THE EFFECTS OF TEMPERATURE DEPENDENT VISCOSITY AND VISCOUS DISSIPATION ON MHD CONVECTION FLOW FROM AN ISOTHERMAL HORIZONTAL CIRCULAR CYLINDER IN THE PRESENCE OF STRESS WORK AND HEAT GENERATION

Temperature dependent viscosity and Viscous Dissipation effects are considered on hydromagnetic natural convection flow from horizontal circular cylinder immersed in an electrically conducting fluid with viscosity proportional to a linear function of temperature in the presence of stress work and heat generation. The partial differential governing equations are transformed to dimensionless forms. The numerical computations are carried out for several values of physical parameters involved in the transformed equations. The resulting nonlinear system of partial differential equations is solved numerically by Keller box method which is an implicit finite difference technique with Newton's linearization method. The features of the flow and heat transfer characteristics for different values of the governing parameters are analyzed and discussed. To support the accuracy of the numerical results, a comparison is made with known results from the open literature for some particular cases of the present study and the results are found to be in good agreement

KYSTE DERMOÏDE DU CONE MEDULLAIRE

Les auteurs rapportent une observation de kyste dermoïde du cône médullaire sans lésion dysraphique associée chez un jeune patient de 19 ans, révélé par l’installation insidieuse depuis environ 06 ans de lombo-sciatalgies gauches tronquées au niveau du genou puis devenu bilatérales 02 mois avant son hospitalisation et associées à des troubles génito-sphinctériennes. L’I.R.M lombaire a montré un processus occupant le canal lombaire s’étendant de L1 à L3 responsable d’un effacement des espaces périmédullaires et un scalloping vertébral en regard. Le patient a été opéré par voie postérieure et a bénéficié d’une exérèse totale de sa tumeur. L’examen anatomopathologique a confirmé le diagnostic. Les suites opératoires ont été favorables

Some discussions of D. Fearnhead and D. Prangle's Read Paper "Constructing summary statistics for approximate Bayesian computation: semi-automatic approximate Bayesian computation"

This report is a collection of comments on the Read Paper of Fearnhead and Prangle (2011), to appear in the Journal of the Royal Statistical Society Series B, along with a reply from the authors

TRACE ELEMENT BIOACCUMULATION IN THE EDIBLE MILK SNAIL (OTALA LACTEA) AND CABRILLA (OTALA PUNCTATA) IN MARRAKECH, MOROCCO

editorial reviewedMorocco is the first land snail exporter in the world and the majority of snail production consists of individuals collected from nature. These gastropods are known to accumulate high levels of trace metals in their tissues hence the main objective of this study. We aimed firstly to investigate the bioaccumulation efficiency of Pb, Cd, Zn, Cu and Ca in Otala spp. snails, the most commonly widespread and the most consumed species in the Marrakech region, and then evaluate the potential risk on human health. Soil, foot, viscera and shell of adult snails were picked from six sampling stations in Al Haouz plain and analysed by ICP-MS. Results showed that the investigated snails accumulated all the examined elements with significant variations among the different tissues. The Principal Component and Bioaccumulation Factor analyses demonstrated that Otala spp. are macroconcentrators for Cd and microconcentrators for Pb. Furthermore, their shell accumulated more Ca, foot accumulated more Cu and viscera accumulated more Zn, Cd and Pb. In addition, the detected concentrations of toxic metals (Pb and Cd) were higher than the maximum admissible limits according to the European regulation except for Pb in the reference station. In conclusion, Otala spp. snails in our region can be used as bioindicators of trace element bioavailability and their consumption must be limited to avoid any possible intoxications

A comparison of functional outcome between amputation and extension prosthesis in the treatment of congenital absence of the fibula with severe limb deformity

Purpose: Complete fibula absence often presents with significant lower-limb deformity. Parental counselling regarding management is paramount in achieving the optimum functional outcome. Amputation offers a single surgical event with minimal complications. This study compares outcomes with an amputation protocol to those using an extension prosthesis. // Method: Thirty-two patients were identified. Nine patients (2 males, 7 females; median age at assessment of 23.5 years) used an extension prosthesis. Twenty-three patients (16 males, 7 females; median age at assessment of eight years) underwent 25 amputations during childhood. Mobility was assessed using SIGAM and K scores. Quality of life was assessed using the PedsQL inventory questionnaire; pain by a verbal severity score. // Results: The 19 Syme and one Boyd amputation in 19 patients were performed early (mean age 15 months). Four Syme and one trans-tibial amputation in four patients took place in older children (mean age 6.6 years). Only two underwent tibial kyphus correction to aid prosthetic fitting. K scores were significantly higher (mean 4 vs 2) and pain scores lower in the amputation group allowing high impact activity compared with community ambulation with an extension prosthesis. The SIGAM and PedsQL scores were all better in the amputation group, but not significantly so. // Conclusion: Childhood amputation for severe limb length inequality and foot deformity in congenital fibula absence offers excellent short-term functional outcome with prosthetic support. The tibial kyphus does not need routine correction and facilitates prosthetic suspension. Accommodative extension prostheses offer reasonable long-term function but outcome scores are lower

