Somatostatin receptor scintigraphy of malignant lymphoma--current status.

Somatostatin receptors have been demonstrated on normal as well as activated human lymphocytes in the circulation and within the reticuloendothelial system such as Peyer's patches and the spleen [1]. Also, lymphocyte function such as proliferation and immunoglobulin synthesis has been showed to be affected by somatostatin [2]. Following the demonstration of the presence of high-density somatostatin receptors in a variety of neuroendocrine derived tumors [3], Reubi et al. subsequently reported visualizing non-Hodgkins lymphoma in four patients imaged with Indium-I1l-[DTPA-D-Phel]-Octreotide, an analogue of somatostatin [4]. Autoradiography utilizing 125I-[Tyr3]-Octreotide was used to demonstrate the diffuse distribution of somatostatin receptors in tissue samples of biopsies taken of the involved sites.They suggested that somatostatin receptors could be used as valuable pathobiochemical tissue markers and potentially useful as an in vivo diagnostic tool for human malignant lymphomas. In ten patients studied with malignant lymphoma (Hodgkins disease and non-Hodgkins lymphomas), lymphoma deposits could be demonstrated [5]. In four patients, additional tumor localizations were observed as compared to the results of combined physical and radiological (CT and ultrasound

Entanglement creation and distribution on a graph of exchange-coupled qutrits

We propose a protocol that allows both the creation and distribution of entanglement, resulting in two distant parties (Alice and Bob) conclusively sharing a bipartite Bell State. The system considered is a graph of three-level objects ("qutrits") coupled by SU(3) exchange operators. The protocol begins with a third party (Charlie) encoding two lattice sites in unentangled states, and allowing unitary evolution under time. Alice and Bob perform a projective measurement on their respective qutrits at a given time, and obtain a maximally-entangled Bell state with a certain probablility. We also consider two further protocols, one based on simple repetition and the other based on successive measurements and conditional resetting, and show that the cumulative probability of creating a Bell state between Alice and Bob tends to unity.Comment: Added seven references, clarified argument for eqn (16

Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans

Mounting evidence shows that phenol-rich beverages exert strong antioxidant activity. However, in vivo evidence has produced conflicting results. In the present study, we studied the impact of the ingestion of 300 mL of black and green tea, alcohol-free red wine, alcohol-free white wine, or water on plasma total antioxidant capacity in five healthy volunteers. Red wine has the highest content of phenolics (3.63 ± 0.48 g QE/L), followed by green tea (2.82 ± 0.07 g QE/L), black tea (1.37 ± 0.15 g QE/L), and white wine (0.31 ± 0.01 g QE/L). Plasma total antioxidant capacity values of subjects who drank green tea rose at 30 min (P < 0.05). After black tea and red wine ingestion, the peaks were at 50 min (P < 0.05 and P < 0.01, respectively). No changes were observed in the control and white wine groups. Red wine and green tea were the most efficient in protecting low density lipoprotein from oxidation driven by peroxyl and ferril radicals, respectively. Phenol-rich beverages are a natural source of antioxidants; however, the phenolic content alone cannot be considered an index of their in vivo antioxidant activity.http://www.sciencedirect.com/science/article/B6T8P-420SK92-B/1/657ecacc07210bc6cfa30dc5753d761

Quantum SASE FEL with a laser wiggler

Quantum effects in high-gain FELs are ruled by the quantum FEL parameter, \u3c1 = pmcy/hkr, which is the ratio between the momentum spread at saturation and the one photon momentum recoil. It has been shown that when 3c\u3c1 64 1 the spectrum of the emitted radiation changes from the broad continuous and chaotic spectrum of the classical regime to a series of discrete and equally spaced very narrow lines, due to transitions between discrete momentum states. In this paper we show that the quantum regime can be achieved using Kilometers long magnetic wigglers or a laser wiggler. In this paper we state the scaling laws necessary to operate a Quantum SASE FEL in the Angstrom region with a laser wiggler. Specific example is given having in mind a high power Ti: Sa laser wiggler at \u3bb= 0.8 \u3bcm, in construction at LNF-INFN Laboratories, for the SPARC/PLASMON-X project

