Evan Harrington : George Meredith\u27s use of comedy as a corrective to sentimentality

Because it leads an individual to increasing loss of perspective, George Meredith considered sentimentality a real tragedy. The deluded sentimentalist convinces himself that all his efforts and attitudes bear him steadily down the road of spiritual progress, when actually he is using his ideals of society as an excuse for willful blindness, a shifting of responsibility, and self-deception. The sentimentalist\u27s primary concern is to cushion himself against hard fact instead of training himself for encountering it, and he accomplishes this by drugging himself against the perception of truth

Differentiation . . . but to what degree? The Ed.D. and Ph.D. in Higher Education Programs

Research into higher education as a field of study is impeded by the lack of an authoritative database of all graduate programs in the United States. One resource used frequently is the Association for the Study of Higher Education (ASHE) database, which is self-reported by the host institutions. In 2008, this database indicated that approximately 77 higher education (HIED) programs awarded the Doctor of Education (Ed.D.), 91 offered the Doctor of Philosophy (Ph.D.), and 35 awarded both degrees. This distribution recalls questions that have marked research in the field for 80 years: how do HIED programs differentiate between the two degrees? Are both degrees really necessary

Institutional Factors Promoting Community College Fundraising

The purpose of this study was to examine the annual revenue received by United States public community college foundations from 2008-2009 in relation to selected variables associated with successful foundation performance. This study replicated and expanded upon the work of Dr. Sharon McEntee Carrier a decade earlier. Linear regression analysis was used to collect descriptive statistics about the frequencies, central tendencies, and distribution of the data. The researchers used linear regression and analysis of variances (ANOVA) to study the relationship between revenue gained in connection with private giving and college foundation operations for fiscal year 2008-2009, the degree to which the college president, chief resource development officer, and foundation board members were rated as playing a critical role in the foundation’s operation, the degree to which meeting institutional strategic goals was rated as an important, the institution’s geographic location, size (based on FTE enrollment), size of endowment, and organizational structure. Variables found to promote fundraising are reported. These include operating budget, campus location, campus enrollment, chief development officer’s engagement, endowment size, and development officer’s sense of satisfaction with the work

Factorised spatial representation learning: application in semi-supervised myocardial segmentation

The success and generalisation of deep learning algorithms heavily depend on learning good feature representations. In medical imaging this entails representing anatomical information, as well as properties related to the specific imaging setting. Anatomical information is required to perform further analysis, whereas imaging information is key to disentangle scanner variability and potential artefacts. The ability to factorise these would allow for training algorithms only on the relevant information according to the task. To date, such factorisation has not been attempted. In this paper, we propose a methodology of latent space factorisation relying on the cycle-consistency principle. As an example application, we consider cardiac MR segmentation, where we separate information related to the myocardium from other features related to imaging and surrounding substructures. We demonstrate the proposed method's utility in a semi-supervised setting: we use very few labelled images together with many unlabelled images to train a myocardium segmentation neural network. Specifically, we achieve comparable performance to fully supervised networks using a fraction of labelled images in experiments on ACDC and a dataset from Edinburgh Imaging Facility QMRI. Code will be made available at https://github.com/agis85/spatial_factorisation.Comment: Accepted in MICCAI 201

A LONGITUDINAL EXAMINATION OF THE RELATIONSHIP OF SELECTED INSTITUTIONAL VARIABLES TO COMMUNITY COLLEGE FOUNDATION REVENUE

The primary purpose of this study was to examine the annual revenue received by United States public Community College Foundations from 2008-2009 in relation to selected variables associated in the literature with successful foundation performance. This study also collected longitudinal data by replicating and expanding upon a similar study conducted by Dr. Sharon McEntee Carrier a decade earlier. Linear regression analysis was used to collect descriptive statistics that described the frequencies, central tendencies, and distribution of the data. The researchers used linear regression and analysis of variances (ANOVA) to study the relationship between revenue gained in connection with private giving and college foundation operations for fiscal year 2008-2009, the degree to which the college president, chief resource development officer, and foundation board members were rated as playing a critical role in the foundation’s operation, the degree to which meeting institutional strategic goals was rated as an important factor in evaluating the foundation’s operation, the institution’s geographic location, size (based on FTE enrollment), size of endowment, and organizational structure. The explanatory variables, foundation operations, the Chief Development Officer’s role in the foundation’s operation, location, size, endowment, and the Chief Development Officer’s perception of how fundraising efforts were appreciated by the institutions served were found to be statistically significant

The role of atrial natriuretic peptide to attenuate inflammation in a mouse skin wound and individually perfused rat mesenteric microvessels.

