Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice

Objective—Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors. Endothelial expression of adhesion molecules that enable infiltration of immune cells is important for lesion development. Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31) is an adhesion and signaling receptor expressed by many cells involved in atherosclerotic lesion development. PECAM-1 transduces signals required for proinflammatory adhesion molecule expression at atherosusceptible sites; thus, it is predicted to be proatherosclerotic. PECAM-1 also inhibits inflammatory responses, on which basis it is predicted to be atheroprotective. Methods and Results—We evaluated herein the effect of PECAM-1 deficiency on development of atherosclerosis in LDL receptor– deficient mice. We found that PECAM-1 has both proatherosclerotic and atheroprotective effects, but that the former dominate in the inner curvature of the aortic arch whereas the latter dominate in the aortic sinus, branching arteries, and descending aorta. Endothelial cell expression of PECAM-1 was sufficient for its atheroprotective effects in the aortic sinus but not in the descending aorta, where the atheroprotective effects of PECAM-1 also required its expression on bone marrow–derived cells. Conclusion—We conclude that PECAM-1 influences initiation and progression of atherosclerosis both positively and negatively, and that it does so in a site-specific manner. (Arterioscler Thromb Vasc Biol. 2008;28:1996-2002

It's about time: Investing in transportation to keep Texas economically competitive - Appendices

APPENDIX A : PAVEMENT QUALITY (Zhanmin Zhang, Michael R. Murphy, Robert Harrison), 7 pages -- APPENDIX B : BRIDGE QUALITY (Jose Weissmann, Angela J. Weissmann), 6 pages -- APPENDIX C : URBAN TRAFFIC CONGESTION (Tim Lomax, David Schrank), 32 pages -- APPENDIX D: RURAL CORRIDORS (Tim Lomax, David Schrank), 6 pages -- APPENDIX E: ADDITIONAL REVENUE SOURCE OPTIONS FOR PAVEMENT AND BRIDGE MAINTENANCE (Mike Murphy, Seokho Chi, Randy Machemehl, Khali Persad, Robert Harrison, Zhanmin Zhang), 81 pages -- APPENDIX F: FUNDING TRANSPORTATION IMPROVEMENTS (David Ellis, Brianne Glover, Nick Norboge, Wally Crittenden), 19 pages -- APPENDIX G: ESTIMATING VEHICLE OPERATING COSTS AND PAVEMENT DETERIORATION (by Robert Harrison), 4 page

Hate speech and the normative foundations of regulation

OA Monitor ExerciseOA Monitor ExerciseOA Monitor ExerciseRacist incidents on American university campuses in the 1980s triggered a storm of publications by scholars who coined the phrase ‘hate speech’ for the legal lexicon. Some of the offences had already been subject to legal or institutional penalties for harassment or vandalism. Several universities nevertheless adopted broad codes of conduct to penalise hateful expression. For two decades, however, the US Supreme Court had been marching in the opposite direction. It was interpreting the Constitution's First Amendment to prevent federal or state government from punishing speakers solely on grounds of the viewpoints they expres

Ciguatera Fish Poisoning: Treatment, Prevention and Management

Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world, and it causes substantial physical and functional impact. It produces a myriad of gastrointestinal, neurologic and/or cardiovascular symptoms which last days to weeks, or even months. Although there are reports of symptom amelioration with some interventions (e.g. IV mannitol), the appropriate treatment for CFP remains unclear to many physicians. We review the literature on the treatments for CFP, including randomized controlled studies and anecdotal reports. The article is intended to clarify treatment options, and provide information about management and prevention of CFP, for emergency room physicians, poison control information providers, other health care providers, and patients

Absolute Radiometric Calibration of TerraSAR-X - Approach and Ground Targets

The German SAR satellite TerraSAR-X was successfully launched in June 2007. During the commissioning phase, the first months after launch, a calibration field campaign was carried out to conduct geometric as well as relative and absolute radiometric calibration. This was necessary to prepare the satellite for scientific and commercial use. This paper addresses results concerning the absolute radiometric accuracy and the reference ground targets involved. The two types of utilized ground targets were trihedral corner reflectors and active transponders. It will be shown that an absolute radiometric accuracy of much better than 1 dB can be achieved using both types of targets

It's about time : investing in transportation to keep Texas economically competitive

This current report, It’s About Time: Investing in Transportation to Keep Texas Economically Competitive, updates the February 2009 report by providing an enhanced analysis of the current state of the Texas transportation system, determining the household costs of under-investing in the system and identifying potential revenue options for funding the system. However, the general conclusion has not changed. There are tremendous needs and high costs associated with “doing nothing new.

Adenosine Conversion of Supraventricular Tachycardia Associated with High-Dose Epinephrine Therapy for Cardiac Arrest

Adenosine has received wide acceptance as the drug of choice for initial treatment of supraventricular tachycardias (supraventricular tachycardia), and as a diagnostic adjunct in hemodynamically stable, wide-complex tachycardias. This report describes the successful use of adenosine for the treatment of supraventricular tachycardia occurring after successful initial resuscitation from ventricular fibrillation, in which a high dose of the epinephrine protocol was used

A SPARK-GAP TRIGGER SYSTEM

The construction and operation of a trigger system designed to fire a 30-kV 5000 A spark gap with a minimum delay following the arrival of a small signal pulse is described. In this particular experiment a 150-MeV/c muon is detected with scintillators on three 6199 phototubes, and the output pulse of the attached tunnel-diode triple-coincidence circuit is amplified and used to trigger the gap. Approximately 32 nanoseconds are needed from passage of the muon to the coincidence output, and approximately 25 nanoseconds are required from the coincidence output to the time of complete breakdown of the gap. These delays represent the shortest times that we could achieve with the particular boundary conditions under which the circuit had to operate. Sufficient detail is given to show how additional savings of nanoseconds could be made under different operating conditions