Marital Status and Car Ownership as Related to Sex Differences in Traffic Accidents and Violations in a Two-Year Period

On the basis of considerable previous work in the collection and tabulation of motor vehicle accidents and traffic violations, the hypothesis that women are better accident risks than men has come to be widely accepted. According to Lauer (3) even when corrections are made for age and amount of driving exposure, women have fewer reported accidents and violations than men. Using this past information as a basis of approach, the present study was made in order to determine if the same relationships hold when the additional factors of marital status and car ownership are considered. Instead of asking questions of the form, Do men have~ more accidents than women? , this study was interested in questions such as, Do married men who own automobiles have more accidents than married women who own automobiles?\u27\u27 Essentially the purpose of the present study was to control on two variables which had hitherto been uncontrolled in comparisons of traffic accidents and violations between the sexes. The data which were available for use were such that only a partial answer to the problem could be obtained, but the information which was gathered was a start in this direction and suggested important future research to be done in the area

Purification of Noisy Entanglement and Faithful Teleportation via Noisy Channels

Two separated observers, by applying local operations to a supply of not-too-impure entangled states ({\em e.g.} singlets shared through a noisy channel), can prepare a smaller number of entangled pairs of arbitrarily high purity ({\em e.g.} near-perfect singlets). These can then be used to faithfully teleport unknown quantum states from one observer to the other, thereby achieving faithful transfrom one observer to the other, thereby achieving faithful transmission of quantum information through a noisy channel. We give upper and lower bounds on the yield $D(M)$ of pure singlets ($\ket{\Psi^-}$) distillable from mixed states $M$, showing $D(M)>0$ if \bra{\Psi^-}M\ket{\Psi^-}>\half.Comment: 4 pages (revtex) plus 1 figure (postscript). See also http://vesta.physics.ucla.edu/~smolin/ . Replaced to correct interchanged $\sigma_x$ and $\sigma_z$ near top of column 2, page

Prospectus, October 24, 1979

SURVEY MAKES WAVES; The Week in Review: Across the globe, In the nation, Throughout the state, Around the town, Etc….; Briefs: College to host math contest, Parkland Players present \u27Dracula\u27, Summary of board listed, Champaign council approves bonds, Women\u27s program seeks young blood, Monticello council to discuss tax rate, Program on strokes to be presented, Arthritis program to be presented, Future educators program tomorrow, Nutritionm health, disease are topics, Store celebrates 1st; Letter to editor: Dean congratulates foreigners; Weekly Calendar; Area high schools to visit campus; S.T.O. raffle winners are announced; Give a little blood, then see blood; Women at Home on Tuesday; Editorial: Censorship at WPCD?; PATH raises grievances; Pumpkins and costumes in contest next week; Lincoln Square has art show; Oktoberfest today: a taste of German; Reviews: Ending to the beat has better taste, B-52s: a glimpse of future and past; Classifieds; Music club has enthusiasm; Athletic and rec fields near completion; V-ball gains momentum; Golf team advances to state; Elam blows off competition: harriers 3rd; PC hosts golf, gets 2nd; Fast Freddy loses again; Fast Freddy Contesthttps://spark.parkland.edu/prospectus_1979/1007/thumbnail.jp

Witness and Worship in Pluralistic America

American society in the twenty- first century poses a myriad of challenges for the church as it seeks to be an effective witness to the Gospel of Jesus Christ. Among these challenges is an increasingly pluralistic cultural and religious context.https://scholar.csl.edu/ebooks/1040/thumbnail.jp

