Compositional analysis of lunar and planetary surfaces using neutron capture gamma rays, 1 January - 31 March 1968

Detection and quantitative determination of hydrogen on planetary and lunar surfaces by neutron capture gamma ray

Development of a position sensitive X-ray detector for use in a light weight X-ray diffractometer

The characteristics of a curved position sensitive X-ray detector are discussed. Emphasis is placed on the analysis of operation in a focusing diffraction geometry. Problems encountered in constructing the sensor are described. Construction drawings of the sensor components are provided

Development of a position sensitive X-ray detector for use in a light weight X-ray diffractometer

A position sensitive proportional counter for use in an X-ray diffractometer is developed to permit drastic reductions in the power and weight requirements of the X-ray source and the elimination of the power, weight, and complexity of a moving slit. The final detector constructed and tested has a window spanning 138 and a free standing anode curved along an arc of 7.1 cm radius. Demonstration spectra of a quartz sample in a Debye-Sherrer geometry indicate a spatial resolution of 0.4 - 0.5 mm (0.3 - 0.4 theta). The lunar diffractometer consumed 25 watts in the X-ray generator and weighed about 20 pounds

Short-term immobilization influences use-dependent cortical plasticity and fine motor performance

Short-term immobilization that reduces muscle use for 8-10h is known to influence cortical excitability and motor performance. However, the mechanisms through which this is achieved, and whether these changes can be used to modify cortical plasticity and motor skill learning, are not known. The purpose of this study was to investigate the influence of short-term immobilization on use-dependent cortical plasticity, motor learning and retention. Twenty-one adults were divided into control and immobilized groups, both of which underwent two experimental sessions on consecutive days. Within each session, transcranial magnetic stimulation (TMS) was used to assess motor-evoked potential (MEP) amplitudes, short- (SICI) and long-interval intracortical inhibition (LICI), and intracortical facilitation (ICF) before and after a grooved pegboard task. Prior to the second training session, the immobilized group underwent 8h of left hand immobilization targeting the index finger, while control subjects were allowed normal limb use. Immobilization produced a reduction in MEP amplitudes, but no change in SICI, LICI or ICF. While motor performance improved for both groups in each session, the level of performance was greater 24-h later in control, but not immobilized subjects. Furthermore, training-related MEP facilitation was greater after, compared with before, immobilization. These results indicate that immobilization can modulate use-dependent plasticity and the retention of motor skills. They also suggest that changes in intracortical excitability are unlikely to contribute to the immobilization-induced modification of cortical excitability.George M. Opie, Alexandra Evans, Michael C. Ridding and John G. Semmle

Using NWP to assess the influence of the Arctic atmosphere on mid-latitude weather and climate

The influence of the Arctic atmosphere on Northern Hemisphere mid-latitude tropospheric weather and climate is explored by comparing the skill of two sets of 14-day weather forecast experiments using the ECMWF model with and without relaxation of the Arctic atmosphere towards ERA-Interim reanalysis data during the integration. Two pathways are identified along which the Arctic influences mid-latitude weather: a pronounced one over Asia and Eastern Europe, and a secondary one over North America. In general, linkages are found to be strongest (weakest) during boreal winter (summer) when the amplitude of stationary planetary waves over the Northern Hemisphere is strongest (weakest). No discernible Arctic impact is found over the North Atlantic and North Pacific region, which is consistent with predominantly southwesterly flow. An analysis of the flow-dependence of the linkages shows that anomalous northerly flow conditions increase the Arctic influence on mid-latitude weather over the continents. Specifically, an anomalous northerly flow from the Kara Sea towards West Asia leads to cold surface temperature anomalies not only over West Asia but also over Eastern and Central Europe. Finally, the results of this study are discussed in the light of potential mid-latitude benefits of improved Arctic prediction capabilities

Dual Adaptation and Adaptive Generalization of the Human Vestibulo-Ocular Reflex

In two experiments, we examined the possibility that the human vestibulo-ocular reflex (VOR) is subject to dual adaptation (the ability to adapt to a sensory rearrangement more rapidly and/or more completely after repeated experience with it) and adaptive generalization (the ability to adapt more readily to a novel sensory rearrangement as a result of prior dual adaptation training). In Experiment 1, the subjects actively turned the head during alternating exposure to a visual-vestibular rearrangement (target/head gain = 0.5) and the normal situation (target/head gain = 0.0). These conditions produced both adaptation and dual adaptation of the VOR but no evidence of adaptive generalization when tested with a target/head gain of 1.0. Experiment 2, in which exposure to the 0.5 gain entailed externally controlled (i.e., passive) whole body rotation, resulted in VOR adaptation but no dual adaptation. As in Experiment 1, no evidence of adaptive generalization was found

