6,798 research outputs found
Quantitative Chevalley-Weil theorem for curves
The classical Chevalley-Weil theorem asserts that for an \'etale covering of
projective varieties over a number field K, the discriminant of the field of
definition of the fiber over a K-rational point is uniformly bounded. We obtain
a fully explicit version of this theorem in dimension 1.Comment: version 4: minor inaccuracies in Lemma 3.4 and Proposition 5.2
correcte
The tetralogy of Birkhoff theorems
We classify the existent Birkhoff-type theorems into four classes: First, in
field theory, the theorem states the absence of helicity 0- and spin 0-parts of
the gravitational field. Second, in relativistic astrophysics, it is the
statement that the gravitational far-field of a spherically symmetric star
carries, apart from its mass, no information about the star; therefore, a
radially oscillating star has a static gravitational far-field. Third, in
mathematical physics, Birkhoff's theorem reads: up to singular exceptions of
measure zero, the spherically symmetric solutions of Einstein's vacuum field
equation with Lambda = 0 can be expressed by the Schwarzschild metric; for
Lambda unequal 0, it is the Schwarzschild-de Sitter metric instead. Fourth, in
differential geometry, any statement of the type: every member of a family of
pseudo-Riemannian space-times has more isometries than expected from the
original metric ansatz, carries the name Birkhoff-type theorem. Within the
fourth of these classes we present some new results with further values of
dimension and signature of the related spaces; including them are some
counterexamples: families of space-times where no Birkhoff-type theorem is
valid. These counterexamples further confirm the conjecture, that the
Birkhoff-type theorems have their origin in the property, that the two
eigenvalues of the Ricci tensor of two-dimensional pseudo-Riemannian spaces
always coincide, a property not having an analogy in higher dimensions. Hence,
Birkhoff-type theorems exist only for those physical situations which are
reducible to two dimensions.Comment: 26 pages, updated references, minor text changes, accepted by Gen.
Relat. Gra
Geodesic equations and algebro-geometric methods
For an investigation of the physical properties of gravitational fields the
observation of massive test particles and light is very useful. The
characteristic features of a given space-time may be decoded by studying the
complete set of all possible geodesic motions. Such a thorough analysis can be
accomplished most effectively by using analytical methods to solve the geodesic
equation. In this contribution, the use of elliptic functions and their
generalizations for solving the geodesic equation in a wide range of well known
space-times, which are part of the general Pleba\'nski-Demia\'nski family of
solutions, will be presented. In addition, the definition and calculation of
observable effects like the perihelion shift will be presented and further
applications of the presented methods will be outlined.Comment: 8 pages, no figures; based on presentation at the conference
"Relativity and Gravitation: 100 Years after Einstein in Prague," Prague,
2012. Relativity and Gravitation, volume 157 of Springer Proceedings in
Physics, p 91. Springer International Publishing, 201
Spotting the diffusion of New Psychoactive Substances over the Internet
Online availability and diffusion of New Psychoactive Substances (NPS)
represent an emerging threat to healthcare systems. In this work, we analyse
drugs forums, online shops, and Twitter. By mining the data from these sources,
it is possible to understand the dynamics of drugs diffusion and their
endorsement, as well as timely detecting new substances. We propose a set of
visual analytics tools to support analysts in tackling NPS spreading and
provide a better insight about drugs market and analysis
Gestational diabetes and pregnancy outcomes - a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria
<p>Abstract</p> <p>Background</p> <p>Two criteria based on a 2 h 75 g OGTT are being used for the diagnosis of gestational diabetes (GDM), those recommended over the years by the World Health Organization (WHO), and those recently recommended by the International Association for Diabetes in Pregnancy Study Group (IADPSG), the latter generated in the HAPO study and based on pregnancy outcomes. Our aim is to systematically review the evidence for the associations between GDM (according to these criteria) and adverse outcomes.</p> <p>Methods</p> <p>We searched relevant studies in MEDLINE, EMBASE, LILACS, the Cochrane Library, CINHAL, WHO-Afro library, IMSEAR, EMCAT, IMEMR and WPRIM. We included cohort studies permitting the evaluation of GDM diagnosed by WHO and or IADPSG criteria against adverse maternal and perinatal outcomes in untreated women. Only studies with universal application of a 75 g OGTT were included. Relative risks (RRs) and their 95% confidence intervals (CI) were obtained for each study. We combined study results using a random-effects model. Inconsistency across studies was defined by an inconsistency index (I<sup>2</sup>) > 50%.</p> <p>Results</p> <p>Data were extracted from eight studies, totaling 44,829 women. Greater risk of adverse outcomes was observed for both diagnostic criteria. When using the WHO criteria, consistent associations were seen for macrosomia (RR = 1.81; 95%CI 1.47-2.22; p < 0.001); large for gestational age (RR = 1.53; 95%CI 1.39-1.69; p < 0.001); perinatal mortality (RR = 1.55; 95% CI 0.88-2.73; p = 0.13); preeclampsia (RR = 1.69; 95%CI 1.31-2.18; p < 0.001); and cesarean delivery (RR = 1.37;95%CI 1.24-1.51; p < 0.001). Less data were available for the IADPSG criteria, and associations were inconsistent across studies (I<sup>2 </sup>≥ 73%). Magnitudes of RRs and their 95%CIs were 1.73 (1.28-2.35; p = 0.001) for large for gestational age; 1.71 (1.38-2.13; p < 0.001) for preeclampsia; and 1.23 (1.01-1.51; p = 0.04) for cesarean delivery. Excluding either the HAPO or the EBDG studies minimally altered these associations, but the RRs seen for the IADPSG criteria were reduced after excluding HAPO.</p> <p>Conclusions</p> <p>The WHO and the IADPSG criteria for GDM identified women at a small increased risk for adverse pregnancy outcomes. Associations were of similar magnitude for both criteria. However, high inconsistency was seen for those with the IADPSG criteria. Full evaluation of the latter in settings other than HAPO requires additional studies.</p
