212 research outputs found

    Single-Stage Experimental Evaluation of Boundary Layer Blowing Techniques for High Lift Stator Blades. III - Data and Performance of Single-Slotted 0.65 Hub Diffusion Factor Stator

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    Test on overall and blade element performance of single slotted 0.65 hub diffusion factor stator with self energized blowing boundary layer contro

    Rings of fire and Grooved Ware settlement at West Kennet, Wiltshire

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    Alasdair Whittle has had a career-long interest in the Neolithic of the Avebury area (Fig. 17.1). In the late 1980s and early 1990s he undertook a major research project in the region to investigate the Neolithic sequence and its environment (Whittle 1993). This included a series of excavations of early Neolithic sites including the causewayed enclosure at Windmill Hill (Whittle et al. 1999), the chambered tomb at Millbarrow (Whittle 1994), and an earthen long barrow at Easton Down (Whittle et al. 1993). A series of trenches were also cut through two palisade enclosures at West Kennet (Whittle 1997). This campaign of new excavation was accompanied by research into the archives of previous investigations, particularly the publication and subsequent dating of Richard Atkinson’s excavation on and within Silbury Hill in 1968–70 (Bayliss et al. 2007a; Whittle 1997) and a reassessment of the date and development of Avebury itself (Pitts and Whittle 1992). The subsequent decades have seen continued work in the Avebury region, given focus by the Archaeological Research Agenda for the Avebury World Heritage site (AAHRG 2001). Alasdair himself has been instrumental in producing refined chronologies for the West Kennet long barrow (Bayliss et al. 2007b) and the causewayed enclosures at Windmill Hill and Knap Hill (Whittle et al. 2011, chapter 3), and in producing synthetic narratives of early Neolithic sites in the region and beyond (Whittle et al. 2007; 2011, chapters 14 and 15). Further understanding of the late Neolithic landscape has been gained through research excavations at the Beckhampton Avenue and Longstones Cove and ditched enclosure (Gillings et al. 2008), and through rescue excavations undertaken in advance of consolidation works at Silbury Hill (Leary et al. 2013a). The latter in particular has done much to improve our understanding of the development and date of Silbury Hill (Marshall et al. 2013; in prep. a; in prep. b), which has been put into context by a recent synthesis of the available scientific dating evidence for the Avebury area by Frances Healy (2016)

    Solar cell process development in the european integrated project crystalclear

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    CrystalClear is a large integrated project funded by the European Commission that aims to drastically reduce the cost of crystalline Si PV modules, down to 1 Euro/Wp. Among the different subprojects, the one dealing with the development of advanced solar cells is relatively large (with 11 partners out of the 15 Crystal Clear partners taking part) and has a crucial role. The goal of the subproject is to develop cell design concepts and manufacturing processes that would enable a reduction in the order of 40% of the cell processing costs per Wp. In this paper, we give an overview of all the development work that has taken place in the CrystalClear solar cells subproject so far. World class results have been achieved, particularly on high efficiency cells on Si ribbons, and on industrial-type solar cells on very thin (120 (j.m thick) substrates

    Recent cadmium exposure among male partners may affect oocyte fertilization during in vitro fertilization (IVF)

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    We recently reported evidence suggesting associations between urine cadmium concentrations, reflecting long-term exposure, measured in 25 female patients (relative risk = 1.41, P = 0.412) and 15 of their male partners (relative risk = 0.19, P = 0.097) and oocyte fertilization in vitro. Blood cadmium concentrations reflect more recent exposure. We here incorporate those measures into our prior data set and employ multivariable log-binomial regression models to generate hypotheses concerning the relative effects of long-term and recent cadmium exposure on oocyte fertilization in vitro. No association is indicated for blood cadmium from women and oocyte fertilization, adjusted for urine cadmium and creatinine, blood lead and mercury, age, race/ethnicity and cigarette smoking (relative risk = 0.88, P = 0.828). However, we suggest an inverse adjusted association between blood cadmium from men and oocyte fertilization (relative risk = 0.66, P = 0.143). These results suggest that consideration of long-term and recent exposures are both important for assessing the effect of partner cadmium levels on oocyte fertilization in vitro

    A cereal problem? What the current chronology of early cereal domesticates might tell us about changes in late fifth and early fourth millennium cal BC Ireland and Britain

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    In the years since the last volume on plant domesticates in Ireland and Britain in the fourth millennium[AQ1] cal BC (Fairburn, A., ed. [2000]. Plants in Neolithic Britain and Beyond. Oxford: Oxbow)[AQ2], a number of significant changes have occurred in archaeological practice. These have included the routine application of a range of archaeological science techniques, including Bayesian statistical modelling. During the same period, large-scale sampling strategies in developer-led professional practice, and especially on large infrastructure projects, have increased the available materials for study. This paper will present a new analysis of radiocarbon results from direct measurements on domesticated plant remains from Ireland and Britain to explore what these can tell us about the nature of the changes in the archaeological record at this time. Cereals may appear after the introduction of practices including monuments in the form of causewayed enclosures, tombs and post-and-slot-built structures, in several regions. This approach is new because it unpacks the ‘Neolithic package’, by comparing direct estimates on plant domesticates with the appearance of other forms of material culture and new site types. ‘Unpacking the package’ here (or in other periods critically engaging with culture historic-derived analytical constructs) is important in three ways, which will be discussed in this paper. As well as allowing us to examine the fine-grained nature of changes, developments in chronological modelling should cause us to re-examine how useful our existing terms of engagement are; we need to think not only about the changes we can produce in the sequence of archaeological knowledge, but also in the structure of it

    Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial

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    <p>Abstract</p> <p>Background</p> <p>Clinical depression is common, debilitating and treatable; one in four people experience it during their lives. The majority of sufferers are treated in primary care and only half respond well to active treatment. Evidence suggests that folate may be a useful adjunct to antidepressant treatment: 1) patients with depression often have a functional folate deficiency; 2) the severity of such deficiency, indicated by elevated homocysteine, correlates with depression severity, 3) low folate is associated with poor antidepressant response, and 4) folate is required for the synthesis of neurotransmitters implicated in the pathogenesis and treatment of depression.</p> <p>Methods/Design</p> <p>The primary objective of this trial is to estimate the effect of folate augmentation in new or continuing treatment of depressive disorder in primary and secondary care. Secondary objectives are to evaluate the cost-effectiveness of folate augmentation of antidepressant treatment, investigate how the response to antidepressant treatment depends on genetic polymorphisms relevant to folate metabolism and antidepressant response, and explore whether baseline folate status can predict response to antidepressant treatment.</p> <p>Seven hundred and thirty patients will be recruited from North East Wales, North West Wales and Swansea. Patients with moderate to severe depression will be referred to the trial by their GP or Psychiatrist. If patients consent they will be assessed for eligibility and baseline measures will be undertaken.</p> <p>Blood samples will be taken to exclude patients with folate and B12 deficiency. Some of the blood taken will be used to measure homocysteine levels and for genetic analysis (with additional consent). Eligible participants will be randomised to receive 5 mg of folic acid or placebo. Patients with B12 deficiency or folate deficiency will be given appropriate treatment and will be monitored in the 'comprehensive cohort study'. Assessments will be at screening, randomisation and 3 subsequent follow-ups.</p> <p>Discussion</p> <p>If folic acid is shown to improve the efficacy of antidepressants, then it will provide a safe, simple and cheap way of improving the treatment of depression in primary and secondary care.</p> <p>Trial registration</p> <p>Current controlled trials ISRCTN37558856</p
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