellite System (GNSS) receivers and Terrestrial Laser Scanning (TLS) devices. Displacements measured on the rock glacier surface have demonstrated both the activity of the rock glacier and the utility of this equipment for the rock glaciers dynamic analysis. The glacier has exhibited the fastest displacements on its west side (over 35 cm yr-1), affected by the Little Ice Age, and frontal area (over 25 cm yr-1). As an indicator of permafrost in marginal environments and its peculiar morphology, La Paúl rock glacier encourages a more prolonged study and to the application of more geomatic techniques for its detailed analysis.Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional (project CGL2015-68144-R)Junta de Extremadura - Fondo Europeo de Desarrollo Regional (project GR10071

ANESTHETIC EFFECT OF TRICAINE METHANESULFONATE IN JUVENILE PAICHES (ARAPAIMA GIGAS)

El presente estudio tuvo por objetivo evaluar la efectividad anestésica del metasulfonato de tricaína (MS-222) en seis paiches (Arapaima gigas) juveniles (180-243 días). Los peces, procedentes de la ciudad de Iquitos, con peso promedio de 730 g, fueron transportados a la Universidad Peruana Cayetano Heredia, en Lima. Los peces fueron expuestos en cuatro oportunidades a cuatro dosis de MS- 222 (25, 50, 75 y 100 mg/L), para evaluar la duración de la inducción y recuperación,así como la tasa de supervivencia post-anestesia. Se registró la frecuencia de ventilación opercular y la frecuencia cardiaca mediante ecografía, y se tomaron muestras de sangre para un análisis de hemograma pre y post-anestesia. El periodo de inducción fue menor y el periodo de recuperación fue mayor a medida que aumentó la concentración del anestésico. No se observaron diferencias estadísticas en los valores hematológicos y fisiológicos pre y post-anestesia. Se concluye que el MS-222 (100 ppm) tiene efectos anestésicos eficientes en paiches juveniles en la concentración de 100 mg/L.The objective of the present study was to evaluate the effectiveness of tricaine methanesulfonate (MS-222) as anesthetic in six juvenile paiches (Arapaima gigas)(180-243 days) with a body weight of 730 g. The specimens were brought from the Iquitos city to the Universidad Peruana Cayetano Heredia in Lima. They were exposed in four opportunities to four doses of MS-222 (25, 50, 75, and 100 mg/L) to evaluate the duration of induction and recovery as well as the survival rate post anesthesia. The opercular ventilation frequency was counted and heart rate was measured by ultrasound. Blood samples were collected and the haemogram values were obtained pre and post anesthesia. The induction period was shorter and the recovery period was higher when the concentration of anesthetic was increased. None statistical differences were found in the haemogram or in physiological values before and after anesthesia. It was concluded that the MS-222 (100 ppm) have efficient anesthetic effects in paiches at the 100 mg/L concentration

High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition

Holder pasteurization (HoP; 62.5 °C, 30 min) is commonly used to ensure the microbiological safety of donor human milk (DHM) but diminishes its nutritional properties. A high-temperature short-time (HTST) system was designed as an alternative for human milk banks. The objective of this study was to evaluate the effect of this HTST system on different nutrients and the bile salt stimulated lipase (BSSL) activity of DHM. DHM was processed in the HTST system and by standard HoP. Macronutrients were measured with a mid-infrared analyzer. Lactose, glucose, myo-inositol, vitamins and lipids were assayed using chromatographic techniques. BSSL activity was determined using a kit. The duration of HTST treatment had a greater influence on the nutrient composition of DHM than did the tested temperature. The lactose concentration and the percentage of phospholipids and PUFAs were higher in HTST-treated than in raw DHM, while the fat concentration and the percentage of monoacylglycerides and SFAs were lower. Other nutrients did not change after HTST processing. The retained BSSL activity was higher after short HTST treatment than that following HoP. Overall, HTST treatment resulted in better preservation of the nutritional quality of DHM than HoP because relevant thermosensitive components (phospholipids, PUFAs, and BSSL) were less affected.This research was funded by grants from the Spanish Research Projects in Health funded by ISCIII-the state plan for scientific and technical research and innovation and European Regional Development Fund (ERDF) (ref. PI12/02128 and PI15/00995) and by ALG2016-75476-R project from the Ministerio de Economía, Industria y Competitividad (Spain). Moreover, this work has received a grant from the Hero Institute for Infant Nutrition (Alcantarilla, Murcia, España; 2012). Additionally, this study was supported by RETICS “Maternal and Child Health and Development Network” (SAMID Network), funded by the PN I+D+i 2008-2011 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and the ERDF (ref. RD12/0026)

Herramienta de modelado disfuncional tridimensional basado en estudios de neuroimagen

