Profile of children diagnosed with cerebral palsy at Universitas Hospital, Bloemfontein, 1991-2001

Cerebral palsy is a term used for a group of non-progressive but often changing motor deficits, which are a result of a lesion of the brain occurring at an early developmental stage. Cerebral palsy may be classified physiologically or topographically. Physiologically, there are five types of cerebral palsy1: spastic, dyskinetic, ataxic, hypotonic, and mixed. Topographically, there are six types1: hemiplegia (one arm and leg on the same side of the body are affected), monoplegia (one limb is affected), diplegia (both legs more affected than arms), quadriplegia (all limbs, body and face symmetrically affected), triplegia (three limbs are affected, usually both legs and one arm), and double hemiplegia (both sides of the body are affected asymmetrically, arms usually more than the legs).For full text, click here:SA Fam Pract 2006;48(3):15-1

Mid-J CO Emission in Nearby Seyfert Galaxies

We study for the first time the complete sub-millimeter spectra (450 GHz to 1550 GHz) of a sample of nearby active galaxies observed with the SPIRE Fourier Transform Spectrometer (SPIRE/FTS) onboard Herschel. The CO ladder (from Jup = 4 to 12) is the most prominent spectral feature in this range. These CO lines probe warm molecular gas that can be heated by ultraviolet photons, shocks, or X-rays originated in the active galactic nucleus or in young star-forming regions. In these proceedings we investigate the physical origin of the CO emission using the averaged CO spectral line energy distribution (SLED) of six Seyfert galaxies. We use a radiative transfer model assuming an isothermal homogeneous medium to estimate the molecular gas conditions. We also compare this CO SLED with the predictions of photon and X-ray dominated region (PDR and XDR) models.Comment: Proceedings of the Torus Workshop 2012 held at the University of Texas at San Antonio, 5-7 December 2012. C. Packham, R. Mason, and A. Alonso-Herrero (eds.); 6 pages, 3 figure

Insights into gas heating and cooling in the disc of NGC 891 from Herschel far-infrared spectroscopy

We present Herschel PACS and SPIRE spectroscopy of the most important far-infrared cooling lines in the nearby edge-on spiral galaxy, NGC 891: [CII] 158 $\mu$m, [NII] 122, 205 $\mu$m, [OI] 63, 145 $\mu$m, and [OIII] 88 $\mu$m. We find that the photoelectric heating efficiency of the gas, traced via the ([CII]+[OII]63)/$F_{\mathrm{TIR}}$ ratio, varies from a mean of 3.5$\times$10$^{-3}$ in the centre up to 8$\times$10$^{-3}$ at increasing radial and vertical distances in the disc. A decrease in ([CII]+[OII]63)/$F_{\mathrm{TIR}}$ but constant ([CII]+[OI]63)/$F_{\mathrm{PAH}}$ with increasing FIR colour suggests that polycyclic aromatic hydrocarbons (PAHs) may become important for gas heating in the central regions. We compare the observed flux of the FIR cooling lines and total IR emission with the predicted flux from a PDR model to determine the gas density, surface temperature and the strength of the incident far-ultraviolet (FUV) radiation field, $G_{0}$. Resolving details on physical scales of ~0.6 kpc, a pixel-by-pixel analysis reveals that the majority of the PDRs in NGC 891's disc have hydrogen densities of 1 < log ($n$/cm$^{-3}$) < 3.5 experiencing an incident FUV radiation field with strengths of 1.7 < log $G_0$ < 3. Although these values we derive for most of the disc are consistent with the gas properties found in PDRs in the spiral arms and inter-arm regions of M51, observed radial trends in $n$ and $G_0$ are shown to be sensitive to varying optical thickness in the lines, demonstrating the importance of accurately accounting for optical depth effects when interpreting observations of high inclination systems. With an empirical relationship between the MIPS 24 $\mu$m and [NII] 205 $\mu$m emission, we estimate an enhancement of the FUV radiation field strength in the far north-eastern side of the disc.Comment: Accepted for publication in A&A. 25 pages, including 17 figures and 3 tables, abstract abridged for arXi

Stimulation programs for pediatric drug research – do children really benefit?

