Practice of Fiducial Marker in Prostate Cancer: A Single-Center Experience with up to 6 Years’ Follow-up Results

We aimed to evaluate the long-term follow-up results of patients with prostate cancer implanted with ultrasound-guided fiducial marker(FM). Forty patients, between 2012-2017 were evaluated. Firstly, the gastrointestinal-genitourinary system side effects were questioned twice immediately after FM implant and in the median 6.5th year and the grading was performed via the NCI CTCAE-V5.0 test and compared. Secondly, in the late period, questions assessing genitourinary-gastrointestinal symptoms were asked using the EORTC QLQ-PR25 Module,and the complication status and patient comfort were assessed The mean symptom value for all patients in the EORTC QLQ-PR25 module was 17,33%. In the first assessment made according to the results obtained by questioning the genitourinarygastrointestinal symptoms related to the FM procedure both after the procedure and in the median 6.5th year,rectal bleeding was present in 2(4%),dysuria 3(6%),hematuria 5(11%) and frequency of urination in 5(11%) patients and in the second assessment,no new symptoms were added and the overall symptom rate decreased. In the first assessment,it was determined via NCI CTCAE-V 5.0 scale that the adverse effects of 9 patients (20%),who were identified with adverse effects,were grade 1 corresponding to mild side effects,and none of the patients experienced grade 2 or higher adverse events. In the second assessment,side effects were defined in 3 patients (7,5%) and grade 1 was mild. The ultrasound-guided FM implant procedure,which is used in prostate cancer radiotherapy is an easy,tolerable and safe technique that does not lead to adverse effects and loss of comfort in patients with long-term follow-u

Atmospheric Pressure Mass Spectrometry of Single Viruses and Nanoparticles by Nanoelectromechanical Systems

Mass spectrometry of intact nanoparticles and viruses can serve as a potent characterization tool for material science and biophysics. Inaccessible by widespread commercial techniques, the mass of single nanoparticles and viruses (>10MDa) can be readily measured by NEMS (Nanoelectromechanical Systems) based Mass Spectrometry, where charged and isolated analyte particles are generated by Electrospray Ionization (ESI) in air and transported onto the NEMS resonator for capture and detection. However, the applicability of NEMS as a practical solution is hindered by their miniscule surface area, which results in poor limit-of-detection and low capture efficiency values. Another hindrance is the necessity to house the NEMS inside complex vacuum systems, which is required in part to focus analytes towards the miniscule detection surface of the NEMS. Here, we overcome both limitations by integrating an ion lens onto the NEMS chip. The ion lens is composed of a polymer layer, which charges up by receiving part of the ions incoming from the ESI tip and consequently starts to focus the analytes towards an open window aligned with the active area of the NEMS electrostatically. With this integrated system, we have detected the mass of gold and polystyrene nanoparticles under ambient conditions and with two orders-of-magnitude improvement in capture efficiency compared to the state-of-the-art. We then applied this technology to obtain the mass spectrum of SARS-CoV-2 and BoHV-1 virions. With the increase in analytical throughput, the simplicity of the overall setup and the operation capability under ambient conditions, the technique demonstrates that NEMS Mass Spectrometry can be deployed for mass detection of engineered nanoparticles and biological samples efficiently.Comment: 38 pages, 6 figure

Examining the use of abdominal compression in stereotactic body radiotherapy for liver metastases: a single center’s experience of 10 years

INTRODUCTION: Stereotactic body radiotherapy (SBRT) with abdominal compression (AC) stands out due to the high tolerance and ease of application in the treatment of liver metastases. The present study aimed to report the safety and efficacy of the AC technique with 10-year follow-up outcomes. MATERIALS AND METHODS: A retrospective review was made of patients in the database who had liver metastases, who did not undergo surgery or any other ablative approach for metastases, and who underwent SBRT with AC. In-field local control (ifLC) and toxicity were evaluated as primary endpoints. RESULTS: The study examined 79 patients who underwent SBRT with AC between 2012 and 2021. Colorectal adenocarcinoma was the most common type of primary tumor (n = 32, 40.5%). The median follow-up was 14 (4–73) months. After treatment, one-year ifLC was 46.4%, six-month ifLC was 76%, one-year out-field local control (ofLC) was 13.6%, and six-month ofLC was 25%. According to the Common Terminology Criteria for Adverse Events Version 5.0, only 8 patients had low-grade acute gastrointestinal toxicity, and no patients had late toxicity. CONCLUSIONS: SBRT with AC is a well-tolerated and effective treatment modality for patients with liver metastases

Membranoproliferative Glomerulonephritis Preceding Non-Hodgkin Lymphoma Recurrence: A Case Report

