Analysis of the career path and survey of the opinions of primary school teachers on the introduction of career regulation

The diploma thesis deals with the analysis of the career path and the survey of the opinions of primary school teachers on the introduction of career regulations. In the theoretical part, it defines pedagogical practice, further education, and professional development of pedagogical workers and the career growth of teachers. The main objective of the empirical part was to describe the opinion of pedagogical workers on the introduction of the proposed career order and to identify the current social influences that influence pedagogical workers when implementing the career order in practice. The secondary objectives were to describe how the professional career of a primary school teacher proceeds and to identify differences in the professional career of teachers in the context of their experience and age. The research investigation was based on a qualitative approach and a semi-structured interview method was used to collect data. The main objective of the work was fulfilled based on the Grounded Theory research design, and secondary objectives were achieved through open coding. From the results of the grounded theory, it became clear that the teaching staff has a negative attitude toward the implementation of career regulation in practice, which is caused by the compilation of attestations, the...Diplomová práce se zabývá analýzou profesní dráhy a průzkumem názorů učitelů základních škol na zavedení kariérního řádu. V teoretické části vymezuje pedagogickou praxi, další vzdělávání a profesní rozvoj pedagogických pracovníků a kariérní růst učitele. Hlavním cílem empirické části bylo popsat názor pedagogických pracovníků na zavedení navrhovaného kariérního řádu a identifikovat současné společenské vlivy, které ovlivňují pedagogické pracovníky při implementaci kariérního řádu do praxe. Vedlejšími cíli bylo popsat, jak probíhá profesní dráha učitele na základní škole a identifikovat rozdíly profesní kariéry učitelů v kontextu jejich zkušeností a věku. Výzkumné šetření bylo založeno na kvalitativním přístupu a ke sběru dat byla použita metoda polostrukturovaného rozhovoru. Hlavní cíl práce byl naplněn na základě výzkumného designu Zakotvené teorie a vedlejších cílů bylo dosaženo prostřednictvím otevřeného kódování. Z výsledků Zakotvené teorie vyšlo najevo, že pedagogičtí pracovníci mají k implementaci kariérního řádu do praxe negativní postoj, který je zapříčiněný jejich obavami z náročnosti skládání atestací, sestavování portfolií a vykazování dalších dokumentů, nedostatky byly také shledávány v procesu vyhodnocování vyjmenovaných procedur. Na základě toho byl sestaven návrh změny kariérního...Katedra andragogiky a managementu vzděláváníFaculty of EducationPedagogická fakult

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats? 190)

R e c e i ve d J a n u a r y 2 3 , 2 0 12 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 . Key words: Prenatal drug exposure -Methamphetamine -Cocaine -MorphineOpen field -Plantar test -Conditioned place preference -LocomotionNociception -Drug-seeking behavior Abstract: The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA-or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar Prague Medical Report / Vol. 113 (2012) No. 3, p. 189-205 test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected

Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit

Transmembrane protein 168 (TMEM168) comprises 697 amino acid residues, including some putative transmembrane domains. It is reported that TMEM168 controls methamphetamine (METH) dependence in the nucleus accumbens (NAc) of mice. Moreover, a strong link between METH dependence-induced adaptive changes in the brain and mood disorders has been evaluated. In the present study, we investigated the effects of accumbal TMEM168 in a battery of behavioral paradigms. The adeno-associated virus (AAV) Tmem168 vector was injected into the NAc of C57BL/6J mice (NAc-TMEM mice). Subsequently, the accumbal TMEM168 mRNA was increased approximately by seven-fold when compared with the NAc-Mock mice (controls). The NAc-TMEM mice reported no change in the locomotor activity, cognitive ability, social interaction, and depression-like behaviors; however, TMEM168 overexpression enhanced anxiety in the elevated-plus maze and light/dark box test. The increased anxiety was reversed by pretreatment with the antianxiety drug diazepam (0.3 mg/kg i.p.). Moreover, the NAc-TMEM mice exhibited decreased prepulse inhibition (PPI) in the startle response test, and the induced schizophrenia-like behavior was reversed by pretreatment with the antipsychotic drug risperidone (0.01 mg/kg i.p.). Furthermore, accumbal TMEM168 overexpression decreased the basal levels of extracellular GABA in the NAc and the high K+ (100 mM)-stimulated GABA elevation; however, the total contents of GABA in the NAc remained unaffected. These results suggest that the TMEM168-regulated GABAergic neuronal system in the NAc might become a novel target while studying the etiology of anxiety and sensorimotor gating deficits

