On Being Degraded in Public Space: An Autoethnography

In the form of an autoethnography, the author analyzes a violent attack he suffered in public and discusses how the incident relates to a degradation ceremony. The author explains why the incident did not meet the required conditions of a successful degradation ceremony and defines a concept called degradation incident. Like a degradation ceremony, a person who experiences a degradation incident is perceived by the public as lower in the local scheme of social types. Unlike a degradation ceremony, transformation of ones total identity is not a required outcome of a degradation incident. The significance of being degraded in public without experiencing a transformation of total identity is discussed

Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data

People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymorphic locus. However the number of infections may not be accurately counted since parasites from multiple infections may carry the same allele. We use simulation to determine the circumstances under which the number of observed genotypes are likely to be substantially less than the number of infections present and investigate the performance of two methods for estimating the numbers of infections from high-resolution genotyping data.THE SIMULATIONS SUGGEST THAT THE PROBLEM IS NOT SUBSTANTIAL IN MOST DATASETS: the disparity between the mean numbers of infections and of observed genotypes was small when there was 20 or more alleles, 20 or more blood samples, a mean number of infections of 6 or less and where the frequency of the most common allele was no greater than 20%. The issue of multiple infections carrying the same allele is unlikely to be a major component of the errors in PCR-based genotyping.Simulations also showed that, with heterogeneity in allele frequencies, the observed frequencies are not a good approximation of the true allele frequencies. The first method that we proposed to estimate the numbers of infections assumes that they are a good approximation and hence did poorly in the presence of heterogeneity. In contrast, the second method by Li et al estimates both the numbers of infections and the true allele frequencies simultaneously and produced accurate estimates of the mean number of infections

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells.

The nucleus pulposus (NP) of intervertebral discs experiences dynamic changes in tissue osmolarity because of diurnal loading of the spine. TonEBP/NFAT5 is a transcription factor that is critical in osmoregulation as well as survival of NP cells in the hyperosmotic milieu. The goal of this study was to investigate whether cyclooxygenase-2 (COX-2) expression is osmoresponsive and dependent on TonEBP, and whether it serves an osmoprotective role. NP cells up-regulated COX-2 expression in hyperosmotic media. The induction of COX-2 depended on elevation of intracellular calcium levels and p38 MAPK pathway, but independent of calcineurin signaling as well as MEK/ERK and JNK pathways. Under hyperosmotic conditions, both COX-2 mRNA stability and its proximal promoter activity were increased. The proximal COX-2 promoter (-1840/+123 bp) contained predicted binding sites for TonEBP, AP-1, NF-κB, and C/EBP-β. While COX-2 promoter activity was positively regulated by both AP-1 and NF-κB, AP-1 had no effect and NF-κB negatively regulated COX-2 protein levels under hyperosmotic conditions. On the other hand, TonEBP was necessary for both COX-2 promoter activity and protein up-regulation in response to hyperosmotic stimuli

Speech Activists in Shopping Centers: Must Property Rights Give Way to Free Expression?

The United States Constitution does not require shopping center owners to allow speech activists to engage in expressive activities on shopping center property. The Supreme Court has authorized states to provide greater protections f6r expressive activities than the Constitution provides. Six state supreme courts have interpreted the constitutions of their states to limit protections to the scope of the United States Constitution. Three state supreme courts have interpreted their constitutions to mandate accommodation of speech activists on private shopping center property. This Comment analyzes the treatment of the shopping center conflict both in the United States Supreme Court and in state courts. The Comment concludes that state authority should be reassessed in view of recent Supreme Court decisions that any taking of property from one private party for use by another is a taking requiring compensation under the United States Constitution

Optimal Mechanisms for Consumer Surplus Maximization

We consider the problem of designing auctions which maximize consumer surplus (i.e., the social welfare minus the payments charged to the buyers). In the consumer surplus maximization problem, a seller with a set of goods faces a set of strategic buyers with private values, each of whom aims to maximize their own individual utility. The seller, in contrast, aims to allocate the goods in a way which maximizes the total buyer utility. The seller must then elicit the values of the buyers in order to decide what goods to award each buyer. The canonical approach in mechanism design to ensure truthful reporting of the private information is to find appropriate prices to charge each buyer in order to align their objective with the objective of the seller. Indeed, there are many celebrated results to this end when the seller's objective is welfare maximization [Clarke, 1971, Groves, 1973, Vickrey, 1961] or revenue maximization [Myerson, 1981]. However, in the case of consumer surplus maximization the picture is less clear -- using high payments to ensure the highest value bidders are served necessarily decreases their surplus utility, but using low payments may lead the seller into serving lower value bidders. Our main result in this paper is a framework for designing mechanisms which maximize consumer surplus. We instantiate our framework in a variety of canonical multi-parameter auction settings (i.e., unit-demand bidders with heterogeneous items, multi-unit auctions, and auctions with divisible goods) and use it to design auctions achieving consumer surplus with optimal approximation guarantees against the total social welfare. Along the way, we answer an open question posed by Hartline and Roughgarden [2008], who, to our knowledge, were the first to study the question of consumer surplus approximation guarantees in single-parameter settings, regarding optimal mechanisms for two bidders

City of Granite Falls Planning Department Internship

This past spring and summer, I have taken part in an internship with the City of Granite Falls, working in the planning department. I have taken 5 internship credits throughout the spring and summer quarters, as well as having been paid for my work over the summer. The primary focus of the internship was assisng the City with their comprehensive plan update, which is due in December of 2024. I worked on updang the Housing Element and Climate Change secon of the City’s comprehensive plan and draing updates to the municipal code. With Granite Falls being a small town with a one-person planning department, I primarily worked independently on my various projects

Achieving Proportionality up to the Maximin Item with Indivisible Goods

We study the problem of fairly allocating indivisible goods and focus on the classic fairness notion of proportionality. The indivisibility of the goods is long known to pose highly non-trivial obstacles to achieving fairness, and a very vibrant line of research has aimed to circumvent them using appropriate notions of approximate fairness. Recent work has established that even approximate versions of proportionality (PROPx) may be impossible to achieve even for small instances, while the best known achievable approximations (PROP1) are much weaker. We introduce the notion of proportionality up to the maximin item (PROPm) and show how to reach an allocation satisfying this notion for any instance involving up to five agents with additive valuations. PROPm provides a well-motivated middle-ground between PROP1 and PROPx, while also capturing some elements of the well-studied maximin share (MMS) benchmark: another relaxation of proportionality that has attracted a lot of attention.Comment: Changes to wording throughout and changes to framing of section