Forensic civism: articulating science, DNA and kinship in contemporary Mexico and Colombia

The article will present the findings of ethnographic research into the Colombian and Mexican forensic systems, introducing the first citizen-led exhumation project made possible through the cooperation of scholars, forensic specialists and interested citizens in Mexico. The coupling, evolution and mutual re-constitution of forensic science will be explored, including new forms of citizenship and nation building projects – all approached as lived experience – in two of Latin America's most complex contexts: organised crime and mass death

Forensic civism: articulating science, DNA and kinship in contemporary Mexico and Colombia

This is the final version of the article. Available from Manchester University Press via the DOI in this record.The article will present the findings of ethnographic research into the Colombian and Mexican forensic systems, introducing the first citizen-led exhumation project made possible through the cooperation of scholars, forensic specialists and interested citizens in Mexico. The coupling evolution and mutual re-constitution of forensic science will be explored, including new forms of citizenship and nation building projects – all approached as lived experience – in two of Latin America‘s most complex contexts: organised crime and mass death.We would like to thank Gobernanza Forense Ciudadana, A.C. and its members for their invaluable help. The article arises from a scholarship granted by the Mexican Council of Science and Technology (CONACYT) to Arely Cruz-Santiago and a COFUND International Junior Research Fellowship to Ernesto Schwartz-Marin at Durham University. The ESRC ‘Citizen-led Forensics’ (ES/M00063X/1) and ‘Public Engagement with Genomics and Race in Latin America’ [Leverhulme RPG- 044: directed by Peter Wade] projects allowed the authors to conduct fieldwork. Last but not least, we thank all the relatives of the disappeared in both countries and the forensic specialists who gave us their time

Colombian forensic genetics as a form of public science: The role of race, nation and common sense in the stabilization of DNA populations

This is the final version of the article. Available from SAGE Publications via the DOI in this record.This article examines the role that vernacular notions of racialized-regional difference play in the constitution and stabilization of DNA populations in Colombian forensic science, in what we frame as a process of public science. In public science, the imaginations of the scientific world and common-sense public knowledge are integral to the production and circulation of science itself. We explore the origins and circulation of a scientific object – ‘La Tabla’, published in Paredes et al. and used in genetic forensic identification procedures – among genetic research institutes, forensic genetics laboratories and courtrooms in Bogotá. We unveil the double life of this central object of forensic genetics. On the one hand, La Tabla enjoys an indisputable public place in the processing of forensic genetic evidence in Colombia (paternity cases, identification of bodies, etc.). On the other hand, the relations it establishes between ‘race’, geography and genetics are questioned among population geneticists in Colombia. Although forensic technicians are aware of the disputes among population geneticists, they use and endorse the relations established between genetics, ‘race’ and geography because these fit with common-sense notions of visible bodily difference and the regionalization of race in the Colombian nation.This article arises out of two projects: ‘Race, genomics and mestizaje (mixture) in Latin America: a comparative approach’ funded by the ESRC (grant RES-062-23-1914) and ‘Public engagement with genomic research and race in Latin America’ funded by The Leverhulme Trust (grant RPG-044)

Incoherent white light solitons in logarithmically saturable noninstantaneous nonlinear media

We analytically demonstrate the existence of white light solitons in logarithmically saturable noninstantaneous nonlinear media. This incoherent soliton has elliptic Gaussian intensity profile, and elliptic Gaussian spatial correlation statistics. The existence curve of the soliton connects the strength of the nonlinearity, the spatial correlation distance as a function of frequency, and the characteristic width of the soliton. For this soliton to exist, the spatial correlation distance must be smaller for larger temporal frequency constituents of the beam

Biorecuperation, the epidemic of violence and COVID-19 in Mexico

This is the final version. Available on open access from Manchester University Press via the DOI in this recordCOVID-19 has reinstated the sovereign enclosures of corpse management that mothers of the disappeared had so successfully challenged in the past decade. To explore how moral duties toward the dead are being renegotiated due to COVID-19, this article puts forward the notion of biorecuperation, understood as an individualised form of forensic care for the dead made possible by the recovery of biological material. Public health imperatives that forbid direct contact with corpses due to the pandemic, interrupt the logics of biorecuperation. Our analysis is based on ten years of experience working with families of the disappeared in Mexico, ethnographic research within Mexico’s forensic science system and online interviews conducted with medics and forensic scientists working at the forefront of Mexico City’s pandemic. In the face of increasing risks of viral contagion and death, this article analyses old and new techniques designed to bypass the prohibitions imposed by the state and its monopoly over corpse management and identificationEconomic and Social Research Council (ESRC

Interactions between physical exercise, associative memory, and genetic risk for Alzheimer's disease.