Serbian KINDL questionnaire for quality of life assessments in healthy children and adolescents: reproducibility and construct validity
<p>Abstract</p> <p>Background</p> <p>The KINDL questionnaire is frequently used to evaluate quality of life (QOL) and the impacts of health conditions on children's everyday living. The objectives of this study were to assess the reproducibility and construct validity of the Serbian KINDL for QOL assessments in healthy children and adolescents.</p> <p>Methods</p> <p>Five hundred and sixty-four healthy children and adolescents completed the KINDL. Reproducibility was analyzed using the intraclass correlation coefficient (ICC). Confirmatory factor analysis (CFA) was performed to assess the structure of the KINDL construct validity.</p> <p>Results</p> <p>The intraclass correlation coefficients ranged from 0.03 to 0.84 for the subscales and total score. A second order CFA model as originally hypothesized was tested: items (24), primary factors (six subscales), and one secondary factor (QOL). The fit indexes derived from a CFA failed to yield appropriate fit between the data and the hypothesized model.</p> <p>Conclusion</p> <p>Majority of the subscales and total KINDL possess appropriate reproducibility for group comparisons. However, a CFA failed to confirm the structure of the original measurement model, indicating that the Serbian version should be revised before wider use for QOL assessments in healthy children and adolescent.</p
Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) - Leptin and incident type 2 diabetes: Risk or protection? Diabetologia 49 : 2086-2096
Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B
Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa. During parasite replication the IMC is formed de novo within the mother cell in a process described as internal budding. We hypothesized that an alveolate specific factor is involved in the specific transport of vesicles from the Golgi to the IMC and identified the small GTPase Rab11B as an alveolate specific Rab-GTPase that localises to the growing end of the IMC during replication of Toxoplasma gondii. Conditional interference with Rab11B function leads to a profound defect in IMC biogenesis, indicating that Rab11B is required for the transport of Golgi derived vesicles to the nascent IMC of the daughter cell. Curiously, a block in IMC biogenesis did not affect formation of sub-pellicular microtubules, indicating that IMC biogenesis and formation of sub-pellicular microtubules is not mechanistically linked. We propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature IMC of the growing daughter parasites
Assembling proteomics data as a prerequisite for the analysis of large scale experiments
<p>Abstract</p> <p>Background</p> <p>Despite the complete determination of the genome sequence of a huge number of bacteria, their proteomes remain relatively poorly defined. Beside new methods to increase the number of identified proteins new database applications are necessary to store and present results of large- scale proteomics experiments.</p> <p>Results</p> <p>In the present study, a database concept has been developed to address these issues and to offer complete information via a web interface. In our concept, the Oracle based data repository system SQL-LIMS plays the central role in the proteomics workflow and was applied to the proteomes of <it>Mycobacterium tuberculosis</it>, <it>Helicobacter pylori</it>, <it>Salmonella typhimurium </it>and protein complexes such as 20S proteasome. Technical operations of our proteomics labs were used as the standard for SQL-LIMS template creation. By means of a Java based data parser, post-processed data of different approaches, such as LC/ESI-MS, MALDI-MS and 2-D gel electrophoresis (2-DE), were stored in SQL-LIMS. A minimum set of the proteomics data were transferred in our public 2D-PAGE database using a Java based interface (Data Transfer Tool) with the requirements of the PEDRo standardization. Furthermore, the stored proteomics data were extractable out of SQL-LIMS via XML.</p> <p>Conclusion</p> <p>The Oracle based data repository system SQL-LIMS played the central role in the proteomics workflow concept. Technical operations of our proteomics labs were used as standards for SQL-LIMS templates. Using a Java based parser, post-processed data of different approaches such as LC/ESI-MS, MALDI-MS and 1-DE and 2-DE were stored in SQL-LIMS. Thus, unique data formats of different instruments were unified and stored in SQL-LIMS tables. Moreover, a unique submission identifier allowed fast access to all experimental data. This was the main advantage compared to multi software solutions, especially if personnel fluctuations are high. Moreover, large scale and high-throughput experiments must be managed in a comprehensive repository system such as SQL-LIMS, to query results in a systematic manner. On the other hand, these database systems are expensive and require at least one full time administrator and specialized lab manager. Moreover, the high technical dynamics in proteomics may cause problems to adjust new data formats. To summarize, SQL-LIMS met the requirements of proteomics data handling especially in skilled processes such as gel-electrophoresis or mass spectrometry and fulfilled the PSI standardization criteria. The data transfer into a public domain via DTT facilitated validation of proteomics data. Additionally, evaluation of mass spectra by post-processing using MS-Screener improved the reliability of mass analysis and prevented storage of data junk.</p
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