Transcranial direct current stimulation (tDCS) in the treatment of depression: Systematic review and meta-analysis of efficacy and tolerability

BACKGROUND Transcranial direct current stimulation (tDCS) is a potential alternative treatment option for major depressive episodes (MDE). OBJECTIVES We address the efficacy and safety of tDCS in MDE. METHODS The outcome measures were Hedges' g for continuous depression ratings, and categorical response and remission rates. RESULTS A random effects model indicated that tDCS was superior to sham tDCS (k=11, N=393, g=0.30, 95% CI=[0.04, 0.57], p=0.027). Adjunctive antidepressant medication and cognitive control training negatively impacted on the treatment effect. The pooled log odds ratios (LOR) for response and remission were positive, but statistically non-significant (response: k=9, LOR=0.36, 95% CI[-0.16, 0.88], p=0.176, remission: k=9, LOR=0.25, 95% CI [-0.42, 0.91], p=0.468). We estimated that for a study to detect the pooled continuous effect (g=0.30) at 80% power (alpha=0.05), a total N of at least 346 would be required (with the total N required to detect the upper and lower bound being 49 and 12,693, respectively). CONCLUSIONS tDCS may be efficacious for treatment of MDE. The data do not support the use of tDCS in treatment-resistant depression, or as an add-on augmentation treatment. Larger studies over longer treatment periods are needed

Conceptual framework for scenarios development in the Water futures and Solutions project

The major purpose of the Water Futures & Solutions (WFaS) initiative is to develop a set of adaptable resilient and robust solutions and a framework to facilitate access to and guidance through them by decision makers facing a variety of water-related challenges to sustainable evelopment, and a set of optional pathways to achieve plausible sustainable development goals by 2050. The WFaS Initiative addresses the multidimensional aspects of the water system and is guided by stakeholders representing these various aspects. The Initiative views freshwater systems as being strongly interweaved with human activities (Economy, Society) and Nature as a whole. Dynamics and health of freshwater systems is critical to human well- being. The Initiative will go beyond scenario production and model comparisons and will focus on exploring solutions and necessary innovations to address the growing water challenges. Solutions can be combinations of technological innovations, regulatory approaches, manageent or institutional changes that improve the balance of water supply and demand, improve water quality, or reduce water-related risks for society. Solutions will often be embedded in and cut across all sectors of social and economic activities. In order to represent the aspirations and interdependencies as described above, the conceptual framework has been developed, to communicate project results to the target audiences. This document describes this conceptual framework that will be used: -to support development of qualitative water scenarios -to identify and select critical dimensions of the water scenarios -to guide integration of scenarios with quantitative models -to guide integration of information from various data sources into the scenarios -to support development and assessment of solutions -to support collaboration between project and stakeholder groups -to facilitate presentation of results to target audiences The WFaS conceptual framework is developed using the 'concept maps' technique (Caqas and Carff, 2005; Novak and Caqas, 2006b). Concept maps method was develop to represent knowledge in an organized way. It allows practitioners to represent concepts and specific relationships between concepts. It is flexible enough to adapt to different knowledge domains to support better understanding and communication between individuals and groups from different backgrounds

Towards Innovative Solutions through Integrative Futures Analysis - Preliminary qualitative scenarios

This report presents preliminary results of developing qualitative global water scenarios. The water scenarios are developed to be consistent with the underlying Shared Socio- Economic Pathways (SSPs). In this way different stakeholders in different contexts (climate, water) can be presented with consistent set of scenarios avoiding confusion and increasing policy impact. Water scenarios are based on the conceptual framework that has been developd specifically for this effort. The framework provides clear representation of important dimensions in the areas of Nature, Economy and Society and Water dimensions that are embedded in them. These critical dimensions are used to describe future changes in a consistent way for all scenarios. Three scenarios are presented based on SSP1, SSP2 and SSP3 respectively. Hydro-economic classes are introduced to further differentiate within scenarios based on economic and water conditions for specific regions and/or countries. In the process of building these preliminary water scenarios assumptions that are presented in this report, the number of challenges have been met. In the conclusions section these challenges are summarized and possible ways of tackling them are described

Deconstructing the lesbian, gay, bisexual, transgender victim of sex trafficking: Harm, exceptionality and religion–sexuality tensions

Contrary to widespread belief, sex trafficking also targets lesbian, gay, bisexual, transgender (LGBT) communities. Contemporary social and political constructions of victimhood lie at the heart of regulatory policies on sex trafficking. Led by the US Department of State, knowledge about LGBT victims of trafficking constitutes the newest frontier in the expansion of criminalization measures. These measures represent a crucial shift. From a burgeoning range of preemptive measures enacted to protect an amorphous class of ‘all potential victims’, now policies are heavily premised on the risk posed by traffickers to ‘victims of special interest’. These constructed identities, however, are at odds with established structures. Drawing on a range of literatures, the core task of this article is to confront some of the complexities and tensions surrounding constructions of LGBT trafficking victims. Specifically, the article argues that discourses of ‘exceptional vulnerability’ and the polarized notions of ‘innocence’ and ‘guilt’ inform hierarchies of victimhood. Based on these insights, the article argues for the need to move beyond monolithic understandings of victims, by reframing the politics of harm accordingly