We tested the hypothesis that the anti-inflammatory actions of atrial natriuretic peptide (ANP) result from the modulation of leukocyte adhesion to inflamed endothelium and not solely ANP ligation of endothelial receptors to stabilize endothelial barrier function. We measured vascular permeability to albumin and accumulation of fluorescent neutrophils in a full-thickness skin wound on the flank of LysM-EGFP mice 24 h after formation. Vascular permeability in individually perfused rat mesenteric microvessels was also measured after leukocytes were washed out of the vessel lumen. Thrombin increased albumin permeability and increased the accumulation of neutrophils. The thrombin-induced inflammatory responses were attenuated by pretreating the wound with ANP (30 min). During pretreatment ANP did not lower permeability, but transiently increased baseline albumin permeability concomitant with the reduction in neutrophil accumulation. ANP did not attenuate acute increases in permeability to histamine and bradykinin in individually perfused rat microvessels. The hypothesis that anti-inflammatory actions of ANP depend solely on endothelial responses that stabilize the endothelial barrier is not supported by our results in either individually perfused microvessels in the absence of circulating leukocytes or the more chronic skin wound model. Our results conform to the alternate hypothesis that ANP modulates the interaction of leukocytes with the inflamed microvascular wall of the 24 h wound. Taken together with our previous observations that ANP reduces deformability of neutrophils and their strength of attachment, rolling, and transvascular migration, these observations provide the basis for additional investigations of ANP as an anti-inflammatory agent to modulate leukocyte-endothelial cell interactions

Characterization of the biofilm forming ability of Staphylococcus pseudintermedius from dogs

BACKGROUND: Staphylococcus pseudintermedius is an opportunistic pathogen of dogs and has emerged as a leading cause of skin, wound and surgical site infections worldwide. Methicillin resistance is common and clinical infections as a result of methicillin-resistant S. pseudintermedius (MRSP) pose a clinical challenge. In other staphylococci, biofilm formation has been shown to be a virulence factor for infection, however, it has received little attention in S. pseudintermedius. The objectives of this study were to evaluate the biofilm forming ability of clinical isolates of S. pseudintermedius obtained from dogs using phenotypic and genotypic techniques. RESULTS: 96% (136/140) of S. pseudintermedius isolates were classified as strong or moderate biofilm producers, with the majority of isolates being able to produce biofilm. There was no difference in biofilm formation between MRSP and MSSP (p=0.8), amongst isolates from clinical infections compared with isolates obtained from colonized dogs (p=0.08), and between isolates from sequence type (ST) 71 and ST 68 (P=0.09). icaA was detected in 77.9% (109/140) of isolates and icaD was detected in 75.7% (106/140) of isolates. Scanning electron microscopic evaluation of S. pseudintermedius biofilm production revealed aggregates of cocci and irregularly produced extracellular polymeric matrix. CONCLUSION: The majority of S. pseudintermedius isolates evaluated in this study were able to produce biofilm and this may be an important virulence factor in the rapid emergence of this bacterium in veterinary hospitals worldwide. Further study into the mechanisms of biofilm formation by S. pseudintermedius is warranted

Geothermal Heating and its Influence on the Meridional Overturning Circulation

The effect of geothermal heating on the meridional overturning circulation is examined using an idealized, coarse-resolution ocean general circulation model. This heating is parameterized as a spatially uniform heat flux of 50 mW m-2 through the (flat) ocean floor, in contrast with previous studies that have considered an isolated hotspot or a series of plumes along the mid-Atlantic ridge. The equilibrated response is largely advective: a deep perturbation of the meridional overturning cell on the order of several Sv is produced, connecting with an upper-level circulation at high latitudes, allowing the additional heat to be released to the atmosphere. Risingmotion in the perturbation deep cell is concentrated near the equator. The upward penetration of this cell is limited by the thermocline, analogous to the role of the stratosphere in limiting the upward penetration of convective plumes in the atmosphere. The magnitude of the advective response is inversely proportional to the deep stratification; with a weaker background meridional overturning circulation and a less stratified abyss, the overturning maximum of the perturbation deep cell is increased. This advective response also cools the low-latitude thermocline. The qualitative behavior is similar in both a single hemisphere and double hemisphere configuration.The anomalous circulation driven by geothermal fluxes is more substantial than previously thought. We are able to understand the structure and strength of the response in the idealized geometry and further extend these ideas to explain the results of Adcroft et al. [2001], where the impact of geothermal heating was examined using a global configuration