Introduction: Membranoproliferative glomerulonephritis has been reported to occur in association with non-Hodgkin’s lymphoma but there is few information about glomerulonephritis response to the treatment of non-Hodgkin’s lymphoma.Case Presentation: A 67 years-old caucasian female admitted to outpatient clinic with peripheral edema complaint. She had mild proteinuria and microhematuria on admission and tuberculosis, non-Hodgkin lymphoma (cured), diabetes mellitus and hypertension history. Her renal biopsy resulted as&nbsp; membranoproliferative&nbsp; glomerulonephritis&nbsp; and&nbsp; after&nbsp; investigations&nbsp; she&nbsp; got&nbsp; recurrent&nbsp; non-Hodgkinlymphoma&nbsp; diagnosis.&nbsp; After&nbsp; successful&nbsp; treatment&nbsp; of&nbsp; her&nbsp; lymphoma&nbsp; her&nbsp; nephrotic&nbsp; syndrome&nbsp; clinicregressed.Conclusion: Membranoproliferative&nbsp; glomerulonephritis&nbsp; has&nbsp; been&nbsp; known&nbsp; to&nbsp; be&nbsp; associated with&nbsp; non-Hodgkin’s&nbsp; lymphoma.&nbsp; There&nbsp; is&nbsp; limited&nbsp; information&nbsp; available&nbsp; concerning&nbsp; the&nbsp; effects&nbsp; of treatment of non-Hodgkin’s lymphoma on the progression of non-Hodgkin’s lymphoma associated membranoproliferative&nbsp; glomerulonephritis.&nbsp; We&nbsp; report&nbsp; a&nbsp; rare&nbsp; case&nbsp; of&nbsp; non-Hodgkin’s&nbsp; lymphoma associated&nbsp; membranoproliferative&nbsp; glomerulonephritis,&nbsp; that&nbsp; continued&nbsp; to&nbsp; be&nbsp; in&nbsp; remission&nbsp; after chemotherapy treatment of lymphoma.</p

The effect of adding selective neck dissection to surgery on adjuvant treatment selection and identification of metastasis in glomus tumors

Glomus tumors are rare tumors with malignant nature. Regional lymph node metastases are even rare and this could be contribute for determine to malignant form. The presence of lymph node involvement directs adjuvant treatment is still controversial. Positive imaging results might be helpful for decision of neck dissection. But results might sometimes be false negative. Here we present a case of malignant glomus tumor with regional lymph node metastasis was treated with neck dissection. [Cukurova Med J 2016; 41(0.100): 75-78

Oral Rehabilitation in a Patient with Major Maxillofacial Trauma: A Case Management

Traumatic injuries may cause anatomic deficiencies in soft and hard tissues. These defects often result in the loss of attached mucosa and alveolar processes, which might reduce potential prosthesis support and require bone and skin grafting. As a result of major maxillofacial trauma, complete or partial avulsion of the palate may require extensive surgical and prosthodontic rehabilitation. The appropriate treatment for the maxillary defect demands a multidisciplinary approach by a team which consists of various fields of dentistry and medicine. The planning prostheses should replace not only missing teeth but also lost soft tissues and bone, and they should include the hard palate, residual alveolar ridges, and, in some instances, the soft palate. This paper describes the treatment procedures including plastic surgery operation procedures and prosthetic rehabilitation in a 19-year-old woman after her severe bicycle accident

Investigation of the Factors Affecting Allograft Kidney Functions: Results of 10 Years

12th Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA) -- OCT 18-21, 2018 -- Trabzon, TURKEYSen, Sait/0000-0002-1100-6657; Gokalp, Cenk/0000-0003-3909-7973WOS: 000500179300016PubMed: 31101175Introduction. Significant improvements in patient and graft survival and reductions in the frequency of acute rejection were obtained in the early period after renal transplantation, but this success was not sufficiently reflected in the long term. Allograft kidney losses in the long term remain a significant problem. in this study, we investigated the specific causes of graft losses in patients who had a good clinical course in the first year but developed graft loss in the long term. Methods. A total of 118 patients who underwent kidney transplantation in 2005 and 2006 in the Organ Transplantation Center of Ege University Medical Faculty Hospital were evaluated. the inclusion criteria were to be older than 18 years and have a serum creatinine value of <2 mg/dL at the 12th month after transplantation. Results. Sixty-one percent of the recipients were male, and the mean age at the time of transplantation was 34 +/- 11 years (18 to 61). We observed 29 graft losses during the mean follow-up period of 129 +/- 35 months (27 to 162). Three of the graft losses were death by functional graft. of the 26 patients with graft loss, 16 had chronic rejection, and 8 had recurrent glomerulonephritis. the relationship between nonimmune causes and graft loss was not detected. Conclusions. in conclusion, nonimmune factors may not be as important as we think in relatively young and healthier recipients. Chronic rejection and recurrent glomerulonephritis are the main causes of long-term graft loss of patients with good graft function at the end of the first year. Improvement of long-term survival will be possible with the prevention and effective treatment of these 2 problems.Turkish Transplantat Ctr Coordinat Asso

SprachmittlerInnen im Integrationsbereich : der Dolmetschpool des Integrationszentrums Paraplü in Steyr

