‘When there are so many we shall have to mourn’: Poetry and Memory in the Second World War

In this thesis, I consider the representation of memory and mourning in the work of a number of poets, written during, or in the years immediately before and after, the Second World War. I consider the notion of memory in relation to the First World War and the early part of the twentieth century, observing the ways poets use existing literary models of mourning, remembrance and commemoration to write about the Second World War. My introduction presents the theoretical and conceptual foundations of the thesis. In Chapter 2, I examine the influence and impact of the work of Freud on Auden and H.D., arguing that mourning Freud’s death in their work is a way to write about the war. Likewise, Chapter 3 looks at the impact of an influential individual, examining the ‘Rilke craze’ of the late thirties and early forties in relation to the war poetry of Auden, Keith Douglas, Hamish Henderson, Sidney Keyes and Alun Lewis, showing how Rilke’s work opened up new possibilities for writing about death. Chapter 4 is dedicated to a study of Hamish Henderson’s long poem Elegies for the Dead in Cyrenaica and the multitude of voices and fragments which it draws upon. The final chapter considers ekphrastic poetry about war memorials, looking at works by Auden, Henderson, Douglas, Jarmain, Sassoon, and Lewis. I argue throughout that poets seek a precedent for the trauma and upheaval of the Second World War by turning or returning to the literature of other conflicts and ruptures in a multidirectional and palimpsestic attempt to make sense of the present and to represent it in poetry. The conclusion follows this idea into the post-war years and up to the present moment, by showing how the work of Keith Douglas has become a touchstone for more recent writers of conflict

All Curled Up: A Numerical Investigation of Shock-Bubble Interactions and the Role of Vortices in Heating Galaxy Clusters

Jets from active galactic nuclei in the centers of galaxy clusters inflate cavities of low density relativistic plasma and drive shock and sound waves into the intracluster medium. When these waves overrun previously inflated cavities, they form a differentially rotating vortex through the Richtmyer-Meshkov instability. The dissipation of energy captured in the vortex can contribute to the feedback of energy into the atmospheres of cool core clusters. Using a series of hydrodynamic simulations we investigate the efficiency of this process: we calculate the kinetic energy in the vortex by decomposing the velocity field into its irrotational and solenoidal parts. Compared to the two-dimensional case, the 3-dimensional Richtmyer-Meshkov instability is about a factor of 2 more efficient. The energy in the vortex field for weak shocks is E_vortex ~ rho_ICM v_shock^2 V_bubble (with dependence on the geometry, density contrast, and shock width). For strong shocks, the vortex becomes dynamically unstable, quickly dissipating its energy via a turbulent cascade. We derive a number of diagnostics for observations and laboratory experiments of shock-bubble interactions, like the shock-vortex standoff distance, which can be used to derive lower limits on the Mach number. The differential rotation of the vortex field leads to viscous dissipation, which is sufficiently efficient to react to cluster cooling and to dissipate the vortex energy within the cooling radius of the cluster for a reasonable range of vortex parameters. For sufficiently large filling factors (of order a few percent or larger), this process could thus contribute significantly to AGN feedback in galaxy clusters.Comment: 16 pages, 24 figure

On the shape of barchan dunes

Barchans are crescent-shaped sand dunes forming in aride regions with unidirectional wind and limited sand supply. We report analytical and numerical results for dune shapes under different environmental conditions as obtained from the so-called `minimal model' of aeolian sand dunes. The profiles of longitudinal vertical slices (i.e. along the wind direction) are analyzed as a function of wind speed and sand supply. Shape transitions can be induced by changes of mass, wind speed and sand supply. Within a minimal extension of the model to the transverse direction the scale-invariant profile of transverse vertical cuts can be derived analytically.Comment: to appear in J. Phys.: Condens. Matter 17 (2005

Reduction of guide needle streak artifact in CT-guided biopsy

Purpose: Computed tomography (CT)–guided core needle biopsy (CNB) can be affected by streak artifact obscuring the needle tip. This study investigates factors that influence the occurrence and severity of streak artifact during CNB. Materials and Methods: Eight coaxial guide needles of two sizes from two manufacturers with and without stylets were imaged in a CT phantom, with CT reconstructed with adaptive statistical iterative reconstruction and filtered back projection. CNB-related streak artifact was quantified with profile analysis in an image-processing program. Differences between maximum attenuation at the needle tip and minimum attenuation in the streak artifact were compared for each variable. Diagnostic acceptability and streak artifact were subjectively assessed on each phantom image and on 40 clinical CNB procedures by three independent blinded reviewers following training case review. Results: Artifact was significantly less with the central stylet removed versus in situ (median, 1,145 HU vs 3,390 HU; P < .001) for all needles, and less for 19-gauge needles versus 17-gauge needles (median, 1,334 HU vs 2,780 HU, respectively; P = .006). There were no differences based on manufacturer (P = .906) or reconstruction algorithm (P = .524). Independent reviews found that streak artifact was significantly reduced when the central stylet was removed (κ = 0.875–1.0; P < .001), and needle tip position was better in cases in which the stylet was removed (κ = 0.231–0.711; P < .001). Conclusions: Streak artifact can be reduced and needle tip visualization improved by confirming final biopsy needle position with the central stylet removed on CT and using smaller-gauge guide needles

Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study.