Mixed State Entanglement and Quantum Error Correction

Entanglement purification protocols (EPP) and quantum error-correcting codes (QECC) provide two ways of protecting quantum states from interaction with the environment. In an EPP, perfectly entangled pure states are extracted, with some yield D, from a mixed state M shared by two parties; with a QECC, an arbi- trary quantum state $|\xi\rangle$ can be transmitted at some rate Q through a noisy channel $\chi$ without degradation. We prove that an EPP involving one- way classical communication and acting on mixed state $\hat{M}(\chi)$ (obtained by sharing halves of EPR pairs through a channel $\chi$) yields a QECC on $\chi$ with rate $Q=D$, and vice versa. We compare the amount of entanglement E(M) required to prepare a mixed state M by local actions with the amounts $D_1(M)$ and $D_2(M)$ that can be locally distilled from it by EPPs using one- and two-way classical communication respectively, and give an exact expression for $E(M)$ when $M$ is Bell-diagonal. While EPPs require classical communica- tion, QECCs do not, and we prove Q is not increased by adding one-way classical communication. However, both D and Q can be increased by adding two-way com- munication. We show that certain noisy quantum channels, for example a 50% depolarizing channel, can be used for reliable transmission of quantum states if two-way communication is available, but cannot be used if only one-way com- munication is available. We exhibit a family of codes based on universal hash- ing able toachieve an asymptotic $Q$ (or $D$) of 1-S for simple noise models, where S is the error entropy. We also obtain a specific, simple 5-bit single- error-correcting quantum block code. We prove that {\em iff} a QECC results in high fidelity for the case of no error the QECC can be recast into a form where the encoder is the matrix inverse of the decoder.Comment: Resubmission with various corrections and expansions. See also http://vesta.physics.ucla.edu/~smolin/ for related papers and information. 82 pages latex including 19 postscript figures included using psfig macro

High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men

Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a model of random virus evolution has made possible for the first time an unambiguous identification of transmitted/founder viruses and a precise estimation of their numbers. Here, we applied this approach to HIV-1 env analyses in a cohort of acutely infected men who have sex with men (MSM) and found that a high proportion (10 of 28; 36%) had been productively infected by more than one virus. In subjects with multivariant transmission, the minimum number of transmitted viruses ranged from 2 to 10 with viral recombination leading to rapid and extensive genetic shuffling among virus lineages. A combined analysis of these results, together with recently published findings based on identical SGA methods in largely heterosexual (HSX) cohorts, revealed a significantly higher frequency of multivariant transmission in MSM than in HSX [19 of 50 subjects (38%) versus 34 of 175 subjects (19%); Fisher's exact p = 0.008]. To further evaluate the SGA strategy for identifying transmitted/founder viruses, we analyzed 239 overlapping 5′ and 3′ half genome or env-only sequences from plasma viral RNA (vRNA) and blood mononuclear cell DNA in an MSM subject who had a particularly well-documented virus exposure history 3–6 days before symptom onset and 14–17 days before peak plasma viremia (47,600,000 vRNA molecules/ml). All 239 sequences coalesced to a single transmitted/founder virus genome in a time frame consistent with the clinical history, and a molecular clone of this genome encoded replication competent virus in accord with model predictions. Higher multiplicity of HIV-1 infection in MSM compared with HSX is consistent with the demonstrably higher epidemiological risk of virus acquisition in MSM and could indicate a greater challenge for HIV-1 vaccines than previously recognized

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

Genetic variants in intron 1 of the fat mass- and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans. However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI-associated FTO index single nucleotide polymorphisms (SNPs). This is most likely explained by different race-specific linkage disequilibrium (LD) patterns and lower correlation overall in AA, which provides the opportunity to fine-map this region and narrow in on the functional variant. To comprehensively explore the 16q12.2/FTO locus and to search for second independent signals in the broader region, we fine-mapped a 646-kb region, encompassing the large FTO gene and the flanking gene RPGRIP1L by investigating a total of 3,756 variants (1,529 genotyped and 2,227 imputed variants) in 20,488 AAs across five studies. We observed associations between BMI and variants in the known FTO intron 1 locus: the SNP with the most significant p-value, rs56137030 (8.3×10-6) had not been highlighted in previous studies. While rs56137030was correlated at r2>0.5 with 103 SNPs in Europeans (including the GWAS index SNPs), this number was reduced to 28 SNPs in AA. Among rs56137030 and the 28 correlated SNPs, six were located within candidate intronic regulatory elements, including rs1421085, for which we predicted allele-specific binding affinity for the transcription factor CUX1, which has recently been implicated in the regulation of FTO. We did not find strong evidence for a second independent signal in the broader region. In summary, this large fine-mapping study in AA has substantially reduced the number of common alleles that are likely to be functional candidates of the known FTO locus. Importantly our study demonstrated that comprehensive fine-mapping in AA provides a powerful approach to narrow in on the functional candidate(s) underlying the initial GWAS findings in European populations