Ziel dieser Masterarbeit war es, die Tätigkeit von LaiendolmetscherInnen im Integrationsbereich, die in der Forschung bislang stiefmütterlich behandelt wurden, zu charakterisieren. Als Forschungsobjekt wurde der Dolmetschpool des Integrationszentrums Paraplü in Steyr ausgewählt, als theoretische Grundlage dienten verschiedene Konzeptualisierungen des Kommunal- und Laiendolmetschens. Im Rahmen von sechs Interviews mit DolmetscherInnen des Pools sollte herausgefunden werden, an welchen Orten und in welchen Situationen die DolmetscherInnen zum Einsatz kommen, wie sich ihr persönlicher, schulischer und beruflicher Werdegang gestaltete, wie sie zu ihrer Tätigkeit für das Integrationszentrum kamen und aus welchen Gründen sie diese aufnahmen. Außerdem sollte die Frage beantwortet werden, mit welchen Herausforderungen diese LaiendolmetscherInnen im Zuge ihrer Tätigkeit konfrontiert werden und welche Strategien sie verwenden, um diesen zu begegnen. Das Datenmaterial wurde auf Basis deduktiv und induktiv gebildeter Kategorien ausgewertet. Dabei konnte die Hypothese, dass die Befragten Unterschiede in Bezug auf Einsatzorte, Dolmetschsituationen, Werdegang, Aufnahme ihrer Tätigkeit, Motivation sowie zu bewältigende Herausforderungen aufweisen, verifiziert werden. Ebenso konnte die Hypothese bestätigt werden, dass die InformantInnen mangels translatorischer Ausbildung einige der von ihnen angewandten Dolmetschstrategien selbst entwickelt haben. Entgegen der dritten Hypothese stellte sich jedoch heraus, dass die InterviewpartnerInnen für beinahe alle Herausforderungen, mit denen sie als DolmetscherInnen konfrontiert werden, geeignete Strategien anzuwenden scheinen und daher so gut wie keinen Bedarf an noch zu entwickelnden Strategien zu haben scheinen. Dennoch wünschen sich die meisten Befragten interessanterweise ein breiteres Angebot an dolmetschspezifischen Weiterbildungen.Lay interpreters working in the field of integration is a topic that has been scarcely discussed in interpreting studies so far. This thesis aims to characterize the work of lay interpreters by conducting a study in the Paraplü Integration Center in Steyr. Various concepts of community interpreting, lay interpreting, integration and migration serve as theoretical basis for this research project. Six interpreters of the Integration Centers pool of interpreters have been interviewed in order to find answers to following questions: Where and in what situations do they interpret; what is their personal and professional background; how and why they began to work as interpreters for the Integration Center; what challenges do they face in their interpreting assignments and what strategies do they apply to meet these challenges. The data were coded using deductive and inductive categories. The first hypothesis stated that there are differences between the participants with regard to their interpreting assignments, their personal and professional backgrounds, how and why they began to work as interpreters and the challenges they face. The second hypothesis stated that the participants developed their applied interpreting strategies by themselves because they did not undergo professional training. Through the analysis, these two hypotheses had been verified whereas the third hypothesis, which stated that the participants had not developed strategies for every challenge they face, was disproven. Whereas the analysis showed that the participants seem to be able to use appropriate strategies for almost every situation and that they need no further strategies, most of them surprisingly mentioned that they would like to have a wider range of further training courses in interpreting in the future.vorgelegt von Raphael DrabekAbweichender Titel laut Übersetzung des Verfassers/der VerfasserinZusammenfassungen in Deutsch und EnglischKarl-Franzens-Universität Graz, Masterarbeit, 2017(VLID)224597

Increase in interventricular septum thickness may be the first sign of cardiovascular change in kidney donors

Sen, Sait/0000-0002-1100-6657; Gokalp, Cenk/0000-0003-3909-7973; Guner Oytun, Merve/0000-0002-7417-5415; DOGDUS, Mustafa/0000-0002-3895-1923WOS: 000507849800001PubMed: 31955456Background Because of the inadequate number of deceased kidney donors, living kidney donation remains an important issue for kidney transplantation. Previous studies have shown that living donation does not differ life expectancy and progression to end-stage renal disease compared with the normal population. in this study, we investigated short-term cardiovascular changes after donor nephrectomy. Methods Thirty-four patients who underwent donor nephrectomy between January 2015 and July 2015 at Ege University Renal Transplantation Unit were included in the study. Arterial stiffness, multifrequency bioimpedance analysis, renal ARFI elastography, and echocardiography performed prior to the donor nephrectomy and 6 months after nephrectomy. Results A total of 34 kidney donors were enrolled in this study. Twenty donors were female (59%) and 14 donors were male (41%). the pathological evaluation of donor kidneys using implantation renal biopsy sample revealed mean Karpinski Renal Score of 1.5 and the mean glomerulosclerosis ratio was 5% for all donated kidneys. Arterial stiffness, systolic and diastolic blood pressure measures, body fluid composition, and left atrial size did not change significantly during the follow-up. However, interventricular septum thickness of donors increased by 1 mm during a 6-month period (9.6 mm vs 10.6 mm, P = .002). Conclusion We observed an increase in interventricular septum thickness in kidney donors during a 6-month follow-up. in order to evaluate the net effect of this change on donor morbidity, prospective studies investigating an increased number of donors with long-term follow-up should be needed