An Extreme-AO Search for Giant Planets around a White Dwarf --VLT/SPHERE performance on a faint target GD 50

CONTEXT. Little is known about the planetary systems around single white dwarfs although there is strong evidence that they do exist. AIMS. We performed a pilot study with the extreme-AO system on the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) on the Very Large Telescopes (VLT) to look for giant planets around a young white dwarf, GD 50. METHODS. We were awarded science verification time on the new ESO instrument SPHERE. Observations were made with the InfraRed Dual-band Imager and Spectrograph in classical imaging mode in H band. RESULTS. Despite the faintness of the target (14.2 mag in R band), the AO loop was closed and a strehl of 37\% was reached in H band. No objects were detected around GD 50. We achieved a 5-sigma contrast of 6.2, 8.0 and 8.25 mags at 0{\farcs}2, 0{\farcs}4 and 0{\farcs}6 and beyond, respectively. We exclude any substellar objects more massive than 4.0 M$_\textrm{J}$ at 6.2 AU, 2.9 M$_\textrm{J}$ at 12.4 AU and 2.8 M$_\textrm{J}$ at 18.6 AU and beyond. This rivals the previous upper limit set by Spitzer. We further show that SPHERE is the most promising instrument available to search for close-in substellar objects around nearby white dwarfs.Comment: A&A letters, accepte

Associations Between Adolescent Sport and Exercise Participation and Device-Assessed Physical Activity in Adulthood: Evidence From the 1970 British Cohort Study

BACKGROUND: Adolescence is a critical period filled with life changes. Early implementation of effective health promotion strategies could help alleviate the morbidity and mortality associated with inactivity. This study investigated whether adolescent participation in exercise and sport is associated with device-assessed physical activity (PA) levels in midlife. METHODS: A total of 2984 participants (41.2% male) from the 1970 British Cohort Study were included. Participants were surveyed at age 16 years on 5 indicators of exercise and sport participation. Total daily PA and moderate to vigorous PA (MVPA) at age 46 years were measured using a thigh-worn accelerometer, worn for 7 days. Associations between each adolescent exercise or sport indicator and adulthood total daily PA and MVPA were examined using linear regressions, adjusting for sex, wear time, body mass index, smoking, disability, malaise, alcohol consumption, social class, education, and self-rated health. RESULTS: In fully adjusted models, adolescents who reported exercising "much more" than others (8.6 min/d; 95% confidence interval, -0.1 to 17.1), who played sports at the park/playground more than once a week (8.5 [3.0-14.0] min/d), and who exercised on the most recent Saturday (3.8 [0.7-6.9] min/d) had higher adult total PA levels than those who reported the lowest activity levels. There was no evidence of an association between greater sport and exercise participation at age 16 y and MVPA at age 46 y. There was no association between sports at school and either measure of adult PA. CONCLUSION: Active adolescents, particularly those who engaged in out-of-school exercise, had higher total daily PA levels, but not MVPA levels, in midlife. This highlights the potential of early PA interventions to improve PA levels in adulthood

Obtaining a marketing authorisation for nitrous oxide

OBJECTIVE: To prepare a Common Technical Document for nitrous oxide (NO) in accordance to European Guidelines, for submission to the Medicine’s Authority to obtain a Marketing Authorisation (MA) and to carry out a project feasibility study. METHOD: Directives and guidelines issued by the European Commission were followed to compile a dossier for NO in the Common Technical Document (CTD) format, in preparation of an abridged application. KEY FINDINGS: The Common Technical Document gave details on the Administrative Information (Module 1), Summaries (Module 2), Quality (Module 3) and Non- Clinical Studies (Module 4) consisting of a detailed scientific bibliography. The active substance manufacturer was inspected and accepted as an approved supplier. A feasibility study which was conducted proved the project feasible. CONCLUSION: The whole manufacturing process of nitrous oxide is well controlled and batches can be produced with a constant level of quality. NO has been used for 150 years for analgesia and anesthesia and has proven safe and effective. Even though its administration is not without risks, it currently has a niche role as an inhalational analgesic and sedative.peer-reviewe