The ‘spirit of sport’, WADAs code review, and the search for an overlapping consensus

In this paper, we argue for the recognition that anti-doping is in itself first and foremost an ethical position. The current World Anti-doping Code formulation of ‘the spirit of sport’ is an acknowledgement of this point and a counterweight against scientific and technicist understandings of the nature of anti-doping itself. We critically review the Code formulations on ‘the spirit of sport’. Based on a theoretical background of various approaches to normative agreement and consensus in a setting of diversity of ‘comprehensive views’, we argue for revision of the Code. Specifically, we argue for a re-formulation of ‘the spirit of sport’ in terms of athlete protection and the preservation of the integrity of sporting competition that could meet requirements on an overlapping consensus among all WADA stakeholders. This is not just a matter of formality and Code acceptance. An overlapping consensus is not a mere modus vivendi but a normative consensus based on fair, honest, and transparent discourse in which participants deliberate in a setting of mutual respect and trust, and of ‘decency’, which is a basis for a consensus that cultivates authentic stakeholder commitment

Working with female offenders in restorative justice frameworks: Effective and ethical practice

Despite a recent increase in restorative justice practice in the criminal justice system, to date there has been no in-depth consideration of the impact of gender in these settings. This paper presents findings from a unique qualitative study on female offenders’ experiences of restorative conferencing in England and Wales, drawing on interviews with practitioners who have worked with female cases, as well as with women who have gone through a restorative justice conference in a perpetrator capacity. Gender specific factors, suggested to be especially valuable for practitioners to consider when delivering effective and ethical restorative conferences with female offenders, are outlined

Genealogies of Slavery

This chapter addresses the concept of slavery, exploring its character and significance as a dark page in history, but also as a specifically criminological and zemiological problem, in the context of international law and human rights. By tracing the ambiguities of slavery in international law and international development, the harms associated with slavery are considered. Harms include both those statutorily proscribed, and those that are not, but that can still be regarded as socially destructive. Traditionally, antislavery has been considered within the parameters of abolition and criminalization. In this context recently, anti-trafficking has emerged as a key issue in contemporary anti-slavery work. While valuable, anti-trafficking is shown to have significant limitations. It advances criminalization and stigmatization of the most vulnerable and further perpetuates harm. At the same time, it identifies structural conditions like poverty, vulnerability, and “unfreedom” of movement only to put them aside. Linked to exploitation, violence and zemia, the chapter brings to the fore some crucial questions concerning the prospects of systemic theory in the investigation of slavery, that highlight the root causes of slavery, primarily poverty and inequality. Therefore, the chapter counterposes an alternative approach in which the orienting target is not abolition of slavery but advancing structural changes against social harm

Resting-State Quantitative Electroencephalography Reveals Increased Neurophysiologic Connectivity in Depression

Symptoms of Major Depressive Disorder (MDD) are hypothesized to arise from dysfunction in brain networks linking the limbic system and cortical regions. Alterations in brain functional cortical connectivity in resting-state networks have been detected with functional imaging techniques, but neurophysiologic connectivity measures have not been systematically examined. We used weighted network analysis to examine resting state functional connectivity as measured by quantitative electroencephalographic (qEEG) coherence in 121 unmedicated subjects with MDD and 37 healthy controls. Subjects with MDD had significantly higher overall coherence as compared to controls in the delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and beta (12–20 Hz) frequency bands. The frontopolar region contained the greatest number of “hub nodes” (surface recording locations) with high connectivity. MDD subjects expressed higher theta and alpha coherence primarily in longer distance connections between frontopolar and temporal or parietooccipital regions, and higher beta coherence primarily in connections within and between electrodes overlying the dorsolateral prefrontal cortical (DLPFC) or temporal regions. Nearest centroid analysis indicated that MDD subjects were best characterized by six alpha band connections primarily involving the prefrontal region. The present findings indicate a loss of selectivity in resting functional connectivity in MDD. The overall greater coherence observed in depressed subjects establishes a new context for the interpretation of previous studies showing differences in frontal alpha power and synchrony between subjects with MDD and normal controls. These results can inform the development of qEEG state and trait biomarkers for MDD

Sports Participation and Juvenile Delinquency: A Meta-Analytic Review

Participation in sports activities is very popular among adolescents, and is frequently encouraged among youth. Many psychosocial health benefits in youth are attributed to sports participation, but to what extent this positive influence holds for juvenile delinquency is still not clear on both the theoretical and empirical level. There is much controversy on whether sports participation should be perceived as a protective or a risk factor for the development of juvenile delinquency. A multilevel meta-analysis of 51 published and unpublished studies, with 48 independent samples containing 431 effect sizes and N = 132,366 adolescents, was conducted to examine the relationship between sports participation and juvenile delinquency and possible moderating factors of this association. The results showed that there is no overall significant association between sports participation and juvenile delinquency, indicating that adolescent athletes are neither more nor less delinquent than non-athletes. Some study, sample and sports characteristics significantly moderated the relationship between sports participation and juvenile delinquency. However, this moderating influence was modest. Implications for theory and practice concerning the use of sports to prevent juvenile delinquency are discussed. Keywords Sports participation Juvenile delinquency Multilevel meta-analysis Revie