The ε4 allele of the APOE gene heightens the risk of late onset Alzheimer's disease. ε4 carriers, may exhibit cognitive and neural changes early on. Given the known memory-enhancing effects of physical exercise, particularly through hippocampal plasticity via endocannabinoid signaling, here we aimed to test whether a single session of physical exercise may benefit memory and underlying neurophysiological processes in young ε3 carriers (ε3/ε4 heterozygotes, risk group) compared with a matched control group (homozygotes for ε3). Participants underwent fMRI while learning picture sequences, followed by cycling or rest before a memory test. Blood samples measured endocannabinoid levels. At the behavioral level, the risk group exhibited poorer associative memory performance, regardless of the exercising condition. At the brain level, the risk group showed increased medial temporal lobe activity during memory retrieval irrespective of exercise (suggesting neural compensatory effects even at baseline), whereas, in the control group, such increase was only detectable after physical exercise. Critically, an exercise-related endocannabinoid increase correlated with task-related hippocampal activation in the control group only. In conclusion, healthy young individuals carrying the ε4 allele may present suboptimal associative memory performance (when compared with homozygote ε3 carriers), together with reduced plasticity (and functional over-compensation) within medial temporal structures

A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men.

Regular physical exercise enhances memory functions, synaptic plasticity in the hippocampus, and brain derived neurotrophic factor (BDNF) levels. Likewise, short periods of exercise, or acute exercise, benefit hippocampal plasticity in rodents, via increased endocannabinoids (especially anandamide, AEA) and BDNF release. Yet, it remains unknown whether acute exercise has similar effects on BDNF and AEA levels in humans, with parallel influences on memory performance. Here we combined blood biomarkers, behavioral, and fMRI measurements to assess the impact of a single session of physical exercise on associative memory and underlying neurophysiological mechanisms in healthy male volunteers. For each participant, memory was tested after three conditions: rest, moderate or high intensity exercise. A long-term memory retest took place 3 months later. At both test and retest, memory performance after moderate intensity exercise was increased compared to rest. Memory after moderate intensity exercise correlated with exercise-induced increases in both AEA and BNDF levels: while AEA was associated with hippocampal activity during memory recall, BDNF enhanced hippocampal memory representations and long-term performance. These findings demonstrate that acute moderate intensity exercise benefits consolidation of hippocampal memory representations, and that endocannabinoids and BNDF signaling may contribute to the synergic modulation of underlying neural plasticity mechanisms

Overexpression of the AtLOS5 gene increased abscisic acid level and drought tolerance in transgenic cotton

Drought is the major environmental stress that limits cotton (Gossypium hirsutum L.) production worldwide. LOS5/ABA3 (LOS5) encodes a molybdenum co-factor and is essential for activating aldehyde oxidase, which is involved in abscisic acid (ABA) biosynthesis. In this study, a LOS5 cDNA of Arabidopsis thaliana was overexpressed in cotton cultivar Zhongmiansuo35 (Z35) by Agrobacterium tumefaciens-mediated transformation. The transformation and overexpression of AtLOS5 were assessed by PCR and RT-PCR analysis. Detached shoots of transgenic cotton showed slower transpirational water loss than those of Z35. When pot-grown 6-week-old seedlings were withheld from watering for 3 d, transgenic cotton accumulated 25% more endogenous ABA and about 20% more proline than Z35 plants. The transgenic plants also showed increased expression of some drought-responding genes such as P5CS and RD22, and enhanced activity of antioxidant enzymes such as superoxide dismutase, peroxidase, and ascorbate peroxidase. Their membrane integrity was considerably improved under water stress, as indicated by reduced malondialdehyde content and electrolyte leakage relative to control plants. When the pot-grown plants were subjected to deficit irrigation for 8 weeks (watering to 50% of field capacity), transgenic plants showed a 13% increase in fresh weight than the wild type under the same drought condition. These results suggest that the AtLOS5 transgenic cotton plants acquired a better drought tolerance through enhanced ABA production and ABA-induced physiological regulations