Rapid grain growth in post-AGB disc systems from far-infrared and sub-millimetre photometry

The timescales on which astronomical dust grows remain poorly understood, with important consequences for our understanding of processes like circumstellar disk evolution and planet formation.A number of post-asymptotic giant branch stars are found to host optically thick, dust- and gas-rich circumstellar discs in Keplerian orbits. These discs exhibit evidence of dust evolution, similar to protoplanetary discs; however since post-AGB discs have substantially shorter lifetimes than protoplanetary discs they may provide new insights on the grain-growth process. We examine a sample of post-AGB stars with discs to determine the FIR and sub-mm spectral index by homogeneously fitting a sample of data from \textit{Herschel}, the SMA and the literature. We find that grain growth to at least hundreds of micrometres is ubiquitous in these systems, and that the distribution of spectral indices is more similar to that of protoplanetary discs than debris discs. No correlation is found with the mid-infrared colours of the discs, implying that grain growth occurs independently of the disc structure in post-AGB discs. We infer that grain growth to $\sim$mm sizes must occur on timescales $<<10^{5}$ yr, perhaps by orders of magnitude, as the lifetimes of these discs are expected to be $\lesssim10^{5}$~yr and all objects have converged to the same state. This growth timescale is short compared to the results of models for protoplanetary discs including fragmentation, and may provide new constraints on the physics of grain growth.Comment: 13 pages, 7 figures. Accepted for publication in MNRA

Patient and Surrogate Views of Community Consultation for Emergency Research

ObjectivePretrial community consultation (CC) is required for emergency research conducted under an exception from informed consent (EFIC) in the United States. CC remains controversial and challenging, and minimal data exist regarding the views of individuals enrolled in EFIC trials on this process. It is important to know whether participants perceive CC to be meaningful and, if so, whom they believe should be consulted.MethodsWe conducted a secondary analysis of data from two studies interviewing patients and surrogates of two recent EFIC trials (PEER‐RAMPART and PEER‐ProTECT). These interviews included similar open‐ and closed‐ended questions regarding participants’ views of the importance of CC, the rationale for their responses, and their views regarding which populations should be included in consultation efforts. A template analytic strategy was used for qualitative analysis of textual data, and descriptive statistics were tabulated to characterize demographic data and instances of major themes.ResultsNinety percent of participants perceived CC to be valuable. Participants’ reasons for finding CC valuable clustered in two categories: 1) as a method of informing the public about the trial to be conducted and 2) as a way of obtaining input and feedback from the community. Participants cited the medical community (43%) and individuals with a connection to the study condition (41%) as the most important groups to involve in consultation efforts; only 5% suggested consulting the general public in the area where the research will be conducted.ConclusionParticipants in EFIC trials and their decision makers generally valued CC as a method of informing and seeking input from the community. Participants felt that the most appropriate groups to consult were the medical community and individuals with connections to the condition under study. Consultation efforts focused on these two groups, rather than the general public, may be more efficient and more meaningful to individuals involved in EFIC trials. These findings also reinforce the importance of the distinction between public disclosure and CC.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139974/1/acem13265-sup-0001-DataSupplementS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139974/2/acem13265_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139974/3/acem13265.pd

XSHOOTER spectroscopy of the enigmatic planetary nebula Lin49 in the Small Magellanic Cloud