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this clinical scenario has been studied using a rat model of stress-induced reinstatement of drug seeking. Here, we first discuss the generality of stress-induced reinstatement to different drugs of abuse, different stressors, and different behavioral procedures. We also discuss neuropharmacological mechanisms, and brain areas and circuits controlling stress-induced reinstatement of drug seeking. We conclude by discussing results from translational human laboratory studies and clinical trials that were inspired by results from rat studies on stress-induced reinstatement. Our main conclusions are (1) The phenomenon of stress-induced reinstatement, first shown with an intermittent footshock stressor in rats trained to self-administer heroin, generalizes to other abused drugs, including cocaine, methamphetamine, nicotine, and alcohol, and is also observed in the conditioned place preference model in rats and mice. This phenomenon, however, is stressor specific and not all stressors induce reinstatement of drug seeking. (2) Neuropharmacological studies indicate the involvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphin, and several other peptide and neurotransmitter systems in stress-induced reinstatement. Neuropharmacology and circuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of stria terminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in other components of the mesocorticolimbic dopamine system (ventral tegmental area, medial prefrontal cortex, orbitofrontal cortex, and nucleus accumbens). (3) Translational human laboratory studies and a recent clinical trial study show the efficacy of alpha-2 adrenoceptor agonists in decreasing stress-induced drug craving and stress-induced initial heroin lapse

Can dissonance engineering improve risk analysis of human–machine systems?

The paper discusses dissonance engineering and its application to risk analysis of human–machine systems. Dissonance engineering relates to sciences and technologies relevant to dissonances, defined as conflicts between knowledge. The richness of the concept of dissonance is illustrated by a taxonomy that covers a variety of cognitive and organisational dissonances based on different conflict modes and baselines of their analysis. Knowledge control is discussed and related to strategies for accepting or rejecting dissonances. This acceptability process can be justified by a risk analysis of dissonances which takes into account their positive and negative impacts and several assessment criteria. A risk analysis method is presented and discussed along with practical examples of application. The paper then provides key points to motivate the development of risk analysis methods dedicated to dissonances in order to identify the balance between the positive and negative impacts and to improve the design and use of future human–machine system by reinforcing knowledge

Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation

Background & Aims: Autoimmune hepatitis can recur after liver transplantation (LT), though the impact of recurrence on patient and graft survival has not been well characterized. We evaluated a large, international, multicenter cohort to identify the probability and risk factors associated with recurrent AIH and the association between recurrent disease and patient and graft survival.Methods: We included 736 patients (77% female, mean age 42 +/- 1 years) with AIH who underwent LT from January 1987 through June 2020, among 33 centers in North America, South America, Europe and Asia. Clinical data before and after LT, biochemical data within the first 12 months after LT, and immunosuppression after LT were analyzed to identify patients at higher risk of AIH recurrence based on histological diagnosis.Results: AIH recurred in 20% of patients after 5 years and 31% after 10 years. Age at LT <= 42 years (hazard ratio [HR] 3.15; 95% CI 1.22-8.16; p = 0.02), use of mycophenolate mofetil post-LT (HR 3.06; 95% CI 1.39-6.73; p = 0.005), donor and recipient sex mismatch (HR 2.57; 95% CI 1.39-4.76; p = 0.003) and high IgG pre-LT (HR 1.04; 95% CI 1.01-1.06; p = 0.004) were associated with higher risk of AIH recurrence after adjusting for other confounders. In multivariate Cox regression, recurrent AIH (as a time-dependent covariate) was significantly associated with graft loss (HR 10.79, 95% CI 5.37-21.66, p <0.001) and death (HR 2.53, 95% CI 1.48-4.33, p = 0.001).Conclusion: Recurrence of AIH following transplant is frequent and is associated with younger age at LT, use of mycophenolate mofetil post-LT, sex mismatch and high IgG pre-LT. We demonstrate an association between disease recurrence and impaired graft and overall survival in patients with AIH, highlighting the importance of ongoing efforts to better characterize, prevent and treat recurrent AIH.Lay summary: Recurrent autoimmune hepatitis following liver transplant is frequent and is associated with some recipient features and the type of immunosuppressive medications use. Recurrent autoimmune hepatitis negatively affects outcomes after liver transplantation. Thus, improved measures are required to prevent and treat this condition. (C) 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Hybrid Particle Swarm and Neural Network Approach for Streamflow Forecasting

In this paper, an artificial neural network (ANN) based on hybrid algorithm combining particle swarm optimization (PSO) with back-propagation (BP) is proposed to forecast the daily streamflows in a catchment located in a semi-arid region in Morocco. The PSO algorithm has a rapid convergence during the initial stages of a global search, while the BP algorithm can achieve faster convergent speed around the global optimum. By combining the PSO with the BP, the hybrid algorithm referred to as BP-PSO algorithm is presented in this paper. To evaluate the performance of the hybrid algorithm, BP neural network is also involved for a comparison purposes. The results show that the neural network model evolved by PSO-BP algorithm has a good predictions and better convergence performance