RESONATE-2 is a phase 3 study of first-line ibrutinib versus chlorambucil in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Patients aged ≥65 years (n = 269) were randomized 1:1 to once-daily ibrutinib 420 mg continuously or chlorambucil 0.5-0.8 mg/kg for ≤12 cycles. With a median (range) follow-up of 60 months (0.1-66), progression-free survival (PFS) and overall survival (OS) benefits for ibrutinib versus chlorambucil were sustained (PFS estimates at 5 years: 70% vs 12%; HR [95% CI]: 0.146 [0.098-0.218]; OS estimates at 5 years: 83% vs 68%; HR [95% CI]: 0.450 [0.266-0.761]). Ibrutinib benefit was also consistent in patients with high prognostic risk (TP53 mutation, 11q deletion, and/or unmutated IGHV) (PFS: HR [95% CI]: 0.083 [0.047-0.145]; OS: HR [95% CI]: 0.366 [0.181-0.736]). Investigator-assessed overall response rate was 92% with ibrutinib (complete response, 30%; 11% at primary analysis). Common grade ≥3 adverse events (AEs) included neutropenia (13%), pneumonia (12%), hypertension (8%), anemia (7%), and hyponatremia (6%); occurrence of most events as well as discontinuations due to AEs decreased over time. Fifty-eight percent of patients continue to receive ibrutinib. Single-agent ibrutinib demonstrated sustained PFS and OS benefit versus chlorambucil and increased depth of response over time

Trust, guilds and kinship in London, 1330-1680

How was trust created and reinforced between the inhabitants of medieval and early modern cities? And how did the social foundations of trusting relationships change over time? Current research highlights the role of kinship, neighbourhood and associations, particularly guilds, in creating ‘relationships of trust’ and social capital in the face of high levels of migration, mortality and economic volatility, but tells us little about their relative importance or how they developed. We uncover a profound shift in the contribution of family and guilds to trust networks among the middling and elite of one of Europe’s major cities, London, over three centuries, from the 1330s to the 1680s. We examine the networks of sureties created to secure the inheritances of children whose fathers died while they were minors, surviving in the records of London’s Orphans Court. Our analysis of almost fifteen thousand networks evaluates the presence of trusting relationships connected with guild membership, family and place over several centuries. We show a profound increase in the role of kinship – a re-embedding of trust within the family - and a decline of the importance of shared guild membership in connecting Londoner’s who secured orphans’ inheritances together. We suggest these developments are best explained as a result of the impact of the Reformation on the form and intensity of sociability fostered by guilds and the enormous growth of the metropolis

CT densitometry as a predictor of pulmonary function in lung cancer patients.

Purpose: Preoperative pulmonary assessment is undertaken in patients with resectable lung cancer to identify those at increased risk of perioperative complications. Guidelines from the American College of Chest Physicians indicate that if the FEV1 and DLCO are ≥60% of predicted, patients are suitable for resection without further evaluation. The aim of our study is to determine if quantitative measures of lung volume and density obtained from pre-operative CT scans correlate with pulmonary function tests. This may allow us to predict pulmonary function in patients with lung cancer and identify patients who would tolerate surgical resection. Materials and Methods: Patients were identified retrospectively from the lung cancer database of a tertiary hospital. Image segmentation software was utilized to estimate total lung volume, normal lung volume (values -500 HU to -910 HU), emphysematous volume (values less than -910 HU), and mean lung density from pre-operative CT studies for each patient and these values were compared to contemporaneous pulmonary function tests. Results: A total of 77 patients were enrolled. FEV1 was found to correlate significantly with the mean lung density (r=.762, p<.001) and the volume of emphysema (r= -.678, p<.001). DLCO correlated significantly with the mean lung density (r =.648, p<.001) and the volume of emphysematous lung (r= -.535, p<.001). Conclusion: The results of this study suggest that both FEV1 and DLCO correlate significantly with volume of emphysema and mean lung density. We now plan to prospectively compare these CT parameters with measures of good and poor outcome postoperatively to identify CT measures that may predict surgical outcome preoperatively

Trust, guilds and kinship in London, 1330-1680

How was trust created and reinforced between the inhabitants of medieval and early modern cities? And how did the social foundations of trusting relationships change over time? Current research highlights the role of kinship, neighbourhood and associations, particularly guilds, in creating ‘relationships of trust’ and social capital in the face of high levels of migration, mortality and economic volatility, but tells us little about their relative importance or how they developed. We uncover a profound shift in the contribution of family and guilds to trust networks among the middling and elite of one of Europe’s major cities, London, over three centuries, from the 1330s to the 1680s. We examine almost 15,000 networks of sureties created to secure orphans’ inheritances to measure the presence of trusting relationships connected by guild membership, family and place. We uncover a profound increase in the role of kinship – a re-embedding of trust within the family - and a decline of the importance of shared guild membership in connecting Londoner’s who secured orphans’ inheritances together. These developments indicate a profound transformation in the social fabric of urban society