70 research outputs found
Towards a formal description of the collapse approach to the inflationary origin of the seeds of cosmic structure
Inflation plays a central role in our current understanding of the universe.
According to the standard viewpoint, the homogeneous and isotropic mode of the
inflaton field drove an early phase of nearly exponential expansion of the
universe, while the quantum fluctuations (uncertainties) of the other modes
gave rise to the seeds of cosmic structure. However, if we accept that the
accelerated expansion led the universe into an essentially homogeneous and
isotropic space-time, with the state of all the matter fields in their vacuum
(except for the zero mode of the inflaton field), we can not escape the
conclusion that the state of the universe as a whole would remain always
homogeneous and isotropic. It was recently proposed in [A. Perez, H. Sahlmann
and D. Sudarsky, "On the quantum origin of the seeds of cosmic structure,"
Class. Quant. Grav. 23, 2317-2354 (2006)] that a collapse (representing physics
beyond the established paradigm, and presumably associated with a
quantum-gravity effect a la Penrose) of the state function of the inflaton
field might be the missing element, and thus would be responsible for the
emergence of the primordial inhomogeneities. Here we will discuss a formalism
that relies strongly on quantum field theory on curved space-times, and within
which we can implement a detailed description of such a process. The picture
that emerges clarifies many aspects of the problem, and is conceptually quite
transparent. Nonetheless, we will find that the results lead us to argue that
the resulting picture is not fully compatible with a purely geometric
description of space-time.Comment: 53 pages, no figures. Revision to match the published versio
Quantum Coherence in a Single Ion due to strong Excitation of a metastable Transition
We consider pump-probe spectroscopy of a single ion with a highly metastable
(probe) clock transition which is monitored by using the quantum jump
technique. For a weak clock laser we obtain the well known Autler-Townes
splitting. For stronger powers of the clock laser we demonstrate the transition
to a new regime. The two regimes are distinguished by the transition of two
complex eigenvalues to purely imaginary ones which can be very different in
magnitude. The transition is controlled by the power of the clock laser. For
pump on resonance we present simple analytical expressions for various
linewidths and line positions.Comment: 6 figures. accepted for publication in PR
Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
Background: Within 2 min of severe ischemia, spreading depolarization (SD) propagates like a wave through compromised gray matter of the higher brain. More SDs arise over hours in adjacent tissue, expanding the neuronal damage. This period represents a therapeutic window to inhibit SD and so reduce impending tissue injury. Yet most neuroscientists assume that the course of early brain injury can be explained by glutamate excitotoxicity, the concept that immediate glutamate release promotes early and downstream brain injury. There are many problems with glutamate release being the unseen culprit, the most practical being that the concept has yielded zero therapeutics over the past 30 years. But the basic science is also flawed, arising from dubious foundational observations beginning in the 1950s Methods: Literature pertaining to excitotoxicity and to SD over the past 60 years is critiqued. Results: Excitotoxicity theory centers on the immediate and excessive release of glutamate with resulting neuronal hyperexcitation. This instigates poststroke cascades with subsequent secondary neuronal injury. By contrast, SD theory argues that although SD evokes some brief glutamate release, acute neuronal damage and the subsequent cascade of injury to neurons are elicited by the metabolic stress of SD, not by excessive glutamate release. The challenge we present here is to find new clinical targets based on more informed basic science. This is motivated by the continuing failure by neuroscientists and by industry to develop drugs that can reduce brain injury following ischemic stroke, traumatic brain injury, or sudden cardiac arrest. One important step is to recognize that SD plays a central role in promoting early neuronal damage. We argue that uncovering the molecular biology of SD initiation and propagation is essential because ischemic neurons are usually not acutely injured unless SD propagates through them. The role of glutamate excitotoxicity theory and how it has shaped SD research is then addressed, followed by a critique of its fading relevance to the study of brain injury. Conclusions: Spreading depolarizations better account for the acute neuronal injury arising from brain ischemia than does the early and excessive release of glutamate.Grants to RDA from the Canadian Heart & Stroke Foundation, National Science Engineering and Research Council and the New Frontiers in Research
Fund, to E.F from the National Research, Development and Innovation Office of Hungary, grant no. K134377; and the EUâs Horizon 2020 research and