Most drugs that are currently prescribed in pediatrics have not been tested in children. Pediatric drug studies are stimulated in the USA by the pediatric exclusivity provision under the Food and Drug Administration Modernization Act (FDAMA) that grants patent extensions when pediatric labeling is provided. We investigated the effectiveness of these programs in stimulating drug research in children, thereby increasing the evidence for safe and effective drug use in the pediatric population. All drugs granted pediatric exclusivity under the FDAMA were analyzed by studying the relevant summaries of medical and clinical pharmacology reviews of the pediatric studies or, if these were unavailable, the labeling information as provided by the manufacturer. A systematic search of the literature was performed to identify drug utilization patterns in children. From July 1998 to August 2006, 135 drug entities were granted pediatric exclusivity. Most frequent drug groups were anti-depressants and mood stabilizers, ACE inhibitors, lipid-lowering preparations, HIV antivirals, and non-steroidal anti-inflammatory and anti-rheumatic drugs. The distribution of the different drugs closely matched the distribution of these drugs over the adult market, and not the drug utilization by children

The Quadrupole Magnets for the LHC Injection Transfer Lines

Two injection transfer lines, each about 2.8 km long, are being built to transfer protons at 450 GeV from the Super Proton Synchrotron (SPS) to the Large Hadron Collider (LHC). A total of 180 quadrupole magnets are required; they are produced in the framework of the contribution of the Russian Federation to the construction of the LHC. The classical quadrupoles, built from laminated steel cores and copper coils, have a core length of 1.4 m, an inscribed diameter of 32 mm and a strength of 53.5 T/m at a current of 530 A. The total weight of one magnet is 1.1 ton. For obtaining the required field quality at the small inscribed diameter, great care in the stamping of the laminations and the assembly of quadrants is necessary. Special instruments have been developed to measure, with a precision of some mm, the variations of the pole gaps over the full length of the magnet and correlate them to the obtained field distribution. The design has been developed in a collaboration between BINP and CERN. Fabrication and the magnetic measurements are done at BINP and should be finished at the end of the year 2000

A Precision Measurement of pp Elastic Scattering Cross Sections at Intermediate Energies

We have measured differential cross sections for \pp elastic scattering with internal fiber targets in the recirculating beam of the proton synchrotron COSY. Measurements were made continuously during acceleration for projectile kinetic energies between 0.23 and 2.59 GeV in the angular range $30 \leq \theta_{c.m.} \leq 90$ deg. Details of the apparatus and the data analysis are given and the resulting excitation functions and angular distributions presented. The precision of each data point is typically better than 4%, and a relative normalization uncertainty of only 2.5% within an excitation function has been reached. The impact on phase shift analysis as well as upper bounds on possible resonant contributions in lower partial waves are discussed.Comment: 23 pages 29 figure

On the origin of M81 group extended dust emission

Galactic cirrus emission at far-infrared wavelengths affects many extragalactic observations. Separating this emission from that associated with extragalactic objects is both important and difficult. In this paper we discuss a particular case, the M81 group, and the identification of diffuse structures prominent in the infrared, but also detected at optical wavelengths. The origin of these structures has previously been controversial, ranging from them being the result of a past interaction between M81 and M82 or due to more local Galactic emission. We show that over an order of a few arcmin scales, the far-infrared (Herschel 250 mu m) emission correlates spatially very well with a particular narrow-velocity (2-3 km s(-1)) component of the Galactic HI. We find no evidence that any of the far-infrared emission associated with these features actually originates in the M81 group. Thus we infer that the associated diffuse optical emission must be due to galactic light-back scattered off dust in our galaxy. Ultraviolet observations pick out young stellar associations around M81, but no detectable far-infrared emission. We consider in detail one of the Galactic cirrus features, finding that the far-infrared HI relation breaks down below arcmin scales and that at smaller scales there can be quite large dust-temperature variation