Measuring the Higgs Sector

If we find a light Higgs boson at the LHC, there should be many observable channels which we can exploit to measure the relevant parameters in the Higgs sector. We use the SFitter framework to map these measurements on the parameter space of a general weak-scale effective theory with a light Higgs state of mass 120 GeV. Our analysis benefits from the parameter determination tools and the error treatment used in new--physics searches, to study individual parameters and their error bars as well as parameter correlations.Comment: 45 pages, Journal version with comments from refere

African American patients with gout: efficacy and safety of febuxostat vs allopurinol

<p>Abstract</p> <p>Background</p> <p>African Americans are twice as likely as Caucasians to develop gout, but they are less likely to be treated with urate-lowering therapy (ULT). Furthermore, African Americans typically present with more comorbidities associated with gout, such as hypertension, obesity, and renal impairment. We determined the efficacy and safety of ULT with febuxostat or allopurinol in African American subjects with gout and associated comorbidities and in comparison to Caucasian gout subjects.</p> <p>Methods</p> <p>This is a secondary analysis of the 6-month Phase 3 CONFIRMS trial. Eligible gouty subjects with baseline serum urate (sUA) ≥ 8.0 mg/dL were randomized 1:1:1 to receive febuxostat 40 mg, febuxostat 80 mg, or allopurinol (300 mg or 200 mg depending on renal function) daily. All subjects received gout flare prophylaxis. Primary efficacy endpoint was the proportion of subjects in each treatment group with sUA < 6.0 mg/dL at the final visit. Additional endpoints included the proportion of subjects with mild or with moderate renal impairment who achieved a target sUA < 6.0 mg/dL at final visit. Adverse events (AEs) were recorded throughout the study.</p> <p>Results</p> <p>Of the 2,269 subjects enrolled, 10.0% were African American and 82.1% were Caucasian. African American subjects were mostly male (89.5%), obese (BMI ≥ 30 kg/m²; 67.1%), with mean baseline sUA of 9.8 mg/dL and mean duration of gout of 10.4 years. The proportions of African American subjects with a baseline history of diabetes, renal impairment, or cardiovascular disease were significantly higher compared to Caucasians (<it>p </it>< 0.001). ULT with febuxostat 80 mg was superior to both febuxostat 40 mg (<it>p </it>< 0.001) and allopurinol (<it>p </it>= 0.004). Febuxostat 40 mg was comparable in efficacy to allopurinol. Significantly more African American subjects with mild or moderate renal impairment achieved sUA < 6.0 mg/dL in the febuxostat 80 group than in either the febuxostat 40 mg or allopurinol group (<it>p </it>< 0.05). Efficacy rates in all treatment groups regardless of renal function were comparable between African American and Caucasian subjects, as were AE rates.</p> <p>Conclusions</p> <p>In African American subjects with significant comorbidities, febuxostat 80 mg is significantly more efficacious than either febuxostat 40 mg or allopurinol 200/300 mg. Febuxostat was well tolerated in this African American population.</p> <p>Please see related article: <url>http://www.biomedcentral.com/1741-7015/10/15</url></p

Measurement of Exclusive π0\pi^0 Electroproduction Structure Functions and their Relationship to Transversity GPDs

Exclusive $\pi^0$ electroproduction at a beam energy of 5.75 GeV has been measured with the Jefferson Lab CLAS spectrometer. Differential cross sections were measured at more than 1800 kinematic values in $Q^2$, $x_B$, $t$, and $\phi_\pi$, in the $Q^2$ range from 1.0 to 4.6 GeV$^2$,\ $-t$ up to 2 GeV$^2$, and $x_B$ from 0.1 to 0.58. Structure functions $\sigma_T +\epsilon \sigma_L, \sigma_{TT}$ and $\sigma_{LT}$ were extracted as functions of $t$ for each of 17 combinations of $Q^2$ and $x_B$. The data were compared directly with two handbag-based calculations including both longitudinal and transversity GPDs. Inclusion of only longitudinal GPDs very strongly underestimates $\sigma_T +\epsilon \sigma_L$ and fails to account for $\sigma_{TT}$ and $\sigma_{LT}$, while inclusion of transversity GPDs brings the calculations into substantially better agreement with the data. There is very strong sensitivity to the relative contributions of nucleon helicity flip and helicity non-flip processes. The results confirm that exclusive $\pi^0$ electroproduction offers direct experimental access to the transversity GPDs.Comment: 6 pages, 2 figure