innovation program under grant agreement No. 739593, and to JPD from the DFG (German research Council) (DFG DR323/5-1,DFG DR 323/10-1) BMBF Bundesministerium fuer Bildung und Forschung (Era-Net Neuron EBio2, with funds from BMBF 01EW2004)
The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention
Background: When a patient arrives in the emergency department following a stroke, a traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help protect their jeopardized neurons. One crucial reason is that we have not identified the molecular mechanisms leading to electrical failure, neuronal swelling, and blood vessel constriction in newly injured gray matter. All three result from a process termed spreading depolarization (SD). Because we only partially understand SD, we lack molecular targets and biomarkers to help neurons survive after losing their blood flow and then undergoing recurrent SD. Methods: In this review, we introduce SD as a single or recurring event, generated in gray matter following lost blood flow, which compromises the Na/K pump. Electrical recovery from each SD event requires so much energy that neurons often die over minutes and hours following initial injury, independent of extracellular glutamate. Results: We discuss how SD has been investigated with various pitfalls in numerous experimental preparations, how overtaxing the Na/K ATPase elicits SD. Elevated K or glutamate are unlikely natural activators of SD. We then turn to the properties of SD itself, focusing on its initiation and propagation as well as on computer modeling. Conclusions: Finally, we summarize points of consensus and contention among the authors as well as where SD research may be heading. In an accompanying review, we critique the role of the glutamate excitotoxicity theory, how it has shaped SD research, and its questionable importance to the study of early brain injury as compared with SD theory.This work was supported by grants from the Heart and Stroke Foundation of Canada and the National Science and Engineering Research Council of Canada to RDA, an NIH grant (NS106901) to CWS, a National Research, Development and Innovation Office of Hungary grant (K1343777) and EU Horizon 2020 research and innovation program (739953) to EF and from DFG Deutsche Forschungsgemeinschaft (German Research Council) (DFG DR 323/5-1), DFG DR 323/10-1, and BMBF Bundesministerium fuer Bildung und Forschung (EraNet Neuron EBio2, with funds from BMBF 01EW2004) to JPD
Decoherence in trapped ions due to polarization of the residual background gas
We investigate the mechanism of damping and heating of trapped ions
associated with the polarization of the residual background gas induced by the
oscillating ions themselves. Reasoning by analogy with the physics of surface
electrons in liquid helium, we demonstrate that the decay of Rabi oscillations
observed in experiments on 9Be+ can be attributed to the polarization phenomena
investigated here. The measured sensitivity of the damping of Rabi oscillations
with respect to the vibrational quantum number of a trapped ion is also
predicted in our polarization model.Comment: 26 pdf pages with 5 figures, http://www.df.ufscar.br/~quantum
Outcome of pathologic fractures of the proximal femur in nonosteogenic primary bone sarcoma
Thermogalvanic effects on the corrosion of copper in heavy brine LiBr solutions
Thermogalvanic corrosion of copper in heavy brine LiBr solutions has been investigated using a zero-resistance ammeter (ZRA). The temperature gradients between copper electrodes immersed in the same LiBr solution result in the formation of thermogalvanic cells with hot anodes, leading to high and sustained thermogalvanic currents. Copper loss rates, calculated using Faraday's law, substantially exceed 0.025 mm yearâ1, a value regarded as the threshold of low corrosion rates. The effects of thermogalvanic coupling on the surface properties of the anode and the cathode have been analysed by means of electrochemical impedance spectroscopy (EIS). The results obtained in this analysis have been related to the process of copper electrodissolution in bromide media
Physics with the KLOE-2 experiment at the upgraded DANE
Investigation at a --factory can shed light on several debated issues
in particle physics. We discuss: i) recent theoretical development and
experimental progress in kaon physics relevant for the Standard Model tests in
the flavor sector, ii) the sensitivity we can reach in probing CPT and Quantum
Mechanics from time evolution of entangled kaon states, iii) the interest for
improving on the present measurements of non-leptonic and radiative decays of
kaons and eta/eta mesons, iv) the contribution to understand the
nature of light scalar mesons, and v) the opportunity to search for narrow
di-lepton resonances suggested by recent models proposing a hidden dark-matter
sector. We also report on the physics in the continuum with the
measurements of (multi)hadronic cross sections and the study of gamma gamma
processes.Comment: 60 pages, 41 figures; added affiliation for one of the authors; added
reference to section
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