El tránsito interdisciplinar a través del tratamiento didáctico de los contenidos matemáticos del preuniversitario.

Carrying out the interdisciplinary transition during the didactic treatment of mathematical contents through the teaching of Mathematics in the senior high level of education, is an aspect that has not been well accomplished due to the disciplinary approach of the documents the professor has at his disposal for his orientation toward the lesson. The scientific results shown in this article, derived from a doctoral thesis, influence the teaching and learning process of Mathematics within the senior high level of education and favor the establishment and revelation of the interdisciplinary relationships through a methodology that favors exactly this kind of transition while the mathematical contents are explained.La realización de un tránsito interdisciplinar durante el tratamiento didáctico de los contenidos matemáticos desde la enseñanza de esta asignatura en el preuniversitario, resulta un aspecto poco logrado, motivado esencialmente por el enfoque mayormente disciplinar que tienen los documentos que orientan al docente para la clase, y las insuficientes tecnologías a su disposición para lograrlo. El este trabajo incide en el proceso de enseñanza-aprendizaje de la Matemática en el preuniversitario para favorecer el establecimiento y revelación de las relaciones interdisciplinarias cuya pertinencia sea factible, a través de la propuesta de una metodología que favorezca el referido tránsito desde la explicación de los contenidos matemáticos. Dicha tecnología constituye un resultado parcial de una tesis doctoral en la etapa de escritura

Efectividad de la funcionalidad familiar de persona que ha intentado suicidarse

RESUMENIntroducción: Para Friedemann toda familia se conforma para funcionar adecuadamente en las dimensiones que la autora ha identificado en su teoría, existiendo momentos críticos cuando uno de sus miembros intenta suicidarse.Objetivo: determinar y analizar la efectividad del funcionamiento familiar con la persona que ha intentado suicidar. Metodología: Se diseñó un estudio descriptivo transversal, con muestreo por conveniencia, con la utilización la ficha sociodemográfica de convivencia familiar y la Escala de Evaluación de la Efectividad de la Funcionalidad Familiar. En total fueron 23 familias donde una persona ha intentado suicidarse.Resultados: La efectividad de la funcionalidad familiar fue baja en el 60,9% de las familias, debido a que presentaron dificultades en su estabilidad y crecimiento familiar.Conclusiones: Las familias se resisten a modificar sus patrones y costumbres y tienen dificultades en la comunicación asertiva. Salud UIS 2011; 43(1): 33-37Palabras clave: Intento de suicidio, salud de la familia, relaciones familiaresABSTRACTIntroduction: For Friedemann a family is made up with the purpose of performing adequately in the dimensions that the author has identified in her theory, but some critical problems appears when one of the members of that family tries to commit suicide. Objective: To determine and analyze the way the individuals family works.Methodology: A transversal descriptive study was designed using a convenient sampling of the individuals family´s convenience social demographic form and the Evaluation Scale for the Effectiveness of the Family´s Function. Twenty three families had a person who had tried suicide.Results: The effectiveness of the family´s function was low in a 60.9% of the families because some difficulties appeared when trying to establish their stability and growth.Conclusions: The families refused to modify their patterns and customs and showed difficulties in their assertive communication. Salud UIS 2011; 43(1): 33-37Keywords: Suicide attempts, family health, family relation

Efectividad de la funcionalidad familiar de persona que ha intentado suicidarse

RESUMENIntroducción: Para Friedemann toda familia se conforma para funcionar adecuadamente en las dimensiones que la autora ha identificado en su teoría, existiendo momentos críticos cuando uno de sus miembros intenta suicidarse.Objetivo: determinar y analizar la efectividad del funcionamiento familiar con la persona que ha intentado suicidar. Metodología: Se diseñó un estudio descriptivo transversal, con muestreo por conveniencia, con la utilización la ficha sociodemográfica de convivencia familiar y la Escala de Evaluación de la Efectividad de la Funcionalidad Familiar. En total fueron 23 familias donde una persona ha intentado suicidarse.Resultados: La efectividad de la funcionalidad familiar fue baja en el 60,9% de las familias, debido a que presentaron dificultades en su estabilidad y crecimiento familiar.Conclusiones: Las familias se resisten a modificar sus patrones y costumbres y tienen dificultades en la comunicación asertiva. Salud UIS 2011; 43(1): 33-37Palabras clave: Intento de suicidio, salud de la familia, relaciones familiaresABSTRACTIntroduction: For Friedemann a family is made up with the purpose of performing adequately in the dimensions that the author has identified in her theory, but some critical problems appears when one of the members of that family tries to commit suicide. Objective: To determine and analyze the way the individuals family works.Methodology: A transversal descriptive study was designed using a convenient sampling of the individuals family´s convenience social demographic form and the Evaluation Scale for the Effectiveness of the Family´s Function. Twenty three families had a person who had tried suicide.Results: The effectiveness of the family´s function was low in a 60.9% of the families because some difficulties appeared when trying to establish their stability and growth.Conclusions: The families refused to modify their patterns and customs and showed difficulties in their assertive communication. Salud UIS 2011; 43(1): 33-37Keywords: Suicide attempts, family health, family relation

The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.

