836 research outputs found
A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F 20 into the treatment paradigm for patients with knee osteoarthritis (Part 2 of 2): economic results
AbstractObjective Viscosupplementation with hylan G-F 20 has recently become registered for treatment of patients with osteoarthritis (OA) of the knee in most parts of the world. The cost effectiveness and cost utility of this new therapeutic modality were determined as part of a Canadian prospective, randomized, 1-year, open-label, multicentered trial.Design A total of 255 patients were randomized to ‘Appropriate care with hylan G-F 20’ (AC+H) or ‘Appropriate care without hylan G-F 20’ (AC). Costs (1999 Canadian dollars) were collected from the societal viewpoint and included all costs related to OA of the knee and OA in all joints. Patients completed a number of outcomes questionnaires including the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Health Utilities Index Mark 3 (HUI3). Data were collected at clinic visits (baseline, 12 months) and by telephone (1, 2, 4, 6, 8, 10, and 12 months).Results The AC+H group over the year had higher costs (1415=2505/patient improved. The incremental cost–utility ratio was $10000/QALY gained. Sensitivity analyses and a second cost perspective gave similar results.Conclusion The cost–utility ratio is below the suggested Canadian adoption threshold. The results provide strong evidence for adoption of treatment with hylan G-F 20 in the patients and settings studied in the trial. Copyright 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved
Determinant representation for some transition probabilities in the TASEP with second class particles
We study the transition probabilities for the totally asymmetric simple
exclusion process (TASEP) on the infinite integer lattice with a finite, but
arbitrary number of first and second class particles. Using the Bethe ansatz we
present an explicit expression of these quantities in terms of the Bethe wave
function. In a next step it is proved rigorously that this expression can be
written in a compact determinantal form for the case where the order of the
first and second class particles does not change in time. An independent
geometrical approach provides insight into these results and enables us to
generalize the determinantal solution to the multi-class TASEP.Comment: Minor revision; journal reference adde
Optimal Hypercontractivity for Fermi Fields and Related Non-Commutative Integration
Optimal hypercontractivity bounds for the fermion oscillator semigroup are
obtained. These are the fermion analogs of the optimal hypercontractivity
bounds for the boson oscillator semigroup obtained by Nelson. In the process,
several results of independent interest in the theory of non-commutative
integration are established. {}.Comment: 18 p., princeton/ecel/7-12-9
Dual Doping of MoP with M Mn,Fe and S to Achieve High Hydrogen Evolution Reaction Activity in Both Acidic and Alkaline Media
Rational design of cost effective, high performance and stable hydrogen evolution reaction HER electrocatalysts in both acidic and alkaline media holds the key to the future hydrogen based economy. Herein, we introduce an effective approach of simultaneous non metal S and metal Fe or Mn doping of MoP to achieve excellent HER performance at different pH. The catalysts show remarkable overpotentials at 10 mA cm 2 of only 65 and 68 mV in 0.5 M H2SO4, and 50 and 51 mV in 1.0 M KOH, respectively, as well as much higher turnover frequencies compared to undoped MoP. Furthermore, the catalysts exhibit outstanding long term stability at a fixed current of 10 mA cm 2 for 40 h. The effects of both dopants, such as electronic structure modification and enhancement of the intrinsic activity, increase of the electrochemically active surface area, and formation of coordinatively unsaturated edge sites, act cooperatively to accelerate the HER at both pH media. Additionally, the presence of oxophilic Mn and Fe at the surface results in Mn or Fe oxide hydroxide species that promote the dissociation of water molecules in alkaline electrolyte. This work introduces a facile and effective design principle that could pave the way towards engineering highly active HER catalysts for a wide pH range
Critical exponents of a multicomponent anisotropic t-J model in one dimension
A recently presented anisotropic generalization of the multicomponent
supersymmetric model in one dimension is investigated. This model of
fermions with general spin- is solved by Bethe ansatz for the ground state
and the low-lying excitations. Due to the anisotropy of the interaction the
model possesses massive modes and one single gapless excitation. The
physical properties indicate the existence of Cooper-type multiplets of
fermions with finite binding energy. The critical behaviour is described by a
conformal field theory with continuously varying exponents depending on
the particle density. There are two distinct regimes of the phase diagram with
dominating density-density and multiplet-multiplet correlations, respectively.