Neural-symbolic computing: An effective methodology for principled integration of machine learning and reasoning

Current advances in Artificial Intelligence and machine learning in general, and deep learning in particular have reached unprecedented impact not only across research communities, but also over popular media channels. However, concerns about interpretability and accountability of AI have been raised by influential thinkers. In spite of the recent impact of AI, several works have identified the need for principled knowledge representation and reasoning mechanisms integrated with deep learning-based systems to provide sound and explainable models for such systems. Neural-symbolic computing aims at integrating, as foreseen by Valiant, two most fundamental cognitive abilities: the ability to learn from the environment, and the ability to reason from what has been learned. Neural-symbolic computing has been an active topic of research for many years, reconciling the advantages of robust learning in neural networks and reasoning and interpretability of symbolic representation. In this paper, we survey recent accomplishments of neural-symbolic computing as a principled methodology for integrated machine learning and reasoning. We illustrate the effectiveness of the approach by outlining the main characteristics of the methodology: principled integration of neural learning with symbolic knowledge representation and reasoning allowing for the construction of explainable AI systems. The insights provided by neural-symbolic computing shed new light on the increasingly prominent need for interpretable and accountable AI systems

Entanglement of two-mode Gaussian states: characterization and experimental production and manipulation

A powerful theoretical structure has emerged in recent years on the characterization and quantification of entanglement in continuous-variable systems. After reviewing this framework, we will illustrate it with an original set-up based on a type-II OPO with adjustable mode coupling. Experimental results allow a direct verification of many theoretical predictions and provide a sharp insight into the general properties of two-mode Gaussian states and entanglement resource manipulation

Continuous variable entanglement sharing in non-inertial frames

We study the distribution of entanglement between modes of a free scalar field from the perspective of observers in uniform acceleration. We consider a two-mode squeezed state of the field from an inertial perspective, and analytically study the degradation of entanglement due to the Unruh effect, in the cases of either one or both observers undergoing uniform acceleration. We find that for two observers undergoing finite acceleration, the entanglement vanishes between the lowest frequency modes. The loss of entanglement is precisely explained as a redistribution of the inertial entanglement into multipartite quantum correlations among accessible and unaccessible modes from a non-inertial perspective. We show that classical correlations are also lost from the perspective of two accelerated observers but conserved if one of the observers remains inertial.Comment: 19 pages, 13 EPS figures (most low-res due to oversize); terminology revise

Effect of Housing Quality on the Mental Health of University Students during the COVID-19 Lockdown

COVID-19 outbreak imposed rapid and severe public policies that consistently impacted the lifestyle habits and mental health of the general population. Despite vaccination, lockdown restrictions are still considered as potential measures to contrast COVID-19 variants spread in several countries. Recent studies have highlighted the impacts of lockdowns on the population\u2019s mental health; however, the role of the indoor housing environment where people spent most of their time has rarely been considered. Data from 8177 undergraduate and graduate students were collected in a large, cross-sectional, web-based survey, submitted to a university in Northern Italy during the first lockdown period from 1 April to 1 May 2020. Logistic regression analysis showed significant associations between moderate and severe depression symptomatology (PHQ-9 scores 65 15), and houses with both poor indoor quality and small dimensions (OR = 4.132), either medium dimensions (OR = 3.249) or big dimensions (OR = 3.522). It was also found that, regardless of housing size, poor indoor quality is significantly associated with moderate\u2013severe depressive symptomatology. Further studies are encouraged to explore the long-term impact of built environment parameter modifications on mental health, and therefore support housing and public health policies

High intensity X/ γ photon beams for nuclear physics and photonics

In this manuscript we review the challenges of Compton back-scattering sources in advancing photon beam performances in the1−20MeVenergy range, underlining the design criteria bringing tomaximum spectral luminosity and briefly describing the main achieve-ments in conceiving and developing new devices (multi-bunch RF cav-ities and Laser recirculators) for the case of ELI-NP Gamma BeamSystem (ELI-NP-GBS)