BACKGROUND AND AIMS Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial dysfunction is one of the earliest manifestations of alcohol-induced injury, restoring mitochondrial activity remains a problematic strategy due to oxidative stress. Here, we identify methylation-controlled J protein (MCJ) as a mediator for ALD progression and hypothesize that targeting MCJ may help in recovering mitochondrial fitness without collateral oxidative damage. APPROACH AND RESULTS C57BL/6 mice [wild-type (Wt)] Mcj knockout and Mcj liver-specific silencing (MCJ-LSS) underwent the NIAAA dietary protocol (Lieber-DeCarli diet containing 5% (vol/vol) ethanol for 10 days, plus a single binge ethanol feeding at day 11). To evaluate the impact of a restored mitochondrial activity in ALD, the liver, gut, and pancreas were characterized, focusing on lipid metabolism, glucose homeostasis, intestinal permeability, and microbiota composition. MCJ, a protein acting as an endogenous negative regulator of mitochondrial respiration, is downregulated in the early stages of ALD and increases with the severity of the disease. Whole-body deficiency of MCJ is detrimental during ALD because it exacerbates the systemic effects of alcohol abuse through altered intestinal permeability, increased endotoxemia, and dysregulation of pancreatic function, which overall worsens liver injury. On the other hand, liver-specific Mcj silencing prevents main ALD hallmarks, that is, mitochondrial dysfunction, steatosis, inflammation, and oxidative stress, as it restores the NAD + /NADH ratio and SIRT1 function, hence preventing de novo lipogenesis and improving lipid oxidation. CONCLUSIONS Improving mitochondrial respiration by liver-specific Mcj silencing might become a novel therapeutic approach for treating ALD.This work was supported by grants from Ministerio de Ciencia e Innovación, Programa Retos-Colaboración RTC2019-007125-1 (for Jorge Simon and Maria Luz Martinez-Chantar); Ministerio de Economía, Industria y Competitividad, Retos a la Sociedad AGL2017- 86927R (for F.M.); Instituto de Salud Carlos III, Proyectos de Investigación en Salud DTS20/00138 and DTS21/00094 (for Jorge Simon and Maria Luz Martinez-Chantar, and Asis Palazon. respectively); Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias co-founded by European Regional Development Fund/European Social Fund, “Investing in your future” PI19/00819, “Una manera de hacer Europa” FIS PI20/00765, and PI21/01067 (for Jose J. G. Marin., Pau Sancho-Bru,. and Mario F. Fraga respectively); Departamento de Industria del Gobierno Vasco (for Maria Luz Martinez-Chantar); Asturias Government (PCTI) co-funding 2018-2023/ FEDER IDI/2021/000077 (for Mario F. Fraga.); Ministerio de Ciencia, Innovación y Universidades MICINN: PID2020-117116RB-I00, CEX2021-001136-S PID2020-117941RB-I00, PID2020-11827RB-I00 and PID2019-107956RA-100 integrado en el Plan Estatal de Investigación Científica y Técnica y Innovación, cofinanciado con Fondos FEDER (for Maria Luz Martinez-Chantar, Francisco J Cubero., Yulia A Nevzorova and Asis Palazon); Ayudas Ramón y Cajal de la Agencia Estatal de Investigación RY2013-13666 and RYC2018- 024183-I (for Leticia Abecia and Asis Palazon); European Research Council Starting Grant 804236 NEXTGEN-IO (for Asis Palazon); The German Research Foundation SFB/TRR57/P04, SFB1382-403224013/ A02 and DFG NE 2128/2-1 (for Francisco J Cubero and Yulia A Nevzorova); National Institute of Health (NIH)/National Institute of Alcohol Abuse and Alcoholism (NIAAA) 1U01AA026972-01 (For Pau Sancho-Bru); Junta de Castilla y León SA074P20 (for Jose J. G. Marin); Junta de Andalucía, Grupo PAIDI BIO311 (for Franz Martin); CIBERER Acciones Cooperativas y Complementarias Intramurales ACCI20-35 (for Mario F. Fraga); Ministerio de Educación, Cultura y Deporte FPU17/04992 (for Silvia Ariño); Fundació Marato TV3 201916-31 (for Jose J. G. Marin.); Ainize Pena-Cearra is a fellow of the University of the Basque Country (UPV/ EHU); BIOEF (Basque Foundation for Innovation and Health Research); Asociación Española contra el Cáncer (Maria Luz Martinez-Chantar and Teresa C. Delgado.); Fundación Científica de la Asociación Española Contra el Cáncer (AECC Scientific Foundation) Rare Tumor Calls 2017 (for Maria Luz Martinez-Chantar); La Caixa Foundation Program (for Maria Luz Martinez-Chantar); Proyecto Desarrollo Tecnologico CIBERehd (for Maria Luz Martinez-Chantar); Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III.S

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research