The Importance and Impact of the Antimonopoly Office in the Czech Republic

The Diploma Thesis is focused on the issue of protection of economic competition. It deals with its politics, structure, distorting competition and last but not least its protection. The objective of the work is to analyze and describe the importance of the Office for the Protection of Competition, its influence and work in relation to the most important cases of the distorting competition in the Czech Republic, mainly in case of cartel agreements, abuse of dominant position, specifically in the period 2010-2015. Fundamental part of the work was based on the research that was crucial for the work. The research collected data in the Czech as well as English language in order to gain theoretical basis. It was necessary to gain and study all available professional information concerning to the topic. Analytical part of the work was based primarily on the description and comparison method. Sources for the analytical part were gained from the regularly published reports of the Office for the Protection of Competition. These data are publicly available information. Conclusion of the work deals with assessment of work of the Office for the Protection of Competition and its influence. Therefore there was confirmed one of the main thesis that had initiated the research. The author of the diploma thesis came to the conclusion that imposing sanctions is not only the most effective tool of the economic protection but also serves as a significant preventive measure

Analysis of the career path and survey of the opinions of primary school teachers on the introduction of career regulation

The diploma thesis deals with the analysis of the career path and the survey of the opinions of primary school teachers on the introduction of career regulations. In the theoretical part, it defines pedagogical practice, further education, and professional development of pedagogical workers and the career growth of teachers. The main objective of the empirical part was to describe the opinion of pedagogical workers on the introduction of the proposed career order and to identify the current social influences that influence pedagogical workers when implementing the career order in practice. The secondary objectives were to describe how the professional career of a primary school teacher proceeds and to identify differences in the professional career of teachers in the context of their experience and age. The research investigation was based on a qualitative approach and a semi-structured interview method was used to collect data. The main objective of the work was fulfilled based on the Grounded Theory research design, and secondary objectives were achieved through open coding. From the results of the grounded theory, it became clear that the teaching staff has a negative attitude toward the implementation of career regulation in practice, which is caused by the compilation of attestations, the..

The monastery in Žďár nad Sázavou in the first > years after its renewal (1676-1705)

This thesis deals with the history of the Cistercian monastery of Žďár nad Sázavou in the second half of the 17th century, specifically from 1676 till 1705. In 1676, after almost four decades since the Cistercian Order had regained control of the seigniory in Žďár and the convent had been re-established, the monks were allowed to elect their own Abbot. Benedikt Zaunmüller, the prior of the monastery of Vyšší Brod, was elected and remained Abbot of Žďár till 1691 when he was forced to resign on health grounds. He was succeeded by Edmund Bagner, the first of the Abbots of the re-established monastery who was elected from the members of the Žďár convent and remained in office till his death in 1705. The scope of this thesis corresponds with the terms of office of these two Abbots who significantly contributed to the improvement in the economic situation of the monastery and the expansion of the personnel of the convent in Žďár and who are indisputably among the significant personalities of the Žďár Abbey. The outset of the thesis provides an overview of the available archival sources and existing literature on the topic. The first chapter outlines the history of the Žďár monastery from its establishment in the middle of the 13th century. The second chapter captures the transformation of the..

The monastery in Žďár nad Sázavou in the first > years after its renewal (1676-1705)

This thesis deals with the history of the Cistercian monastery of Žďár nad Sázavou in the second half of the 17th century, specifically from 1676 till 1705. In 1676, after almost four decades since the Cistercian Order had regained control of the seigniory in Žďár and the convent had been re-established, the monks were allowed to elect their own Abbot. Benedikt Zaunmüller, the prior of the monastery of Vyšší Brod, was elected and remained Abbot of Žďár till 1691 when he was forced to resign on health grounds. He was succeeded by Edmund Bagner, the first of the Abbots of the re-established monastery who was elected from the members of the Žďár convent and remained in office till his death in 1705. The scope of this thesis corresponds with the terms of office of these two Abbots who significantly contributed to the improvement in the economic situation of the monastery and the expansion of the personnel of the convent in Žďár and who are indisputably among the significant personalities of the Žďár Abbey. The outset of the thesis provides an overview of the available archival sources and existing literature on the topic. The first chapter outlines the history of the Žďár monastery from its establishment in the middle of the 13th century. The second chapter captures the transformation of the..

Drug sensitization in rats prenatally exposed to methamphetamine

Methamphetamine (MA) is a psychostimulant drug with high potential for abuse. Psychostimulants were shown to cause behavioral sensitization - a progressive increase of their psychomotor activating effects. Since half of MA users are women of reproductive age, there is an increased risk of negative consequences for their children. The aim of my dissertation thesis was to find out whether prenatal MA exposure is able to increase sensitivity to the same drug in adulthood. Pregnant dams were injected daily with MA 5 mg/kg or saline (S) subcutaneously (s.c.) during the whole gestation. The absolute control group of adult females (C) was not exposed to any injection application. To test the sensitivity of the offspring to MA in adulthood, half of each prenatally exposed group (MA, S, C) were administered MA 1 mg/kg while the other half received S s.c. The sensitizing effect of prenatal MA exposure was tested in the open field, elevated plus maze, Laboras (Metris B.V., Netherlands), Morris water maze, tail-flick test and in the tests of susceptibility to epileptic seizures. Our results showed that the animals prenatally exposed to MA were more susceptible to flurothyl seizures and demonstrated better performance in the test of memory. On the other hand, acute MA application in adulthood increased motor activity,..