Reproducibility of neuroplastic responses induced by continuous theta-burst stimulation

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An analytic model for a cooperative ballistic deposition in one dimension

We formulate a model for a cooperative ballistic deposition (CBD) process whereby the incoming particles are correlated with the ones already adsorbed via attractive force. The strength of the correlation is controlled by a tunable parameter $a$ that interpolates the classical car parking problem at $a=0$, the ballistic deposition at $a=1$ and the CBD model at $a>1$. The effects of the correlation in the CBD model are as follows. The jamming coverage $q(a)$ increases with the strength of attraction $a$ due to an ever increasing tendency of cluster formation. The system almost reaches the closest packing structure as $a\to\infty$ but never forms a percolating cluster which is typical to 1D system. In the large $a$ regime, the mean cluster size $k$ increases as $a^{1/2}$. Furthermore, the asymptotic approach towards the closest packing is purely algebraic both with $a$ as $q(\infty)-q(a) \sim a^{-1/2}$ and with $k$ as $q(\infty)-q(k) \sim k^{-1}$ where $q(\infty)\simeq 1$.Comment: 9 pages (in Revtex4), 9 eps figures; Submitted to publicatio

Evidence for Contemporary Switching of the O-Antigen Gene Cluster between Shiga Toxin-Producing Escherichia coli Strains Colonizing Cattle

Shiga toxin-producing Escherichia coli (STEC) comprise a group of zoonotic enteric pathogens with ruminants, especially cattle, as the main reservoir. O-antigens are instrumental for host colonization and bacterial niche adaptation. They are highly immunogenic and, therefore, targeted by the adaptive immune system. The O-antigen is one of the most diverse bacterial cell constituents and variation not only exists between different bacterial species, but also between individual isolates/strains within a single species. We recently identified STEC persistently infecting cattle and belonging to the different serotypes O156:H25 (n = 21) and O182:H25 (n = 15) that were of the MLST sequence types ST300 or ST688. These STs differ by a single nucleotide in purA only. Fitness-, virulence-associated genome regions, and CRISPR/CAS (clustered regularly interspaced short palindromic repeats/CRISPR associated sequence) arrays of these STEC O156:H25 and O182:H25 isolates were highly similar, and identical genomic integration sites for the stx converting bacteriophages and the core LEE, identical Shiga toxin converting bacteriophage genes for stx1a, identical complete LEE loci, and identical sets of chemotaxis and flagellar genes were identified. In contrast to this genomic similarity, the nucleotide sequences of the O-antigen gene cluster (O-AGC) regions between galF and gnd and very few flanking genes differed fundamentally and were specific for the respective serotype. Sporadic aEPEC O156:H8 isolates (n = 5) were isolated in temporal and spatial proximity. While the O-AGC and the corresponding 5′ and 3′ flanking regions of these aEPEC isolates were identical to the respective region in the STEC O156:H25 isolates, the core genome, the virulence associated genome regions and the CRISPR/CAS elements differed profoundly. Our cumulative epidemiological and molecular data suggests a recent switch of the O-AGC between isolates with O156:H8 strains having served as DNA donors. Such O-antigen switches can affect the evaluation of a strain's pathogenic and virulence potential, suggesting that NGS methods might lead to a more reliable risk assessment

Inner ear tissue preservation by rapid freezing: improving fixation by high-pressure freezing and hybrid methods

In the preservation of tissues in as ‘close to life’ state as possible, rapid freeze fixation has many benefits over conventional chemical fixation. One technique by which rapid freeze-fixation can be achieved, high pressure freezing (HPF), has been shown to enable ice crystal artefact-free freezing and tissue preservation to greater depths (more than 40μm) than other quick-freezing methods. Despite increasingly becoming routine in electron microscopy, the use of HPF for the fixation of inner ear tissue has been limited. Assessment of the quality of preservation showed routine HPF techniques were suitable for preparation of inner ear tissues in a variety of species. Good preservation throughout the depth of sensory epithelia was achievable. Comparison to chemically fixed tissue indicated that fresh frozen preparations exhibited overall superior structural preservation of cells. However, HPF fixation caused characteristic artefacts in stereocilia that suggested poor quality freezing of the actin bundles. The hybrid technique of pre-fixation and high pressure freezing was shown to produce cellular preservation throughout the tissue, similar to that seen in HPF alone. Pre-fixation HPF produced consistent high quality preservation of stereociliary actin bundles. Optimising the preparation of samples with minimal artefact formation allows analysis of the links between ultrastructure and function in inner ear tissues