Consistency check of planned adaptive option on helical tomotherapy.

This study aims to evaluate a new Planned Adaptive software (TomoTherapy Inc., Madison, WI) of the helical tomotherapy system by retrospective verification and adaptive re-planning of radiation treatment. Four patients with different disease sites (brain, nasal cavity, lungs, prostate) were planned in duplicate using the diagnostic planning kVCT data set and MVCT studies of the first treatment fraction with the same optimization parameters for both plan types. The dosimetric characteristics of minimum, maximum, and mean dose to the targets as well as to organs at risk were compared. Both sets of plans were used for calculation of dose distributions in a water-equivalent phantom. Corresponding measurements of these plans in phantom were carried out with the use of radiographic film and ion chamber. In the case of the lung and prostate cancer patients, changes in dosimetric parameters compared to data generated with the kVCT study alone were less than 2%. Certain changes for the nasal cavity and brain cancer patients were greater than 2%, but they were explained in part by anatomy changes that occurred during the time between kVCT and MVCT studies. The Planned Adaptive software allows for adaptive radiotherapy planning using the MVCT studies obtained by the helical tomotherapy imaging system

Steering the Field Quality in the Production of the Main Quadrupoles of the Large Hadron Collider

The main issues concerning the field quality in the main quadrupoles of the Large Hadron Collider are presented. We show the trend plots for the focusing strength and multipoles at room temperature covering more than 2/3 of the production. We describe the correction of the coil layout to improve b6 at injection field level. A non-negligible fraction of the quadrupoles has been manufactured with collars featuring a magnetic permeability somewhat higher than the specified limits. We show plots for this anomaly. Field quality correlations to measurements in operational conditions are discussed. The dependence of field quality on cable manufacturer is analyse

Insights into gas heating and cooling in the disc of NGC 891 from Herschel far-infrared spectroscopy

We present Herschel PACS and SPIRE spectroscopy of the most important far-infrared cooling lines in the nearby edge-on spiral galaxy, NGC 891: [CII] 158 $\mu$m, [NII] 122, 205 $\mu$m, [OI] 63, 145 $\mu$m, and [OIII] 88 $\mu$m. We find that the photoelectric heating efficiency of the gas, traced via the ([CII]+[OII]63)/$F_{\mathrm{TIR}}$ ratio, varies from a mean of 3.5$\times$10$^{-3}$ in the centre up to 8$\times$10$^{-3}$ at increasing radial and vertical distances in the disc. A decrease in ([CII]+[OII]63)/$F_{\mathrm{TIR}}$ but constant ([CII]+[OI]63)/$F_{\mathrm{PAH}}$ with increasing FIR colour suggests that polycyclic aromatic hydrocarbons (PAHs) may become important for gas heating in the central regions. We compare the observed flux of the FIR cooling lines and total IR emission with the predicted flux from a PDR model to determine the gas density, surface temperature and the strength of the incident far-ultraviolet (FUV) radiation field, $G_{0}$. Resolving details on physical scales of ~0.6 kpc, a pixel-by-pixel analysis reveals that the majority of the PDRs in NGC 891's disc have hydrogen densities of 1 < log ($n$/cm$^{-3}$) < 3.5 experiencing an incident FUV radiation field with strengths of 1.7 < log $G_0$ < 3. Although these values we derive for most of the disc are consistent with the gas properties found in PDRs in the spiral arms and inter-arm regions of M51, observed radial trends in $n$ and $G_0$ are shown to be sensitive to varying optical thickness in the lines, demonstrating the importance of accurately accounting for optical depth effects when interpreting observations of high inclination systems. With an empirical relationship between the MIPS 24 $\mu$m and [NII] 205 $\mu$m emission, we estimate an enhancement of the FUV radiation field strength in the far north-eastern side of the disc.Comment: Accepted for publication in A&A. 25 pages, including 17 figures and 3 tables, abstract abridged for arXi

The physical characteristics of the gas in the disk of Centaurus A using the Herschel Space Observatory

We search for variations in the disk of Centaurus A of the emission from atomic fine structure lines using Herschel PACS and SPIRE spectroscopy. In particular we observe the [C II](158 $\mu$m), [N II](122 and 205 $\mu$m), [O I](63 and 145 $\mu$m) and [O III](88 $\mu$m) lines, which all play an important role in cooling the gas in photo-ionized and photodissociation regions. We determine that the ([C II]+[O I]$_{63}$)/$F_{TIR}$ line ratio, a proxy for the heating efficiency of the gas, shows no significant radial trend across the observed region, in contrast to observations of other nearby galaxies. We determine that 10 - 20% of the observed [C II] emission originates in ionized gas. Comparison between our observations and a PDR model shows that the strength of the far-ultraviolet radiation field, $G_0$, varies between $10^{1.75}$ and $10^{2.75}$ and the hydrogen nucleus density varies between $10^{2.75}$ and $10^{3.75}$ cm$^{-3}$, with no significant radial trend in either property. In the context of the emission line properties of the grand-design spiral galaxy M51 and the elliptical galaxy NGC 4125, the gas in Cen A appears more characteristic of that in typical disk galaxies rather than elliptical galaxies.Comment: Accepted for publication in the Astrophysical Journal. 22 pages, 10 figures, 5 table

