Low-cost resin infusion mould tooling for carbon fibre composites manufacture

This article describes the research to date carried out under the BAE Systems/Engineering and Physical Sciences Research Council (EPSRC)-funded programme ‘Flapless Aerial Vehicle Integrated Interdisciplinary Research’ (FLAVIIR), aimed at developing innovative technologies for the low-cost manufacture of next-generation Unmanned Aerial Vehicles. The aim of the researchers in FLAVIIR was to develop low-cost innovative tooling technologies to enable the affordable manufacture of complex composite aerospace structures. The advances in tooling technology were achieved through the application of rapid prototyping, tooling and manufacture technologies to provide rapidly configured and reconfigurable tool concepts, for low-cost resin infusion moulding. This article introduces three tooling innovations: reconfigurable tooling concept, variable cavity tooling, and porous cavity tooling

El Efecto del Priming Asociativo Verbal Mediante un Paradigma de Producción “Implícita” en el Acceso al Léxico

Varios trabajos han investigado las particularidades del  priming  semántico y del priming asociativo verbal durante la producción de una palabra. No obstante, el rol de las relaciones asociativas en el proceso de producción (principalmente en la denominación de imágenes) ha sido menos estudiado; y por lo tanto, la caracterización de su efecto y su localización no son totalmente claros.  El objetivo principal del presente trabajo experimental fue confirmar la presencia de un efecto de  priming  asociativo verbal utilizando una tarea de detección del fonema inicial del nombre  del objeto-target. La realización de esta tarea exige la recuperación de la forma fonológica del nombre del objeto sin dar lugar a su articulación efectiva, como sí ocurre en la tarea de denominación de imágenes. Para ello, se llevaron a cabo dos experimentos. El experimento 1 mostró un efecto de facilitación asociativa verbal en la condición de asociados (en comparación a una condición control) sin la puesta en juego de los procesos articulatorios. El segundo experimento tuvo como objetivo confirmar la naturaleza no estratégica del efecto de facilitación asociativa que se encontró en el experimento 1. Los datos obtenidos permiten confirmar que el acceso a la forma fonológica del nombre de un objeto puede ser facilitado por la presentación previa de una palabra inductora o “prime” asociativamente relacionada (caracterización del efecto). Y dadas las particularidades del paradigma utilizado, el efecto observado de facilitación ocurre a un nivel pre-articulatorio (a nivel de la forma fonológica) de procesamiento (localización del efecto)

Blood-biomarkers and devices for atrial fibrillation screening : Lessons learned from the AFRICAT (Atrial Fibrillation Research In CATalonia) study

AFRICAT is a prospective cohort study intending to develop an atrial fibrillation (AF) screening program through the combination of blood markers, rhythm detection devices, and long-term monitoring in our community. In particular, we aimed to validate the use of NT-proBNP, and identify new blood biomarkers associated with AF. Also, we aimed to compare AF detection using various wearables and long-term Holter monitoring. 359 subjects aged 65-75 years with hypertension and diabetes were included in two phases: Phase I (n = 100) and Phase II (n = 259). AF diagnosis was performed by baseline 12-lead ECG, 4 weeks of Holter monitoring (Nuubo TM), and/or medical history. An aptamer array including 1310 proteins was measured in the blood of 26 patients. Candidates were selected according to p-value, logFC and biological function to be tested in verification and validation phases. Several screening devices were tested and compared: AliveCor, Watch BP, MyDiagnostick and Fibricheck. AF was present in 34 subjects (9.47%). The aptamer array revealed 41 proteins with differential expression in AF individuals. TIMP-2 and ST-2 were the most promising candidates in the verification analysis, but none of them was further validated. NT-proBNP (log-transformed) (OR = 1.934; p<0.001) was the only independent biomarker to detect AF in the whole cohort. Compared to an ECG, WatchBP had the highest sensitivity (84.6%) and AUC (0.895 [0.780-1]), while MyDiagnostick showed the highest specificity (97.10%). The inclusion and monitoring of a cohort of primary care patients for AF detection, together with the testing of biomarkers and screening devices provided useful lessons about AF screening in our community. An AF screening strategy using rhythm detection devices and short monitoring periods among high-risk patients with high NT-proBNP levels could be feasible

The emergence of automaticity in reading: effects of orthographic depth and word decoding ability on an adjusted Stroop measure

Abstract Aims How long does it take for word reading to become automatic? Does the appearance and development of automaticity differ as a function of orthographic depth (e.g. French vs. English)? These questions were addressed in a longitudinal study of English and French beginning readers. The study focused on automaticity as obligatory processing as measured in the Stroop test. Method Measures of decoding ability and the Stroop effect were taken at three time points during the first grade (and 2nd grade in the UK) in 84 children. The study was the first to adjust the classic Stroop effect for inhibition (of distracting colors). Results The adjusted Stroop effect was zero in the absence of reading ability, and it was found to develop in tandem with decoding ability. After a further control for decoding, no effects of age or orthography were found on the adjusted Stroop measure. Conclusion The results are in line with theories of the development of whole word recognition that emphasize the importance of the acquisition of the basic orthographic code

Top table of the differential expressed proteins between AF and no AF

S1 Table: Top table of the differential expressed proteins between AF and no AF. Results from the discovery study.Results from the discovery study. Proteins selected to be verified in the whole Phase 1 are highlighted in grey. Proteins in bold but not highlighted were already tested in the whole phase 1 as part of a previous published work.Peer reviewe