Goldsworthy, M.R.

Hodyl, N.A.

Pitcher, J.B.

Ridding, M.C.

Semmler, J.G.

Vallence, A-M

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MEP AMPLITUDE (mV) SESSION SUBJECT Session 1 Session 2 Session 3 PLASTICITY  (%change from BL) Left: Raw MEP amplitudes probed at 150% RMT before (open) and after (filled) cTBS in each of the three sessions.  * and # denote statistical significance at P < .012 and P < .05 respectively.   Bottom: Subject response variability to cTBS probed 150% RMT in each of the three sessions. Data represent mean percentage change of post-cTBS MEP amplitudes from baseline, with positive and negative values indicating an increase and decrease in MEP amplitudes following cTBS respectively.  Reproducibility of neuroplastic responses induced by continuous theta-burst stimulation.   Ann-Maree Vallence 1 2 , Mitchell R Goldsworthy 1 , Nicolette A Hodyl 1, John G Semmler 3, Julia B Pitcher 1, Michael C Ridding 1  1 Robinson Research Institute, University of Adelaide 2 School of Psychology and Exercise Science, Murdoch University  3 Discipline of Physiology, School of Medical Sciences, University of Adelaide  Introduction: The therapeutic potential of non-invasive brain stimulation (NIBS) is dependent on the development of protocols that induce robust and functionally relevant cortical changes that outlast the period of stimulation. A current limiting factor of NIBS is intra- and inter-subject variability in NIBS-induced neuroplastic responses. At present, there are very little data on intra-subject reliability of continuous theta-burst stimulation (cTBS)-induced neuroplastic responses.   Methods: To investigate the reproducibility of neuroplastic responses induced by cTBS, motor evoked potential (MEP) input-output (IO) curves were obtained before and after cTBS in three separate experimental sessions.   Results: First, significant MEP suppression was observed following cTBS at the upper end of the IO curve (150-180% resting motor threshold; RMT). At 150% RMT, significant MEP suppression and strong relationships between neuroplastic responses were observed across experimental sessions.       Second, a significant linear relationship was evident between cTBS-induced MEP suppression (probed at an intensity that evoked MEPs ~50% of the maximal MEP) and the interval between experimental sessions.  Discussion: The current study provides the first comprehensive investigation of the between session reproducibility of cTBS-induced neuroplastic responses. Results suggest that 150% RMT is the most reliable TMS intensity to probe cTBS-induced neuroplastic responses and provide some evidence to suggest that short intervals between experimental sessions administering NIBS protocols is associated with increased NIBS-induced plasticity responses. 

Reproducibility of neuroplastic responses induced by continuous theta-burst stimulation

https://researchrepository.murdoch.edu.au/id/eprint/55326/1/neuroplastic.pdf

Reproducibility of neuroplastic responses induced by continuous theta-burst stimulation

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