The Bending Magnets for the Proton Transfer Line of CNGS

The project "CERN neutrinos to Gran Sasso (CNGS)", a collaboration between CERN and the INFN (Gran Sasso Laboratory) in Italy, will study neutrino oscillations in a long base-line experiment. High-energy protons will be extracted from the CERN SPS accelerator, transported through a 727 m long transfer line and focused onto a graphite target to produce a beam of pions and kaons and subsequently neutrinos. The transfer line requires a total of 78 dipole magnets. They were produced in the framework of an in-kind contribution of Germany via DESY to the CNGS project. The normal conducting dipoles, built from laminated steel cores and copper coils, have a core length of 6.3 m, a 37 mm gap height and a nominal field range of 1.38 T - 1.91 T at a maximum current of 4950 A. The magnet design was a collaboration between CERN and BINP. The half-core production was subcontracted to EFREMOV Institute; the coil fabrication, magnet assembly and the field measurements were concluded at BINP in June 2004. The main design issues and results of the acceptance tests, including mechanical, electrical and magnetic field measurements, are discussed

The Quadrupole Magnets for the LHC Injection Transfer Lines

Two injection transfer lines, each about 2.8 km long, are being built to transfer protons at 450 GeV from the Super Proton Synchrotron (SPS) to the Large Hadron Collider (LHC). A total of 180 quadrupole magnets are required; they are produced in the framework of the contribution of the Russian Federation to the construction of the LHC. The classical quadrupoles, built from laminated steel cores and copper coils, have a core length of 1.4 m, an inscribed diameter of 32 mm and a strength of 53.5 T/m at a current of 530 A. The total weight of one magnet is 1.1 ton. For obtaining the required field quality at the small inscribed diameter, great care in the stamping of the laminations and the assembly of quadrants is necessary. Special instruments have been developed to measure, with a precision of some mm, the variations of the pole gaps over the full length of the magnet and correlate them to the obtained field distribution. The design has been developed in a collaboration between BINP and CERN. Fabrication and the magnetic measurements are done at BINP and should be finished at the end of the year 2000

Stimulation programs for pediatric drug research – do children really benefit?

Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants patent extensions when pediatric labeling is provided. We investigated the effectiveness of these programs in stimulating drug research in children, thereby increasing the evidence for safe and effective drug use in the pediatric population. All drugs granted pediatric exclusivity under the FDAMA were analyzed by studying the relevant summaries of medical and clinical pharmacology reviews of the pediatric studies or, if these were unavailable, the labeling information as provided by the manufacturer. A systematic search of the literature was performed to identify drug utilization patterns in children. From July 1998 to August 2006, 135 drug entities were granted pediatric exclusivity. Most frequent drug groups were anti-depressants and mood stabilizers, ACE inhibitors, lipid-lowering preparations, HIV antivirals, and non-steroidal anti-inflammatory and anti-rheumatic drugs. The distribution of the different drugs closely matched the distribution of these drugs over the adult market, and not the drug utilization by children

Performance of the LHC Arc Superconducting Quadrupoles Towards the End of their Series Fabrication

The fabrication of the 408 main arc quadrupole magnets and their cold masses will come to an end in summer 2006. A rich collection of measurement and test data has been accumulated and their analysis is presented in this paper. These data cover the fabrication and the efficiency in the use of the main components, the geometrical measurements and the achieved dimensional precision, the warm magnetic measurements in the factory and the performance at cold conditions, especially the training behaviour. The scrap rate of the Nb-Ti/Cu conductor as well as that of other components turned out to be acceptably low and the quench performance measured was in general very good. Most quadrupoles measured so far exceeded the operating field gradient with one or no quench. The multipole content at cold was measured for a limited number of quadrupoles in order to verify the warm-to-cold correlation. From the point of view of field quality, all quadrupoles could be accepted for the machine. The measures taken to overcome the problem of a too high permeability of a batch of collars are discussed

On the origin of M81 group extended dust emission

Galactic cirrus emission at far-infrared wavelengths affects many extragalactic observations. Separating this emission from that associated with extragalactic objects is both important and difficult. In this paper we discuss a particular case, the M81 group, and the identification of diffuse structures prominent in the infrared, but also detected at optical wavelengths. The origin of these structures has previously been controversial, ranging from them being the result of a past interaction between M81 and M82 or due to more local Galactic emission. We show that over an order of a few arcmin scales, the far-infrared (Herschel 250 mu m) emission correlates spatially very well with a particular narrow-velocity (2-3 km s(-1)) component of the Galactic HI. We find no evidence that any of the far-infrared emission associated with these features actually originates in the M81 group. Thus we infer that the associated diffuse optical emission must be due to galactic light-back scattered off dust in our galaxy. Ultraviolet observations pick out young stellar associations around M81, but no detectable far-infrared emission. We consider in detail one of the Galactic cirrus features, finding that the far-infrared HI relation breaks down below arcmin scales and that at smaller scales there can be quite large dust-temperature variation

A Precision Measurement of pp Elastic Scattering Cross Sections at Intermediate Energies

We have measured differential cross sections for \pp elastic scattering with internal fiber targets in the recirculating beam of the proton synchrotron COSY. Measurements were made continuously during acceleration for projectile kinetic energies between 0.23 and 2.59 GeV in the angular range $30 \leq \theta_{c.m.} \leq 90$ deg. Details of the apparatus and the data analysis are given and the resulting excitation functions and angular distributions presented. The precision of each data point is typically better than 4%, and a relative normalization uncertainty of only 2.5% within an excitation function has been reached. The impact on phase shift analysis as well as upper bounds on possible resonant contributions in lower partial waves are discussed.Comment: 23 pages 29 figure