Measurement of Spin Correlation Parameters ANN_{NN}, ASS_{SS}, and A_SL{SL} at 2.1 GeV in Proton-Proton Elastic Scattering

At the Cooler Synchrotron COSY/J\"ulich spin correlation parameters in elastic proton-proton (pp) scattering have been measured with a 2.11 GeV polarized proton beam and a polarized hydrogen atomic beam target. We report results for A$_{NN}$, A$_{SS}$, and A_${SL}$ for c.m. scattering angles between 30$^o$ and 90$^o$. Our data on A$_{SS}$ -- the first measurement of this observable above 800 MeV -- clearly disagrees with predictions of available of pp scattering phase shift solutions while A$_{NN}$ and A_${SL}$ are reproduced reasonably well. We show that in the direct reconstruction of the scattering amplitudes from the body of available pp elastic scattering data at 2.1 GeV the number of possible solutions is considerably reduced.Comment: 4 pages, 4 figure

The spatially resolved correlation between [NII] 205μm line emission and the 24μm continuum in nearby galaxies

A correlation between the 24 μm continuum and the [Nii] 205 μm line emission may arise if both quantities trace the star formation activity on spatially-resolved scales within a galaxy, yet has so far only been observed in the nearby edge-on spiral galaxy NGC 891. We therefore assess whether the [Nii] 205−24 μm emission correlation has some physical origin or is merely an artefact of line-of-sight projection effects in an edge-on disc. We search for the presence of a correlation in Herschel and Spitzer observations of two nearby face-on galaxies, M 51 and M 83, and the interacting Antennae galaxies NGC 4038 and 4039. We show that not only is this empirical relationship also observed in face-on galaxies, but also that the correlation appears to be governed by the star formation rate (SFR). Both the nuclear starburst in M 83 and the merger-induced star formation in NGC 4038/9 exhibit less [Nii] emission per unit SFR surface density than the normal star-forming discs. These regions of intense star formation exhibit stronger ionization parameters, as traced by the 70/160 μm far-infrared (FIR) colour. These observations suggest the presence of higher ionization lines that may become more important for gas cooling, thereby reducing the observed [Nii] 205 μm line emission in regions with higher star formation rates. Finally, we present a general relation between the [Nii] 205 μm line flux density and SFR density for normal star-forming galaxies, yet note that future studies should extend this analysis by including observations with wider spatial coverage for a larger sample of galaxies

Herschel-SPIRE Imaging Spectroscopy of Molecular Gas in M82

We present new Herschel-SPIRE imaging spectroscopy (194-671 microns) of the bright starburst galaxy M82. Covering the CO ladder from J=4-3 to J=13-12, spectra were obtained at multiple positions for a fully sampled ~ 3 x 3 arcminute map, including a longer exposure at the central position. We present measurements of 12CO, 13CO, [CI], [NII], HCN, and HCO+ in emission, along with OH+, H2O+ and HF in absorption and H2O in both emission and absorption, with discussion. We use a radiative transfer code and Bayesian likelihood analysis to model the temperature, density, column density, and filling factor of multiple components of molecular gas traced by 12CO and 13CO, adding further evidence to the high-J lines tracing a much warmer (~ 500 K), less massive component than the low-J lines. The addition of 13CO (and [CI]) is new and indicates that [CI] may be tracing different gas than 12CO. No temperature/density gradients can be inferred from the map, indicating that the single-pointing spectrum is descriptive of the bulk properties of the galaxy. At such a high temperature, cooling is dominated by molecular hydrogen. Photon-dominated region (PDR) models require higher densities than those indicated by our Bayesian likelihood analysis in order to explain the high-J CO line ratios, though cosmic-ray enhanced PDR models can do a better job reproducing the emission at lower densities. Shocks and turbulent heating are likely required to explain the bright high-J emission.Comment: Accepted to The Astrophysical Journal. 17 pages + 20 pages of appendix figure