We performed a detailed spectroscopic analysis of the fullerene C60-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC) using XSHOOTER at the European Southern Observatory Very Large Telescope and the Spitzer/Infrared Spectrograph instruments. We derived nebular abundances for nine elements. We used TLUSTY to derive photospheric parameters for the central star. Lin49 is C-rich and metal-deficient PN (Z ∼ 0.0006). The nebular abundances are in good agreement with asymptotic giant branch nucleosynthesis models for stars with initial mass 1.25 M⊙ and metallicity Z = 0.001. Using the TLUSTY synthetic spectrum of the central star to define the heating and ionizing source, we constructed the photoionization model with CLOUDY that matches the observed spectral energy distribution (SED) and the line fluxes in the UV to far-IR wavelength ranges simultaneously. We could not fit the ∼1–5 μm SED using a model with 0.005–0.1-μm-sized graphite grains and a constant hydrogen density shell owing to the prominent near-IR excess, while at other wavelengths the model fits the observed values reasonably well. We argue that the near-IR excess might indicate either (1) the presence of very small particles in the form of small carbon clusters, small graphite sheets, or fullerene precursors, or (2) the presence of a high-density structure surrounding the central star. We found that SMC C60 PNe show a near-IR excess component to lesser or greater degree. This suggests that these C60 PNe might maintain a structure nearby their central star

Valutazione di alcune performance diagnostiche di kit ELISA per la diagnosi sierologica di Anemia Infettiva Equina (AIE)

Data on evaluation of some diagnostic parameters of all ELISA kits available in Italy for the serodiagnosis of AIE are presented and discussed. Ten laboratories were involved using a panel of 30 sera ran with 4 commercial kits and 2 in-house kits. Kits were also evaluated using a panel of sera from vaccinated animals at different days post vaccination (p.v.). All sera were also tested in agar gel immunodiffusion (AGID). The parameters evaluated were: diagnostic sensitivity (DSe) and specificity (DSp), Cohen K, weighted Cohen K, coefficient of variation (CV), accordance, concordance. Analysis of these parameters indicates that all kits have a higher sensitivity than AGID, even if a complete evaluation, as indicated by OIE (1) should be carried out

Impact of a brief group intervention to enhance parenting and the home learning environment for children aged 6-36 months: A cluster randomised controlled trial

This is the final version of the article. Available from the publisher via the DOI in this record.This study evaluated the effectiveness of a group parenting intervention designed to strengthen the home learning environment of children from disadvantaged families. Two cluster randomised controlled superiority trials were conducted in parallel and delivered within existing services: a 6-week parenting group (51 locations randomised; 986 parents) for parents of infants (aged 6-12 months), and a 10-week facilitated playgroup (58 locations randomised; 1200 parents) for parents of toddlers (aged 12-36 months). Each trial had three conditions: intervention (smalltalk group-only); enhanced intervention with home coaching (smalltalk plus); and 'standard'/usual practice controls. Parent-report and observational measures were collected at baseline, 12 and 32 weeks follow-up. Primary outcomes were parent verbal responsivity and home learning activities at 32 weeks. In the infant trial, there were no differences by trial arm for the primary outcomes at 32 weeks. In the toddler trial at 32-weeks, participants in the smalltalk group-only trial showed improvement compared to the standard program for parent verbal responsivity (effect size (ES) = 0.16; 95% CI 0.01, 0.36) and home learning activities (ES = 0.17; 95% CI 0.01, 0.38) but smalltalk plus did not. For the secondary outcomes in the infant trial, several initial differences favouring smalltalk plus were evident at 12 weeks, but not maintained to 32 weeks. For the toddler trial, differences in secondary outcomes favouring smalltalk plus were evident at 12 weeks and maintained to 32 weeks. These trials provide some evidence of the benefits of a parenting intervention focused on the home learning environment for parents of toddlers but not infants. TRIAL REGISTRATION: 8 September 2011; ACTRN12611000965909 .This research was commissioned and funded by the Victorian Government Department of Education and Early Childhood Development (DEECD), and designed and conducted at the Parenting Research Centre. NH, EW, SB, AS, MT, MY and JN were employees of the Parenting Research Centre when this study was conducted. EW was part-funded by the Centre for Research Excellence in Child Language at Murdoch Childrens Research Institute (NHMRC grant 1023493). NH, EW, SB and JN are funded by the Australian Communities Foundation (Coronella sub-fund) at La Trobe University. OU is supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South West Peninsula at the Royal Devon and Exeter NHS Foundation Trust. Views expressed are those of the authors and not necessarily those of DEECD, NIHR, NHS or the Department of Health