Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Panel I: Creating Change: Advances in State and Local Election Law Approaches

PANEL I : CREATING CHANGE: ADVANCES IN STATE AND LOCAL ELECTION LAW APPROACHES Deborah Dinner, Associate Professor, Emory University School of Law; Faculty Advisor, Emory Law Journal (Moderator) Richard Briffault, Joseph P. Chamberlain Professor of Litigation, Columbia Law SchoolBryan L. Sells, Attorney, The Law Office of Bryan L. Sells, LLCAbby K. Wood, Associate Professor of Law, Political Science and Public Policy, USC Gould School of La

Panel I: Creating Change: Advances in State and Local Election Law Approaches

PANEL I : CREATING CHANGE: ADVANCES IN STATE AND LOCAL ELECTION LAW APPROACHES Deborah Dinner, Associate Professor, Emory University School of Law; Faculty Advisor, Emory Law Journal (Moderator) Richard Briffault, Joseph P. Chamberlain Professor of Litigation, Columbia Law SchoolBryan L. Sells, Attorney, The Law Office of Bryan L. Sells, LLCAbby K. Wood, Associate Professor of Law, Political Science and Public Policy, USC Gould School of La

Panel I: The Right to Vote

Panel on voting rights featuring Gilda R. Daniels (University of Baltimore School of Law), Atiba Ellis (Marquette University Law School), Anthony Michael Kreis (Georgia State University College of Law), and Bryan Sells (The Law Office of Bryan L. Sells, LLC)

Factors relating to the use of family therapy with adolescent marijuana abusers

This study reported on the results of the use of family therapy by marijuana-abusing adolescents. The investigators used a statewide each admission for state supported services. Data on 38,281 adolescent admissions were reported on their age at first use, age of admission, severity of use, ethnic and racial attributes, gender, place of residence, employment status, insurance coverage, and presence of comorbid conditions. The results showed that adolescents most likely to use family therapy were unemployed, white, less than 13 years of age, living in urban areas, experienced in marijuana use and have been judged to have a comorbid condition. Insurance coverage or gender did not influence the likelihood for adolescents to receive family therapy. The authors make recommendations on reducing the barriers to access to family therapy that were found by this study.info:eu-repo/semantics/publishedVersio