El modelado disfuncional basado en estudios de neuroimagen mejora la comprensión de los cambios estructurales provocados ante la presencia de lesiones cerebrales. Actualmente, existen numerosas herramientas para el análisis y procesado de estudios de neuroimagen. Algunas de ellas, como el 3D Slicer, BrainVoyager y el FreeSurfer permiten la creación y navegación sobre modelos tridimensionales cerebrales sin alteraciones estructurales. Sin embargo, no se han detectado herramientas que permitan modelar tridimensionalmente lesiones a partir de estudios de neuroimagen, concretamente de estudios de resonancia magnética. El objetivo de este trabajo es el diseño de una metodología que permite la creación de este tipo de modelos y su visualización y navegación

SEROPREVALENCIA DE Neospora caninum EN CANINOS DE DOS DISTRITOS DE LA PROVINCIA DE CHACHAPOYAS

El Neospora caninum, parásito del canino, es ampliamente conocido como causante de abortos y mortalidad neonatal en bovinos a nivel mundial. El objetivo del presente estudio fue determinar la seroprevalencia de N. caninum en caninos de los distritos de Molinopampa y Leymebamba, provincia de Chachapoyas, Amazonas. Se evaluaron 142 sueros de caninos (63 de Molinopampa y 79 de Leymebamba) para la detección de anticuerpos mediante la prueba de Inmufluorescencia Indirecta (IFI). El 28.9 ± 7.5% de los caninos presentaron anticuerpos contra N. caninum. Seroprevalencias de 34.9 ± 11.8% y 24.1 ± 9.4% fueron halladas en caninos de los distritos de Molinopampa y Leymebamaba, respectivamente. Estos resultados demuestran la existencia de una seroprevalencia moderadamente alta de caninos infectados con N. caninum en la región estudiada.Neospora caninum is a parasite of dogs that causes high rates of abortion and neonatal mortality in cattle throughout the world. The objective of the study was to determine the prevalence of Neospora caninum in dogs from districts of Molinopampa and Leymebamba, province of Chachapoyas, Amazonas. A total of 142 serum samples were evaluated (63 from Molinopampa and 79 from Leymebamba) for the detection of antibodies using the indirect immunofluorescence test (IFAT). The 28.9 ± 7.5% of the animals were positive to N. caninum. A seroprevalence of 34.9 ± 11.8% and 24.1 ± 9.4% were found in dogs of Molinopampa and Leymebamba districts, respectively. This results demonstrate the existence of a high seroprevalence of dogs infected with Neospora caninum in the region

The traditional maximal lactate steady state test versus the 5× 2000 m test

Here, we compared the maximal lactate steady state velocity (vMLSS) estimated from a single-visit protocol (v5 × 2000) to the traditional multi-day protocol (vMLSS). Furthermore, we determined whether there was a lactate steady state during the time limits (Tlim) at vMLSS or v5 × 2000. Eight runners completed a half marathon (HM), the traditional protocol to determine the vMLSS and the 5 × 2000 m test in a randomised order, and a Tlim at vMLSS and at v5 × 2000 in a randomised order. The vMLSS (13.56 ± 0.90 km·h − 1 ) was higher than the v5 × 2000 (12.93 ± 0.90 km·h − 1 , p = 0.001) and comparable to the vHM (13.34 ± 0.75 km·h − 1 ). The vMLSS (r = 0.83) and the v5 × 2000 (r = 0.91) were associated with the vHM but were not indicative of the competition pace. The Tlim at vMLSS (64 ± 15 min) was lower than the Tlim at v5 × 2000 (94 ± 21 min) and the HM time (95 ± 5 min). In both Tlim, lactate was lower at 45 min than upon fi nishing the eff ort and was predictive of its duration (p < 0.05). Our results indicate that the 5 × 2000 m test can be equally useful to assess runners as the traditional MLSS protocol and that there is no lactate steady state during the Tlim at vMLSS or at v5 × 200

Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer

Pancreatic cancer (PC) remains one of the most aggressive tumors with an increasing incidence rate and reduced survival. Although surgical resection is the only potentially curative treatment for PC, only 15-20% of patients are resectable at diagnosis. To select the most appropriate treatment and thus improve outcomes, the diagnostic and therapeutic strategy for each patient with PC should be discussed within a multidisciplinary expert team. Clinical decision-making should be evidence-based, considering the staging of the tumor, the performance status and preferences of the patient. The aim of this guideline is to provide practical and evidence-based recommendations for the management of PC

Brain injury MRI simulator based on theoretical models of neuroanatomic damage

In order to improve the body of knowledge about brain injury impairment is essential to develop image database with different types of injuries. This paper proposes a new methodology to model three types of brain injury: stroke, tumor and traumatic brain injury; and implements a system to navigate among simulated MRI studies. These studies can be used on research studies, to validate new processing methods and as an educational tool, to show different types of brain injury and how they affect to neuroanatomic structures

Hydrogenation of 4-nitrochlorobenzene catalysed by cobalt nanoparticles supported on nitrogen-doped activated carbon

