Visibility diagrams and experimental stripe structure in the quantum Hall effect

We analyze various properties of the visibility diagrams that can be used in the context of modular symmetries and confront them to some recent experimental developments in the Quantum Hall Effect. We show that a suitable physical interpretation of the visibility diagrams which permits one to describe successfully the observed architecture of the Quantum Hall states gives rise naturally to a stripe structure reproducing some of the experimental features that have been observed in the study of the quantum fluctuations of the Hall conductance. Furthermore, we exhibit new properties of the visibility diagrams stemming from the structure of subgroups of the full modular group.Comment: 8 pages in plain TeX, 7 figures in a single postscript fil

Stress transmission in granular matter

The transmission of forces through a disordered granular system is studied by means of a geometrical-topological approach that reduces the granular packing into a set of layers. This layered structure constitutes the skeleton through which the force chains set up. Given the granular packing, and the region where the force is applied, such a skeleton is uniquely defined. Within this framework, we write an equation for the transmission of the vertical forces that can be solved recursively layer by layer. We find that a special class of analytical solutions for this equation are L\'evi-stable distributions. We discuss the link between criticality and fragility and we show how the disordered packing naturally induces the formation of force-chains and arches. We point out that critical regimes, with power law distributions, are associated with the roughness of the topological layers. Whereas, fragility is associated with local changes in the force network induced by local granular rearrangements or by changes in the applied force. The results are compared with recent experimental observations in particulate matter and with computer simulations.Comment: 14 pages, Latex, 5 EPS figure

Modular Groups, Visibility Diagram and Quantum Hall Effect

We consider the action of the modular group $\Gamma (2)$ on the set of positive rational fractions. From this, we derive a model for a classification of fractional (as well as integer) Hall states which can be visualized on two ``visibility" diagrams, the first one being associated with even denominator fractions whereas the second one is linked to odd denominator fractions. We use this model to predict, among some interesting physical quantities, the relative ratios of the width of the different transversal resistivity plateaus. A numerical simulation of the tranversal resistivity plot based on this last prediction fits well with the present experimental data.Comment: 17 pages, plain TeX, 4 eps figures included (macro epsf.tex), 1 figure available from reques

A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors

Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and similarly for B7.1 (CD80), through binding to CTLA-4. Moreover, direct interactions between B7-H1 and B7.1 molecules are also likely to participate in the immunoevasion mechanism. In this study, we used a mouse model of tumor dormancy, DA1-3b leukemia cells. We previously showed that a minor population of DA1-3b cells persists in equilibrium with the immune system for long periods of time, and that the levels of surface expression of B7-H1 and B7.1 molecules correlates with the dormancy time. We found that leukemia cells DA1-3b/d365 cells, which derived from long-term dormant tumors and overexpressed B7-H1 and B7.1 molecules, were highly permissive to Ad5FB4, a human adenovirus serotype 5 (Ad5) vector pseudotyped with chimeric human-bovine fibers. Both B7-H1 and B7.1 were required for Ad5FB4-cell binding and entry, since (i) siRNA silencing of one or the other B7 gene transcript resulted in a net decrease in the cell binding and Ad5FB4-mediated transduction of DA1-3b/d365; and (ii) plasmid-directed expression of B7.1 and B7-H1 proteins conferred to Ad5FB4-refractory human cells a full permissiveness to this vector. Binding data and flow cytometry analysis suggested that B7.1 and B7-H1 molecules played different roles in Ad5FB4-mediated transduction of DA1-3b/d365, with B7.1 involved in cell attachment of Ad5FB4, and B7-H1 in Ad5FB4 internalization. BRET analysis showed that B7.1 and B7-H1 formed heterodimeric complexes at the cell surface, and that Ad5FB4 penton, the viral capsomere carrying the fiber projection, could negatively interfere with the formation of B7.1/B7-H1 heterodimers, or modify their conformation. As interactors of B7-H1/B7.1 molecules, Ad5FB4 particles and/or their penton capsomeres represent potential therapeutic agents targeting cancer cells that had developed immunoevasion mechanisms

Correction par bloc des transitoires de la caméra infrarouge ISOPIIOT C-100 avec un modèle non linéaire dissymétrique

Les photo-détecteurs utilisés en astronomie infrarouge à très bas niveau de flux présentent généralement une rémanence lors d'un changement d'illumination. Ce phénomène transitoire est non linéaire et dissymétrique selon que le flux entrant croît ou décroît. Pour le détecteur ISOPHOT C-100 embarqué sur le satellite ISO, nous avons montré qu'un modèle semi-empirique permet de décrire avec une bonne précision (de l'ordre de quelques pour-cent) ces transitoires. Une méthode d'inversion permet de corriger ces transitoires. Les limitations de l'approche sont détaillées