The effective mass of the charge carriers is calculated. In comparison to the
limit of isotropic interactions the mass is strongly enhanced in general.Comment: 10 pages, 3 Postscript figures appended as uuencoded compressed
tar-file to appear in Z. Phys. B, preprint Cologne-94-474
Influence of thermal fluctuations on quantum phase transitions in one-dimensional disordered systems: Charge density waves and Luttinger liquids
The low temperature phase diagram of 1D weakly disordered quantum systems
like charge or spin density waves and Luttinger liquids is studied by a
\emph{full finite temperature} renormalization group (RG) calculation. For
vanishing quantum fluctuations this approach is amended by an \emph{exact}
solution in the case of strong disorder and by a mapping onto the \emph{Burgers
equation with noise} in the case of weak disorder, respectively. At \emph{zero}
temperature we reproduce the quantum phase transition between a pinned
(localized) and an unpinned (delocalized) phase for weak and strong quantum
fluctuations, respectively, as found previously by Fukuyama or Giamarchi and
Schulz.
At \emph{finite} temperatures the localization transition is suppressed: the
random potential is wiped out by thermal fluctuations on length scales larger
than the thermal de Broglie wave length of the phason excitations. The
existence of a zero temperature transition is reflected in a rich cross-over
phase diagram of the correlation functions. In particular we find four
different scaling regions: a \emph{classical disordered}, a \emph{quantum
disordered}, a \emph{quantum critical} and a \emph{thermal} region. The results
can be transferred directly to the discussion of the influence of disorder in
superfluids. Finally we extend the RG calculation to the treatment of a
commensurate lattice potential. Applications to related systems are discussed
as well.Comment: 19 pages, 7 figure
Onset of magnetism in B2 transition metals aluminides
Ab initio calculation results for the electronic structure of disordered bcc
Fe(x)Al(1-x) (0.4<x<0.75), Co(x)Al(1-x) and Ni(x)Al(1-x) (x=0.4; 0.5; 0.6)
alloys near the 1:1 stoichiometry, as well as of the ordered B2 (FeAl, CoAl,
NiAl) phases with point defects are presented. The calculations were performed
using the coherent potential approximation within the Korringa-Kohn-Rostoker
method (KKR-CPA) for the disordered case and the tight-binding linear
muffin-tin orbital (TB-LMTO) method for the intermetallic compounds. We studied
in particular the onset of magnetism in Fe-Al and Co-Al systems as a function
of the defect structure. We found the appearance of large local magnetic
moments associated with the transition metal (TM) antisite defect in FeAl and
CoAl compounds, in agreement with the experimental findings. Moreover, we found
that any vacancies on both sublattices enhance the magnetic moments via
reducing the charge transfer to a TM atom. Disordered Fe-Al alloys are
ferromagnetically ordered for the whole range of composition studied, whereas
Co-Al becomes magnetic only for Co concentration >0.5.Comment: 11 pages with 9 embedded postscript figures, to be published in
Phys.Rev.
Endogenous Risks and Learning in Climate Change Decision Analysis
We analyze the effects of risks and learning on climate change decisions. A two-stage, dynamic, climate change stabilization problem is formulated. The explicit incorporation of ex-post learning induces risk aversion among ex-ante decisions, which is characterized in linear models by VaR- and CVaR-type risk measures. Combined with explicit introduction of "safety" constraints, it creates a "hit-or-miss" type decision-making situation and shows that, even in linear models, learning may lead to either less-or more restrictive ex-ante emission reductions. We analyze stylized elements of the model in order to identify the key factors driving outcomes, in particular, the critical role of quantiles of probability distributions characterizing key uncertainties
Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: a 31P MRS study
Background: Impaired homeostasis of hepatic ATP has been associated with NAFLD. An intravenous fructose infusion has been shown to be an effective challenge to monitor the depletion and subsequent recovery of hepatic ATP reserves using 31P MRS.
Aims: The purpose of this study was to evaluate the effects of an oral rather than intravenous fructose challenge on hepatic ATP reserves in healthy subjects.
Methods: Self-reported healthy males were recruited. Following an overnight fast, baseline liver glycogen and lipid levels were measured using Magnetic Resonance Spectroscopy (MRS). Immediately after consuming a 500 ml 75 g fructose drink (1275 kJ) subjects were scanned continuously for 90 min to acquire dynamic 31P MRS measurements of liver ATP reserves.
Results: A significant effect on ATP reserves was observed across the time course (P < 0.05). Mean ATP levels reached a minimum at 50 min which was markedly lower than baseline (80 ± 17% baseline, P < 0.05). Subsequently, mean values tended to rise but did not reach statistical significance above minimum. The time to minimum ATP levels across subjects was negatively correlated with BMI (R2 ¼ 0.74, P < 0.005). Rates of ATP recovery were not significantly correlated with BMI or liver fat levels, but were negatively correlated with baseline glycogen levels (R2 ¼ 0.7, P < 0.05).
Conclusions: Depletion of ATP reserves can be measured non-invasively following an oral fructose challenge using 31P
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