The hydrogenation of nitroarenes to produce the corresponding amines using dihydrogen as reducing agent has an important industrial role, since it allows to obtain important added-value products. This reaction needs the help of a catalyst to proceed. Many catalysts have been already tested and studied. Most of them are based on noble metals supported on metal oxides. These catalysts perform well, but they are expensive and thus, alternative systems are needed. In this context, cobalt-based catalysts have emerged as adequate alternatives, despite cobalt nanoparticles per se are not very active for this reaction. A way to improve the catalytic activity of cobalt nanoparticles is by supporting them on a support with functional groups that are able to change their intrinsic properties and to enhance their catalytic properties. In this sense, N-containing carbons are promising candidates to be used as support, since nitrogen functionalities may modify the catalytic properties of cobalt. In this work, cobalt nanoparticles supported on N-doped activated carbons have been prepared and studied as catalysts for the hydrogenation of 1-chloro-4-nitrobencene to the corresponding chloro-aniline. It is demonstrated that the catalytic activity is enhanced by the presence of nitrogen species in the support. When the temperature of the catalyst activation treatment (reduction under flowing hydrogen) is increased, the catalytic activity increases drastically in the presence of nitrogen functionalities on the support. The catalysts have been characterised by transmission electron microscopy (TEM), temperature-programmed reduction (TPR), X-ray diffraction, X-ray photoelectron spectroscopi (XPS) and N2 adsorption at 77 K. It has been found that the enhanced catalytic activity was due to two different factors, namely the interaction of the cobalt particles with the nitrogen functional groups (forming Co4N), and the development of mesopores in the support during the activation process that increases the accessibility of reactants to the active sites.Authors acknowledge financial support by MINECO (Spain) through the projects MAT2017-86992-R and MAT2016-80285-P and the European Union for the project “eForFuel”, grant agreement 763911. J. C. S. R. would like to thank the Spanish Ministry of Science and Innovation for financial support through the Ramón y Cajal Program, Grant: RYC-2015-19230 J. C. S. R. would also like to thank Junta de Andalucía for financial support through the projects PY18-RE-0012 and IE18_0047_FUNDACIÓN LOYOLA

Detection of parasites in marine fish for human consumption in Lima

El presente estudio tuvo como objetivo evaluar la presencia de parásitos en cinco especies de peces marinos (Sarda chiliensis chiliensis – bonito, Scomber japonicus peruanus – caballa, Trachurus picturatus murphyi – jurel, Mugil cephalus – lisa, y Coryphaena hippurus – perico) destinados al consumo humano. Se utilizaron 150 peces (30 por especie) procedentes de los terminales pesqueros de Chorrillos y Villa María del Triunfo en la provincia de Lima, Perú, entre enero a marzo de 2014. Se encontraron 13 especies de parásitos: monogeneos (Monocotile sp), digeneos (Dinurus sp), protozoos (Henneguya sp), acantocéfalo (Rhadinorhynchus sp), cestodos (Diphyllobothrium pacificum, Hepatoxylon trichiuri, Tentacularia coryphaenae, Nybelinia sp), nematodos (Anisakis simplex, Anisakis physeteris, Contracaecum sp, Proleptus sp) y artrópodos (Caligus sp). El 61.3% de los especímenes presentaron al menos un parásito, habiendo una mayor prevalencia en lisa (86.7%), seguida de perico (76.7%). Asimismo, la mayor carga parasitaria se observó en lisa (424) y bonito (376). Los parásitos más frecuentes fueron Hepatoxylon trichiuri, Nybelinia sp y Proleptus sp. Asimismo, se encontraron parásitos de importancia en salud pública, como el Anisakis sp en todas las especies, a excepción de la lisa, y del Diphyllobothrium pacificum en bonito y perico.The aim of this study was to evaluate the presence of parasites in five species of marine fish (Sarda chiliensis chiliensis [Eastern Pacific bonito], Scomber japonicus peruanus [Pacific chub mackerel], Trachurus picturatus murphyi [Chilean jack mackerel], Mugil cephalus [flathead grey mullet], and Coryphaena hippurus [common dolphinfish]) intended for human consumption. A total of 150 fish were used (30 per species) from the fishing terminals of Chorrillos and Villa María del Triunfo in the province of Lima, Peru, between January to March 2014. It was found 13 species of parasites: monogeneans (Monocotile sp), digenea (Dinurus sp), protozoa (Henneguya sp), acanthocephalan (Rhadinorhynchus sp), cestoda (Diphyllobothrium pacificum, Hepatoxylon trichiuri, Tentacularia coryphaenae, Nybelinia sp), nematoda (Anisakis simplex, Anisakis physeteris, Contracaecum sp, Proleptus sp) and arthropods (Caligus sp). The results showed that 61.3% of the specimens had at least one parasite, having the flathead grey mullet a higher prevalence (86.7%), followed by the common dolphinfish (76.7%). Similarly, greater parasite load was observed in flathead grey mullet (424) and Eastern Pacific bonito (376). The most common parasites were Hepatoxylon trichiuri, Nybelinia sp and Proleptus sp. Parasites of public health importance were found shuch as Anisakis sp in all species except for the flathead grey mullet and Diphyllobothrium pacificum in Eastern Pacific bonito and common dolphinfish