Digital Security & Grantcraft Guide : an Introduction Guide for Funders

Digital security breaches can cause harm to grantees, as well as their clients, beneficiaries, and partner organizations. These threats also pose a risk to grantmakers and to the larger strategies of impacted organizations. Security leaks can compromise an organization's ability to carry out its work, and can erode trust between civil society actors.This guide is to help grant­makers both assess and address digital security concerns. It explores the types of digital threats against civil society and the obstacles to addressing them. It explains how to conduct a digital security "triage" of grants to elevate the digital security of your whole grant portfolio; while playing special attention to the highest risk grantees. And it provides suggestions for pathways to think more systematically about digital security

Trpc2 pseudogenization dynamics in bats reveal ancestral vomeronasal signaling, then pervasive loss

This work was supported by the National Science Foundation Graduate Research Fellowship and NSF-DEB 144214

The Impact on New Mexico’s Budget of Allowing Same-Sex Couples to Marry

This analysis by UCLA’s Williams Institute on Sexual Orientation Law and Public Policy, estimates the impact of allowing same-sex couples to marry on New Mexico’s state budget. Using the best data available, allowing same-sex couples to marry will result in a net gain of approximately $1.5 million to$2 million each year for the State. This net impact will be the result of savings in expenditures on state means-tested public benefit programs and an increase in sales and lodging tax revenue from weddings and wedding-related tourism

A Content Analysis of Catholic School Written Discipline Policies

School discipline has traditionally endorsed the use of exclusionary practices (i.e. suspension and expulsion). Such practices can have a negative short- and long-term impact on student lives, and tend to be enforced disproportionately with certain student populations. Although public school discipline policies have received increased scrutiny in recent years, Catholic school policies have received very little attention. This study presents the results of a content analysis of the written discipline policies of 33 Catholic secondary schools from two dioceses within a major metropolitan area. Results suggest that although variability exists in the types of behaviors included in formal written policies, schools in this sample rely heavily on exclusionary practices as possible consequences to many behaviors, even relatively minor ones. Further, they include positive or restorative consequences minimally, if at all. Suggestions for future research related to discipline practices in Catholic schools are made

Real-World Evaluation of Universal Germline Screening for Cancer Treatment-Relevant Pharmacogenes

The purpose of this study was to determine the frequency of clinically actionable treatment-relevant germline pharmacogenomic variants in patients with cancer and assess the real-world clinical utility of universal screening using whole-exome sequencing in this population. Cancer patients underwent research-grade germline whole-exome sequencing as a component of sequencing for somatic variants. Analysis in a clinical bioinformatics pipeline identified clinically actionable pharmacogenomic variants. Clinical Pharmacogenetics Implementation Consortium guidelines defined clinical actionability. We assessed clinical utility by reviewing electronic health records to determine the frequency of patients receiving pharmacogenomically actionable anti-cancer agents and associated outcomes. This observational study evaluated 291 patients with cancer. More than 90% carried any clinically relevant pharmacogenetic variant. At least one disease-relevant variant impacting anti-cancer agents was identified in 26.5% (77/291). Nine patients with toxicity-associated pharmacogenomic variants were treated with a relevant medication: seven UGT1A1 intermediate metabolizers were treated with irinotecan, one intermediate DPYD metabolizer was treated with 5-fluorouracil, and one TPMT poor metabolizer was treated with mercaptopurine. These individuals were more likely to experience treatment-associated toxicities than their wild-type counterparts (p = 0.0567). One UGT1A1 heterozygote died after a single dose of irinotecan due to irinotecan-related adverse effects. Identifying germline pharmacogenomic variants was feasible using whole-exome sequencing. Actionable pharmacogenetic variants are common and relevant to patients undergoing cancer treatment. Universal pharmacogenomic screening can be performed using whole-exome sequencing data originally obtained for quality control purposes and could be considered for patients who are candidates for irinotecan, 5-fluorouracil, capecitabine, and mercaptopurine

The Ursinus Weekly, October 17, 1968

Fraternities hopeful as Homecoming approaches; Reigning Queen to be selected in regal runoff • Student teachers gain experience • Frosh elect officers; President sets goals • Curtain Club changes name to ProTheatre • Ryan Brothers highlights UC folk concert • Editorial: A matter of concern • On love and hate • Coke culture to stay Glenesk tells Forum • Letters • Dr. Byerly raps Greeks; Calls rushing degrading • Freshmen induction: Questionable success • Intruders in concert • Exchange column • Another view: Ursinus change • Opinion: Political commentary • Expansion necessitates dormitory renovations • SFARC minutes • Ursinus students to participate in TV program • U.C. students speak at pre-med meeting • Parents feted at gala event • Bear Gridders fall to Johns Hopkins and Lebanon Valley; Streaking Harriers extend undefeated string to fifteen • Grau predicts comeback for soccer squad • A little bit about everything or not much about anything • UC hockey team edges Penn, 2-1 as Cash scores decisive goal • Ursinus must stop Muhlenberg offense • Sig Rho and Apes are on top in I.T. fraternity division; Flowers down Day Study, 13-6 • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1164/thumbnail.jp

Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

SummaryMany human cancers are dramatically accelerated by chronic inflammation. However, the specific cellular and molecular elements mediating this effect remain largely unknown. Using a murine model of pancreatic intraepithelial neoplasia (PanIN), we found that KrasG12D induces expression of functional IL-17 receptors on PanIN epithelial cells and also stimulates infiltration of the pancreatic stroma by IL-17-producing immune cells. Both effects are augmented by associated chronic pancreatitis, resulting in functional in vivo changes in PanIN epithelial gene expression. Forced IL-17 overexpression dramatically accelerates PanIN initiation and progression, while inhibition of IL-17 signaling using genetic or pharmacologic techniques effectively prevents PanIN formation. Together, these studies suggest that a hematopoietic-to-epithelial IL-17 signaling axis is a potent and requisite driver of PanIN formation

A scoping review of trauma informed approaches in acute, crisis, emergency, and residential mental health care

Experiences of trauma in childhood and adulthood are highly prevalent among service users accessing acute, crisis, emergency, and residential mental health services. These settings, and restraint and seclusion practices used, can be extremely traumatic, leading to a growing awareness for the need for trauma informed care (TIC). The aim of TIC is to acknowledge the prevalence and impact of trauma and create a safe environment to prevent re-traumatisation. This scoping review maps the TIC approaches delivered in these settings and reports related service user and staff experiences and attitudes, staff wellbeing, and service use outcomes.We searched seven databases (EMBASE; PsycINFO; MEDLINE; Web of Science; Social Policy and Practice; Maternity and Infant Care Database; Cochrane Library Trials Register) between 24/02/2022-10/03/2022, used backwards and forwards citation tracking, and consulted academic and lived experience experts, identifying 4244 potentially relevant studies. Thirty-one studies were included.Most studies (n = 23) were conducted in the USA and were based in acute mental health services (n = 16). We identified few trials, limiting inferences that can be drawn from the findings. The Six Core Strategies (n = 7) and the Sanctuary Model (n = 6) were the most commonly reported approaches. Rates of restraint and seclusion reportedly decreased. Some service users reported feeling trusted and cared for, while staff reported feeling empathy for service users and having a greater understanding of trauma. Staff reported needing training to deliver TIC effectively.TIC principles should be at the core of all mental health service delivery. Implementing TIC approaches may integrate best practice into mental health care, although significant time and financial resources are required to implement organisational change at scale. Most evidence is preliminary in nature, and confined to acute and residential services, with little evidence on community crisis or emergency services. Clinical and research developments should prioritise lived experience expertise in addressing these gaps